Gene: KIF1B

23095
CMT2|CMT2A|CMT2A1|HMSNII|KLP|NBLST1
kinesin family member 1B
protein-coding
1p36.22
Ensembl:ENSG00000054523 MIM:605995 Vega:OTTHUMG00000001817 UniprotKB:O60333
NG_008069.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.130e-1 (AD)  9.877e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF1A0.898
IARS20.883
KIF5C0.871
SCRN10.868
DCAF70.866
CDC42BPB0.863
ILF30.862
TOP2B0.859
CBX50.854
SERINC10.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.753
OR4F29-0.752
ODAM-0.206
GSC-0.205
NANOGNB-0.2
IRX3-0.191
HCRT-0.189
OXT-0.186
S100A3-0.185
PDZK1IP1-0.184

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIF1B mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of KIF1B mRNA"19095052
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of KIF1B mRNA"27291303
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIF1B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIF1B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIF1B mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIF1B mRNA"25510870
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KIF1B mRNA"20816883
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of KIF1B mRNA"20206263
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of KIF1B mRNA20829426
D020106AcrylamideAcrylamide results in decreased expression of KIF1B mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KIF1B mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KIF1B mRNA16483693
D001205Ascorbic AcidAscorbic Acid results in decreased expression of KIF1B mRNA15372504
D001280AtrazineAtrazine results in decreased expression of KIF1B mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of KIF1B mRNA22323515
D001554BenzeneBenzene results in increased expression of KIF1B mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KIF1B mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KIF1B mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KIF1B mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KIF1B mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of KIF1B mRNA"26238291
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of KIF1B mRNA25566086
D001622BetaineBetaine results in increased expression of KIF1B mRNA26391144
C006780bisphenol Abisphenol A results in increased expression of KIF1B mRNA26063408
C006780bisphenol Abisphenol A affects the expression of KIF1B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KIF1B gene28505145
D002101Cacodylic AcidCacodylic Acid results in increased expression of KIF1B mRNA17720352
D002994ClofibrateClofibrate results in decreased expression of KIF1B mRNA22300585
C018021cobaltous chloridecobaltous chloride results in increased expression of KIF1B mRNA19320972|1937684
D003300CopperCopper results in decreased expression of KIF1B mRNA26293553
D019327Copper SulfateCopper Sulfate results in increased expression of KIF1B mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of KIF1B mRNA19770486
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in increased expression of KIF1B mRNA26873546
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of KIF1B mRNA21266533
D002945CisplatinCisplatin results in increased expression of KIF1B mRNA21151649
D002117CalcitriolCalcitriol results in decreased expression of KIF1B mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of KIF1B mRNA21592394
D004112DimercaprolDimercaprol inhibits the reaction [Mustard Gas results in decreased expression of KIF1B mRNA]16377760
D004221DisulfiramDisulfiram results in decreased expression of KIF1B mRNA20530235
D004237DiuronDiuron results in increased expression of KIF1B mRNA21551480
D004317DoxorubicinKIF1B protein affects the susceptibility to Doxorubicin16217747
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in increased expression of KIF1B mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of KIF1B mRNA26873546
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KIF1B mRNA17606305
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KIF1B mRNA17942748
D005485FlutamideFlutamide results in increased expression of KIF1B mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of KIF1B mRNA23649840
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KIF1B protein18951874
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of KIF1B mRNA19376150
C492448ICG 001ICG 001 results in decreased expression of KIF1B mRNA26191083
D007213IndomethacinIndomethacin inhibits the reaction [Mustard Gas results in decreased expression of KIF1B mRNA]16377760
D007545IsoproterenolIsoproterenol results in decreased expression of KIF1B mRNA20003209
C544151jinfukangjinfukang results in decreased expression of KIF1B mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of KIF1B mRNA24796395
C008261lead acetatelead acetate affects the expression of KIF1B mRNA21147602
C008261lead acetatelead acetate results in decreased expression of KIF1B mRNA21829687
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of KIF1B mRNA22563483
D008731MethoxychlorMethoxychlor affects the expression of KIF1B mRNA20829426
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of KIF1B mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of KIF1B promoter"26251327
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF1B mRNA"15329391
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of KIF1B protein24625837
C517284monomethyl phthalatemonomethyl phthalate affects the expression of KIF1B mRNA26924002
D009151Mustard GasDimercaprol inhibits the reaction [Mustard Gas results in decreased expression of KIF1B mRNA]16377760
D009151Mustard GasIndomethacin inhibits the reaction [Mustard Gas results in decreased expression of KIF1B mRNA]16377760
D009151Mustard GasMustard Gas results in decreased expression of KIF1B mRNA16377760
D009151Mustard GasMustard Gas results in increased expression of KIF1B mRNA15674844
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of KIF1B mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KIF1B mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of KIF1B mRNA19167457
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of KIF1B mRNA22563483
D010269ParaquatParaquat results in increased expression of KIF1B mRNA22563483
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KIF1B mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of KIF1B mRNA19095052
D010416PentachlorophenolPentachlorophenol results in increased expression of KIF1B mRNA24642059
D010634PhenobarbitalPhenobarbital affects the expression of KIF1B mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of KIF1B mRNA18301758
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of KIF1B mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of KIF1B mRNA21278054
C428725pyridabenpyridaben results in increased expression of KIF1B mRNA22563483
D011794QuercetinQuercetin results in decreased expression of KIF1B protein14750173
C009166retinol acetateretinol acetate results in increased expression of KIF1B mRNA16772331
D012402RotenoneRotenone affects the expression of KIF1B mRNA23263842
D012402RotenoneRotenone affects the expression of KIF1B protein23263842
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of KIF1B mRNA23806026
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of KIF1B mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of KIF1B mRNA21795629
D014284TriiodothyronineTriiodothyronine results in increased expression of KIF1B mRNA15953391
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of KIF1B mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of KIF1B mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KIF1B mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KIF1B mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KIF1B mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KIF1B mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KIF1B mRNA21215274
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KIF1B protein18951874
D013893ThiramThiram results in decreased expression of KIF1B mRNA20530235
C009495titanium dioxidetitanium dioxide results in decreased expression of KIF1B mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of KIF1B mRNA28065790
C012589trichostatin Atrichostatin A results in increased expression of KIF1B mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of KIF1B mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of KIF1B mRNA28973697
D014501UraniumUranium results in increased expression of KIF1B mRNA15672453
C005460uranyl acetateuranyl acetate results in increased expression of KIF1B mRNA15672453
D014520UrethaneUrethane results in increased expression of KIF1B mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of KIF1B mRNA23179753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of KIF1B gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of KIF1B mRNA25423262
D014747VinblastineKIF1B protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin affects the expression of KIF1B mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of KIF1B mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of KIF1B mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of KIF1B mRNA20044591
D015032ZincZinc deficiency results in increased expression of KIF1B mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003777microtubule motor activity-IBA21873635  
GO:0003777microtubule motor activity-ISS-  
GO:0005515protein binding-IPI15324660  16225668  17353931  20852589  25416956  
GO:0005524ATP binding-IEA-  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-IEA-  
GO:0008574ATP-dependent microtubule motor activity, plus-end-directed-IBA21873635  
GO:0016887ATPase activity-IBA21873635  
GO:0016887ATPase activity-ISS-  
GO:0019894kinesin binding-TAS10341097  
GO:0019900kinase binding-IEA-  
GO:0097110scaffold protein binding-IEA-  
GO:1990939ATP-dependent microtubule motor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0007018microtubule-based movement-IBA21873635  
GO:0007018microtubule-based movement-ISS-  
GO:0007270neuron-neuron synaptic transmission-ISS-  
GO:0007274neuromuscular synaptic transmission-ISS-  
GO:0008089anterograde axonal transport-ISS-  
GO:0010628positive regulation of gene expression-IEA-  
GO:0016192vesicle-mediated transport-IBA21873635  
GO:0030705cytoskeleton-dependent intracellular transport-IBA21873635  
GO:0030705cytoskeleton-dependent intracellular transport-ISS-  
GO:0032418lysosome localization-IEA-  
GO:0047497mitochondrion transport along microtubule-IEA-  
GO:1904647response to rotenone-IEA-  
GO:1990048anterograde neuronal dense core vesicle transport-IEA-  
GO:1990049retrograde neuronal dense core vesicle transport-IEA-  
GO:1990090cellular response to nerve growth factor stimulus-IEA-  
GO:1990778protein localization to cell periphery-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
GO:0005871kinesin complex-IBA21873635  
GO:0005874microtubule-IBA21873635  
GO:0005874microtubule-IEA-  
GO:0005875microtubule associated complex-ISS-  
GO:0030424axon-IBA21873635  
GO:0030425dendrite-IBA21873635  
GO:0030659cytoplasmic vesicle membrane-ISS-  
GO:0031410cytoplasmic vesicle-IBA21873635  
GO:0031410cytoplasmic vesicle-ISS-  
GO:0043005neuron projection-IBA21873635  
GO:0043005neuron projection-ISS-  
GO:1904115axon cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6811434COPI-dependent Golgi-to-ER retrograde trafficTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS
R-HSA-983189KinesinsTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301715Hereditary Paraganglioma-Pheochromocytoma Syndromes (1993)Kirmani S-
27122668Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort. (2016 Apr 28)Chen JHWorld J Gastroenterol