Gene info: ID 231

Gene: AKR1B1

GENE ID: 231

Synonyms: ADR|ALDR1|ALR2|AR

Description: aldo-keto reductase family 1 member B

Gene type: protein-coding

Location: 7q33

dbXrefs: Ensembl:ENSG00000085662 MIM:103880 Vega:OTTHUMG00000155322 UniprotKB:P15121

RefSeq: NC_000007.14

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.169e-1 (AD) 3.221e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SNX17	0.959
COPS6	0.951
CCT7	0.95
USF1	0.948
VPS4A	0.946
EMC4	0.946
PSMB7	0.945
CUEDC2	0.944
PEF1	0.944
CFL1	0.943

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.824
OR4F29	-0.788
MTRNR2L6	-0.282
KLRB1	-0.261
MTRNR2L9	-0.259
MTRNR2L10	-0.255
C8orf74	-0.238
KCNJ15	-0.23
GPR171	-0.225
C9orf153	-0.224

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00143	Glutathione	Small Molecule	70-18-8	Approved\|Investigational\|Nutraceutical	Target
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target
DB00605	Sulindac	Small Molecule	38194-50-2	Approved\|Investigational	Target
DB01689	Inhibitor Idd 384	Small Molecule		Experimental	Target
DB02007	alpha-D-glucose 6-phosphate	Small Molecule		Experimental	Target
DB02020	Alrestatin	Small Molecule	51411-04-2	Experimental	Target
DB02021	Fidarestat	Small Molecule	136087-85-9	Experimental	Target
DB02101	(S,R)-fidarestat	Small Molecule	-	Experimental	Target
DB02132	Zenarestat	Small Molecule	112733-06-9	Experimental	Target
DB02383	Tolrestat	Small Molecule	82964-04-3	Withdrawn	Target
DB02518	N-Acetylalanine	Small Molecule	97-69-8	Experimental	Target
DB02712	Sorbinil	Small Molecule	68367-52-2	Experimental\|Investigational	Target
DB02834	IDD552	Small Molecule		Experimental	Target
DB02994	Cacodylic acid	Small Molecule	75-60-5	Experimental	Target
DB03461	2'-Monophosphoadenosine 5'-Diphosphoribose	Small Molecule		Experimental	Target
DB04272	Citric Acid	Small Molecule	77-92-9	Approved\|Nutraceutical	Target
DB05327	Ranirestat	Small Molecule	147254-64-6	Investigational	Target
DB05383	Pimagedine	Small Molecule	79-17-4	Investigational	Target
DB05533	QR-333	Small Molecule		Investigational	Target
DB06246	Exisulind	Small Molecule	59973-80-7	Investigational	Target
DB07028	(2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID	Small Molecule		Experimental	Target
DB07030	(5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID	Small Molecule		Experimental	Target
DB07063	{3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID	Small Molecule		Experimental	Target
DB07093	{3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACID	Small Molecule		Experimental	Target
DB07139	3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid	Small Molecule		Experimental	Target
DB07187	6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE	Small Molecule		Experimental	Target
DB07450	(R)-minalrestat	Small Molecule		Experimental	Target
DB07498	4-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACID	Small Molecule		Experimental	Target
DB07999	{4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACID	Small Molecule		Experimental	Target
DB08000	2-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDE	Small Molecule		Experimental	Target
DB08084	IDD594	Small Molecule		Experimental	Target
DB08098	{[5-(5-nitro-2-furyl)-1,3,4-oxadiazol-2-yl]thio}acetic acid	Small Molecule		Experimental	Target
DB08449	2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid	Small Molecule		Experimental	Target
DB08772	3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of AKR1B1 mRNA"	17690111
C026486	1,2,5,6-dibenzanthracene	"[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of AKR1B1 mRNA"	18711122
C026486	1,2,5,6-dibenzanthracene	"[1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of AKR1B1 mRNA"	18711122
C026486	1,2,5,6-dibenzanthracene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of AKR1B1 mRNA"	18711122
C040756	1,2-naphthoquinone	"AKR1B1 protein results in increased reduction of 1,2-naphthoquinone"	10510318
C002591	16-ketoestrone	AKR1B1 protein results in increased reduction of 16-ketoestrone	10510318
C031903	1-UFT protocol	AKR1B1 protein results in decreased susceptibility to 1-UFT protocol	16734730
C026978	2,3-butylene glycol	"[AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol"	23295224
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of AKR1B1 mRNA"	17547211
C043231	2,3-hexanedione	"AKR1B1 protein results in increased reduction of 2,3-hexanedione"	10510318\|2329522
C043231	2,3-hexanedione	"[AKR1B1 protein results in increased reduction of 2,3-hexanedione] which results in increased chemical synthesis of Hexanones"	23295224
C013186	2,3-pentanedione	"AKR1B1 protein results in increased reduction of 2,3-pentanedione"	23295224
C013186	2,3-pentanedione	"[AKR1B1 protein results in increased reduction of 2,3-pentanedione] which results in increased chemical synthesis of Pentanones"	23295224
C057349	2,4-decadienal	"AKR1B1 protein results in increased reduction of 2,4-decadienal"	9890881
C502503	2,4-heptadienal	"AKR1B1 protein results in increased reduction of 2,4-heptadienal"	9890881
C079389	2,4-hexadienal	"AKR1B1 protein results in increased reduction of 2,4-hexadienal"	21329684\|9890881
C079389	2,4-hexadienal	"AKR1B1 protein results in increased reduction of 2,4-hexadienal metabolite"	21329684
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]	17640564
C412886	2,4-nonadienal	"AKR1B1 protein results in increased reduction of 2,4-nonadienal"	9890881
C012796	2-butenal	AKR1B1 protein results in increased reduction of 2-butenal	21329684\|9890881
C012796	2-butenal	AKR1B1 protein results in increased reduction of 2-butenal metabolite	21329684
C059341	2-chlorobenzaldehyde	AKR1B1 protein results in increased reduction of 2-chlorobenzaldehyde	10510318
C476489	(2E)-decenal	AKR1B1 protein affects the reduction of (2E)-decenal	11306073
C064600	2-heptenal	AKR1B1 protein results in increased reduction of 2-heptenal	9890881
C051750	2-hexenal	AKR1B1 protein affects the reduction of 2-hexenal	11306073
C051750	2-hexenal	AKR1B1 protein results in increased reduction of 2-hexenal	21329684\|9890881
C051750	2-hexenal	AKR1B1 protein results in increased reduction of 2-hexenal metabolite	21329684
C013166	2-nonenal	AKR1B1 protein affects the reduction of 2-nonenal	11306073
C013166	2-nonenal	AKR1B1 protein results in increased reduction of 2-nonenal	9890881
C057348	2-octenal	AKR1B1 protein affects the reduction of 2-octenal	11306073
C057348	2-octenal	AKR1B1 protein results in increased reduction of 2-octenal	9890881
C064599	2-pentenal	AKR1B1 protein affects the reduction of 2-pentenal	11306073
C064599	2-pentenal	AKR1B1 protein results in increased reduction of 2-pentenal	9890881
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of AKR1B1 mRNA	12958071
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]	18588981
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 protein]	18588981
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [NFE2L2 protein results in increased expression of AKR1B1 mRNA]	18588981
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [NFE2L2 protein results in increased expression of AKR1B1 protein]	18588981
C050571	3-nitrobenzaldehyde	AKR1B1 protein results in increased reduction of 3-nitrobenzaldehyde	10510318
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of AKR1B1 mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B1 mRNA"	27188386
C044135	4-hydroxy-2-decenal	AKR1B1 protein affects the reduction of 4-hydroxy-2-decenal	11306073
C045934	4-hydroxy-2-hexenal	AKR1B1 protein affects the reduction of 4-hydroxy-2-hexenal	11306073
C045934	4-hydroxy-2-hexenal	AKR1B1 protein results in increased reduction of 4-hydroxy-2-hexenal	9890881
C027576	4-hydroxy-2-nonenal	AKR1B1 protein affects the reduction of 4-hydroxy-2-nonenal	11306073
C027576	4-hydroxy-2-nonenal	AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal	10510318\|2132968
C027576	4-hydroxy-2-nonenal	AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal metabolite	21329684
C046538	4-hydroxy-2-octenal	AKR1B1 protein affects the reduction of 4-hydroxy-2-octenal	11306073
C046538	4-hydroxy-2-octenal	AKR1B1 protein results in increased reduction of 4-hydroxy-2-octenal	9890881
C117714	4-hydroxyequilenin-o-quinone	[AKR1B1 protein co-treated with NADP] results in increased reduction of and affects the activity of 4-hydroxyequilenin-o-quinone	21910479
C057180	4-hydroxyretinal	AKR1B1 protein results in increased reduction of 4-hydroxyretinal	19014918
C029915	4-nitrobenzaldehyde	AKR1B1 protein results in increased reduction of 4-nitrobenzaldehyde	10510318
C099660	4-oxoretinaldehyde	AKR1B1 protein results in increased reduction of 4-oxoretinaldehyde	19014918
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B1 mRNA"	27188386
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of AKR1B1 mRNA"	26238291
C005399	9,10-phenanthrenequinone	"AKR1B1 protein results in increased reduction of 9,10-phenanthrenequinone"	10510318
C005399	9,10-phenanthrenequinone	"AKR1B1 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone"	21910479
D000082	Acetaminophen	Acetaminophen results in increased expression of AKR1B1 mRNA	22230336
D000093	Acetoin	AKR1B1 protein results in increased reduction of Acetoin	23295224
D000093	Acetoin	"[AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol"	23295224
D000093	Acetoin	[AKR1B1 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin	23295224
D000171	Acrolein	AKR1B1 protein results in decreased susceptibility to Acrolein	14676331
D000171	Acrolein	alrestatin inhibits the reaction [AKR1B1 protein results in decreased susceptibility to Acrolein]	14676331
D000171	Acrolein	alrestatin inhibits the reaction [[Ethoxyquin results in increased activity of AKR1B1 protein] which results in decreased susceptibility to Acrolein]	14676331
D000171	Acrolein	Glutathione promotes the reaction [AKR1B1 protein results in decreased susceptibility to Acrolein]	14676331
D000171	Acrolein	AKR1B1 protein affects the reduction of Acrolein	11306073
D000171	Acrolein	AKR1B1 protein results in increased reduction of Acrolein	10510318\|2132968
D000171	Acrolein	AKR1B1 protein results in increased reduction of Acrolein metabolite	21329684
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of AKR1B1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of AKR1B1 mRNA	22100608\|2715375
D000393	Air Pollutants	Air Pollutants analog results in increased expression of AKR1B1 mRNA	21757418
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of AKR1B1 mRNA	28522335
D024502	alpha-Tocopherol	alpha-Tocopherol results in increased expression of AKR1B1 mRNA	16908007
C016212	alrestatin	alrestatin inhibits the reaction [AKR1B1 protein results in decreased susceptibility to Acrolein]	14676331
C016212	alrestatin	alrestatin inhibits the reaction [AKR1B1 protein results in decreased susceptibility to glycolaldehyde]	14676331
C016212	alrestatin	alrestatin inhibits the reaction [[Ethoxyquin results in increased activity of AKR1B1 protein] which results in decreased susceptibility to Acrolein]	14676331
C016212	alrestatin	alrestatin inhibits the reaction [[Ethoxyquin results in increased activity of AKR1B1 protein] which results in decreased susceptibility to glycolaldehyde]	14676331
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of AKR1B1 mRNA	16483693
D052179	Antigens, Plant	"[zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased abundance of Reactive Oxygen Species]"	21334316
D052179	Antigens, Plant	"[zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased secretion of Dinoprostone]"	21334316
D052179	Antigens, Plant	"[zopolrestat results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to Antigens, Plant"	21334316
D000965	Antimony	Antimony results in decreased expression of AKR1B1 mRNA	17547211
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in decreased expression of AKR1B1 mRNA	17547211
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in increased expression of AKR1B1 mRNA	28713220
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of AKR1B1 mRNA	17547211
D001205	Ascorbic Acid	Ascorbic Acid results in increased reduction of AKR1B1 protein modified form	19061876
D001280	Atrazine	Atrazine results in decreased expression of AKR1B1 mRNA	25929836
C051597	Bandrowski's base	Bandrowski's base results in increased expression of AKR1B1 mRNA	20566472
C017228	benzo(a)pyrene 7,8-dihydrodiol	"[AKR1B1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol"	21910479
C076588	benzo(a)pyrene-7,8-dione	"[AKR1B1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione"	21910479
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of AKR1B1 mRNA	17690111
D019817	Benzoic Acid	Benzoic Acid results in increased expression of AKR1B1 mRNA	20566472
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of AKR1B1 mRNA	26001963
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of AKR1B1 mRNA"	17690111
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of AKR1B1 mRNA	17690111
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of AKR1B1 mRNA	17690111
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of AKR1B1 mRNA	20106945\|2231617
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of AKR1B1 mRNA"	18711122
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [sodium arsenite results in increased expression of AKR1B1 protein]	16456883
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of AKR1B1 protein	16456883
D001564	Benzo(a)pyrene	sodium arsenite promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1B1 protein]	16456883
D019905	Benzyl Alcohol	AKR1B1 protein results in increased oxidation of Benzyl Alcohol	17194029
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKR1B1 mRNA	21215737
C038328	BEP protocol	BEP protocol results in increased expression of AKR1B1 mRNA	18987330
D001622	Betaine	Betaine results in decreased expression of AKR1B1 mRNA	26391144
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1B1 mRNA	28628672
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in increased expression of AKR1B1 mRNA	15912405
C006780	bisphenol A	bisphenol A affects the expression of AKR1B1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of AKR1B1 protein	20219716
C006780	bisphenol A	bisphenol A results in increased expression of AKR1B1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of AKR1B1 gene	28505145
C006780	bisphenol A	[Fructose co-treated with bisphenol A] results in increased expression of AKR1B1 protein	26930160
D000069286	Bortezomib	Bortezomib results in increased expression of AKR1B1 mRNA	21215737
D000069286	Bortezomib	Bortezomib results in increased expression of AKR1B1 protein	21215737
D003931	Diacetyl	AKR1B1 protein results in increased reduction of Diacetyl	23295224
D003931	Diacetyl	[AKR1B1 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin	23295224
C018475	butyraldehyde	AKR1B1 protein affects the reduction of butyraldehyde	11306073
C018475	butyraldehyde	AKR1B1 protein results in increased reduction of butyraldehyde	9890881
D002104	Cadmium	Cadmium results in decreased expression of AKR1B1 mRNA	17547211
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of AKR1B1 mRNA	17547211
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of AKR1B1 protein	24527689
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of AKR1B1 mRNA	24794047
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester results in decreased activity of AKR1B1 protein	27163852
C081643	candesartan	candesartan results in decreased expression of AKR1B1 mRNA	14871019
D000069287	Capecitabine	AKR1B1 protein results in decreased susceptibility to Capecitabine	16734730
C031639	caprylic aldehyde	AKR1B1 protein affects the reduction of caprylic aldehyde	11306073
D002330	Carmustine	AKR1B1 mRNA affects the susceptibility to Carmustine	16365179
C099555	CD 437	CD 437 results in decreased expression of AKR1B1 mRNA	12958071
C445667	CD 666	CD 666 results in decreased activity of AKR1B1 protein	23220004
D002509	Cephaloridine	Cephaloridine results in increased expression of AKR1B1 mRNA	18172885
D002108	Ceruletide	Ceruletide results in increased expression of AKR1B1 protein	18024178
D002857	Chromium	Chromium results in decreased expression of AKR1B1 mRNA	17547211
D002911	Chrysenes	AKR1B1 protein results in increased reduction of and affects the activity of Chrysenes	21910479
C020722	cinnamyl alcohol	cinnamyl alcohol results in increased expression of AKR1B1 mRNA	20566472
D009249	NADP	"[AKR1B1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol"	21910479
D009249	NADP	[AKR1B1 protein co-treated with NADP] results in increased reduction of and affects the activity of 4-hydroxyequilenin-o-quinone	21910479
D009249	NADP	"[AKR1B1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione"	21910479
D009249	NADP	NADP binds to AKR1B1 protein binds to fidarestat	23295227
D009249	NADP	NADP results in increased activity of AKR1B1 protein	23295224
D003300	Copper	Copper binds to and results in increased oxidation of and results in decreased activity of AKR1B1 protein	16615933
D003300	Copper	Copper promotes the reaction [AKR1B1 protein binds to AKR1B1 protein]	16615933
D003300	Copper	CRYAA protein inhibits the reaction [Copper promotes the reaction [AKR1B1 protein binds to AKR1B1 protein]]	16615933
D003300	Copper	CRYAA protein inhibits the reaction [Copper results in increased oxidation of and results in decreased activity of AKR1B1 protein]	16615933
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of AKR1B1 mRNA	20971185
D003300	Copper	Copper deficiency results in decreased expression of AKR1B1 protein	18993053
D003300	Copper	Copper results in increased expression of AKR1B1 mRNA	22465980
D003474	Curcumin	Curcumin results in increased expression of AKR1B1 mRNA	18200517
D003474	Curcumin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]	17640564
D003474	Curcumin	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]	18588981
D003474	Curcumin	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 protein]	18588981
D003474	Curcumin	AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]	17640564
D003474	Curcumin	Curcumin results in increased activity of AKR1B1 protein	17640564
D003474	Curcumin	Curcumin results in increased expression of AKR1B1 mRNA	17640564\|1829998
D003474	Curcumin	Curcumin results in increased expression of AKR1B1 protein	17640564\|1858898
D003474	Curcumin	NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]	17640564\|1858898
D003474	Curcumin	NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]	18588981
D003474	Curcumin	pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]	17640564
D003474	Curcumin	SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]	17640564
D016572	Cyclosporine	Cyclosporine results in decreased expression of AKR1B1 mRNA	25562108\|2798913
D016572	Cyclosporine	Cyclosporine results in increased expression of AKR1B1 mRNA	20106945
D003630	Daunorubicin	AKR1B1 protein results in increased reduction of Daunorubicin	10510318
D003634	DDT	DDT results in decreased expression of AKR1B1 mRNA	27894940
D003634	DDT	DDT results in increased expression of AKR1B1 mRNA	22230338
C021170	decanaldehyde	AKR1B1 protein affects the reduction of decanaldehyde	11306073
C021170	decanaldehyde	AKR1B1 protein results in increased reduction of decanaldehyde	9890881
C017184	dehydroretinal	AKR1B1 protein results in increased reduction of dehydroretinal	19014918
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of AKR1B1 mRNA]	27941970
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1B1 mRNA	28628672
D016190	Carboplatin	Carboplatin results in increased expression of AKR1B1 mRNA	18172885
C041517	dibenzo(a,l)pyrene	"[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of AKR1B1 mRNA"	18711122
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of AKR1B1 mRNA	21266533
D002945	Cisplatin	Cisplatin results in decreased expression of AKR1B1 protein	16803524
D002945	Cisplatin	Cisplatin results in increased expression of AKR1B1 mRNA	18172885
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased expression of AKR1B1 mRNA	27894940
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of AKR1B1 mRNA	19638242
D004101	Dihydroxydihydrobenzopyrenes	AKR1B1 protein results in increased reduction of and affects the activity of Dihydroxydihydrobenzopyrenes	21910479
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of AKR1B1 mRNA	17547211
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of AKR1B1 mRNA	25380136
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of AKR1B1 mRNA	20566472
D004221	Disulfiram	Disulfiram results in increased expression of AKR1B1 mRNA	20566472
D004237	Diuron	Diuron results in increased expression of AKR1B1 mRNA	21551480\|2515243
C025034	doxifluridine	AKR1B1 protein results in decreased susceptibility to doxifluridine	16734730
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of AKR1B1 protein	23301498
D000431	Ethanol	Ethanol results in decreased expression of AKR1B1 mRNA	15353170
D005015	Ethoxyquin	alrestatin inhibits the reaction [[Ethoxyquin results in increased activity of AKR1B1 protein] which results in decreased susceptibility to Acrolein]	14676331
D005015	Ethoxyquin	alrestatin inhibits the reaction [[Ethoxyquin results in increased activity of AKR1B1 protein] which results in decreased susceptibility to glycolaldehyde]	14676331
D005015	Ethoxyquin	Ethoxyquin results in increased activity of AKR1B1 protein	14676331
D005015	Ethoxyquin	Ethoxyquin results in increased expression of AKR1B1 mRNA	14676331
D005015	Ethoxyquin	Ethoxyquin results in increased expression of AKR1B1 protein	14676331
D005054	Eugenol	Eugenol results in increased expression of AKR1B1 mRNA	20566472
C006012	fenofibric acid	AKR1B1 protein results in increased reduction of fenofibric acid	27599626
C077139	fidarestat	fidarestat binds to and results in decreased activity of AKR1B1 protein	23295227
C077139	fidarestat	NADP binds to AKR1B1 protein binds to fidarestat	23295227
C082360	fipronil	fipronil results in increased expression of AKR1B1 mRNA	23962444
C007738	fluoranthene	[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of AKR1B1 mRNA	17690111
C007738	fluoranthene	"[1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of AKR1B1 mRNA"	18711122
D005485	Flutamide	Flutamide results in decreased expression of AKR1B1 mRNA	21126777
D005485	Flutamide	Flutamide results in increased expression of AKR1B1 protein	17311803
D005492	Folic Acid	Folic Acid results in decreased expression of AKR1B1 mRNA	7531211
D004397	Fonofos	Fonofos results in increased methylation of AKR1B1 promoter	22847954
D005632	Fructose	[Fructose co-treated with bisphenol A] results in increased expression of AKR1B1 protein	26930160
D005839	Gentamicins	Gentamicins results in increased expression of AKR1B1 mRNA	22061828
D005947	Glucose	AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol]	25451566
D005947	Glucose	AKR1B1 protein results in increased metabolism of Glucose	9890881
D005978	Glutathione	Glutathione promotes the reaction [AKR1B1 protein results in decreased susceptibility to Acrolein]	14676331
D005978	Glutathione	Glutathione promotes the reaction [AKR1B1 protein results in decreased susceptibility to glycolaldehyde]	14676331
D005978	Glutathione	AKR1B1 protein binds to Glutathione	11306073
D005978	Glutathione	Glutathione results in increased glutathionylation of AKR1B1 protein modified form	19061876
D005978	Glutathione	Glutathione results in increased reduction of AKR1B1 protein modified form	19061876
D005985	Glyceraldehyde	AKR1B1 protein results in increased reduction of Glyceraldehyde	19014918
C010972	glycolaldehyde	AKR1B1 protein results in decreased susceptibility to glycolaldehyde	14676331
C010972	glycolaldehyde	alrestatin inhibits the reaction [AKR1B1 protein results in decreased susceptibility to glycolaldehyde]	14676331
C010972	glycolaldehyde	alrestatin inhibits the reaction [[Ethoxyquin results in increased activity of AKR1B1 protein] which results in decreased susceptibility to glycolaldehyde]	14676331
C010972	glycolaldehyde	Glutathione promotes the reaction [AKR1B1 protein results in decreased susceptibility to glycolaldehyde]	14676331
D006037	Glyoxal	AKR1B1 protein results in increased reduction of Glyoxal	10510318
C010974	glyphosate	glyphosate results in decreased expression of AKR1B1 mRNA	26302742
D006139	Guaiacol	Guaiacol metabolite results in increased activity of AKR1B1 protein	14676331
C046204	heptanal	AKR1B1 protein affects the reduction of heptanal	11306073
C046204	heptanal	AKR1B1 protein results in increased reduction of heptanal	9890881
D006588	Hexanones	"[AKR1B1 protein results in increased reduction of 2,3-hexanedione] which results in increased chemical synthesis of Hexanones"	23295224
D006588	Hexanones	[AKR1B1 protein results in increased reduction of Hexanones] which results in increased chemical synthesis of propioin	23295224
C080043	hexyl cinnamic aldehyde	hexyl cinnamic aldehyde results in increased expression of AKR1B1 mRNA	20566472
D017313	Fenretinide	Fenretinide results in decreased expression of AKR1B1 mRNA	28973697
C073346	hydroxypentenal	AKR1B1 protein affects the reduction of hydroxypentenal	11306073
C073346	hydroxypentenal	AKR1B1 protein results in increased reduction of hydroxypentenal	9890881
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1B1 mRNA	28628672
D007213	Indomethacin	Indomethacin results in increased expression of AKR1B1 mRNA	28201806
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AKR1B1 mRNA	25613284
D007510	Isatin	AKR1B1 protein results in increased reduction of Isatin	10510318
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1B1 mRNA	28628672
C036643	isoeugenol	isoeugenol results in increased expression of AKR1B1 mRNA	20566472
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of AKR1B1 mRNA	26752646
D019344	Lactic Acid	Lactic Acid results in increased expression of AKR1B1 mRNA	20566472
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of AKR1B1 mRNA"	24972896
D008070	Lipopolysaccharides	[sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species]	21334316
D008070	Lipopolysaccharides	[sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]	21334316
D008070	Lipopolysaccharides	[sorbinil results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to Lipopolysaccharides	21334316
C025340	manganese chloride	manganese chloride results in increased expression of AKR1B1 mRNA	22281203
D008628	Mercury	Mercury results in decreased expression of AKR1B1 mRNA	17547211
C033069	methyl salicylate	methyl salicylate results in increased expression of AKR1B1 mRNA	20566472
C008493	methylselenic acid	methylselenic acid results in increased expression of AKR1B1 mRNA	18548127
D009020	Morphine	Morphine results in decreased expression of AKR1B1 protein	23056601
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of AKR1B1 protein"	22001959
D009281	Naphthalenes	AKR1B1 protein results in increased reduction of and affects the activity of Naphthalenes	21910479
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of AKR1B1 mRNA	25380136
C010463	n-hexanal	AKR1B1 protein affects the reduction of n-hexanal	11306073
C010463	n-hexanal	AKR1B1 protein affects the reduction of n-hexanal analog	11306073
C010463	n-hexanal	AKR1B1 protein results in increased reduction of n-hexanal	9890881
C026385	n-hexane	n-hexane results in increased expression of AKR1B1 mRNA	20566472
C022838	nickel chloride	nickel chloride results in decreased expression of AKR1B1 mRNA	17547211
C029938	nickel sulfate	nickel sulfate results in increased expression of AKR1B1 mRNA	20566472
D020030	Nitric Oxide Donors	Nitric Oxide Donors results in increased nitrosation of AKR1B1 protein	19061876
C008664	nonanal	AKR1B1 protein affects the reduction of nonanal	11306073
C008664	nonanal	AKR1B1 protein affects the reduction of nonanal analog	11306073
C008664	nonanal	AKR1B1 protein results in increased reduction of nonanal	9890881
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of AKR1B1 mRNA	20971185
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of AKR1B1 mRNA	25729387
D010100	Oxygen	AKR1B1 protein inhibits the reaction [Oxygen deficiency results in increased phosphorylation of EIF2AK3 protein]	19041636
D010100	Oxygen	AKR1B1 protein inhibits the reaction [Oxygen deficiency results in increased phosphorylation of EIF2A protein]	19041636
D017239	Paclitaxel	AKR1B1 protein results in increased susceptibility to Paclitaxel	16734730
D010278	Parathion	Parathion results in increased methylation of AKR1B1 promoter	22847954
C046012	pentanal	AKR1B1 protein affects the reduction of pentanal	11306073
C046012	pentanal	AKR1B1 protein results in increased reduction of pentanal	9890881
D010422	Pentanones	"[AKR1B1 protein results in increased reduction of 2,3-pentanedione] which results in increased chemical synthesis of Pentanones"	23295224
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of AKR1B1 mRNA	23602845
D015232	Dinoprostone	[sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]	21334316
D015232	Dinoprostone	"[zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased secretion of Dinoprostone]"	21334316
D010634	Phenobarbital	Phenobarbital affects the expression of AKR1B1 mRNA	19084549
D010658	Phenylglyoxal	AKR1B1 protein results in increased reduction of Phenylglyoxal	10510318
C006253	pirinixic acid	pirinixic acid results in decreased activity of AKR1B1 protein	17194029
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of AKR1B1 mRNA	17547211
D011374	Progesterone	Progesterone results in decreased expression of AKR1B1 mRNA	23018184
D011374	Progesterone	Progesterone results in increased expression of AKR1B1 mRNA	23018184
D011374	Progesterone	Progesterone results in decreased expression of AKR1B1 mRNA	19690047
D019840	2-Propanol	2-Propanol results in increased expression of AKR1B1 mRNA	20566472
C523189	propioin	[AKR1B1 protein results in increased reduction of Hexanones] which results in increased chemical synthesis of propioin	23295224
C005556	propionaldehyde	AKR1B1 protein affects the reduction of propionaldehyde analog	11306073
C005556	propionaldehyde	AKR1B1 protein results in increased reduction of propionaldehyde	9890881
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]	17640564
D011765	Pyruvaldehyde	AKR1B1 protein results in increased reduction of Pyruvaldehyde	10510318
D011794	Quercetin	Quercetin results in increased expression of AKR1B1 mRNA	21632981
D017382	Reactive Oxygen Species	[sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species]	21334316
D017382	Reactive Oxygen Species	"[zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased abundance of Reactive Oxygen Species]"	21334316
C059514	resveratrol	resveratrol results in increased expression of AKR1B1 mRNA	25905778
D012172	Retinaldehyde	AKR1B1 protein results in increased reduction of Retinaldehyde	19014918
D012172	Retinaldehyde	AKR1B1 protein results in increased metabolism of Retinaldehyde metabolite	23220004
C093642	SB 203580	SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]	17640564
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased secretion of AKR1B1 protein	25895662
C009277	sodium arsenate	sodium arsenate results in increased expression of AKR1B1 mRNA	12727804
C017947	sodium arsenite	sodium arsenite results in increased expression of AKR1B1 mRNA	20886546\|2871322
C017947	sodium arsenite	Benzo(a)pyrene promotes the reaction [sodium arsenite results in increased expression of AKR1B1 protein]	16456883
C017947	sodium arsenite	sodium arsenite promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1B1 protein]	16456883
C017947	sodium arsenite	sodium arsenite results in increased expression of AKR1B1 protein	16456883
C016104	sodium bichromate	sodium bichromate results in decreased expression of AKR1B1 mRNA	24612858
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased expression of AKR1B1 mRNA	20566472
C026411	sorbinil	sorbinil inhibits the reaction [AKR1B1 protein results in decreased expression of CDH1 mRNA]	28137510
C026411	sorbinil	sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of ACTA2 mRNA]	28137510
C026411	sorbinil	sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of FN1 mRNA]	28137510
C026411	sorbinil	sorbinil inhibits the reaction [AKR1B1 protein results in increased expression of FN1 protein]	28137510
C026411	sorbinil	sorbinil inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK1 protein]	28137510
C026411	sorbinil	sorbinil inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK3 protein]	28137510
C026411	sorbinil	sorbinil results in decreased activity of AKR1B1 protein	21334316
C026411	sorbinil	[sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species]	21334316
C026411	sorbinil	[sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]	21334316
C026411	sorbinil	[sorbinil results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to Lipopolysaccharides	21334316
C026411	sorbinil	[sorbinil results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to TNF protein	21334316
D013012	Sorbitol	AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol]	25451566
D013012	Sorbitol	AKR1B1 protein results in increased abundance of Sorbitol	25541468
D013012	Sorbitol	AKR1B1 protein results in increased chemical synthesis of Sorbitol	9890881
D013311	Streptozocin	Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK1 protein]	25541468
D013311	Streptozocin	Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK3 protein]	25541468
D013311	Streptozocin	Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK8 protein]	25541468
D013311	Streptozocin	Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK9 protein]	25541468
D013467	Sulindac	Sulindac analog binds to and results in decreased activity of AKR1B1 protein	25532697
D013467	Sulindac	Sulindac binds to and results in decreased activity of AKR1B1 protein	25532697
C025463	sulindac sulfone	sulindac sulfone binds to and results in decreased activity of AKR1B1 protein	25532697
C047246	temozolomide	AKR1B1 mRNA affects the susceptibility to temozolomide	16365179
C012568	terbufos	terbufos results in increased methylation of AKR1B1 promoter	22847954
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of AKR1B1 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of AKR1B1 mRNA	20106945\|2229881
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of AKR1B1 mRNA	19684285\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of AKR1B1 mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AKR1B1 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in decreased phosphorylation of AKR1B1 protein	21439344
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of AKR1B1 mRNA	25729387
C113580	U 0126	U 0126 inhibits the reaction [AKR1B1 protein results in increased expression of FN1 protein]	28137510
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of AKR1B1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of AKR1B1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of AKR1B1 mRNA	23179753\|2438349
D014801	Vitamin A	AKR1B1 protein results in decreased susceptibility to Vitamin A	19014918
D014801	Vitamin A	AKR1B1 protein results in decreased susceptibility to Vitamin A metabolite	19014918
D014810	Vitamin E	Vitamin E results in increased expression of AKR1B1 mRNA	19244175
C088658	zoledronic acid	zoledronic acid results in increased expression of AKR1B1 mRNA	24714768
C067172	zopolrestat	zopolrestat results in decreased activity of AKR1B1 protein	21334316
C067172	zopolrestat	"[zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased abundance of Reactive Oxygen Species]"	21334316
C067172	zopolrestat	"[zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased secretion of Dinoprostone]"	21334316
C067172	zopolrestat	"[zopolrestat results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to Antigens, Plant"	21334316

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	-	EXP	1420136 15272156
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	-	IBA	21873635
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	-	IDA	8435445
GO:0008106	alcohol dehydrogenase (NADP+) activity	-	IBA	21873635
GO:0009055	electron transfer activity	-	TAS	2112546
GO:0016491	oxidoreductase activity	-	IBA	21873635
GO:0043795	glyceraldehyde oxidoreductase activity	-	IDA	20837989

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001894	tissue homeostasis	-	IEA	-
GO:0003091	renal water homeostasis	-	IEA	-
GO:0005975	carbohydrate metabolic process	-	TAS	2112546
GO:0006061	sorbitol biosynthetic process	-	IEA	-
GO:0006700	C21-steroid hormone biosynthetic process	-	TAS	-
GO:0009414	response to water deprivation	-	IEA	-
GO:0018931	naphthalene metabolic process	-	IEA	-
GO:0022900	electron transport chain	-	IEA	-
GO:0031098	stress-activated protein kinase signaling cascade	-	IEA	-
GO:0035809	regulation of urine volume	-	IEA	-
GO:0042415	norepinephrine metabolic process	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IEA	-
GO:0044597	daunorubicin metabolic process	-	IMP	20837989
GO:0044598	doxorubicin metabolic process	-	IMP	20837989
GO:0046370	fructose biosynthetic process	-	TAS	-
GO:0046427	positive regulation of JAK-STAT cascade	-	IEA	-
GO:0048661	positive regulation of smooth muscle cell proliferation	-	IEA	-
GO:0055114	oxidation-reduction process	-	IDA	8435445
GO:0060135	maternal process involved in female pregnancy	-	IEA	-
GO:0071475	cellular hyperosmotic salinity response	-	IDA	8435445
GO:0072061	inner medullary collecting duct development	-	IEA	-
GO:0097066	response to thyroid hormone	-	IEA	-
GO:0097238	cellular response to methylglyoxal	-	IEA	-
GO:1901653	cellular response to peptide	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	TAS	2112546
GO:0005654	nucleoplasm	-	IDA	-
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0032838	plasma membrane bounded cell projection cytoplasm	-	IEA	-
GO:0033010	paranodal junction	-	IEA	-
GO:0042629	mast cell granule	-	IEA	-
GO:0043220	Schmidt-Lanterman incisure	-	IEA	-
GO:0048471	perinuclear region of cytoplasm	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 20458337 23533145
GO:0097454	Schwann cell microvillus	-	IEA	-

KEGG ID	KEGG Term
hsa00040	Pentose and glucuronate interconversions
hsa00051	Fructose and mannose metabolism
hsa00052	Galactose metabolism
hsa00561	Glycerolipid metabolism
hsa00620	Pyruvate metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-196071	Metabolism of steroid hormones	TAS
R-HSA-196108	Pregnenolone biosynthesis	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-5652084	Fructose metabolism	TAS
R-HSA-5652227	Fructose biosynthesis	TAS
R-HSA-71387	Metabolism of carbohydrates	TAS
R-HSA-8957322	Metabolism of steroids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19028477	Cancer biomarker AKR1B10 and carbonyl metabolism. (2009 Mar 16)	Balendiran GK	Chem Biol Interact
24598757	Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design. (2014 Mar)	Cousido-Siah A	Acta Crystallogr D Biol Crystallogr