Gene: FOXO3

2309
AF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3A
forkhead box O3
protein-coding
6q21
Ensembl:ENSG00000118689 MIM:602681 Vega:OTTHUMG00000015327 UniprotKB:O43524
NC_000006.12
PubMed
0   ANCO-SNPs
ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.856e-1 (AD)  4.131e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12416929chr6:108882205FOXO3Promoter1.136e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LONP20.944
CKAP50.942
MARCH60.938
CLASP10.935
CS0.933
QRICH10.931
ACSL30.931
RPRD20.93
FBXO210.929
DSTYK0.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.65
OR4F29-0.608
KLRB1-0.363
TFPI2-0.36
KLF17-0.34
CD8B-0.334
SH2D1A-0.325
KLRF1-0.324
GZMA-0.321
TBX21-0.321

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C07258116-hydroxycleroda-3,13(14)-dien-15,16-olide"16-hydroxycleroda-3,13(14)-dien-15,16-olide results in increased expression of FOXO3 mRNA"21530604
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of FOXO3 protein"23318440
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[OGT mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased phosphorylation of FOXO3 protein"23029544
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of FOXO3 mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of FOXO3 mRNA"19095052
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in increased localization of FOXO3 protein20012470
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-oneresveratrol promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in increased localization of FOXO3 protein]20012470
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein]24787138
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FOXO3 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"2,4,4'-trichlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]"20840854
C0817662,4,4'-trichlorobiphenyl"2,4,4'-trichlorobiphenyl results in decreased phosphorylation of FOXO3 protein"20840854
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]"20840854|2495403
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased phosphorylation of FOXO3 protein"20840854|2495403
C0140242,4,5,2',4',5'-hexachlorobiphenyl"Okadaic Acid inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]]"24954032
C0098282,4,5,2',5'-pentachlorobiphenyl"2,4,5,2',5'-pentachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]"20840854
C0098282,4,5,2',5'-pentachlorobiphenyl"2,4,5,2',5'-pentachlorobiphenyl results in decreased phosphorylation of FOXO3 protein"20840854
C0098282,4,5,2',5'-pentachlorobiphenyl"MDM2 mutant form inhibits the reaction [2,4,5,2',5'-pentachlorobiphenyl results in decreased phosphorylation of FOXO3 protein]"20840854
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of and results in increased activity of FOXO3 protein19211844
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of FOXO3 protein23099361
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein]16179367
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of FOXO3 protein]23159718
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of FOXO3 protein]19293636
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of FOXO3 protein16179367
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of and results in increased phosphorylation of FOXO3 protein]23159718
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein]19168439
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and affects the localization of FOXO3 protein]]25471227
C0295362-oxothiazolidine-4-carboxylic acid2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese affects the localization of FOXO3 protein]24787138
C0295362-oxothiazolidine-4-carboxylic acid2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese results in increased expression of FOXO3 protein]24787138
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]"20840854
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased phosphorylation of FOXO3 protein"20840854
C0230353,4,5,3',4'-pentachlorobiphenyl"MDM2 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased phosphorylation of FOXO3 protein]"20840854
C5307733,5-diethoxycarbonyl-1,4-dihydrocollidine"3,5-diethoxycarbonyl-1,4-dihydrocollidine affects the localization of FOXO3 protein"23620592
C5307733,5-diethoxycarbonyl-1,4-dihydrocollidine"CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine affects the localization of FOXO3 protein]"23620592
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of FOXO3 mRNA18544908
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of FOXO3 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of FOXO3 protein]"23159718
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucose affects the localization of and results in increased phosphorylation of FOXO3 protein]"23159718
C0815104-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of and results in increased localization of FOXO3 protein19380174
C0275764-hydroxy-2-nonenalFOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]]24633890
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]]"26271894
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Cadmium results in increased phosphorylation of FOXO3 protein]"27492225
C5505476-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein]"20370652
C5505476-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide"[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased localization of FOXO3 protein"20370652
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of FOXO3 mRNA"19936915
D000082AcetaminophenAcetaminophen results in increased expression of FOXO3 mRNA21420995|2669055
D000082AcetaminophenAcetaminophen affects the expression of FOXO3 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of FOXO3 mRNA18544908
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of FOXO3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FOXO3 mRNA]17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of FOXO3 protein]20883752
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Simvastatin results in increased phosphorylation of FOXO3 protein]20883752
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Glucose results in decreased phosphorylation of FOXO3 protein]25471227
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Glucose results in increased phosphorylation of FOXO3 protein]23159718
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FOXO3 mRNA19770486
C412373AG 1879[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]23673518
C412373AG 1879[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]23673518
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of FOXO3 protein]22266097
C011512alpha-naphthoflavone[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of FOXO3 mRNA29094188
D000968Antimycin AAntimycin A results in decreased expression of FOXO3 protein24040102
D000968Antimycin A[FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]24040102
D000968Antimycin AFOXO3 mutant form affects the reaction [[Antimycin A co-treated with resveratrol] affects the expression of SOD2 mRNA]24040102
D000968Antimycin AFOXO3 mutant form affects the reaction [[Antimycin A co-treated with resveratrol] affects the expression of SOD2 protein]24040102
C025657arsenic acidarsenic acid affects the localization of FOXO3 protein26763397
C006632arsenic trioxidearsenic trioxide results in decreased expression of FOXO3 mRNA22521957
C006632arsenic trioxidearsenic trioxide results in increased expression of and results in decreased phosphorylation of and results in increased localization of FOXO3 protein22988968
C006632arsenic trioxidearsenic trioxide results in increased expression of and results in increased localization of FOXO3 mRNA22988968
C006632arsenic trioxideTNF protein inhibits the reaction [arsenic trioxide results in increased expression of FOXO3 mRNA]22988968
C006632arsenic trioxideTNF protein inhibits the reaction [arsenic trioxide results in increased expression of FOXO3 protein]22988968
C015001arsenitearsenite results in increased phosphorylation of FOXO3 protein24024143
C015001arsenitewortmannin inhibits the reaction [arsenite results in increased phosphorylation of FOXO3 protein]24024143
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of FOXO3 mRNA"17331233
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA]16964424
D001280AtrazineAtrazine results in decreased expression of FOXO3 mRNA22378314
D001564Benzo(a)pyrene"2,4,4'-trichlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]"20840854
D001564Benzo(a)pyrene"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]"20840854|2495403
D001564Benzo(a)pyrene"2,4,5,2',5'-pentachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]"20840854
D001564Benzo(a)pyrene"3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]"20840854
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased phosphorylation of FOXO3 protein20840854|2495403
D001564Benzo(a)pyreneEstradiol inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]24954032
D001564Benzo(a)pyrenefostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]]24954032
D001564Benzo(a)pyreneFOXO3 mutant form promotes the reaction [Benzo(a)pyrene affects the localization of TP53 protein]24954032
D001564Benzo(a)pyrene"Okadaic Acid inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]]"24954032
D001564Benzo(a)pyreneOkadaic Acid inhibits the reaction [Estradiol inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]]24954032
D001564Benzo(a)pyreneOkadaic Acid inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]]24954032
D001564Benzo(a)pyreneTetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]24954032
D001564Benzo(a)pyreneBenzo(a)pyrene affects the reaction [AHR protein binds to FOXO3 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FOXO3 mRNA19770486|2171566
D001599Berberine[Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO3 protein26712469
D001599BerberineBerberine results in increased expression of and results in increased acetylation of FOXO3 protein26712469
D004958EstradiolEstradiol inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]24954032
D004958EstradiolEstradiol results in decreased expression of FOXO3 mRNA19167446
D004958EstradiolEstradiol results in decreased phosphorylation of FOXO3 protein24954032
D004958EstradiolOkadaic Acid inhibits the reaction [Estradiol inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]]24954032
C044887beta-methylcholinebeta-methylcholine affects the expression of FOXO3 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of FOXO3 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of FOXO3 mRNA25181051
D0151248-Bromo Cyclic Adenosine MonophosphateFOXO1 protein affects the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of FOXO3 mRNA]16709600
D0151248-Bromo Cyclic Adenosine Monophosphate[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO3 mRNA]16709600
D0151248-Bromo Cyclic Adenosine Monophosphate[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO3 protein]16709600
D0151248-Bromo Cyclic Adenosine Monophosphate[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of FOXO3 mRNA16709600
D002083Butylated Hydroxyanisole[propylparaben co-treated with Butylated Hydroxyanisole] results in increased expression of FOXO3 mRNA25086368
D002104CadmiumCadmium results in increased expression of FOXO3 mRNA25490952
D002104CadmiumNitric Oxide inhibits the reaction [Cadmium results in increased expression of FOXO3 mRNA]25490952
D002104Cadmiumspermine nitric oxide complex inhibits the reaction [Cadmium results in increased expression of FOXO3 mRNA]25490952
D002104Cadmium"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Cadmium results in increased phosphorylation of FOXO3 protein]"27492225
D002104CadmiumCadmium results in increased expression of and results in increased phosphorylation of FOXO3 protein27492225
D002104CadmiumCadmium results in increased expression of FOXO3 mRNA27492225
D002104CadmiumFOXO3 affects the reaction [Cadmium results in increased expression of BECN1 mRNA]27492225
D002104CadmiumFOXO3 affects the reaction [Cadmium results in increased expression of MAP1LC3B mRNA]27492225
D002104CadmiumFOXO3 affects the susceptibility to Cadmium27492225
D019256Cadmium Chloride[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]23673518
D019256Cadmium Chloride[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]23673518
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of FOXO3 protein23673518
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of FOXO3 protein23673518
D019256Cadmium ChlorideFOXO3 protein results in decreased susceptibility to Cadmium Chloride23673518
D019256Cadmium ChlorideKN 93 inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]23673518
D019256Cadmium ChlorideKN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]23673518
D019256Cadmium Chloride[picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]23673518
D019256Cadmium Chloride[picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]23673518
D019256Cadmium ChlorideSB 203580 inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]23673518
D019256Cadmium ChlorideSB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]23673518
D019256Cadmium Chloride[tyrphostin AG 1478 results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]23673518
D019256Cadmium Chloridewortmannin inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]23673518
D019256Cadmium Chloridewortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]23673518
D002220CarbamazepineCarbamazepine affects the expression of FOXO3 mRNA24752500
C054133casticincasticin results in decreased expression of FOXO3 mRNA27862857
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of FOXO3 mRNA24763279
D002737ChloropreneChloroprene results in increased expression of FOXO3 mRNA23125180
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of FOXO3 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FOXO3 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of FOXO3 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of FOXO3 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FOXO3 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of FOXO3 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of FOXO3 mRNA20106945
C089595cylindrospermopsincylindrospermopsin results in increased expression of FOXO3 mRNA23726867
C515055darinaparsindarinaparsin results in decreased expression of FOXO3 protein25316819
D003907DexamethasoneDexamethasone promotes the reaction [EP300 protein binds to FOXO3 gene]26758684
D003907DexamethasoneDexamethasone results in increased expression of FOXO3 mRNA22733784|2675868
D003907DexamethasoneDexamethasone results in increased expression of FOXO3 protein22733784
D003907DexamethasonePIK3R1 mutant form inhibits the reaction [Dexamethasone results in increased expression of FOXO3 mRNA]22733784
D003973DiatrizoateDiatrizoate affects the phosphorylation of FOXO3 protein21036957
D003976DiazinonDiazinon results in increased methylation of FOXO3 gene22964155
D002945CisplatinCisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]21092744
D002945Cisplatin[Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of BCL2L11 protein21092744
D002945Cisplatin[Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of CDKN1B protein21092744
D002945CisplatinCisplatin results in decreased expression of FOXO3 mRNA27392435
D002945CisplatinCisplatin results in decreased phosphorylation of FOXO3 protein21092744
D002945CisplatinCisplatin results in increased expression of and results in increased localization of and results in increased activity of FOXO3 protein21092744
D002945CisplatinSirolimus promotes the reaction [Cisplatin results in increased expression of and results in increased localization of and results in increased activity of FOXO3 protein]21092744
D002945CisplatinCisplatin results in decreased phosphorylation of FOXO3 protein24823295
D002945CisplatinCisplatin results in increased expression of FOXO3 mRNA24823295
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased activity of FOXO3 protein27589886
D004008DiclofenacDiclofenac affects the expression of FOXO3 mRNA24752500
D004008DiclofenacDiclofenac results in decreased expression of FOXO3 mRNA26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of FOXO3 mRNA26924002
D004026DieldrinDieldrin affects the expression of FOXO3 mRNA22546817
D004041Dietary FatsDietary Fats results in decreased expression of FOXO3 mRNA23954404
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FOXO3 protein"21785161
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of FOXO3 mRNA26924002
D004317DoxorubicinBIRC5 protein inhibits the reaction [FOXO3 protein results in increased susceptibility to Doxorubicin]19211844
D004317DoxorubicinDoxorubicin results in increased phosphorylation of FOXO3 protein17935137|2585634
D004317Doxorubicin[FOXO3 protein results in decreased expression of BIRC5 protein] which results in increased susceptibility to Doxorubicin19211844
D004317DoxorubicinFOXO3 protein results in increased susceptibility to Doxorubicin19211844
D004317Doxorubicinwortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO3 protein]17935137
D004317DoxorubicinDoxorubicin results in increased expression of FOXO3 mRNA25896364|2832987
D004317DoxorubicinDoxorubicin results in decreased phosphorylation of FOXO3 protein23639627
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased phosphorylation of FOXO3 protein"25856345
C060311eckoleckol results in increased phosphorylation of FOXO3 protein24700636
C060311eckolFOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein]24700636
C031818enterotoxin B, staphylococcal"enterotoxin B, staphylococcal results in decreased expression of FOXO3 mRNA"25556216
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FOXO3 protein23301498
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of FOXO3 protein29175576
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in decreased phosphorylation of FOXO3 protein23099361
D000431Ethanol[Ethanol co-treated with FOXO3 protein] results in increased expression of BCL2L11 mRNA26470730
D000431Ethanol[Ethanol co-treated with FOXO3 protein] results in increased expression of TNFSF10 mRNA26470730
D000431Ethanol[Ethanol co-treated with FOXO3 protein] results in increased expression of TNFSF10 protein26470730
D000431Ethanol[Ethanol co-treated with FOXO3 protein] results in increased susceptibility to TNFSF10 protein26470730
D000431EthanolEthanol inhibits the reaction [FOXO3 protein results in increased expression of BCL2 mRNA]26470730
D000431EthanolEthanol inhibits the reaction [FOXO3 protein results in increased expression of BCL2 protein]26470730
D000431EthanolEthanol inhibits the reaction [FOXO3 protein results in increased expression of BIRC2 mRNA]26470730
D000431EthanolEthanol inhibits the reaction [FOXO3 protein results in increased expression of BIRC3 mRNA]26470730
D000431EthanolEthanol inhibits the reaction [FOXO3 protein results in increased expression of BNIP3L mRNA]26470730
D000431EthanolEthanol inhibits the reaction [FOXO3 protein results in increased expression of TNFRSF1B mRNA]26470730
D000431EthanolEthanol promotes the reaction [FOXO3 protein binds to BCL2L11 promoter]26470730
D000431EthanolEthanol promotes the reaction [FOXO3 protein binds to BCL2 promoter]26470730
D000431EthanolEthanol promotes the reaction [FOXO3 protein binds to TNFSF10 promoter]26470730
D000431EthanolEthanol promotes the reaction [FOXO3 protein modified form binds to BCL2L11 gene]26470730
D000431EthanolEthanol promotes the reaction [FOXO3 protein modified form binds to TNFSF10 gene]26470730
D000431EthanolEthanol promotes the reaction [FOXO3 protein results in increased expression of IL10 mRNA]26470730
D000431EthanolEthanol promotes the reaction [FOXO3 protein results in increased expression of TNF mRNA]26470730
D000431EthanolEthanol promotes the reaction [FOXO3 protein results in increased expression of TNFRSF8 mRNA]26470730
D000431EthanolEthanol promotes the reaction [FOXO3 protein results in increased expression of TNFRSF9 mRNA]26470730
D000431EthanolEthanol results in increased phosphorylation of FOXO3 protein26470730
D000431Ethanol[Ethanol results in increased phosphorylation of FOXO3 protein] promotes the reaction [FOXO3 protein modified form binds to BCL2L11 gene]26470730
D000431Ethanol[Ethanol results in increased phosphorylation of FOXO3 protein] promotes the reaction [FOXO3 protein modified form binds to TNFSF10 gene]26470730
D000431Ethanol[Ethanol results in increased phosphorylation of FOXO3 protein] which results in decreased expression of BCL2 mRNA26470730
D000431Ethanol[Ethanol results in increased phosphorylation of FOXO3 protein] which results in decreased expression of BCL2 protein26470730
D000431EthanolFOXO3 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Ethanol results in decreased expression of ATG5 mRNA]]24582693
D000431Ethanolpyrazolanthrone inhibits the reaction [Ethanol results in increased phosphorylation of FOXO3 protein]26470730
D000431EthanolEthanol affects the localization of FOXO3 protein24095927
D000431EthanolEthanol promotes the reaction [FOXO3 protein binds to MAP1LC3B promoter]25460735
D000431EthanolEthanol results in decreased phosphorylation of and results in increased acetylation of FOXO3 protein24095927
D000431EthanolEthanol results in increased expression of and results in decreased phosphorylation of FOXO3 protein25460735
D000431EthanolEthanol results in increased expression of FOXO3 mRNA25460735
D000431EthanolFOXO3 gene mutant form inhibits the reaction [Ethanol results in increased expression of ATG14 mRNA]24095927
D000431EthanolFOXO3 gene mutant form inhibits the reaction [Ethanol results in increased expression of BNIP3 mRNA]24095927
D000431EthanolFOXO3 gene mutant form inhibits the reaction [Ethanol results in increased expression of MAP1LC3B mRNA]24095927
D000431EthanolFOXO3 gene mutant form inhibits the reaction [Ethanol results in increased expression of ULK1 mRNA]24095927
D000431EthanolFOXO3 protein affects the reaction [Ethanol results in increased expression of ATG7 mRNA]24095927
D000431EthanolFOXO3 protein affects the reaction [Ethanol results in increased expression of BECN1 mRNA]24095927
D000431EthanolFOXO3 protein affects the reaction [Ethanol results in increased expression of BECN1 protein]24095927
D000431EthanolFOXO3 protein affects the reaction [Ethanol results in increased expression of MAP1LC3B mRNA]24095927
D000431EthanolNR1H4 gene mutant form inhibits the reaction [Ethanol affects the localization of FOXO3 protein]25460735
D000431EthanolNR1H4 gene mutant form inhibits the reaction [Ethanol promotes the reaction [FOXO3 protein binds to MAP1LC3B promoter]]25460735
D000431EthanolNR1H4 gene mutant form inhibits the reaction [Ethanol results in increased expression of and results in decreased phosphorylation of FOXO3 protein]25460735
D000431EthanolNR1H4 gene mutant form inhibits the reaction [Ethanol results in increased expression of FOXO3 mRNA]25460735
D000431Ethanolresveratrol inhibits the reaction [Ethanol results in increased acetylation of FOXO3 protein]24095927
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FOXO3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FOXO3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of FOXO3 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of FOXO3 mRNA28189721
D005047EtoposideBIRC5 protein inhibits the reaction [FOXO3 protein results in increased susceptibility to Etoposide]19211844
D005047EtoposideEtoposide results in increased phosphorylation of FOXO3 protein17935137
D005047Etoposide[FOXO3 protein results in decreased expression of BIRC5 protein] which results in increased susceptibility to Etoposide19211844
D005047EtoposideFOXO3 protein results in increased susceptibility to Etoposide19211844
D005047Etoposidewortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO3 protein]17935137
C017690fenvaleratefenvalerate affects the methylation of FOXO3 gene23548413
D005472FluorouracilFOXO3 affects the susceptibility to Fluorouracil15067352
D005485FlutamideFlutamide results in increased phosphorylation of and results in decreased activity of FOXO3 protein20850791
C040313fostriecinfostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]]24954032
C069837fullerene C60fullerene C60 results in decreased expression of FOXO3 mRNA19167457
C039281furanfuran results in increased expression of FOXO3 mRNA26194646
C419708gefitinibFOXO3 protein results in increased susceptibility to gefitinib18089711
C419708gefitinibgefitinib results in decreased phosphorylation of and affects the localization of FOXO3 protein18089711
D019833Genistein"FOXO3 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of CAT mRNA]]"28688900
D019833Genistein"FOXO3 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of CAT protein]]"28688900
D019833Genistein"FOXO3 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SOD2 mRNA]]"28688900
D019833Genistein"FOXO3 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SOD2 protein]]"28688900
D019833GenisteinGenistein affects the expression of FOXO3 mRNA18431742
D019833GenisteinGenistein affects the expression of FOXO3 protein18431742
D019833GenisteinGenistein affects the localization of FOXO3 protein18431742
D019833GenisteinGenistein inhibits the reaction [HIST3H3 protein modified form binds to FOXO3 promoter]18431742
D019833Genistein"Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased acetylation of and affects the localization of FOXO3 protein]"28688900
D019833GenisteinGenistein inhibits the reaction [SIRT1 protein binds to FOXO3 promoter]18431742
D019833GenisteinGenistein results in decreased phosphorylation of FOXO3 protein18431742
D019833Genistein[[Genistein results in increased expression of PTEN protein] which results in decreased activity of AKT1 protein] which results in increased activity of FOXO3 protein18431742
D019833Genistein"MIR34A mRNA inhibits the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased acetylation of and affects the localization of FOXO3 protein]]"28688900
D019833Genistein"SIRT1 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased acetylation of and affects the localization of FOXO3 protein]]"28688900
D005947GlucoseAKT1 protein promotes the reaction [Glucose affects the phosphorylation of and affects the activity of FOXO3 protein]20370652
D005947GlucoseFOXO3 protein promotes the reaction [Glucose results in increased cleavage of and results in increased activity of CASP1 protein]20370652
D005947GlucoseFOXO3 protein promotes the reaction [Glucose results in increased cleavage of and results in increased activity of CASP3 protein]20370652
D005947GlucoseGlucose affects the phosphorylation of and affects the activity of FOXO3 protein20370652
D005947GlucoseGlucose results in increased localization of FOXO3 protein20370652
D005947GlucoseGlucose results in increased phosphorylation of FOXO3 protein23090186
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased phosphorylation of FOXO3 protein]23090186
D005947Glucose[[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein] which results in decreased susceptibility to Glucose20370652
D005947Glucose2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of and results in increased phosphorylation of FOXO3 protein]23159718
D005947Glucose2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and affects the localization of FOXO3 protein]]25471227
D005947Glucose"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucose affects the localization of and results in increased phosphorylation of FOXO3 protein]"23159718
D005947GlucoseAcetylcysteine inhibits the reaction [Glucose results in decreased phosphorylation of FOXO3 protein]25471227
D005947GlucoseAcetylcysteine inhibits the reaction [Glucose results in increased phosphorylation of FOXO3 protein]23159718
D005947GlucoseGlucose results in decreased phosphorylation of and affects the localization of FOXO3 protein25471227
D005947GlucoseGlucose results in increased phosphorylation of and affects the localization of FOXO3 protein23159718
D005947Glucoseresveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and affects the localization of FOXO3 protein]25471227
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of FOXO3 mRNA24763279
C529376GYY 4137GYY 4137 inhibits the reaction [AGT protein results in decreased expression of FOXO3 protein]28503736
C529376GYY 4137SIRT3 protein affects the reaction [GYY 4137 inhibits the reaction [AGT protein results in decreased expression of FOXO3 protein]]28503736
D006859Hydrogen"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]]"26271894
D006859HydrogenHydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein]26271894
D006859HydrogenHydrogen results in increased expression of FOXO3 protein26271894
D006861Hydrogen PeroxideFOXO3 protein results in increased susceptibility to Hydrogen Peroxide16709600
D006861Hydrogen PeroxideHIF1A protein affects the reaction [Hydrogen Peroxide results in increased expression of FOXO3 protein]25108166
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of FOXO3 mRNA16709600
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of FOXO3 protein16709600|2510816
D006861Hydrogen Peroxide[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO3 mRNA]16709600
D006861Hydrogen Peroxide[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO3 protein]16709600
D006861Hydrogen Peroxide"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [Hydrogen Peroxide results in increased expression of FOXO3 protein]"25108166
D006861Hydrogen PeroxideQuercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO3 protein]25108166
D006861Hydrogen PeroxideAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of FOXO3 protein]20883752
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of FOXO3 protein20883752
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of FOXO3 protein21159781
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of FOXO3 protein19168439|2315971
D006861Hydrogen PeroxideSHC1 protein affects the reaction [Hydrogen Peroxide results in increased phosphorylation of FOXO3 protein]19168439
C477872IC 87114IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein]16179367
C477872IC 87114IC 87114 results in decreased phosphorylation of FOXO3 protein16179367
C056599icariinicariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]25472572
C056599icariinNiacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]]25472572
C056599icariinicariin affects the localization of FOXO3 protein25472572
C572449INK128INK128 affects the localization of FOXO3 protein26536665
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FOXO3 mRNA25613284
D007529IsoflavonesIsoflavones results in increased expression of FOXO3 mRNA17374662
D007529IsoflavonesIsoflavones results in increased expression of FOXO3 protein17374662
D007545IsoproterenolIsoproterenol results in increased expression of FOXO3 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of FOXO3 mRNA26397223
C072105KN 93KN 93 inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]23673518
C072105KN 93KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]23673518
D007854LeadLead affects the expression of FOXO3 mRNA28903495
C045463leflunomideleflunomide results in increased expression of FOXO3 mRNA28988120
C533894LG 100815LG 100815 results in increased expression of FOXO3 mRNA16951191
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 promotes the reaction [FOXO3 protein binds to BCL2 promoter]"26470730
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 promotes the reaction [FOXO3 protein binds to TNFSF10 promoter]"26470730
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of FOXO3 protein"26470730
C433788lipopolysaccharide, E. coli O26-B6"pyrazolanthrone inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of FOXO3 protein]"26470730
C433788lipopolysaccharide, E. coli O26-B6"FOXO3 protein affects the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of BCL2 mRNA]"26470730
C433788lipopolysaccharide, E. coli O26-B6"FOXO3 protein affects the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNFSF10 mRNA]"26470730
D008070Lipopolysaccharides2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of FOXO3 protein]19293636
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of FOXO3 protein19293636
D008070Lipopolysaccharidesresveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of FOXO3 protein]19293636
D008315MalondialdehydeFOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Malondialdehyde]]24633890
C569869malondialdehyde-low density lipoprotein, human"FOXO3 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of CAT mRNA]]"28688900
C569869malondialdehyde-low density lipoprotein, human"FOXO3 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of CAT protein]]"28688900
C569869malondialdehyde-low density lipoprotein, human"FOXO3 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SOD2 mRNA]]"28688900
C569869malondialdehyde-low density lipoprotein, human"FOXO3 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SOD2 protein]]"28688900
C569869malondialdehyde-low density lipoprotein, human"Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased acetylation of and affects the localization of FOXO3 protein]"28688900
C569869malondialdehyde-low density lipoprotein, human"malondialdehyde-low density lipoprotein, human results in increased acetylation of and affects the localization of FOXO3 protein"28688900
C569869malondialdehyde-low density lipoprotein, human"MIR34A mRNA inhibits the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased acetylation of and affects the localization of FOXO3 protein]]"28688900
C569869malondialdehyde-low density lipoprotein, human"SIRT1 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased acetylation of and affects the localization of FOXO3 protein]]"28688900
D008345Manganese2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein]24787138
D008345Manganese2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese affects the localization of FOXO3 protein]24787138
D008345Manganese2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese results in increased expression of FOXO3 protein]24787138
D008345ManganeseManganese affects the localization of FOXO3 protein24787138
D008345ManganeseManganese results in increased expression of and results in increased phosphorylation of FOXO3 protein24787138
D008345ManganeseSB 203580 inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein]24787138
D017258Medroxyprogesterone AcetateFOXO1 protein affects the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of FOXO3 mRNA]16709600
D017258Medroxyprogesterone Acetate[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO3 mRNA]16709600
D017258Medroxyprogesterone Acetate[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO3 protein]16709600
D017258Medroxyprogesterone Acetate[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of FOXO3 mRNA16709600
D008731MethoxychlorMethoxychlor results in decreased expression of FOXO3 mRNA23303685
D008731MethoxychlorMethoxychlor results in increased methylation of FOXO3 gene23303685
D008748Methylcholanthrene[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of FOXO3 mRNA29094188
D008752Methylene ChlorideMethylene Chloride results in increased expression of FOXO3 mRNA28392392
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of FOXO3 mRNA"26251327
C008493methylselenic acidmethylselenic acid results in decreased phosphorylation of and results in increased activity of FOXO3 protein17339365
D008790MetoprololMetoprolol results in decreased expression of FOXO3 protein18703049
D015735MifepristoneMifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of FOXO3 protein]22266097
D016686MonocrotalineMonocrotaline results in decreased phosphorylation of FOXO3 protein18801959
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of FOXO3 mRNA26924002
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of FOXO3 mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FOXO3 mRNA16357179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FOXO3 mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FOXO3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FOXO3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FOXO3 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of FOXO3 mRNA19812364
C051752nefazodonenefazodone results in increased expression of FOXO3 mRNA27288927
C022838nickel chloridenickel chloride results in increased expression of FOXO3 mRNA17312168
C022838nickel chloridenickel chloride affects the expression of FOXO3 mRNA22546817
D009569Nitric OxideNitric Oxide inhibits the reaction [Cadmium results in increased expression of FOXO3 mRNA]25490952
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [Hydrogen Peroxide results in increased expression of FOXO3 protein]"25108166
C090577N,N'-bis(salicylideneamino)ethane-manganese(II)"N,N'-bis(salicylideneamino)ethane-manganese(II) inhibits the reaction [SOD2 gene mutant form results in decreased expression of FOXO3 protein]"21195081
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of FOXO3 mRNA"12756304
D009638Norepinephrine2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein]19168439
D009638NorepinephrineNorepinephrine results in increased phosphorylation of FOXO3 protein19168439
D009638NorepinephrineSHC1 protein affects the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein]19168439
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of FOXO3 mRNA"16951191
D019319Okadaic Acid"Okadaic Acid inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]]"24954032
D019319Okadaic AcidOkadaic Acid inhibits the reaction [Estradiol inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]]24954032
D019319Okadaic AcidOkadaic Acid inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]]24954032
D010100OxygenOxygen deficiency results in decreased expression of FOXO3 mRNA22711276
D010100OxygenValproic Acid affects the reaction [Oxygen deficiency results in decreased expression of FOXO3 mRNA]22711276
D010100Oxygenvorinostat inhibits the reaction [Oxygen deficiency results in decreased expression of FOXO3 mRNA]22711276
D010100Oxygenicariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]25472572
D010100OxygenNiacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]]25472572
D010100OxygenNiacinamide promotes the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of FOXO3 protein]25472572
D010100Oxygen[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein25472572
D010100Oxygenresveratrol inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of FOXO3 protein]25472572
D010100OxygenSIRT1 mutant form promotes the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of FOXO3 protein]25472572
D010100OxygenOxygen deficiency results in increased expression of FOXO3 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of FOXO3 mRNA]22629407
D010100Oxygen[Oxygen deficiency co-treated with Oxygen] affects the localization of and results in decreased phosphorylation of FOXO3 protein21159781
D010269ParaquatFOXO3 mutant form inhibits the reaction [Paraquat results in increased expression of BCL2L11 mRNA]23620592
D010269ParaquatFOXO3 protein results in increased susceptibility to Paraquat23620592
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of FOXO3 mRNA19095052
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased activity of FOXO3 protein27589886
C560873PF 5168899PF 5168899 inhibits the reaction [IGF1 protein affects the localization of FOXO3 protein]21402045
D010634PhenobarbitalPhenobarbital affects the expression of FOXO3 mRNA23091169
C415032picropodophyllin[picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]23673518
C415032picropodophyllin[picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]23673518
C006253pirinixic acidpirinixic acid results in decreased expression of FOXO3 mRNA18445702
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of FOXO3 mRNA24583197
C045950propiconazolepropiconazole results in decreased expression of FOXO3 mRNA21278054
C006068propylparaben[propylparaben co-treated with Butylated Hydroxyanisole] results in increased expression of FOXO3 mRNA25086368
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Ethanol results in increased phosphorylation of FOXO3 protein]26470730
C432165pyrazolanthrone"pyrazolanthrone inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of FOXO3 protein]"26470730
C031280pyrazolepyrazole results in decreased expression of FOXO3 mRNA17945193
D011794QuercetinQuercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO3 protein]25108166
D011794QuercetinQuercetin results in decreased phosphorylation of FOXO3 protein23099361
C059514resveratrolFOXO3 protein affects the reaction [resveratrol results in decreased expression of CCND1 protein]21179458
C059514resveratrolFOXO3 protein affects the reaction [resveratrol results in increased expression of BCL2L11 protein alternative form]21179458
C059514resveratrolFOXO3 protein affects the reaction [resveratrol results in increased expression of CDKN1B protein]21179458
C059514resveratrolFOXO3 protein affects the reaction [resveratrol results in increased expression of NOS3 mRNA]23583951
C059514resveratrolFOXO3 protein affects the reaction [resveratrol results in increased expression of NOS3 protein]23583951
C059514resveratrolFOXO3 protein affects the reaction [resveratrol results in increased expression of TNFRSF10A protein]21179458
C059514resveratrolFOXO3 protein affects the reaction [resveratrol results in increased expression of TNFRSF10B protein]21179458
C059514resveratrolFOXO3 protein results in decreased susceptibility to resveratrol20012470
C059514resveratrolMAT2B mutant form inhibits the reaction [resveratrol results in increased expression of FOXO3 protein]23814050
C059514resveratrolNiacinamide inhibits the reaction [resveratrol results in increased expression of FOXO3 protein]23022493
C059514resveratrolPARP1 protein affects the reaction [resveratrol results in increased expression of FOXO3 protein]25533949
C059514resveratrolresveratrol affects the localization of and results in increased activity of FOXO3 protein17513867
C059514resveratrolresveratrol affects the localization of FOXO3 protein23022493|2397518
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of FOXO3 protein]17513867
C059514resveratrolresveratrol inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of FOXO3 protein]25472572
C059514resveratrolresveratrol promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in increased localization of FOXO3 protein]20012470
C059514resveratrolresveratrol promotes the reaction [FOXO3 protein binds to CDKN1B promoter]17513867
C059514resveratrolresveratrol promotes the reaction [FOXO3 protein binds to FASLG promoter]17513867
C059514resveratrolresveratrol promotes the reaction [FOXO3 protein binds to NOS3 promoter]23583951
C059514resveratrolresveratrol promotes the reaction [SIRT1 protein binds to FOXO3 protein]21713995
C059514resveratrolresveratrol promotes the reaction [[SIRT1 protein binds to FOXO3 protein] which binds to RUNX2 3' UTR]21713995
C059514resveratrolresveratrol promotes the reaction [[[SIRT1 protein binds to FOXO3 protein] which binds to RUNX2 3' UTR] which results in increased expression of RUNX2 mRNA]21713995
C059514resveratrolresveratrol results in decreased phosphorylation of and results in increased localization of FOXO3 protein20012470
C059514resveratrolresveratrol results in decreased phosphorylation of FOXO3 protein18222423|2117945
C059514resveratrolresveratrol results in increased acetylation of and results in increased expression of FOXO3 protein25533949
C059514resveratrolresveratrol results in increased activity of FOXO3 protein21209944|2171399
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] which results in increased expression of FOXO3 protein21713995
C059514resveratrolresveratrol results in increased expression of FOXO3 mRNA23975182
C059514resveratrolresveratrol results in increased expression of FOXO3 protein23022493|2358395
C059514resveratrolSIRT1 protein affects the reaction [resveratrol results in increased expression of FOXO3 protein]23022493
C059514resveratrolSTF-118804 inhibits the reaction [resveratrol results in increased expression of FOXO3 protein]25533949
C059514resveratrolresveratrol results in decreased expression of FOXO3 protein27070252
C059514resveratrol"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein]"20370652
C059514resveratrol[FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]]24040102
C059514resveratrolFOXO3 mutant form affects the reaction [[Antimycin A co-treated with resveratrol] affects the expression of SOD2 mRNA]24040102
C059514resveratrolFOXO3 mutant form affects the reaction [[Antimycin A co-treated with resveratrol] affects the expression of SOD2 protein]24040102
C059514resveratrolresveratrol inhibits the reaction [Ethanol results in increased acetylation of FOXO3 protein]24095927
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased phosphorylation of FOXO3 protein]23090186
C059514resveratrolresveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of FOXO3 protein]19293636
C059514resveratrolresveratrol inhibits the reaction [ZMPSTE24 gene mutant form results in increased acetylation of FOXO3 protein]23217256
C059514resveratrolresveratrol results in decreased phosphorylation of FOXO3 protein21980390|2309018
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] which results in decreased localization of FOXO3 protein20370652
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein20370652
C059514resveratrol[[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein] which results in decreased susceptibility to Glucose20370652
C059514resveratrolresveratrol results in increased expression of FOXO3 mRNA22610192|2397518
C059514resveratrol2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and affects the localization of FOXO3 protein]]25471227
C059514resveratrolresveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and affects the localization of FOXO3 protein]25471227
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in increased expression of FOXO3 protein]23792339
C059514resveratrolresveratrol results in decreased expression of FOXO3 protein23792339
C059514resveratrolresveratrol results in increased expression of FOXO3 protein18077353|2404041
C059514resveratrolFOXO3 protein affects the reaction [resveratrol results in increased expression of TNFSF10 protein]21179458
C059514resveratrolFOXO3 protein affects the susceptibility to resveratrol21179458
C059514resveratrolresveratrol results in increased activity of FOXO3 protein mutant form21179458
C093642SB 203580SB 203580 inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]23673518
C093642SB 203580SB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]23673518
C093642SB 203580SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein]24787138
D012643SeleniumSelenium results in decreased phosphorylation of and results in increased activity of FOXO3 protein17339365
D012834SilverSilver results in increased expression of FOXO3 mRNA26014281
D019821SimvastatinAcetylcysteine inhibits the reaction [Simvastatin results in increased phosphorylation of FOXO3 protein]20883752
D019821SimvastatinIGF1 protein inhibits the reaction [Simvastatin affects the localization of FOXO3 protein]27734117
D019821SimvastatinSimvastatin affects the localization of FOXO3 protein27734117
D019821SimvastatinSimvastatin results in increased phosphorylation of FOXO3 protein20883752
D019821SimvastatinSimvastatin results in decreased expression of FOXO3 protein19001041
D019821SimvastatinSimvastatin results in decreased phosphorylation of FOXO3 protein19001041
D020123SirolimusCisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]21092744
D020123Sirolimus[Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of BCL2L11 protein21092744
D020123Sirolimus[Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of CDKN1B protein21092744
D020123SirolimusSirolimus promotes the reaction [Cisplatin results in increased expression of and results in increased localization of and results in increased activity of FOXO3 protein]21092744
D020123SirolimusSirolimus results in decreased degradation of and results in increased phosphorylation of FOXO3 protein21092744
D020123Sirolimus[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein21092744
C017947sodium arsenitesodium arsenite affects the expression of FOXO3 mRNA19590694
C017947sodium arsenitesodium arsenite results in decreased expression of FOXO3 protein modified form23219847
C017947sodium arseniteSIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [FOXO3 protein binds to PPARGC1A promoter]]25979314
C017947sodium arseniteSIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [FOXO3 protein binds to SOD2 promoter]]25979314
C017947sodium arseniteSIRT3 protein inhibits the reaction [sodium arsenite results in increased phosphorylation of and affects the localization of and results in decreased activity of FOXO3 protein]25979314
C017947sodium arsenitesodium arsenite inhibits the reaction [FOXO3 protein binds to PPARGC1A promoter]25979314
C017947sodium arsenitesodium arsenite inhibits the reaction [FOXO3 protein binds to SIRT3 protein]25979314
C017947sodium arsenitesodium arsenite inhibits the reaction [FOXO3 protein binds to SOD2 promoter]25979314
C017947sodium arsenitesodium arsenite results in increased acetylation of FOXO3 protein25979314
C017947sodium arsenitesodium arsenite results in increased expression of FOXO3 mRNA19822182
C017947sodium arsenitesodium arsenite results in increased expression of FOXO3 protein23143138
C017947sodium arsenitesodium arsenite results in increased phosphorylation of and affects the localization of and results in decreased activity of FOXO3 protein25979314
C025451sodium bisulfideSIRT3 protein affects the reaction [sodium bisulfide inhibits the reaction [AGT protein results in decreased expression of FOXO3 protein]]28503736
C025451sodium bisulfidesodium bisulfide inhibits the reaction [AGT protein results in decreased expression of FOXO3 protein]28503736
D012980Sodium SalicylateSodium Salicylate results in decreased phosphorylation of FOXO3 protein21303813
D012980Sodium SalicylateSodium Salicylate results in increased expression of FOXO3 protein21303813
D053260SootSoot results in increased expression of FOXO3 mRNA26551751
C091861spermine nitric oxide complexspermine nitric oxide complex inhibits the reaction [Cadmium results in increased expression of FOXO3 mRNA]25490952
C525422SRT1720FOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]]24633890
C525422SRT1720FOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Malondialdehyde]]24633890
C525422SRT1720FOXO3 protein promotes the reaction [SRT1720 results in increased expression of HMOX1 mRNA]24633890
C525422SRT1720FOXO3 protein promotes the reaction [SRT1720 results in increased expression of NQO1 mRNA]24633890
C525422SRT1720FOXO3 protein promotes the reaction [SRT1720 results in increased expression of SOD2 mRNA]24633890
C525422SRT1720FOXO3 protein promotes the reaction [SRT1720 results in increased expression of SOD2 protein]24633890
C000593977STF-118804STF-118804 inhibits the reaction [resveratrol results in increased expression of FOXO3 protein]25533949
D013311StreptozocinStreptozocin results in increased expression of FOXO3 protein modified form17082237
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in increased expression of FOXO3 protein]23792339
D013311StreptozocinStreptozocin results in decreased expression of FOXO3 protein18703049
D013311StreptozocinStreptozocin results in increased expression of FOXO3 protein23792339
D013311StreptozocinStreptozocin results in increased expression of FOXO3 protein modified form17082237
D013629TamoxifenTamoxifen affects the expression of FOXO3 mRNA17555576
C001803tempoltempol affects the phosphorylation of FOXO3 protein24550650
D013739TestosteroneTestosterone results in decreased phosphorylation of FOXO3 protein20403060
D013739TestosteroneTestosterone results in increased activity of and results in increased localization of FOXO3 protein20032061
D013739TestosteroneTestosterone deficiency results in increased phosphorylation of and results in decreased activity of FOXO3 protein20850791
D013739TestosteroneTestosterone inhibits the reaction [Testosterone deficiency results in increased expression of FOXO3 mRNA]19926828
D013739TestosteroneTestosterone inhibits the reaction [Testosterone deficiency results in increased expression of FOXO3 protein]19926828
D013739TestosteroneTestosterone inhibits the reaction [Testosterone deficiency results in increased phosphorylation of and results in decreased activity of FOXO3 protein]20850791
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of FOXO3 protein]22266097
D013749Tetrachlorodibenzodioxinfostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]]24954032
D013749TetrachlorodibenzodioxinMifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of FOXO3 protein]22266097
D013749TetrachlorodibenzodioxinOkadaic Acid inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]]24954032
D013749TetrachlorodibenzodioxinPGR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of FOXO3 protein]22266097
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]24954032
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased phosphorylation of FOXO3 protein22266097|2495403
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of FOXO3 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of FOXO3 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FOXO3 promoter]21889950
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FOXO3 mRNA18796159|1977048
D013755Tetradecanoylphorbol AcetateFOXO3 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2]21705328
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased phosphorylation of FOXO3 protein21705328
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased activity of FOXO3 protein21705328
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FOXO3 mRNA25613284
D008063Thioctic AcidThioctic Acid results in decreased acetylation of FOXO3 protein22327056
D008063Thioctic Acid[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein22327056
C009495titanium dioxidetitanium dioxide results in increased expression of FOXO3 mRNA29128614
D014028Tobacco Smoke PollutionFOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]]24633890
D014028Tobacco Smoke PollutionFOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Malondialdehyde]]24633890
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased oxidation of FOXO3 protein24633890
D014212TretinoinTretinoin results in increased expression of FOXO3 mRNA23830798
C050414tripterinetripterine results in increased phosphorylation of FOXO3 protein25903958
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FOXO3 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of FOXO3 mRNA28973697
C101044tyrphostin AG 1478[tyrphostin AG 1478 results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]23673518
D014520UrethaneUrethane results in increased expression of FOXO3 mRNA28818685
D014635Valproic AcidValproic Acid affects the reaction [Oxygen deficiency results in decreased expression of FOXO3 mRNA]22711276
D014635Valproic AcidValproic Acid results in decreased expression of FOXO3 mRNA19101580|2800136
D014635Valproic AcidValproic Acid results in increased methylation of FOXO3 gene28853863|2915479
D014635Valproic AcidValproic Acid affects the expression of FOXO3 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of FOXO3 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of FOXO3 mRNA23034163|2386920
D009536Niacinamide[Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO3 protein26712469
D009536NiacinamideNiacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]]25472572
D009536NiacinamideNiacinamide inhibits the reaction [resveratrol results in increased expression of FOXO3 protein]23022493
D009536NiacinamideNiacinamide promotes the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of FOXO3 protein]25472572
D009536NiacinamideNiacinamide results in increased expression of and results in increased acetylation of FOXO3 protein26712469
C111237vorinostatvorinostat inhibits the reaction [Oxygen deficiency results in decreased expression of FOXO3 mRNA]22711276
C009687wortmanninwortmannin inhibits the reaction [arsenite results in increased phosphorylation of FOXO3 protein]24024143
C009687wortmanninwortmannin inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]23673518
C009687wortmanninwortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]23673518
C009687wortmanninwortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO3 protein]17935137
C009687wortmanninwortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO3 protein]17935137
C009687wortmanninwortmannin results in decreased phosphorylation of FOXO3 protein25856345
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FOXO3 mRNA16357179
D019345Zinc AcetateZinc Acetate results in increased expression of FOXO3 mRNA16357179
D019287Zinc SulfateZinc Sulfate results in increased expression of FOXO3 mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001221transcription cofactor binding-IEA-  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA20371612  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-IDA21329882  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA14734530  
GO:0005515protein binding-IPI10102273  11864996  14976264  15084259  15084260  15126506  
16809346  18393360  18593906  21532621  21621563  21909281  
22761832  23283301  25241761  25609649  29445193  
GO:0008013beta-catenin binding-IPI15905404  
GO:0008134transcription factor binding-IBA21873635  
GO:0019901protein kinase binding-IPI16751106  18593906  21329882  
GO:0031490chromatin DNA binding-ISS-  
GO:0034246mitochondrial sequence-specific DNA-binding transcription factor activity-IMP29445193  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IDA10102273  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IDA20371612  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP18787191  
GO:0001542ovulation from ovarian follicle-IEA-  
GO:0001544initiation of primordial ovarian follicle growth-IEA-  
GO:0001547antral ovarian follicle growth-IEA-  
GO:0001556oocyte maturation-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-ISS-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006390mitochondrial transcription-IMP29445193  
GO:0006417regulation of translation-IDA21329882  
GO:0007568aging-IEA-  
GO:0008286insulin receptor signaling pathway-IBA21873635  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030330DNA damage response, signal transduction by p53 class mediator-IEA-  
GO:0031667response to nutrient levels-IEA-  
GO:0033209tumor necrosis factor-mediated signaling pathway-IMP15084260  
GO:0034599cellular response to oxidative stress-ISS-  
GO:0042593glucose homeostasis-IBA21873635  
GO:0043065positive regulation of apoptotic process-IDA20371612  
GO:0043525positive regulation of neuron apoptotic process-IMP10102273  
GO:0045648positive regulation of erythrocyte differentiation-IDA14734530  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA10102273  15084260  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA10102273  14734530  
GO:0048854brain morphogenesis-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0071386cellular response to corticosterone stimulus-IEA-  
GO:0071456cellular response to hypoxia-IEA-  
GO:0071548response to dexamethasone-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IEA-  
GO:0097150neuronal stem cell population maintenance-IEA-  
GO:0097192extrinsic apoptotic signaling pathway in absence of ligand-IEA-  
GO:1901300positive regulation of hydrogen peroxide-mediated programmed cell death-IEA-  
GO:1903428positive regulation of reactive oxygen species biosynthetic process-IEA-  
GO:1904646cellular response to amyloid-beta-IEA-  
GO:1990090cellular response to nerve growth factor stimulus-IEA-  
GO:1990785response to water-immersion restraint stress-IEA-  
GO:2000177regulation of neural precursor cell proliferation-IEA-  
GO:2000353positive regulation of endothelial cell apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA10102273  15084260  16751106  21329882  22761832  23283301  23640897  25327288  
GO:0005634nucleus-IMP29445193  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA10102273  15084260  16751106  20371612  21329882  23283301  
GO:0005739mitochondrioncolocalizes_withIDA23283301  
GO:0005741mitochondrial outer membrane-IDA29445193  
GO:0005759mitochondrial matrixcolocalizes_withIDA29445193  
GO:0005829cytosol-IDA23640897  
GO:0005829cytosol-TAS-  
GO:0032991protein-containing complex-IDA23283301  29445193  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05213Endometrial cancer
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-1181150Signaling by NODALTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseIEA
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-198693AKT phosphorylates targets in the nucleusTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5674400Constitutive Signaling by AKT1 E17K in CancerTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsIEA
R-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsTAS
R-HSA-8863678Neurodegenerative DiseasesIEA
R-HSA-8863678Neurodegenerative DiseasesTAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationTAS
R-HSA-8952158RUNX3 regulates BCL2L11 (BIM) transcriptionTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9020591Interleukin-12 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24804734Shorter men live longer: association of height with longevity and FOXO3 genotype in American men of Japanese ancestry. (2014)He QPLoS One
25484085Autophagy and ethanol neurotoxicity. (2014)Luo JAutophagy
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