Gene: ENDOD1

23052
-
endonuclease domain containing 1
protein-coding
11q21
Ensembl:ENSG00000149218 Vega:OTTHUMG00000167835 UniprotKB:O94919
NC_000011.10
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.135e-1 (AD)  7.906e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs654499chr11:95110343 (GRCh38.p7)C>A / C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCARB20.912
SLC11A20.889
DYNC1I20.873
SMARCA50.869
PICALM0.868
SRP540.868
TMEM87A0.866
TM9SF30.864
C5orf150.861
CHMP2B0.86

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.653
OR4F29-0.631
MTRNR2L6-0.27
MTRNR2L9-0.247
HMHB1-0.22
MOGAT2-0.211
MTRNR2L10-0.205
C17orf112-0.188
OR4F16-0.186
MTRNR2L1-0.181

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of ENDOD1 mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of ENDOD1 mRNA]"19414516
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ENDOD1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ENDOD1 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENDOD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENDOD1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ENDOD1 mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of ENDOD1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of ENDOD1 mRNA17562736
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of ENDOD1 mRNA]"19414516
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ENDOD1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ENDOD1 mRNA19770486
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of ENDOD1 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ENDOD1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ENDOD1 mRNA15034205|2222880
D001663BilirubinBilirubin results in decreased expression of ENDOD1 mRNA20196124
C006780bisphenol Abisphenol A results in decreased expression of ENDOD1 mRNA25181051|2698221
D019256Cadmium ChlorideCadmium Chloride affects the expression of ENDOD1 mRNA22110744
D002110CaffeineCaffeine results in decreased expression of ENDOD1 mRNA20864626
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ENDOD1 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ENDOD1 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of ENDOD1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of ENDOD1 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of ENDOD1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ENDOD1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of ENDOD1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of ENDOD1 mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of ENDOD1 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in increased expression of ENDOD1 mRNA25562108
D003907DexamethasoneDexamethasone results in decreased expression of ENDOD1 mRNA12782123
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ENDOD1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ENDOD1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ENDOD1 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of ENDOD1 mRNA22609946
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ENDOD1 mRNA24535843
C118739entinostatentinostat results in increased expression of ENDOD1 mRNA27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ENDOD1 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ENDOD1 gene20938992
D017313FenretinideFenretinide results in decreased expression of ENDOD1 mRNA28973697
D007529IsoflavonesIsoflavones results in decreased expression of ENDOD1 mRNA17374662
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ENDOD1 mRNA27392435
D007854LeadLead affects the expression of ENDOD1 mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ENDOD1 mRNA25613284
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ENDOD1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] affects the expression of ENDOD1 mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ENDOD1 gene20938992
C013598methoxyacetic acidmethoxyacetic acid results in decreased expression of ENDOD1 mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ENDOD1 mRNA20864626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ENDOD1 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ENDOD1 mRNA24810058
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of ENDOD1 mRNA20864626
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ENDOD1 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in increased expression of ENDOD1 mRNA19812364
C028007nickel monoxidenickel monoxide results in increased expression of ENDOD1 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of ENDOD1 mRNA22714537
D010100OxygenOxygen deficiency results in increased expression of ENDOD1 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of ENDOD1 mRNA]22629407
D010416PentachlorophenolPentachlorophenol results in increased expression of ENDOD1 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ENDOD1 mRNA28511854
D010634PhenobarbitalPhenobarbital affects the expression of ENDOD1 mRNA19159669
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ENDOD1 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of ENDOD1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of ENDOD1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of ENDOD1 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENDOD1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ENDOD1 mRNA26272509
D011441PropylthiouracilPropylthiouracil results in decreased expression of ENDOD1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of ENDOD1 mRNA21632981
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ENDOD1 mRNA19059307
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of ENDOD1 mRNA19167446
C016104sodium bichromatesodium bichromate affects the expression of ENDOD1 mRNA22110744
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ENDOD1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] affects the expression of ENDOD1 mRNA26378955
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of ENDOD1 mRNA19059307
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of ENDOD1 mRNA25172293
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ENDOD1 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ENDOD1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ENDOD1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ENDOD1 mRNA15034205|1946511
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ENDOD1 mRNA28065790
C012589trichostatin Atrichostatin A results in increased expression of ENDOD1 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of ENDOD1 mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ENDOD1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0004519endonuclease activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0090305nucleic acid phosphodiester bond hydrolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04210Apoptosis
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal