Gene: EXPH5

23086
SLAC2-B|SLAC2B
exophilin 5
protein-coding
11q22.3
Ensembl:ENSG00000110723 MIM:612878 Vega:OTTHUMG00000166536 UniprotKB:Q8NEV8
NG_042852.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.825e-1 (AD)  1.905e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12146448chr11:108513934 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB11FIP10.607
GPC60.603
NR2F20.579
NPR30.577
ITGA40.575
DSG20.572
THSD7A0.568
MYO1B0.553
GCNT20.543
SRL0.541

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLDND2-0.285
FAM178B-0.283
GPIHBP1-0.277
KIF19-0.266
FEZF2-0.256
NRN1L-0.247
HAPLN2-0.231
SH2D1B-0.23
LAIR2-0.229
OR4F5-0.226

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of EXPH5 mRNA19933214
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of EXPH5 mRNA"19692669
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of EXPH5 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EXPH5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EXPH5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EXPH5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EXPH5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of EXPH5 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EXPH5 mRNA27153756
D000447AldehydesAldehydes results in increased expression of EXPH5 mRNA25014914
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EXPH5 mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of EXPH5 mRNA22323515
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of EXPH5 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EXPH5 mRNA"20018196
C006780bisphenol Abisphenol A results in decreased expression of EXPH5 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of EXPH5 mRNA26079696
D002104CadmiumCadmium results in decreased expression of EXPH5 mRNA24067728
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of EXPH5 mRNA20938992
D016572CyclosporineCyclosporine results in decreased expression of EXPH5 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of EXPH5 mRNA20106945
D002945CisplatinCisplatin results in decreased expression of EXPH5 mRNA27392435
C118739entinostatentinostat results in increased expression of EXPH5 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EXPH5 mRNA22079256
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of EXPH5 mRNA20938992
C069837fullerene C60fullerene C60 results in decreased expression of EXPH5 mRNA19167457
D017313FenretinideFenretinide results in increased expression of EXPH5 mRNA28973697
C544151jinfukangjinfukang results in decreased expression of EXPH5 mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of EXPH5 mRNA20938992
C029938nickel sulfatenickel sulfate results in decreased expression of EXPH5 mRNA22714537
C046012pentanalpentanal results in increased expression of EXPH5 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EXPH5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of EXPH5 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EXPH5 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of EXPH5 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of EXPH5 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of EXPH5 mRNA28903501
C005556propionaldehydepropionaldehyde results in increased expression of EXPH5 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EXPH5 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of EXPH5 mRNA23221170
C017947sodium arsenitesodium arsenite results in decreased expression of EXPH5 mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EXPH5 mRNA25975270|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EXPH5 mRNA19933214
D014212TretinoinTretinoin results in increased expression of EXPH5 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of EXPH5 mRNA24935251|2670570
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of EXPH5 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EXPH5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EXPH5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EXPH5 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of EXPH5 mRNA23179753|2438349
D014638VanadatesVanadates results in decreased expression of EXPH5 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EXPH5 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of EXPH5 mRNA26682919
C111237vorinostatvorinostat results in increased expression of EXPH5 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0017137Rab GTPase binding-IBA21873635  
GO:0017137Rab GTPase binding-IPI16880209  
GO ID GO Term Qualifier Evidence PubMed
GO:0003334keratinocyte development-IMP23176819  
GO:0006886intracellular protein transport-IEA-  
GO:0045921positive regulation of exocytosis-IBA21873635  
GO:0045921positive regulation of exocytosis-IMP19966785  
GO:0050714positive regulation of protein secretion-IBA21873635  
GO:0050714positive regulation of protein secretion-IMP19966785  
GO:0071985multivesicular body sorting pathway-IBA21873635  
GO:0071985multivesicular body sorting pathway-IMP19966785  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-IBA21873635  
GO:0005768endosome-IDA19966785  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal