Gene: NCOA6

23054
AIB3|ASC2|NRC|PRIP|RAP250|TRBP
nuclear receptor coactivator 6
protein-coding
20q11.22
Ensembl:ENSG00000198646 MIM:605299 Vega:OTTHUMG00000032311 UniprotKB:Q14686
NC_000020.11
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.198e-2 (AD)  7.640e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6060038chr20:34769912 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs6141509chr20:34731584 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NSD10.935
SMG70.931
CREBBP0.929
ARID1B0.928
SEC24C0.927
PRPF80.927
TRRAP0.925
ZNF3840.923
CBFA2T20.92
PRR14L0.918

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.597
OR4F29-0.558
KLRB1-0.332
KLRF1-0.307
GZMK-0.304
CD3G-0.299
CD8B-0.297
KLRC2-0.296
TFPI2-0.291
OR4F16-0.286

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NCOA6 protein binds to and results in increased activity of NR1I3 protein]"15764585
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NCOA6 protein binds to CYP2B6 gene]"15764585
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NCOA6 protein binds to CYP3A4 gene]"15764585
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"androstan-3-ol inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NCOA6 protein binds to CYP2B6 gene]]"15764585
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NCOA6 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP1A2 mRNA]"15764585
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NCOA6 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B10 mRNA]"15764585
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NCOA6 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NCOA6 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NCOA6 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NCOA6 mRNA"28973690
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOA6 protein modified form]"28751236
D000082AcetaminophenNCOA6 protein promotes the reaction [NR1I3 protein results in increased susceptibility to Acetaminophen]15764585
D000082AcetaminophenAcetaminophen affects the expression of NCOA6 mRNA17562736
D000450Aldosterone[Aldosterone binds to NR3C2 protein] which binds to NCOA6 protein alternative form15761029
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NCOA6 mRNA16483693
C000658androstan-3-ol"androstan-3-ol inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NCOA6 protein binds to CYP2B6 gene]]"15764585
C000658androstan-3-olandrostan-3-ol inhibits the reaction [NCOA6 protein binds to and results in increased activity of NR1I3 protein]15764585
D001280AtrazineAtrazine results in decreased expression of NCOA6 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of NCOA6 mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NCOA6 mRNA"19150397
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to NCOA6 protein]23665804
D004958EstradiolNCOA6 protein results in decreased susceptibility to Estradiol23079602
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of NCOA6 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of NCOA6 mRNA26364221
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOA6 protein modified form]28751236
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NCOA6 mRNA28628672
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of NCOA6 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of NCOA6 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of NCOA6 mRNA25979313
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NCOA6 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of NCOA6 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of NCOA6 mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NCOA6 protein23301498
D005557FormaldehydeFormaldehyde results in decreased expression of NCOA6 mRNA20655997
C069837fullerene C60fullerene C60 results in increased expression of NCOA6 mRNA19167457
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NCOA6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NCOA6 mRNA28628672
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NCOA6 mRNA"24972896
D008727MethotrexateMethotrexate results in decreased expression of NCOA6 mRNA24449571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NCOA6 mRNA"26251327
D015741Metribolone[Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA6 protein modified form]28751236
D015741MetriboloneMetribolone results in increased expression of NCOA6 mRNA17010196
D009151Mustard GasMustard Gas results in decreased expression of NCOA6 mRNA26392148
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NCOA6 mRNA25729387
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NCOA6 mRNA19710929
D012293RifampinNCOA6 promotes the reaction [Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP2C9 mRNA]]21292004
D012293RifampinRifampin promotes the reaction [[HNF4A co-treated with NCOA6] results in increased expression of CYP2C9 mRNA]21292004
D012293RifampinRifampin promotes the reaction [[HNF4A co-treated with NCOA6] results in increased expression of CYP3A4 mRNA]21292004
D012293RifampinRifampin promotes the reaction [NCOA6 protein binds to HNF4A protein]21292004
C061133tamibarotenetamibarotene results in decreased expression of NCOA6 mRNA15498508
D013629TamoxifenTamoxifen inhibits the reaction [ESR1 protein binds to NCOA6 protein]23665804
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of NCOA6 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NCOA6 mRNA21570461
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NCOA6 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of NCOA6 mRNA15498508
C057693troglitazonetroglitazone results in decreased expression of NCOA6 mRNA28973697
D014520UrethaneUrethane results in increased expression of NCOA6 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of NCOA6 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of NCOA6 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NCOA6 gene25560391
C025643vinclozolinvinclozolin results in increased expression of NCOA6 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-ISS-  
GO:0003713transcription coactivator activity-IDA10567404  11443112  
GO:0005515protein binding-IPI10866662  11443112  12482968  14645241  17021013  17178841  
17500065  17925232  19047629  19433796  23870121  27705803  
GO:0019899enzyme binding-IPI12039952  
GO:0030331estrogen receptor binding-TAS11443112  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IBA21873635  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IPI11443112  
GO:0046965retinoid X receptor binding-TAS11443112  
GO:0046966thyroid hormone receptor binding-IDA11443112  
GO:0051427hormone receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006260DNA replication-NAS11443112  
GO:0006281DNA repair-NAS11443112  
GO:0006310DNA recombination-NAS11443112  
GO:0006352DNA-templated transcription, initiation-IDA10567404  
GO:0006974cellular response to DNA damage stimulus-IDA17500065  
GO:0007420brain development-ISS-  
GO:0007507heart development-ISS-  
GO:0009725response to hormone-TAS11443112  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0030099myeloid cell differentiation-IDA11302752  
GO:0030520intracellular estrogen receptor signaling pathway-NAS11443112  
GO:0042921glucocorticoid receptor signaling pathway-NAS11443112  
GO:0045893positive regulation of transcription, DNA-templated-TAS12519782  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA11443112  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA11443112  17500065  
GO:0005634nucleus-NAS10567404  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
GO:0005667transcription factor complex-TAS11443112  
GO:0005829cytosol-IDA-  
GO:0035097histone methyltransferase complex-IBA21873635  
GO:0035097histone methyltransferase complex-IDA17500065  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1368082RORA activates gene expressionTAS
R-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expressionIEA
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-1989781PPARA activates gene expressionIEA
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)IEA
R-HSA-400253Circadian ClockTAS
R-HSA-400253Circadian ClockIEA
R-HSA-556833Metabolism of lipidsTAS
R-HSA-556833Metabolism of lipidsIEA
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal