Gene: FOXO1

2308
FKH1|FKHR|FOXO1A
forkhead box O1
protein-coding
13q14.11
Ensembl:ENSG00000150907 MIM:136533 Vega:OTTHUMG00000016775 UniprotKB:Q12778
NG_023244.1
PubMed
ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.745e-1 (AD)  4.428e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FERMT20.889
USP30.864
PDLIM50.858
YAP10.856
LRP100.854
CYBRD10.853
PARD30.852
S1PR10.85
RHOBTB30.848
STOM0.846

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.593
CALHM1-0.59
RTP1-0.572
AGMAT-0.557
MCHR1-0.553
PIP5KL1-0.535
KCNB2-0.525
NEUROD6-0.521
EPHA5-0.521
SLC7A4-0.52

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [FOXO1 protein binds to CDKN1A promoter]"24769335
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [FOXO1 protein binds to FOXO1 promoter]"24769335|2476933
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [FOXO1 protein binds to G6PC promoter]"24769335
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to FOXO1 protein]"24769335
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of FOXO1 mRNA"24769335
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of FOXO1 protein"24769335
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"Testosterone metabolite inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [FOXO1 protein binds to CDKN1A promoter]]"24769335
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"Testosterone metabolite inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [FOXO1 protein binds to FOXO1 promoter]]"24769335|2476933
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"Testosterone metabolite inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [FOXO1 protein binds to G6PC promoter]]"24769335
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[ERBB2 gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased phosphorylation of FOXO1 protein"20453058
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[OGT mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased phosphorylation of FOXO1 protein"23029544
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased phosphorylation of FOXO1 protein"20453058
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PTEN gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased phosphorylation of FOXO1 protein"20453058
C0545892,4,6-triphenyl-1,3-dioxane"2,4,6-triphenyl-1,3-dioxane inhibits the reaction [FOXO1 protein binds to G6PC promoter]"23231652
C0545892,4,6-triphenyl-1,3-dioxane"2,4,6-triphenyl-1,3-dioxane inhibits the reaction [FOXO1 protein binds to PCK1 promoter]"23231652
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased localization of FOXO1 protein]12438947
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein]26385185
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of FOXO1 protein]]25171655
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and affects the localization of FOXO1 protein20181797
C0013902-hydroxyestradiol2-hydroxyestradiol results in decreased expression of FOXO1 protein23685341
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of FOXO1 mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FOXO1 mRNA"27509375
C5515283-(8-amino-1-(2-phenylquinolin-7-yl)imidazo(1,5-a)pyrazin-3-yl)-1-methylcyclobutanol"3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo(1,5-a)pyrazin-3-yl)-1-methylcyclobutanol inhibits the reaction [INS protein affects the localization of FOXO1 protein]"24933099
C0005923534-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline"4-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline inhibits the reaction [FOXO1 protein binds to G6PC promoter]"23231652
C0005923534-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline"4-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline inhibits the reaction [FOXO1 protein binds to PCK1 promoter]"23231652
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FOXO1 mRNA"18648102
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Dexamethasone affects the localization of FOXO1 protein]20181797
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
C0652504-hydroxy-equilenin4-hydroxy-equilenin results in increased expression of FOXO1 mRNA15135645
C0140364-hydroxyestradiol4-hydroxyestradiol results in decreased expression of FOXO1 protein23685341
C4067344-methylene-2-octyl-5-oxofuran-3-carboxylic acid4-methylene-2-octyl-5-oxofuran-3-carboxylic acid results in decreased phosphorylation of FOXO1 protein21442130
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol affects the localization of FOXO1 protein]"25065674
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased stability of FOXO1 protein]"25065674
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of FOXO1 protein"25065674
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased phosphorylation of FOXO1 protein"25065674
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of FOXO1 protein]"25065674
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"PRKAA2 protein affects the reaction [(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol affects the localization of FOXO1 protein]]"25065674
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Progesterone promotes the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]]"21768169
C1062506,7-dimethoxy-3-phenylquinoxaline"6,7-dimethoxy-3-phenylquinoxaline inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein]"26385185
C5505476-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]]"25665036
C0469389,11-linoleic acid"9,11-linoleic acid affects the localization of FOXO1 protein"15992797
D000082AcetaminophenAcetaminophen results in increased expression of FOXO1 mRNA21420995
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cyclosporine results in increased expression of and affects the localization of FOXO1 protein modified form]23765110
C027696acipimoxacipimox results in increased expression of FOXO1 mRNA25352640
D000171AcroleinAcrolein results in increased phosphorylation of FOXO1 protein20525806
C031143AICA ribonucleotideAICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of CAT mRNA]25065674
C031143AICA ribonucleotideAICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of SOD2 mRNA]25065674
C031143AICA ribonucleotideAICA ribonucleotide results in increased activity of FOXO1 protein25065674
C031143AICA ribonucleotideAICA ribonucleotide results in increased expression of FOXO1 protein25065674
C031143AICA ribonucleotideAICA ribonucleotide results in increased phosphorylation of FOXO1 protein25065674
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FOXO1 mRNA16483693
D000968Antimycin A[Antimycin A co-treated with resveratrol] results in decreased acetylation of FOXO1 protein24040102
D000968Antimycin AAntimycin A results in decreased expression of FOXO1 protein24040102
D000968Antimycin AFOXO1 mutant form affects the reaction [[Antimycin A co-treated with resveratrol] affects the expression of SOD2 mRNA]24040102
D000968Antimycin AFOXO1 mutant form affects the reaction [[Antimycin A co-treated with resveratrol] affects the expression of SOD2 protein]24040102
D000968Antimycin A[FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]24040102
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of FOXO1 mRNA24449571
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Herbicides results in decreased expression of FOXO1 mRNA]"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of FOXO1 mRNA]"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [triclopyr results in decreased expression of FOXO1 mRNA]"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide results in decreased expression of FOXO1 mRNA"21318024
C025657arsenic acidarsenic acid affects the localization of FOXO1 protein26763397
C006632arsenic trioxidearsenic trioxide results in increased expression of FOXO1 mRNA23911876
C015001arsenitearsenite results in increased phosphorylation of FOXO1 protein24024143
C015001arsenitewortmannin inhibits the reaction [arsenite results in increased phosphorylation of FOXO1 protein]24024143
D001194AsbestosAsbestos results in decreased expression of FOXO1 mRNA27042963
D001194Asbestos[Asbestos results in decreased expression of FOXO1 mRNA] which results in decreased susceptibility to Asbestos27042963
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased phosphorylation of FOXO1 protein"17191120
D001374Azacitidine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate co-treated with Azacitidine] results in increased expression of FOXO1 mRNA20823114
D001379AzathioprineAzathioprine inhibits the reaction [IGF1 protein results in increased phosphorylation of FOXO1 protein]23958494
C547126AZM551248AZM551248 results in decreased expression of FOXO1 mRNA22323515
C040929bafilomycin A1bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]]24889822
C487081belinostatbelinostat results in increased expression of FOXO1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene affects the activity of FOXO1 protein20624995
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of FOXO1 protein]"25065674
D001599Berberine[Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO1 protein26712469
D001599BerberineBerberine results in increased expression of and results in increased acetylation of FOXO1 protein26712469
D004958EstradiolEstradiol affects the expression of FOXO1 mRNA14699072
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate co-treated with Azacitidine] results in increased expression of FOXO1 mRNA20823114
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of FOXO1 mRNA20823114
D004958Estradiol"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]"21768169
D004958Estradiol"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
D004958Estradiol"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
D004958Estradiol"Progesterone promotes the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]]"21768169
D004958EstradiolEstradiol results in increased expression of FOXO1 mRNA23144751
C511635bis(allixinato)oxovanadium(IV)[bis(allixinato)oxovanadium(IV) results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein17805585
C511635bis(allixinato)oxovanadium(IV)bis(allixinato)oxovanadium(IV) results in increased phosphorylation of FOXO1 protein17805585
C511635bis(allixinato)oxovanadium(IV)[bis(allixinato)oxovanadium(IV) results in increased phosphorylation of FOXO1 protein] inhibits the reaction [[FOXO1 protein binds to G6PC promoter] which results in increased expression of G6PC mRNA]17805585
C006780bisphenol Abisphenol A affects the methylation of FOXO1 promoter27334623
D0151248-Bromo Cyclic Adenosine MonophosphateFOXO1 protein affects the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of FOXO3 mRNA]16709600
D0151248-Bromo Cyclic Adenosine MonophosphateFOXO1 protein affects the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of SOD2 mRNA]16709600
D0151248-Bromo Cyclic Adenosine MonophosphateFOXO1 protein affects the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased secretion of IGFBP1 protein]16709600
D0151248-Bromo Cyclic Adenosine MonophosphateFOXO1 protein affects the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased secretion of PRL protein]16709600
D0151248-Bromo Cyclic Adenosine MonophosphateHydrogen Peroxide inhibits the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of FOXO1 mRNA]16709600
D0151248-Bromo Cyclic Adenosine MonophosphateHydrogen Peroxide inhibits the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of FOXO1 protein]16709600
D0151248-Bromo Cyclic Adenosine Monophosphate[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of FOXO1 mRNA16709600
D0151248-Bromo Cyclic Adenosine Monophosphate[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of FOXO1 protein16709600
D002065BuspironeBuspirone results in increased expression of FOXO1 mRNA24136188
C027561butylbenzyl phthalatebutylbenzyl phthalate results in increased expression of and results in increased acetylation of FOXO1 protein27923775
D020148Butyric AcidButyric Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein]27270450
D002104CadmiumCadmium results in decreased expression of FOXO1 mRNA25490952
D002104CadmiumNitric Oxide inhibits the reaction [Cadmium results in decreased expression of FOXO1 mRNA]25490952
D002104Cadmiumspermine nitric oxide complex inhibits the reaction [Cadmium results in decreased expression of FOXO1 mRNA]25490952
D002104CadmiumCadmium results in increased expression of FOXO1 mRNA27492225
D002104CadmiumCadmium results in increased expression of FOXO1 protein27492225
C081643candesartancandesartan inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]21255808
C081643candesartan[GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]21255808
D002220CarbamazepineCarbamazepine affects the expression of FOXO1 mRNA24752500
D012721CarbarylCarbaryl results in decreased expression of FOXO1 mRNA27829164
D002737ChloropreneChloroprene results in increased expression of FOXO1 mRNA23125180
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of FOXO1 mRNA16197558
D002922CiguatoxinsCiguatoxins affects the expression of FOXO1 mRNA18353800
C007095cobaltiprotoporphyrin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of FOXO1 protein]]25171655
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of FOXO1 protein]25171655
C007095cobaltiprotoporphyrincobaltiprotoporphyrin promotes the reaction [FOXO1 protein binds to HMOX1 promoter]24255720
C007095cobaltiprotoporphyrincobaltiprotoporphyrin results in increased expression of FOXO1 mRNA24255720
C007095cobaltiprotoporphyrincobaltiprotoporphyrin results in increased expression of FOXO1 protein24255720
C007095cobaltiprotoporphyrinFOXO1 mutant form affects the reaction [cobaltiprotoporphyrin results in increased expression of SOD2 mRNA]24255720
C007095cobaltiprotoporphyrinFOXO1 mutant form inhibits the reaction [cobaltiprotoporphyrin results in increased expression of CAT mRNA]24255720
C007095cobaltiprotoporphyrinFOXO1 mutant form inhibits the reaction [cobaltiprotoporphyrin results in increased expression of CAT protein]24255720
C007095cobaltiprotoporphyrinFOXO1 mutant form inhibits the reaction [cobaltiprotoporphyrin results in increased expression of CYCS mRNA]24255720
C007095cobaltiprotoporphyrinFOXO1 mutant form inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA]24255720
C007095cobaltiprotoporphyrinFOXO1 mutant form inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]24255720
C007095cobaltiprotoporphyrinFOXO1 mutant form inhibits the reaction [cobaltiprotoporphyrin results in increased expression of PTGS1 mRNA]24255720
C007095cobaltiprotoporphyrinFOXO1 mutant form inhibits the reaction [cobaltiprotoporphyrin results in increased expression of PTGS2 mRNA]24255720
C007095cobaltiprotoporphyrinFOXO1 mutant form inhibits the reaction [cobaltiprotoporphyrin results in increased expression of PTGS2 protein]24255720
C007095cobaltiprotoporphyrinFOXO1 mutant form inhibits the reaction [cobaltiprotoporphyrin results in increased expression of SOD2 protein]24255720
C007095cobaltiprotoporphyrinNFE2L2 protein affects the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of FOXO1 protein]]25171655
D003042CocaineCocaine results in decreased expression of FOXO1 mRNA17898221
D003287Contrast MediaContrast Media results in decreased phosphorylation of FOXO1 protein25603236
D003287Contrast MediaPlant Extracts inhibits the reaction [Contrast Media results in decreased phosphorylation of FOXO1 protein]25603236
D003300CopperCopper affects the localization of FOXO1 protein16973122
D003300CopperCopper results in increased phosphorylation of FOXO1 protein16973122
D003300Copperwortmannin inhibits the reaction [Copper affects the localization of FOXO1 protein]16973122
D003300Copperwortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO1 protein]16973122
D019327Copper SulfateCopper Sulfate affects the localization of FOXO1 protein16973122|2493309
D019327Copper SulfateCopper Sulfate results in increased phosphorylation of FOXO1 protein16973122
D019327Copper Sulfatewortmannin inhibits the reaction [Copper Sulfate affects the localization of FOXO1 protein]16973122
D019327Copper Sulfatewortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of FOXO1 protein]16973122
D003471CuprizoneCuprizone results in increased expression of FOXO1 mRNA26577399
D003474CurcuminCurcumin results in decreased phosphorylation of FOXO1 protein18790744
D003474CurcuminCurcumin results in increased expression of FOXO1 mRNA18403477
D016572CyclosporineCyclosporine results in decreased expression of FOXO1 mRNA20106945
D016572CyclosporineAcetylcysteine inhibits the reaction [Cyclosporine results in increased expression of and affects the localization of FOXO1 protein modified form]23765110
D016572CyclosporineCyclosporine results in increased expression of and affects the localization of FOXO1 protein modified form23765110
C014347decitabine[decitabine co-treated with vorinostat] affects the expression of FOXO1 mRNA17330099
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of FOXO1 protein15976193
D003907DexamethasoneDexamethasone results in increased expression of FOXO1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FOXO1 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of FOXO1 protein22733784
D003907Dexamethasone4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Dexamethasone affects the localization of FOXO1 protein]20181797
D003907DexamethasoneDexamethasone affects the localization of FOXO1 protein20181797
D003907DexamethasoneDexamethasone affects the localization of [MAPK14 protein modified form binds to FOXO1 protein]20181797
D003907DexamethasoneDexamethasone inhibits the reaction [YWHAH protein binds to FOXO1 protein]20181797
D003907DexamethasoneDexamethasone promotes the reaction [FOXO1 protein binds to SIRT1 protein]20181797
D003907Dexamethasone[Dexamethasone promotes the reaction [FOXO1 protein binds to SIRT1 protein]] which results in decreased acetylation of FOXO1 protein20181797
D003907DexamethasoneDexamethasone promotes the reaction [MAPK14 protein modified form binds to FOXO1 protein]20181797
D003907DexamethasoneDexamethasone results in decreased acetylation of FOXO1 protein20181797
D003907DexamethasoneDexamethasone results in decreased phosphorylation of FOXO1 protein20181797
D003907DexamethasoneDexamethasone results in increased expression of FOXO1 mRNA20032058|2109414
D003907DexamethasoneDexamethasone results in increased expression of FOXO1 protein21094144
D003907DexamethasoneINS1 protein inhibits the reaction [Dexamethasone affects the localization of FOXO1 protein]20181797
D003907DexamethasoneINS1 protein inhibits the reaction [Dexamethasone inhibits the reaction [YWHAH protein binds to FOXO1 protein]]20181797
D003907DexamethasoneINS1 protein inhibits the reaction [Dexamethasone results in decreased acetylation of FOXO1 protein]20181797
D003907DexamethasoneINS1 protein inhibits the reaction [Dexamethasone results in decreased phosphorylation of FOXO1 protein]20181797
D003907DexamethasoneNiacinamide inhibits the reaction [Dexamethasone results in decreased acetylation of FOXO1 protein]20181797
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of FOXO1 mRNA]20032058|2109414
D003973DiatrizoateDiatrizoate results in decreased phosphorylation of FOXO1 protein25603236
D003973DiatrizoatePlant Extracts inhibits the reaction [Diatrizoate results in decreased phosphorylation of FOXO1 protein]25603236
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate co-treated with Azacitidine] results in increased expression of FOXO1 mRNA20823114
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of FOXO1 mRNA20823114
D002945CisplatinCisplatin results in decreased expression of FOXO1 mRNA27392435
D004008DiclofenacDiclofenac affects the expression of FOXO1 mRNA24752500
C000944dicrotophosdicrotophos results in increased expression of FOXO1 mRNA28302478
D004041Dietary Fats[Dietary Fats co-treated with Glucose] results in decreased expression of FOXO1 mRNA23884882
D004041Dietary Fats[Dietary Fats co-treated with Glucose] results in decreased expression of FOXO1 protein23884882
D004041Dietary Fatsresveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of FOXO1 mRNA]23884882
D004041Dietary Fatsresveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of FOXO1 protein]23884882
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of FOXO1 mRNA]"19467301
D004041Dietary FatsDietary Fats affects the expression of FOXO1 mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of FOXO1 mRNA18042831
D004041Dietary FatsDietary Fats results in decreased phosphorylation of FOXO1 protein27417254
D004041Dietary FatsDietary Fats results in increased expression of and results in decreased phosphorylation of FOXO1 protein27417254
D004041Dietary FatsDietary Fats results in increased expression of FOXO1 mRNA19467301
D004041Dietary Fats"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in increased expression of and results in decreased phosphorylation of FOXO1 protein]"27417254
D004041Dietary FatsSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of FOXO1 protein]26522834
D004041Dietary Fats[Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of FOXO1 protein26522834
D004041Dietary FatsButyric Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein]27270450
D004041Dietary Fats[Dietary Fats co-treated with Ethanol] results in increased expression of FOXO1 mRNA24275070
D004041Dietary Fats[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein27270450
D004041Dietary FatsDietary Fats results in increased expression of FOXO1 mRNA24275070
D004041Dietary FatsMetformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein]27270450
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of and results in decreased phosphorylation of FOXO1 protein25280772
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of FOXO1 mRNA25280772
D002117CalcitriolCalcitriol results in decreased expression of FOXO1 mRNA26485663
D002117CalcitriolCalcitriol results in increased expression of FOXO1 mRNA16002434
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [VEGFA protein results in increased phosphorylation of FOXO1 protein]15308628
D004178DiquatDiquat results in increased expression of FOXO1 mRNA27057282
D004178Diquatprocyanidin B2 inhibits the reaction [Diquat results in increased expression of FOXO1 mRNA]27057282
D004317DoxorubicinDoxorubicin results in increased phosphorylation of FOXO1 protein17935137
D004317Doxorubicinwortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO1 protein]17935137
D004317Doxorubicin"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]]"25665036
D004317DoxorubicinDoxorubicin results in increased acetylation of FOXO1 protein25665036
D004317DoxorubicinDoxorubicin results in increased expression of FOXO1 mRNA28329872
D004317Doxorubicinresveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]25665036
D004317Doxorubicinsirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]]25665036
D004642EmodinEmodin results in increased expression of FOXO1 mRNA16045814
C118739entinostatentinostat results in increased expression of FOXO1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
D000431EthanolEthanol results in increased acetylation of FOXO1 protein20007851
D000431Ethanol[resveratrol co-treated with Ethanol] results in increased expression of FOXO1 mRNA18755807
D000431Ethanolrosiglitazone inhibits the reaction [Ethanol results in increased acetylation of FOXO1 protein]20007851
D000431Ethanol[Dietary Fats co-treated with Ethanol] results in increased expression of FOXO1 mRNA24275070
D000431EthanolEthanol results in decreased acetylation of FOXO1 protein23544086
D000431Ethanoltauroursodeoxycholic acid inhibits the reaction [Ethanol results in decreased acetylation of FOXO1 protein]23544086
D005047EtoposideEtoposide results in increased phosphorylation of FOXO1 protein17935137
D005047Etoposidewortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO1 protein]17935137
C580814EUK-172EUK-172 inhibits the reaction [Hydrogen Peroxide results in increased expression of and affects the localization of FOXO1 protein]23041154
D005557FormaldehydeFormaldehyde results in decreased expression of FOXO1 mRNA20655997
D005632FructoseFructose results in increased expression of and affects the localization of FOXO1 protein23533474
D005632FructoseFructose results in increased expression of and results in increased phosphorylation of FOXO1 protein23533474
D005632FructoseFructose results in increased expression of FOXO1 mRNA19196556
D005632FructoseQuercetin inhibits the reaction [Fructose results in increased expression of and affects the localization of FOXO1 protein]23533474
D005632FructoseQuercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of FOXO1 protein]23533474
D005632Fructoserosiglitazone inhibits the reaction [Fructose results in increased expression of FOXO1 mRNA]19196556
C007835geniposidegeniposide inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]22819839
D005947GlucoseGlucose results in increased acetylation of and results in decreased activity of FOXO1 protein23494737
D005947GlucoseSIRT3 protein inhibits the reaction [Glucose results in increased acetylation of FOXO1 protein]23494737
D005947Glucose[Dietary Fats co-treated with Glucose] results in decreased expression of FOXO1 mRNA23884882
D005947Glucose[Dietary Fats co-treated with Glucose] results in decreased expression of FOXO1 protein23884882
D005947Glucoseresveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of FOXO1 mRNA]23884882
D005947Glucoseresveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of FOXO1 protein]23884882
D005947GlucoseFOXO1 protein inhibits the reaction [Glucose results in decreased expression of ADIPOR1 mRNA]24413998
D005947GlucoseFOXO1 protein inhibits the reaction [Glucose results in decreased expression of ADIPOR1 protein]24413998
D005947GlucoseFOXO1 protein mutant form results in increased abundance of Glucose15788402
D005947GlucoseFOXO1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of ADIPOR1 mRNA]]24413998
D005947GlucoseFOXO1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of ADIPOR1 protein]]24413998
D005947GlucoseFOXO1 protein results in decreased susceptibility to Glucose24413998
D005947GlucoseFOXO1 protein results in increased abundance of Glucose15788402
D005947GlucoseGlucose results in increased phosphorylation of and results in decreased activity of FOXO1 protein24413998
D005947GlucoseINS1 protein inhibits the reaction [FOXO1 protein results in increased abundance of Glucose]15788402
D005947GlucoseINS1 protein promotes the reaction [FOXO1 protein mutant form results in increased abundance of Glucose]15788402
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased phosphorylation of and results in decreased activity of FOXO1 protein]24413998
D005947Glucoseresveratrol promotes the reaction [FOXO1 protein results in increased abundance of Glucose]15788402
D006540Herbicides"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Herbicides results in decreased expression of FOXO1 mRNA]"21318024
D006540HerbicidesHerbicides results in decreased expression of FOXO1 mRNA21318024
D017313FenretinideFenretinide results in decreased expression of FOXO1 mRNA28973697
D006854HydrocortisoneHydrocortisone results in increased expression of FOXO1 mRNA21267416
D006861Hydrogen PeroxideHydrogen Peroxide results in increased localization of FOXO1 protein15788402
D006861Hydrogen PeroxideEUK-172 inhibits the reaction [Hydrogen Peroxide results in increased expression of and affects the localization of FOXO1 protein]23041154
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of FOXO1 mRNA]16709600
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of FOXO1 protein]16709600
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased phosphorylation of FOXO1 protein19451193
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of and affects the localization of FOXO1 protein23041154
D006861Hydrogen PeroxideFOXO1 protein affects the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]27057282
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of and affects the localization of FOXO1 protein27057282
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of FOXO1 mRNA27057282
D006861Hydrogen Peroxideprocyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of and affects the localization of FOXO1 protein]27057282
D006861Hydrogen Peroxideprocyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO1 mRNA]27057282
D006861Hydrogen Peroxidebafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]]24889822
D006861Hydrogen PeroxideFOXO1 mRNA inhibits the reaction [Hydrogen Peroxide results in increased cleavage of and results in increased activity of CASP3 protein]26354380
D006861Hydrogen PeroxideFOXO1 mRNA inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein]26354380
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of FOXO1 protein21159781
D006861Hydrogen PeroxideHydrogen Peroxide results in increased acetylation of FOXO1 protein24889822
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of FOXO1 protein26354380
D006861Hydrogen Peroxideresveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]24889822
D006861Hydrogen PeroxideSIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]]24889822
D006861Hydrogen Peroxidesirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]]24889822
D006861Hydrogen Peroxidesirtinol promotes the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]24889822
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [FOXO1 protein binds to SIRT1 protein]15788402
D006861Hydrogen PeroxideHydrogen Peroxide results in increased localization of [FOXO1 protein binds to SIRT1 protein]15788402
D006861Hydrogen PeroxideINS protein inhibits the reaction [Hydrogen Peroxide results in increased localization of FOXO1 protein]15788402
D006861Hydrogen PeroxideNiacinamide inhibits the reaction [Hydrogen Peroxide results in increased localization of FOXO1 protein]15788402
D006861Hydrogen Peroxide[resveratrol co-treated with Hydrogen Peroxide] results in increased localization of FOXO1 protein15788402
D006918HydroxyureaHydroxyurea results in increased expression of FOXO1 mRNA27208086
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FOXO1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FOXO1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FOXO1 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased phosphorylation of FOXO1 protein15618457
D007649KetamineKetamine results in decreased expression of FOXO1 mRNA20080153
C045463leflunomideleflunomide results in increased expression of FOXO1 mRNA28988120
C038753leptomycin Bleptomycin B affects the localization of FOXO1 protein26026911
C038753leptomycin Bleptomycin B results in increased localization of FOXO1 protein15788402
C027820ligustilideligustilide results in decreased phosphorylation of FOXO1 protein23973442
C027820ligustilideligustilide results in decreased phosphorylation of FOXO1 protein23973442
D008070Lipopolysaccharides2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of FOXO1 protein]]25171655
D008070Lipopolysaccharidescobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of FOXO1 protein]25171655
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of FOXO1 protein25171655
D008070LipopolysaccharidesNFE2L2 protein affects the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of FOXO1 protein]]25171655
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate co-treated with Azacitidine] results in increased expression of FOXO1 mRNA20823114
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of FOXO1 mRNA20823114
D017258Medroxyprogesterone AcetateFOXO1 protein affects the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of FOXO3 mRNA]16709600
D017258Medroxyprogesterone AcetateFOXO1 protein affects the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of SOD2 mRNA]16709600
D017258Medroxyprogesterone AcetateFOXO1 protein affects the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased secretion of IGFBP1 protein]16709600
D017258Medroxyprogesterone AcetateFOXO1 protein affects the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased secretion of PRL protein]16709600
D017258Medroxyprogesterone AcetateHydrogen Peroxide inhibits the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of FOXO1 mRNA]16709600
D017258Medroxyprogesterone AcetateHydrogen Peroxide inhibits the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of FOXO1 protein]16709600
D017258Medroxyprogesterone Acetate[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of FOXO1 mRNA16709600
D017258Medroxyprogesterone Acetate[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of FOXO1 protein16709600
D008687MetforminMetformin results in decreased expression of FOXO1 mRNA24428821
D008687MetforminMetformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein]27270450
D008727MethotrexateMethotrexate affects the expression of FOXO1 mRNA18502557
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in increased expression of and results in decreased phosphorylation of FOXO1 protein]"27417254
D008775MethylprednisoloneMethylprednisolone results in increased expression of FOXO1 protein21931329
D008775MethylprednisoloneTestosterone inhibits the reaction [Methylprednisolone results in increased expression of FOXO1 protein]21931329
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of FOXO1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FOXO1 mRNA"23634900
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FOXO1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FOXO1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FOXO1 mRNA"25926378
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of FOXO1 mRNA19812364
D009525NiacinNiacin results in decreased phosphorylation of and results in increased activity of FOXO1 protein20303128
D009538Nicotine[Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein12511591
D009569Nitric OxideNitric Oxide inhibits the reaction [Cadmium results in decreased expression of FOXO1 mRNA]25490952
D019787Linoleic AcidLinoleic Acid results in decreased expression of FOXO1 protein17374693
C507134ON 01910ON 01910 affects the phosphorylation of FOXO1 protein19198627
C000594117ON123300ON123300 results in decreased phosphorylation of FOXO1 protein26174628
D010100OxygenOxygen deficiency results in increased expression of FOXO1 mRNA23624791
D010100Oxygen[Oxygen deficiency co-treated with Oxygen] affects the localization of and results in decreased phosphorylation of FOXO1 protein21159781
D019308Palmitic Acidcandesartan inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]21255808
D019308Palmitic Acid[GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]21255808
D019308Palmitic AcidGCG protein inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]21255808
D019308Palmitic AcidPalmitic Acid results in decreased phosphorylation of FOXO1 protein21255808
D019308Palmitic Acidgeniposide inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]22819839
D019308Palmitic AcidPalmitic Acid results in decreased phosphorylation of FOXO1 protein22819839
D019308Palmitic AcidPalmitic Acid results in increased localization of FOXO1 protein22968147
D019308Palmitic Acidresveratrol inhibits the reaction [Palmitic Acid results in increased localization of FOXO1 protein]22968147
D000073878Palm OilPalm Oil results in decreased expression of FOXO1 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of FOXO1 mRNA26272509
D010416PentachlorophenolPentachlorophenol results in increased expression of FOXO1 mRNA23892564
D010656PhenylephrinePhenylephrine promotes the reaction [FOXO1 protein results in increased expression of TNF mRNA]16020479
D010656PhenylephrinePhenylephrine results in increased expression of and results in decreased phosphorylation of and affects the localization of FOXO1 protein16020479
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
D010833Phytic Acid[resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of FOXO1 mRNA18657603
D010846Picloram"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of FOXO1 mRNA]"21318024
D010846PicloramPicloram results in decreased expression of FOXO1 mRNA21318024
C498077piperlongumininepiperlonguminine affects the localization of FOXO1 protein26026911
C498077piperlongumininepiperlonguminine inhibits the reaction [FOXO1 protein binds to XPO1 protein]26026911
C006253pirinixic acidpirinixic acid results in increased expression of FOXO1 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased phosphorylation of FOXO1 protein19748123
D010936Plant ExtractsPlant Extracts inhibits the reaction [Contrast Media results in decreased phosphorylation of FOXO1 protein]25603236
D010936Plant ExtractsPlant Extracts inhibits the reaction [Diatrizoate results in decreased phosphorylation of FOXO1 protein]25603236
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of FOXO1 mRNA28903501
C017674procyanidinprocyanidin results in decreased phosphorylation of FOXO1 protein15827326
C479580procyanidin B2FOXO1 protein affects the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]27057282
C479580procyanidin B2procyanidin B2 inhibits the reaction [Diquat results in increased expression of FOXO1 mRNA]27057282
C479580procyanidin B2procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of and affects the localization of FOXO1 protein]27057282
C479580procyanidin B2procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO1 mRNA]27057282
D011374Progesterone"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
D011374Progesterone"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]"21768169
D011374Progesterone"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
D011374Progesterone"Progesterone promotes the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [FOXO1 protein binds to G6PC promoter]]]"21768169
D011374ProgesteroneProgesterone results in increased expression of FOXO1 mRNA20864642
D011374ProgesteroneProgesterone results in decreased expression of FOXO117510236
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein]26385185
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein]26385185
D011794Quercetin[resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of FOXO1 mRNA18657603
D011794QuercetinQuercetin inhibits the reaction [Fructose results in increased expression of and affects the localization of FOXO1 protein]23533474
D011794QuercetinQuercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of FOXO1 protein]23533474
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of FOXO1 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FOXO1 mRNA19059307
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]25554529
C059514resveratrol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol affects the localization of FOXO1 protein]"25065674
C059514resveratrol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased stability of FOXO1 protein]"25065674
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in decreased expression of CCND1 protein]21179458
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in increased expression of BCL2L11 protein alternative form]21179458
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in increased expression of CDKN1B protein]21179458
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in increased expression of NOS3 mRNA]23583951
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in increased expression of NOS3 protein]23583951
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in increased expression of TNFRSF10A protein]21179458
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in increased expression of TNFRSF10B protein]21179458
C059514resveratrolFOXO1 protein results in decreased susceptibility to resveratrol20012470
C059514resveratrolresveratrol affects the localization of and results in decreased phosphorylation of FOXO1 protein21980390
C059514resveratrolresveratrol affects the localization of FOXO1 protein25065674
C059514resveratrolresveratrol inhibits the reaction [AKT1 protein results in increased phosphorylation of FOXO1 protein]16343977
C059514resveratrolresveratrol promotes the reaction [FOXO1 protein binds to NOS3 promoter]23583951
C059514resveratrolresveratrol promotes the reaction [FOXO1 protein results in increased expression of CAT mRNA]25065674
C059514resveratrolresveratrol promotes the reaction [FOXO1 protein results in increased expression of SOD2 mRNA]25065674
C059514resveratrolresveratrol results in decreased phosphorylation of FOXO1 protein21179458
C059514resveratrolresveratrol results in decreased ubiquitination of FOXO1 protein25065674
C059514resveratrolresveratrol results in increased activity of FOXO1 protein23583951|2506567
C059514resveratrolresveratrol results in increased expression of FOXO1 protein23583951
C059514resveratrolresveratrol results in increased phosphorylation of FOXO1 protein25065674
C059514resveratrolresveratrol results in increased stability of FOXO1 protein25065674
C059514resveratrolresveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of FOXO1 mRNA]23884882
C059514resveratrolresveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of FOXO1 protein]23884882
C059514resveratrol"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]]"25665036
C059514resveratrol[Antimycin A co-treated with resveratrol] results in decreased acetylation of FOXO1 protein24040102
C059514resveratrolFOXO1 mutant form affects the reaction [[Antimycin A co-treated with resveratrol] affects the expression of SOD2 mRNA]24040102
C059514resveratrolFOXO1 mutant form affects the reaction [[Antimycin A co-treated with resveratrol] affects the expression of SOD2 protein]24040102
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in increased expression of ADIPOQ protein]20980258
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in increased expression of GSTK1 protein]20980258
C059514resveratrol[FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]24040102
C059514resveratrolFOXO1 protein promotes the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of FBXO32 mRNA]]24534773
C059514resveratrolFOXO1 protein promotes the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of TRIM63 mRNA]]24534773
C059514resveratrol[resveratrol co-treated with Ethanol] results in increased expression of FOXO1 mRNA18755807
C059514resveratrol[resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of FOXO1 mRNA18657603
C059514resveratrolresveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]25665036
C059514resveratrolresveratrol inhibits the reaction [stearic acid results in decreased expression of FOXO1 protein]17374693
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in increased acetylation of FOXO1 protein]24889822
C059514resveratrolresveratrol inhibits the reaction [TNF protein results in increased expression of and results in decreased phosphorylation of FOXO1 protein]24534773
C059514resveratrolresveratrol promotes the reaction [FOXO1 protein results in increased expression of G6PC mRNA]16917544
C059514resveratrolresveratrol promotes the reaction [FOXO1 protein results in increased expression of IGFBP1 mRNA]16917544
C059514resveratrolresveratrol results in decreased phosphorylation of and results in decreased acetylation of and results in increased localization of FOXO1 protein20026400
C059514resveratrolresveratrol results in decreased phosphorylation of FOXO1 protein20980258|2198039
C059514resveratrolresveratrol results in increased expression of FOXO1 mRNA25338179
C059514resveratrolresveratrol results in increased phosphorylation of FOXO1 protein24534773|2514019
C059514resveratrolsirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]]25665036
C059514resveratrolbafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]]24889822
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in increased expression of G6PC mRNA]15788402
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in increased expression of IGFBP1 mRNA]15788402
C059514resveratrolFOXO1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of ADIPOR1 mRNA]]24413998
C059514resveratrolFOXO1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of ADIPOR1 protein]]24413998
C059514resveratrolFOXO1 protein promotes the reaction [resveratrol inhibits the reaction [HNF4A protein binds to GCK promoter]]19740748
C059514resveratrolFOXO1 protein promotes the reaction [resveratrol results in decreased activity of GCK protein]19740748
C059514resveratrolFOXO1 protein promotes the reaction [resveratrol results in decreased expression of GCK mRNA]19740748
C059514resveratrolFOXO1 protein results in increased susceptibility to resveratrol24413998
C059514resveratrolresveratrol inhibits the reaction [AGT protein promotes the reaction [SIRT1 protein binds to FOXO1 protein]]26955731
C059514resveratrolresveratrol inhibits the reaction [AGT protein results in increased acetylation of FOXO1 protein]26955731
C059514resveratrolresveratrol inhibits the reaction [CREBBP protein results in increased acetylation of FOXO1 protein]19740748
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased phosphorylation of and results in decreased activity of FOXO1 protein]24413998
C059514resveratrolresveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]24889822
C059514resveratrolresveratrol inhibits the reaction [Palmitic Acid results in increased localization of FOXO1 protein]22968147
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in decreased expression of FOXO1 mRNA]22733486
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of and results in decreased activity of FOXO1 protein]22733486
C059514resveratrolresveratrol promotes the reaction [FOXO1 protein binds to GCK promoter]19740748
C059514resveratrolresveratrol promotes the reaction [FOXO1 protein binds to HNF4A protein]19740748
C059514resveratrol[resveratrol promotes the reaction [FOXO1 protein binds to HNF4A protein]] which results in decreased expression of GCK mRNA19740748
C059514resveratrolresveratrol promotes the reaction [FOXO1 protein binds to RAB7A promoter]24889822
C059514resveratrolresveratrol promotes the reaction [FOXO1 protein results in increased abundance of Glucose]15788402
C059514resveratrolresveratrol results in decreased acetylation of FOXO1 protein19740748
C059514resveratrolresveratrol results in decreased expression of FOXO1 protein modified form23479127
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] which results in increased acetylation of and results in decreased degradation of FOXO1 protein18077353
C059514resveratrolresveratrol results in increased expression of FOXO1 protein18077353|2097282
C059514resveratrolresveratrol results in increased localization of and results in increased activity of FOXO1 protein18077353
C059514resveratrol[resveratrol results in increased localization of and results in increased activity of FOXO1 protein] which results in increased expression of FBXO32 mRNA18077353
C059514resveratrolSIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]]24889822
C059514resveratrolSIRT1 protein promotes the reaction [resveratrol promotes the reaction [FOXO1 protein binds to RAB7A promoter]]24889822
C059514resveratrolsirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]]24889822
C059514resveratrolresveratrol results in decreased expression of FOXO1 mRNA17851734
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in increased expression of TNFSF10 protein]21179458
C059514resveratrolFOXO1 protein affects the susceptibility to resveratrol21179458
C059514resveratrolNiacinamide inhibits the reaction [resveratrol results in increased localization of FOXO1 protein]15788402
C059514resveratrol"PRKAA2 protein affects the reaction [(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol affects the localization of FOXO1 protein]]"25065674
C059514resveratrolPRKAA2 protein affects the reaction [resveratrol promotes the reaction [FOXO1 protein results in increased expression of CAT mRNA]]25065674
C059514resveratrolPRKAA2 protein affects the reaction [resveratrol promotes the reaction [FOXO1 protein results in increased expression of SOD2 mRNA]]25065674
C059514resveratrolPRKAA2 protein affects the reaction [resveratrol results in decreased ubiquitination of FOXO1 protein]25065674
C059514resveratrolresveratrol affects the localization of and results in increased activity of FOXO1 protein mutant form21179458
C059514resveratrolresveratrol affects the localization of FOXO1 protein21179458
C059514resveratrol[resveratrol co-treated with Hydrogen Peroxide] results in increased localization of FOXO1 protein15788402
C059514resveratrolresveratrol results in increased localization of FOXO1 protein15788402
C089730rosiglitazonerosiglitazone inhibits the reaction [Ethanol results in increased acetylation of FOXO1 protein]20007851
C089730rosiglitazonerosiglitazone inhibits the reaction [Fructose results in increased expression of FOXO1 mRNA]19196556
C089730rosiglitazonerosiglitazone results in increased expression of FOXO1 mRNA21373642
C089730rosiglitazoneSIRT6 affects the reaction [rosiglitazone results in increased expression of FOXO1 mRNA]21373642
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of FOXO1 mRNA"21148743
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FOXO1 mRNA25895662
D019821Simvastatin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased localization of FOXO1 protein]12438947
D019821SimvastatinSimvastatin results in decreased localization of FOXO1 protein12438947
D019821SimvastatinSimvastatin affects the localization of FOXO1 protein19001041
D019821SimvastatinSimvastatin results in decreased phosphorylation of FOXO1 protein19001041
D019821SimvastatinSimvastatin results in increased phosphorylation of FOXO1 protein18826357
D020123SirolimusSirolimus results in increased phosphorylation of FOXO1 protein16227402
D020123SirolimusSirolimus affects the localization of FOXO1 protein20622751
D020123SirolimusSirolimus results in increased expression of FOXO1 mRNA20622751
D020123SirolimusSirolimus results in increased expression of FOXO1 protein20622751
C439060sirtinolsirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]]25665036
C439060sirtinolsirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]]24889822
C439060sirtinolsirtinol promotes the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]24889822
C439060sirtinolsirtinol results in increased acetylation of FOXO1 protein24889822
C017947sodium arsenitesodium arsenite affects the localization of FOXO1 protein24535192
C017947sodium arsenitesodium arsenite results in increased acetylation of FOXO1 protein25610880
C017947sodium arsenitesodium arsenite results in increased expression of FOXO1 mRNA19822182
D012965Sodium ChlorideSodium Chloride results in decreased expression of FOXO1 mRNA23634900
D018038Sodium SeleniteSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of FOXO1 protein]26522834
C091861spermine nitric oxide complexspermine nitric oxide complex inhibits the reaction [Cadmium results in decreased expression of FOXO1 mRNA]25490952
C570705spirotetramatspirotetramat results in increased expression of FOXO1 mRNA27917277
C000601293SRT3025SRT3025 inhibits the reaction [TNFSF11 protein results in increased acetylation of FOXO1 protein]26287518
C000601293SRT3025SRT3025 results in increased expression of FOXO1 mRNA26287518
C031183stearic acidresveratrol inhibits the reaction [stearic acid results in decreased expression of FOXO1 protein]17374693
C031183stearic acidstearic acid results in decreased expression of FOXO1 protein17374693
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]25554529
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in increased acetylation of FOXO1 protein]24889822
D013311StreptozocinSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of FOXO1 protein]26522834
D013311Streptozocin[Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of FOXO1 protein26522834
D013311StreptozocinStreptozocin results in increased acetylation of FOXO1 protein24889822
D013311StreptozocinButyric Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein]27270450
D013311Streptozocin[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein27270450
D013311StreptozocinMetformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein]27270450
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in decreased expression of FOXO1 mRNA]22733486
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of and results in decreased activity of FOXO1 protein]22733486
D013311StreptozocinStreptozocin results in decreased expression of FOXO1 mRNA22733486
D013311StreptozocinStreptozocin results in increased phosphorylation of and results in decreased activity of FOXO1 protein22733486
D013469SulpirideSulpiride affects the localization of FOXO1 protein modified form26466350
C013698tallowtallow affects the expression of FOXO1 mRNA19680557
D013629TamoxifenESR1 protein affects the reaction [Tamoxifen results in increased expression of FOXO1 mRNA]14699072
D013629TamoxifenTamoxifen affects the expression of FOXO1 mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of FOXO1 mRNA19059307
D013629TamoxifenTamoxifen affects the expression of FOXO1 mRNA20937368
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Ethanol results in decreased acetylation of FOXO1 protein]23544086
D013739Testosterone"Testosterone metabolite inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [FOXO1 protein binds to CDKN1A promoter]]"24769335
D013739Testosterone"Testosterone metabolite inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [FOXO1 protein binds to FOXO1 promoter]]"24769335|2476933
D013739Testosterone"Testosterone metabolite inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [FOXO1 protein binds to G6PC promoter]]"24769335
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of FOXO1 mRNA]20032058|2109414
D013739TestosteroneTestosterone inhibits the reaction [Methylprednisolone results in increased expression of FOXO1 protein]21931329
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of FOXO1 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOXO1 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOXO1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FOXO1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FOXO1 mRNA25613284
D014118Toxins, Biological"Toxins, Biological affects the expression of FOXO1 mRNA"19682533
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid affects the localization of FOXO1 protein"15992797
D014212TretinoinTretinoin results in increased expression of FOXO1 mRNA21934132
D014212TretinoinTretinoin results in decreased expression of FOXO1 mRNA24977338
C011559tributyltintributyltin results in decreased expression of FOXO1 mRNA28011154
C447082tricarbonyldichlororuthenium (II) dimer2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein]26385185
C447082tricarbonyldichlororuthenium (II) dimer"6,7-dimethoxy-3-phenylquinoxaline inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein]"26385185
C447082tricarbonyldichlororuthenium (II) dimerAKT1 protein promotes the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein]26385185
C447082tricarbonyldichlororuthenium (II) dimerFOXO1 protein promotes the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 protein]26385185
C447082tricarbonyldichlororuthenium (II) dimerProtein Kinase Inhibitors inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein]26385185
C447082tricarbonyldichlororuthenium (II) dimerpyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein]26385185
C447082tricarbonyldichlororuthenium (II) dimertricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein26385185
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of FOXO1 mRNA24935251|2627250
C012589trichostatin A[Niacinamide co-treated with trichostatin A] inhibits the reaction [FOXO1 protein binds to SIRT1 protein]15788402
C012589trichostatin Atrichostatin A affects the localization of FOXO1 protein15788402
C032742triclopyr"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [triclopyr results in decreased expression of FOXO1 mRNA]"21318024
C032742triclopyrtriclopyr results in decreased expression of FOXO1 mRNA21318024
C057693troglitazonetroglitazone results in decreased expression of FOXO1 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXO1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of FOXO1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of FOXO1 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of FOXO1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of FOXO1 mRNA20546886
C025643vinclozolinvinclozolin affects the expression of FOXO1 mRNA19015723
D009536Niacinamide[Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO1 protein26712469
D009536NiacinamideNiacinamide results in increased expression of and results in increased acetylation of FOXO1 protein26712469
D009536NiacinamideNiacinamide inhibits the reaction [FOXO1 protein results in increased expression of G6PC mRNA]16917544
D009536NiacinamideNiacinamide inhibits the reaction [FOXO1 protein results in increased expression of IGFBP1 mRNA]16917544
D009536NiacinamideNiacinamide inhibits the reaction [Dexamethasone results in decreased acetylation of FOXO1 protein]20181797
D009536NiacinamideNiacinamide inhibits the reaction [FOXO1 protein binds to SIRT1 protein]20181797
D009536NiacinamideNiacinamide results in increased expression of FOXO1 mRNA17851734
D009536NiacinamideNiacinamide affects the localization of FOXO1 protein15788402
D009536Niacinamide[Niacinamide co-treated with trichostatin A] inhibits the reaction [FOXO1 protein binds to SIRT1 protein]15788402
D009536NiacinamideNiacinamide inhibits the reaction [Hydrogen Peroxide results in increased localization of FOXO1 protein]15788402
D009536NiacinamideNiacinamide inhibits the reaction [resveratrol results in increased localization of FOXO1 protein]15788402
D009536NiacinamideNiacinamide results in increased acetylation of FOXO1 protein15788402
D014810Vitamin EVitamin E results in decreased expression of FOXO1 mRNA19244175
C111237vorinostat[decitabine co-treated with vorinostat] affects the expression of FOXO1 mRNA17330099
C009687wortmanninwortmannin inhibits the reaction [arsenite results in increased phosphorylation of FOXO1 protein]24024143
C009687wortmanninwortmannin inhibits the reaction [Copper affects the localization of FOXO1 protein]16973122
C009687wortmanninwortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO1 protein]16973122
C009687wortmanninwortmannin inhibits the reaction [Copper Sulfate affects the localization of FOXO1 protein]16973122
C009687wortmanninwortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of FOXO1 protein]16973122
C009687wortmanninwortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO1 protein]17935137
C009687wortmanninwortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO1 protein]17935137
C009687wortmanninwortmannin inhibits the reaction [Zinc affects the localization of FOXO1 protein]16973122
C009687wortmanninwortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO1 protein]16973122
C009687wortmanninwortmannin inhibits the reaction [Zinc Sulfate affects the localization of FOXO1 protein]16973122
C009687wortmanninwortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO1 protein]16973122
D015032Zincwortmannin inhibits the reaction [Zinc affects the localization of FOXO1 protein]16973122
D015032Zincwortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO1 protein]16973122
D015032ZincZinc affects the localization of FOXO1 protein16973122
D015032ZincZinc results in increased phosphorylation of FOXO1 protein16973122
D015032ZincZinc inhibits the reaction [FOXO1 protein results in increased expression of CAT protein]22427991
D019287Zinc Sulfatewortmannin inhibits the reaction [Zinc Sulfate affects the localization of FOXO1 protein]16973122
D019287Zinc Sulfatewortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO1 protein]16973122
D019287Zinc SulfateZinc Sulfate affects the localization of FOXO1 protein16973122
D019287Zinc SulfateZinc Sulfate results in increased phosphorylation of FOXO1 protein16973122
C088658zoledronic acidzoledronic acid results in decreased expression of FOXO1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000989transcription factor activity, transcription factor binding-IEA-  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0001223transcription coactivator binding-IEA-  
GO:0003682chromatin binding-ISS22510882  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0005515protein binding-IPI11237865  11353774  15220471  15692560  15890677  17030088  
18235501  18408765  18786403  20543840  24983498  25241761  
25609649  
GO:0008013beta-catenin binding-IDA15905404  
GO:0008134transcription factor binding-IBA21873635  
GO:0031625ubiquitin protein ligase binding-IPI20543840  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IDA12228231  
GO:0051721protein phosphatase 2A binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001568blood vessel development-IEA-  
GO:0001659temperature homeostasis-ISS22510882  
GO:0001678cellular glucose homeostasis-ISS22510882  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006473protein acetylation-ISS22510882  
GO:0006914autophagy-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0006974cellular response to DNA damage stimulus-ISS-  
GO:0008286insulin receptor signaling pathway-IBA21873635  
GO:0008286insulin receptor signaling pathway-ISS-  
GO:0009267cellular response to starvation-IDA20543840  
GO:0009267cellular response to starvation-ISS22510882  
GO:0010508positive regulation of autophagy-IMP20543840  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0031018endocrine pancreas development-TAS-  
GO:0032869cellular response to insulin stimulus-ISS-  
GO:0032873negative regulation of stress-activated MAPK cascade-IDA19696738  
GO:0034599cellular response to oxidative stress-ISS-  
GO:0035947regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter-IEA-  
GO:0042593glucose homeostasis-IBA21873635  
GO:0043065positive regulation of apoptotic process-IMP20543840  
GO:0043066negative regulation of apoptotic process-IDA10871843  
GO:0045444fat cell differentiation-ISS22510882  
GO:0045599negative regulation of fat cell differentiation-ISS-  
GO:0045722positive regulation of gluconeogenesis-IEA-  
GO:0045732positive regulation of protein catabolic process-IMP20543840  
GO:0045892negative regulation of transcription, DNA-templated-ISS22510882  
GO:0045893positive regulation of transcription, DNA-templated-IDA7862145  10871843  12228231  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA10871843  12228231  
GO:0070166enamel mineralization-IEA-  
GO:0070301cellular response to hydrogen peroxide-IEA-  
GO:0070417cellular response to cold-ISS22510882  
GO:0071455cellular response to hyperoxia-IDA20543840  
GO:0071549cellular response to dexamethasone stimulus-IEA-  
GO:0071732cellular response to nitric oxide-ISS-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IEA-  
GO:0097009energy homeostasis-ISS22510882  
GO:0097150neuronal stem cell population maintenance-IEA-  
GO:1902617response to fluoride-IEA-  
GO:1903243negative regulation of cardiac muscle hypertrophy in response to stress-ISS-  
GO:2000177regulation of neural precursor cell proliferation-IEA-  
GO:2000377regulation of reactive oxygen species metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA11311120  12228231  18680538  20543840  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA11237865  11311120  12228231  20543840  
GO:0005739mitochondrion-ISS22510882  
GO:0005829cytosol-ISS22510882  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04910Insulin signaling pathway
hsa05200Pathways in cancer
hsa05215Prostate cancer
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-186712Regulation of beta-cell developmentIEA
R-HSA-186712Regulation of beta-cell developmentTAS
R-HSA-198693AKT phosphorylates targets in the nucleusTAS
R-HSA-210745Regulation of gene expression in beta cellsIEA
R-HSA-210745Regulation of gene expression in beta cellsTAS
R-HSA-211163AKT-mediated inactivation of FOXO1ATAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5674400Constitutive Signaling by AKT1 E17K in CancerTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-9006925Intracellular signaling by second messengersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26116372MiR-21: an environmental driver of malignant melanoma? (2015 Jun 27)Melnik BCJ Transl Med
26373813Differential Contributions of Alcohol and Nicotine-Derived Nitrosamine Ketone (NNK) to White Matter Pathology in the Adolescent Rat Brain. (2015 Nov)Tong MAlcohol Alcohol
26321514Upregulated hepatic expression of mitochondrial PEPCK triggers initial gluconeogenic reactions in the HCV-3 patients. (2015 Aug)Sheikh TIAsian Pac J Trop Med
23435205Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma. (2013 Apr 1)Brait MCell Cycle
20107753[Acne vulgaris. Role of diet]. (2010 Feb)Melnik BHautarzt
29448096AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis. (2018 Mar 4)Liu JQBiochem Biophys Res Commun
24489705Association study to evaluate FoxO1 and FoxO3 gene in CHD in Han Chinese. (2014)Zhao YPLoS One
28542447Exploratory plasma proteomic analysis in a randomized crossover trial of aspirin among healthy men and women. (2017)Wang XPLoS One
25273948Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort. (2014 Oct 2)Kedenko LBMC Med Genet