Gene: VWA8

23078
KIAA0564
von Willebrand factor A domain containing 8
protein-coding
13q14.11
Ensembl:ENSG00000102763 MIM:617509 Vega:OTTHUMG00000016799 UniprotKB:A3KMH1
NC_000013.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.580e-1 (AD)  3.076e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7981912chr13:41622807 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHD60.885
KIAA11090.863
LONP20.856
LRBA0.846
TRAK10.844
VPS13B0.842
NF10.842
NCOA20.839
RBBP40.839
RALGAPA10.838

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.546
OR4F29-0.505
MTRNR2L6-0.292
NANOGNB-0.286
MTRNR2L10-0.269
MTRNR2L9-0.266
ADAM18-0.263
OR4F16-0.262
SPINK8-0.26
MTRNR2L8-0.255

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VWA8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VWA8 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of VWA8 mRNA21420995
D001151ArsenicArsenic affects the methylation of VWA8 gene25304211
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of VWA8 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of VWA8 mRNA21632981|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of VWA8 mRNA23735875
C038328BEP protocolBEP protocol results in decreased expression of VWA8 mRNA18987330
C006780bisphenol Abisphenol A affects the expression of VWA8 mRNA25181051
D002065BuspironeBuspirone results in increased expression of VWA8 mRNA24136188
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of VWA8 mRNA28472532
D002994ClofibrateClofibrate results in increased expression of VWA8 mRNA23811191|2527062
C118739entinostatentinostat results in increased expression of VWA8 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VWA8 mRNA"27188386
D018120FinasterideFinasteride results in increased expression of VWA8 mRNA24136188
D005485FlutamideFlutamide results in decreased expression of VWA8 mRNA24793618
D005897GlafenineGlafenine results in decreased expression of VWA8 mRNA24136188
C045463leflunomideleflunomide results in increased expression of VWA8 mRNA24136188
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of VWA8 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of VWA8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of VWA8 mRNA"25620056
C051752nefazodonenefazodone results in increased expression of VWA8 mRNA24136188
C012655nimesulidenimesulide results in increased expression of VWA8 mRNA24136188
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of VWA8 mRNA28558994
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of VWA8 mRNA28558994
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of VWA8 mRNA28558994
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of VWA8 mRNA28558994
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of VWA8 mRNA28511854
C006253pirinixic acidpirinixic acid results in increased expression of VWA8 mRNA23811191|2527062
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of VWA8 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of VWA8 mRNA23012394
C012526quercitrinquercitrin results in decreased expression of VWA8 mRNA25193878
C016104sodium bichromatesodium bichromate affects the expression of VWA8 mRNA22110744
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of VWA8 mRNA21215274
C057693troglitazonetroglitazone results in decreased expression of VWA8 mRNA28973697
C406224valdecoxibvaldecoxib results in increased expression of VWA8 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of VWA8 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of VWA8 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of VWA8 gene28853863

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO:0016887ATPase activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal