Gene: ZNF423

23090
Ebfaz|JBTS19|NPHP14|OAZ|Roaz|ZFP423|Zfp104|hOAZ
zinc finger protein 423
protein-coding
16q12.1
Ensembl:ENSG00000102935 MIM:604557 Vega:OTTHUMG00000173491 UniprotKB:Q2M1K9
NG_032972.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.430e-1 (AD)  1.055e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GOLIM40.831
PSD20.83
TNS30.827
AMOT0.822
GRIN2C0.821
PCDHGC30.82
ALDH6A10.819
ACBD70.817
ADCYAP1R10.816
FAT10.815

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.395
DPP4-0.386
ENPP6-0.381
HS3ST2-0.381
OR4F29-0.365
NRG1-0.363
NPFFR2-0.356
ADTRP-0.354
L3MBTL4-0.346
THEMIS-0.345

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZNF423 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZNF423 mRNA"27188386
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of ZNF423 mRNA"25351596
D001280AtrazineAtrazine results in increased expression of ZNF423 mRNA22378314
C006780bisphenol Abisphenol A affects the expression of ZNF423 mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of ZNF423 mRNA28938450
C006780bisphenol Abisphenol A results in decreased expression of ZNF423 mRNA25181051
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ZNF423 mRNA24763279
D003561CytarabineCytarabine results in increased expression of ZNF423 mRNA21198554
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ZNF423 mRNA20170705|2686566
D019833GenisteinGenistein results in decreased expression of ZNF423 mRNA26865667
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ZNF423 mRNA24763279
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ZNF423 protein26067464
D007854LeadLead affects the expression of ZNF423 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of ZNF423 mRNA"24972896
D018021Lithium ChlorideLithium Chloride results in decreased expression of ZNF423 mRNA23527032
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ZNF423 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZNF423 mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ZNF423 mRNA23649840
C502851quinocetonequinocetone results in increased expression of ZNF423 mRNA27046791
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ZNF423 mRNA25351596
C017947sodium arsenitesodium arsenite affects the methylation of ZNF423 gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ZNF423 mRNA20106945|2163298
D014212TretinoinTretinoin results in decreased expression of ZNF423 mRNA21934132
D014415TunicamycinTunicamycin results in decreased expression of ZNF423 mRNA22378314
D014635Valproic AcidValproic Acid results in decreased expression of ZNF423 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of ZNF423 gene29154799
C111237vorinostatvorinostat results in decreased expression of ZNF423 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IBA21873635  
GO:0003677DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0005515protein binding-IPI19345331  22863007  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0007219Notch signaling pathway-ISS-  
GO:0007399nervous system development-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0030513positive regulation of BMP signaling pathway-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-IDA10660046  
GO:0045893positive regulation of transcription, DNA-templated-IDA10660046  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA10660046  
GO:0005654nucleoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28264723Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome. (2017 Mar 7)Lin XBMC Med