Gene: HECW1

23072
NEDL1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
protein-coding
7p14.1-p13
Ensembl:ENSG00000002746 MIM:610384 Vega:OTTHUMG00000128917 UniprotKB:Q76N89
NC_000007.14
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.392e-1 (AD)  1.608e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13226386chr7:43528505 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs17723330chr7:43247294 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs17172185chr7:43247240 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTPRT0.978
STXBP5L0.977
DLGAP10.969
PTPN30.969
ATP8A20.968
OPCML0.967
AAK10.967
MAP3K90.964
FRMPD40.964
PRKCE0.963

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.63
HEY2-0.627
YES1-0.604
COPZ2-0.597
ROM1-0.59
MYL3-0.583
AGTRAP-0.582
RNF135-0.582
CHST14-0.581
REST-0.578

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of HECW1 mRNA19933214
D001151ArsenicArsenic affects the methylation of HECW1 gene25304211
D001280AtrazineAtrazine results in decreased expression of HECW1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of HECW1 gene25435355
C006780bisphenol Abisphenol A results in increased expression of HECW1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of HECW1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of HECW1 mRNA29097150
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of HECW1 mRNA25522274
D004390ChlorpyrifosChlorpyrifos results in decreased expression of HECW1 mRNA20350560
D003033Coal TarCoal Tar results in decreased expression of HECW1 mRNA27858113
D004041Dietary FatsDietary Fats results in increased expression of HECW1 mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of HECW1 mRNA21318169
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HECW1 mRNA29097150
D007649KetamineKetamine results in decreased expression of HECW1 mRNA20080153
C008261lead acetatelead acetate results in decreased expression of HECW1 mRNA21829687
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of HECW1 mRNA27935865
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of HECW1 mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of HECW1 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of HECW1 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of HECW1 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in decreased expression of HECW1 mRNA24780913
C017947sodium arsenitesodium arsenite results in increased expression of HECW1 mRNA25879800
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HECW1 mRNA19933214
D013849ThimerosalThimerosal results in increased expression of HECW1 mRNA27188386
D014635Valproic AcidValproic Acid results in increased methylation of HECW1 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of HECW1 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO:0061630ubiquitin protein ligase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-IBA21873635  
GO:0016567protein ubiquitination-IBA21873635  
GO:0016567protein ubiquitination-IEA-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0045732positive regulation of protein catabolic process-IBA21873635  
GO:0048814regulation of dendrite morphogenesis-IBA21873635  
GO:0090090negative regulation of canonical Wnt signaling pathway-TAS-  
GO:2000650negative regulation of sodium ion transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-4641258Degradation of DVLTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal