Gene: PEG10

23089
EDR|HB-1|MEF3L|Mar2|Mart2|RGAG3|RTL2|SIRH1
paternally expressed 10
protein-coding
7q21.3
Ensembl:ENSG00000242265 MIM:609810 Vega:OTTHUMG00000155578 UniprotKB:Q86TG7
NG_011340.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.079e-2 (AD)  1.040e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11562309chr7:94286473PEG10Promoter1.906e-6Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
B3GALNT10.878
CSNK1G30.866
CDK170.864
TUSC30.864
PKIA0.861
KBTBD60.86
HSDL10.857
OCRL0.856
MAPK10.855
PEG30.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.487
OR4F29-0.446
CSAG1-0.393
FZD10-0.364
MAGEA12-0.338
P2RY14-0.333
ANPEP-0.328
MTRNR2L6-0.316
MTRNR2L8-0.314
RUNX3-0.311

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PEG10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PEG10 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in decreased expression of PEG10 mRNA"26238291
D000082AcetaminophenAcetaminophen results in increased expression of PEG10 mRNA21420995|2906747
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PEG10 mRNA24449571
D001379AzathioprineAzathioprine results in decreased expression of PEG10 mRNA22623647
C487081belinostatbelinostat results in increased expression of PEG10 mRNA19606018
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PEG10 mRNA20106945|2163298
D004958EstradiolEstradiol results in decreased expression of PEG10 mRNA20106945
D004958EstradiolEstradiol results in increased expression of PEG10 mRNA23019147
C006780bisphenol Abisphenol A affects the expression of PEG10 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of PEG10 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PEG10 mRNA20147733
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PEG10 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of PEG10 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PEG10 mRNA24982889|2882391
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PEG10 protein28823913
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of PEG10 promoter28823913
C018021cobaltous chloridecobaltous chloride results in decreased expression of PEG10 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of PEG10 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of PEG10 mRNA17211630
D016572CyclosporineCyclosporine results in decreased expression of PEG10 mRNA20106945|2556210
C014347decitabinedecitabine affects the expression of PEG10 mRNA17145863
D003976DiazinonDiazinon results in increased methylation of PEG10 gene22964155
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of PEG10 mRNA28962523
C000944dicrotophosdicrotophos results in increased expression of PEG10 mRNA28302478
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of PEG10 mRNA23999411
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PEG10 mRNA20170705|2686566
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PEG10 mRNA23649840
D005472FluorouracilPEG10 protein affects the susceptibility to Fluorouracil16217747
D005557FormaldehydeFormaldehyde results in decreased expression of PEG10 mRNA23649840
C001277geldanamycingeldanamycin results in increased expression of PEG10 mRNA26705709
D019833GenisteinGenistein results in increased expression of PEG10 mRNA23019147|2686566
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PEG10 mRNA24231268
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PEG10 mRNA24796395|2530787
C410337K 7174K 7174 results in decreased expression of PEG10 mRNA24086573
C045463leflunomideleflunomide results in decreased expression of PEG10 mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PEG10 mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PEG10 mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PEG10 mRNA23649840
D009532NickelNickel results in decreased expression of PEG10 mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of PEG10 mRNA22714537
D010081OxazoloneOxazolone results in increased expression of PEG10 mRNA23999411
D052638Particulate MatterParticulate Matter results in decreased expression of PEG10 mRNA22178795
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PEG10 protein26879310
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PEG10 mRNA19710929
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PEG10 mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of PEG10 mRNA21795739
D011374ProgesteroneProgesterone results in increased expression of PEG10 mRNA18070364
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PEG10 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of PEG10 mRNA21632981
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PEG10 mRNA25351596
D014284TriiodothyronineTriiodothyronine results in increased expression of PEG10 mRNA23397585
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PEG10 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PEG10 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PEG10 mRNA26290441
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PEG10 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of PEG10 mRNA16249480
C012589trichostatin Atrichostatin A affects the expression of PEG10 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PEG10 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of PEG10 mRNA25572481
D014635Valproic AcidValproic Acid affects the expression of PEG10 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of PEG10 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PEG10 mRNA19101580|2317975
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PEG10 gene25560391
C111237vorinostatvorinostat results in increased expression of PEG10 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI15611116  21903422  25416956  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-IDA15611116  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005737cytoplasm-IDA15611116  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29490428DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions. (2018 Feb 28)Gomih AInt J Cancer
22677950Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. (2012 Jul)Liu YEpigenetics