Gene: AKR1B1

231
ADR|ALDR1|ALR2|AR
aldo-keto reductase family 1 member B
protein-coding
7q33
Ensembl:ENSG00000085662 MIM:103880 Vega:OTTHUMG00000155322 UniprotKB:P15121
NC_000007.14
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.169e-1 (AD)  3.221e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNX170.959
COPS60.951
CCT70.95
USF10.948
VPS4A0.946
EMC40.946
PSMB70.945
CUEDC20.944
PEF10.944
CFL10.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.824
OR4F29-0.788
MTRNR2L6-0.282
KLRB1-0.261
MTRNR2L9-0.259
MTRNR2L10-0.255
C8orf74-0.238
KCNJ15-0.23
GPR171-0.225
C9orf153-0.224

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00605SulindacSmall Molecule38194-50-2Approved|InvestigationalTarget
DB01689Inhibitor Idd 384Small MoleculeExperimentalTarget
DB02007alpha-D-glucose 6-phosphateSmall MoleculeExperimentalTarget
DB02020AlrestatinSmall Molecule51411-04-2ExperimentalTarget
DB02021FidarestatSmall Molecule136087-85-9ExperimentalTarget
DB02101(S,R)-fidarestatSmall Molecule-ExperimentalTarget
DB02132ZenarestatSmall Molecule112733-06-9ExperimentalTarget
DB02383TolrestatSmall Molecule82964-04-3WithdrawnTarget
DB02518N-AcetylalanineSmall Molecule97-69-8ExperimentalTarget
DB02712SorbinilSmall Molecule68367-52-2Experimental|InvestigationalTarget
DB02834IDD552Small MoleculeExperimentalTarget
DB02994Cacodylic acidSmall Molecule75-60-5ExperimentalTarget
DB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall MoleculeExperimentalTarget
DB04272Citric AcidSmall Molecule77-92-9Approved|NutraceuticalTarget
DB05327RanirestatSmall Molecule147254-64-6InvestigationalTarget
DB05383PimagedineSmall Molecule79-17-4InvestigationalTarget
DB05533QR-333Small MoleculeInvestigationalTarget
DB06246ExisulindSmall Molecule59973-80-7InvestigationalTarget
DB07028(2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACIDSmall MoleculeExperimentalTarget
DB07030(5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACIDSmall MoleculeExperimentalTarget
DB07063{3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACIDSmall MoleculeExperimentalTarget
DB07093{3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACIDSmall MoleculeExperimentalTarget
DB071393-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acidSmall MoleculeExperimentalTarget
DB071876-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONESmall MoleculeExperimentalTarget
DB07450(R)-minalrestatSmall MoleculeExperimentalTarget
DB074984-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACIDSmall MoleculeExperimentalTarget
DB07999{4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACIDSmall MoleculeExperimentalTarget
DB080002-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDESmall MoleculeExperimentalTarget
DB08084IDD594Small MoleculeExperimentalTarget
DB08098{[5-(5-nitro-2-furyl)-1,3,4-oxadiazol-2-yl]thio}acetic acidSmall MoleculeExperimentalTarget
DB084492-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acidSmall MoleculeExperimentalTarget
DB087723,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACIDSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of AKR1B1 mRNA"17690111
C0264861,2,5,6-dibenzanthracene"[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of AKR1B1 mRNA"18711122
C0264861,2,5,6-dibenzanthracene"[1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of AKR1B1 mRNA"18711122
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of AKR1B1 mRNA"18711122
C0407561,2-naphthoquinone"AKR1B1 protein results in increased reduction of 1,2-naphthoquinone"10510318
C00259116-ketoestroneAKR1B1 protein results in increased reduction of 16-ketoestrone10510318
C0319031-UFT protocolAKR1B1 protein results in decreased susceptibility to 1-UFT protocol16734730
C0269782,3-butylene glycol"[AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol"23295224
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of AKR1B1 mRNA"17547211
C0432312,3-hexanedione"AKR1B1 protein results in increased reduction of 2,3-hexanedione"10510318|2329522
C0432312,3-hexanedione"[AKR1B1 protein results in increased reduction of 2,3-hexanedione] which results in increased chemical synthesis of Hexanones"23295224
C0131862,3-pentanedione"AKR1B1 protein results in increased reduction of 2,3-pentanedione"23295224
C0131862,3-pentanedione"[AKR1B1 protein results in increased reduction of 2,3-pentanedione] which results in increased chemical synthesis of Pentanones"23295224
C0573492,4-decadienal"AKR1B1 protein results in increased reduction of 2,4-decadienal"9890881
C5025032,4-heptadienal"AKR1B1 protein results in increased reduction of 2,4-heptadienal"9890881
C0793892,4-hexadienal"AKR1B1 protein results in increased reduction of 2,4-hexadienal"21329684|9890881
C0793892,4-hexadienal"AKR1B1 protein results in increased reduction of 2,4-hexadienal metabolite"21329684
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]17640564
C4128862,4-nonadienal"AKR1B1 protein results in increased reduction of 2,4-nonadienal"9890881
C0127962-butenalAKR1B1 protein results in increased reduction of 2-butenal21329684|9890881
C0127962-butenalAKR1B1 protein results in increased reduction of 2-butenal metabolite21329684
C0593412-chlorobenzaldehydeAKR1B1 protein results in increased reduction of 2-chlorobenzaldehyde10510318
C476489(2E)-decenalAKR1B1 protein affects the reduction of (2E)-decenal11306073
C0646002-heptenalAKR1B1 protein results in increased reduction of 2-heptenal9890881
C0517502-hexenalAKR1B1 protein affects the reduction of 2-hexenal11306073
C0517502-hexenalAKR1B1 protein results in increased reduction of 2-hexenal21329684|9890881
C0517502-hexenalAKR1B1 protein results in increased reduction of 2-hexenal metabolite21329684
C0131662-nonenalAKR1B1 protein affects the reduction of 2-nonenal11306073
C0131662-nonenalAKR1B1 protein results in increased reduction of 2-nonenal9890881
C0573482-octenalAKR1B1 protein affects the reduction of 2-octenal11306073
C0573482-octenalAKR1B1 protein results in increased reduction of 2-octenal9890881
C0645992-pentenalAKR1B1 protein affects the reduction of 2-pentenal11306073
C0645992-pentenalAKR1B1 protein results in increased reduction of 2-pentenal9890881
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of AKR1B1 mRNA12958071
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]18588981
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 protein]18588981
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [NFE2L2 protein results in increased expression of AKR1B1 mRNA]18588981
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [NFE2L2 protein results in increased expression of AKR1B1 protein]18588981
C0505713-nitrobenzaldehydeAKR1B1 protein results in increased reduction of 3-nitrobenzaldehyde10510318
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of AKR1B1 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B1 mRNA"27188386
C0441354-hydroxy-2-decenalAKR1B1 protein affects the reduction of 4-hydroxy-2-decenal11306073
C0459344-hydroxy-2-hexenalAKR1B1 protein affects the reduction of 4-hydroxy-2-hexenal11306073
C0459344-hydroxy-2-hexenalAKR1B1 protein results in increased reduction of 4-hydroxy-2-hexenal9890881
C0275764-hydroxy-2-nonenalAKR1B1 protein affects the reduction of 4-hydroxy-2-nonenal11306073
C0275764-hydroxy-2-nonenalAKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal10510318|2132968
C0275764-hydroxy-2-nonenalAKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal metabolite21329684
C0465384-hydroxy-2-octenalAKR1B1 protein affects the reduction of 4-hydroxy-2-octenal11306073
C0465384-hydroxy-2-octenalAKR1B1 protein results in increased reduction of 4-hydroxy-2-octenal9890881
C1177144-hydroxyequilenin-o-quinone[AKR1B1 protein co-treated with NADP] results in increased reduction of and affects the activity of 4-hydroxyequilenin-o-quinone21910479
C0571804-hydroxyretinalAKR1B1 protein results in increased reduction of 4-hydroxyretinal19014918
C0299154-nitrobenzaldehydeAKR1B1 protein results in increased reduction of 4-nitrobenzaldehyde10510318
C0996604-oxoretinaldehydeAKR1B1 protein results in increased reduction of 4-oxoretinaldehyde19014918
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B1 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of AKR1B1 mRNA"26238291
C0053999,10-phenanthrenequinone"AKR1B1 protein results in increased reduction of 9,10-phenanthrenequinone"10510318
C0053999,10-phenanthrenequinone"AKR1B1 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone"21910479
D000082AcetaminophenAcetaminophen results in increased expression of AKR1B1 mRNA22230336
D000093AcetoinAKR1B1 protein results in increased reduction of Acetoin23295224
D000093Acetoin"[AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol"23295224
D000093Acetoin[AKR1B1 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin23295224
D000171AcroleinAKR1B1 protein results in decreased susceptibility to Acrolein14676331
D000171Acroleinalrestatin inhibits the reaction [AKR1B1 protein results in decreased susceptibility to Acrolein]14676331
D000171Acroleinalrestatin inhibits the reaction [[Ethoxyquin results in increased activity of AKR1B1 protein] which results in decreased susceptibility to Acrolein]14676331
D000171AcroleinGlutathione promotes the reaction [AKR1B1 protein results in decreased susceptibility to Acrolein]14676331
D000171AcroleinAKR1B1 protein affects the reduction of Acrolein11306073
D000171AcroleinAKR1B1 protein results in increased reduction of Acrolein10510318|2132968
D000171AcroleinAKR1B1 protein results in increased reduction of Acrolein metabolite21329684
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AKR1B1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AKR1B1 mRNA22100608|2715375
D000393Air PollutantsAir Pollutants analog results in increased expression of AKR1B1 mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of AKR1B1 mRNA28522335
D024502alpha-Tocopherolalpha-Tocopherol results in increased expression of AKR1B1 mRNA16908007
C016212alrestatinalrestatin inhibits the reaction [AKR1B1 protein results in decreased susceptibility to Acrolein]14676331
C016212alrestatinalrestatin inhibits the reaction [AKR1B1 protein results in decreased susceptibility to glycolaldehyde]14676331
C016212alrestatinalrestatin inhibits the reaction [[Ethoxyquin results in increased activity of AKR1B1 protein] which results in decreased susceptibility to Acrolein]14676331
C016212alrestatinalrestatin inhibits the reaction [[Ethoxyquin results in increased activity of AKR1B1 protein] which results in decreased susceptibility to glycolaldehyde]14676331
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AKR1B1 mRNA16483693
D052179Antigens, Plant"[zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased abundance of Reactive Oxygen Species]"21334316
D052179Antigens, Plant"[zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased secretion of Dinoprostone]"21334316
D052179Antigens, Plant"[zopolrestat results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to Antigens, Plant"21334316
D000965AntimonyAntimony results in decreased expression of AKR1B1 mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of AKR1B1 mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in increased expression of AKR1B1 mRNA28713220
C006632arsenic trioxidearsenic trioxide results in decreased expression of AKR1B1 mRNA17547211
D001205Ascorbic AcidAscorbic Acid results in increased reduction of AKR1B1 protein modified form19061876
D001280AtrazineAtrazine results in decreased expression of AKR1B1 mRNA25929836
C051597Bandrowski's baseBandrowski's base results in increased expression of AKR1B1 mRNA20566472
C017228benzo(a)pyrene 7,8-dihydrodiol"[AKR1B1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol"21910479
C076588benzo(a)pyrene-7,8-dione"[AKR1B1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione"21910479
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of AKR1B1 mRNA17690111
D019817Benzoic AcidBenzoic Acid results in increased expression of AKR1B1 mRNA20566472
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AKR1B1 mRNA26001963
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of AKR1B1 mRNA"17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of AKR1B1 mRNA17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of AKR1B1 mRNA17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AKR1B1 mRNA20106945|2231617
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of AKR1B1 mRNA"18711122
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [sodium arsenite results in increased expression of AKR1B1 protein]16456883
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AKR1B1 protein16456883
D001564Benzo(a)pyrenesodium arsenite promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1B1 protein]16456883
D019905Benzyl AlcoholAKR1B1 protein results in increased oxidation of Benzyl Alcohol17194029
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKR1B1 mRNA21215737
C038328BEP protocolBEP protocol results in increased expression of AKR1B1 mRNA18987330
D001622BetaineBetaine results in decreased expression of AKR1B1 mRNA26391144
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1B1 mRNA28628672
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of AKR1B1 mRNA15912405
C006780bisphenol Abisphenol A affects the expression of AKR1B1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of AKR1B1 protein20219716
C006780bisphenol Abisphenol A results in increased expression of AKR1B1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of AKR1B1 gene28505145
C006780bisphenol A[Fructose co-treated with bisphenol A] results in increased expression of AKR1B1 protein26930160
D000069286BortezomibBortezomib results in increased expression of AKR1B1 mRNA21215737
D000069286BortezomibBortezomib results in increased expression of AKR1B1 protein21215737
D003931DiacetylAKR1B1 protein results in increased reduction of Diacetyl23295224
D003931Diacetyl[AKR1B1 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin23295224
C018475butyraldehydeAKR1B1 protein affects the reduction of butyraldehyde11306073
C018475butyraldehydeAKR1B1 protein results in increased reduction of butyraldehyde9890881
D002104CadmiumCadmium results in decreased expression of AKR1B1 mRNA17547211
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of AKR1B1 mRNA17547211
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AKR1B1 protein24527689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AKR1B1 mRNA24794047
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester results in decreased activity of AKR1B1 protein27163852
C081643candesartancandesartan results in decreased expression of AKR1B1 mRNA14871019
D000069287CapecitabineAKR1B1 protein results in decreased susceptibility to Capecitabine16734730
C031639caprylic aldehydeAKR1B1 protein affects the reduction of caprylic aldehyde11306073
D002330CarmustineAKR1B1 mRNA affects the susceptibility to Carmustine16365179
C099555CD 437CD 437 results in decreased expression of AKR1B1 mRNA12958071
C445667CD 666CD 666 results in decreased activity of AKR1B1 protein23220004
D002509CephaloridineCephaloridine results in increased expression of AKR1B1 mRNA18172885
D002108CeruletideCeruletide results in increased expression of AKR1B1 protein18024178
D002857ChromiumChromium results in decreased expression of AKR1B1 mRNA17547211
D002911ChrysenesAKR1B1 protein results in increased reduction of and affects the activity of Chrysenes21910479
C020722cinnamyl alcoholcinnamyl alcohol results in increased expression of AKR1B1 mRNA20566472
D009249NADP"[AKR1B1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7,8-dihydrodiol"21910479
D009249NADP[AKR1B1 protein co-treated with NADP] results in increased reduction of and affects the activity of 4-hydroxyequilenin-o-quinone21910479
D009249NADP"[AKR1B1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione"21910479
D009249NADPNADP binds to AKR1B1 protein binds to fidarestat23295227
D009249NADPNADP results in increased activity of AKR1B1 protein23295224
D003300CopperCopper binds to and results in increased oxidation of and results in decreased activity of AKR1B1 protein16615933
D003300CopperCopper promotes the reaction [AKR1B1 protein binds to AKR1B1 protein]16615933
D003300CopperCRYAA protein inhibits the reaction [Copper promotes the reaction [AKR1B1 protein binds to AKR1B1 protein]]16615933
D003300CopperCRYAA protein inhibits the reaction [Copper results in increased oxidation of and results in decreased activity of AKR1B1 protein]16615933
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of AKR1B1 mRNA20971185
D003300CopperCopper deficiency results in decreased expression of AKR1B1 protein18993053
D003300CopperCopper results in increased expression of AKR1B1 mRNA22465980
D003474CurcuminCurcumin results in increased expression of AKR1B1 mRNA18200517
D003474Curcumin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]17640564
D003474Curcumin3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]18588981
D003474Curcumin3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 protein]18588981
D003474CurcuminAKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]17640564
D003474CurcuminCurcumin results in increased activity of AKR1B1 protein17640564
D003474CurcuminCurcumin results in increased expression of AKR1B1 mRNA17640564|1829998
D003474CurcuminCurcumin results in increased expression of AKR1B1 protein17640564|1858898
D003474CurcuminNFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]17640564|1858898
D003474CurcuminNFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]18588981
D003474Curcuminpyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]17640564
D003474CurcuminSB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]17640564
D016572CyclosporineCyclosporine results in decreased expression of AKR1B1 mRNA25562108|2798913
D016572CyclosporineCyclosporine results in increased expression of AKR1B1 mRNA20106945
D003630DaunorubicinAKR1B1 protein results in increased reduction of Daunorubicin10510318
D003634DDTDDT results in decreased expression of AKR1B1 mRNA27894940
D003634DDTDDT results in increased expression of AKR1B1 mRNA22230338
C021170decanaldehydeAKR1B1 protein affects the reduction of decanaldehyde11306073
C021170decanaldehydeAKR1B1 protein results in increased reduction of decanaldehyde9890881
C017184dehydroretinalAKR1B1 protein results in increased reduction of dehydroretinal19014918
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of AKR1B1 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1B1 mRNA28628672
D016190CarboplatinCarboplatin results in increased expression of AKR1B1 mRNA18172885
C041517dibenzo(a,l)pyrene"[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of AKR1B1 mRNA"18711122
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of AKR1B1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of AKR1B1 protein16803524
D002945CisplatinCisplatin results in increased expression of AKR1B1 mRNA18172885
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in decreased expression of AKR1B1 mRNA27894940
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of AKR1B1 mRNA19638242
D004101DihydroxydihydrobenzopyrenesAKR1B1 protein results in increased reduction of and affects the activity of Dihydroxydihydrobenzopyrenes21910479
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of AKR1B1 mRNA17547211
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of AKR1B1 mRNA25380136
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of AKR1B1 mRNA20566472
D004221DisulfiramDisulfiram results in increased expression of AKR1B1 mRNA20566472
D004237DiuronDiuron results in increased expression of AKR1B1 mRNA21551480|2515243
C025034doxifluridineAKR1B1 protein results in decreased susceptibility to doxifluridine16734730
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of AKR1B1 protein23301498
D000431EthanolEthanol results in decreased expression of AKR1B1 mRNA15353170
D005015Ethoxyquinalrestatin inhibits the reaction [[Ethoxyquin results in increased activity of AKR1B1 protein] which results in decreased susceptibility to Acrolein]14676331
D005015Ethoxyquinalrestatin inhibits the reaction [[Ethoxyquin results in increased activity of AKR1B1 protein] which results in decreased susceptibility to glycolaldehyde]14676331
D005015EthoxyquinEthoxyquin results in increased activity of AKR1B1 protein14676331
D005015EthoxyquinEthoxyquin results in increased expression of AKR1B1 mRNA14676331
D005015EthoxyquinEthoxyquin results in increased expression of AKR1B1 protein14676331
D005054EugenolEugenol results in increased expression of AKR1B1 mRNA20566472
C006012fenofibric acidAKR1B1 protein results in increased reduction of fenofibric acid27599626
C077139fidarestatfidarestat binds to and results in decreased activity of AKR1B1 protein23295227
C077139fidarestatNADP binds to AKR1B1 protein binds to fidarestat23295227
C082360fipronilfipronil results in increased expression of AKR1B1 mRNA23962444
C007738fluoranthene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of AKR1B1 mRNA17690111
C007738fluoranthene"[1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of AKR1B1 mRNA"18711122
D005485FlutamideFlutamide results in decreased expression of AKR1B1 mRNA21126777
D005485FlutamideFlutamide results in increased expression of AKR1B1 protein17311803
D005492Folic AcidFolic Acid results in decreased expression of AKR1B1 mRNA7531211
D004397FonofosFonofos results in increased methylation of AKR1B1 promoter22847954
D005632Fructose[Fructose co-treated with bisphenol A] results in increased expression of AKR1B1 protein26930160
D005839GentamicinsGentamicins results in increased expression of AKR1B1 mRNA22061828
D005947GlucoseAKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol]25451566
D005947GlucoseAKR1B1 protein results in increased metabolism of Glucose9890881
D005978GlutathioneGlutathione promotes the reaction [AKR1B1 protein results in decreased susceptibility to Acrolein]14676331
D005978GlutathioneGlutathione promotes the reaction [AKR1B1 protein results in decreased susceptibility to glycolaldehyde]14676331
D005978GlutathioneAKR1B1 protein binds to Glutathione11306073
D005978GlutathioneGlutathione results in increased glutathionylation of AKR1B1 protein modified form19061876
D005978GlutathioneGlutathione results in increased reduction of AKR1B1 protein modified form19061876
D005985GlyceraldehydeAKR1B1 protein results in increased reduction of Glyceraldehyde19014918
C010972glycolaldehydeAKR1B1 protein results in decreased susceptibility to glycolaldehyde14676331
C010972glycolaldehydealrestatin inhibits the reaction [AKR1B1 protein results in decreased susceptibility to glycolaldehyde]14676331
C010972glycolaldehydealrestatin inhibits the reaction [[Ethoxyquin results in increased activity of AKR1B1 protein] which results in decreased susceptibility to glycolaldehyde]14676331
C010972glycolaldehydeGlutathione promotes the reaction [AKR1B1 protein results in decreased susceptibility to glycolaldehyde]14676331
D006037GlyoxalAKR1B1 protein results in increased reduction of Glyoxal10510318
C010974glyphosateglyphosate results in decreased expression of AKR1B1 mRNA26302742
D006139GuaiacolGuaiacol metabolite results in increased activity of AKR1B1 protein14676331
C046204heptanalAKR1B1 protein affects the reduction of heptanal11306073
C046204heptanalAKR1B1 protein results in increased reduction of heptanal9890881
D006588Hexanones"[AKR1B1 protein results in increased reduction of 2,3-hexanedione] which results in increased chemical synthesis of Hexanones"23295224
D006588Hexanones[AKR1B1 protein results in increased reduction of Hexanones] which results in increased chemical synthesis of propioin23295224
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde results in increased expression of AKR1B1 mRNA20566472
D017313FenretinideFenretinide results in decreased expression of AKR1B1 mRNA28973697
C073346hydroxypentenalAKR1B1 protein affects the reduction of hydroxypentenal11306073
C073346hydroxypentenalAKR1B1 protein results in increased reduction of hydroxypentenal9890881
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1B1 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of AKR1B1 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AKR1B1 mRNA25613284
D007510IsatinAKR1B1 protein results in increased reduction of Isatin10510318
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1B1 mRNA28628672
C036643isoeugenolisoeugenol results in increased expression of AKR1B1 mRNA20566472
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AKR1B1 mRNA26752646
D019344Lactic AcidLactic Acid results in increased expression of AKR1B1 mRNA20566472
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of AKR1B1 mRNA"24972896
D008070Lipopolysaccharides[sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species]21334316
D008070Lipopolysaccharides[sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]21334316
D008070Lipopolysaccharides[sorbinil results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to Lipopolysaccharides21334316
C025340manganese chloridemanganese chloride results in increased expression of AKR1B1 mRNA22281203
D008628MercuryMercury results in decreased expression of AKR1B1 mRNA17547211
C033069methyl salicylatemethyl salicylate results in increased expression of AKR1B1 mRNA20566472
C008493methylselenic acidmethylselenic acid results in increased expression of AKR1B1 mRNA18548127
D009020MorphineMorphine results in decreased expression of AKR1B1 protein23056601
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of AKR1B1 protein"22001959
D009281NaphthalenesAKR1B1 protein results in increased reduction of and affects the activity of Naphthalenes21910479
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of AKR1B1 mRNA25380136
C010463n-hexanalAKR1B1 protein affects the reduction of n-hexanal11306073
C010463n-hexanalAKR1B1 protein affects the reduction of n-hexanal analog11306073
C010463n-hexanalAKR1B1 protein results in increased reduction of n-hexanal9890881
C026385n-hexanen-hexane results in increased expression of AKR1B1 mRNA20566472
C022838nickel chloridenickel chloride results in decreased expression of AKR1B1 mRNA17547211
C029938nickel sulfatenickel sulfate results in increased expression of AKR1B1 mRNA20566472
D020030Nitric Oxide DonorsNitric Oxide Donors results in increased nitrosation of AKR1B1 protein19061876
C008664nonanalAKR1B1 protein affects the reduction of nonanal11306073
C008664nonanalAKR1B1 protein affects the reduction of nonanal analog11306073
C008664nonanalAKR1B1 protein results in increased reduction of nonanal9890881
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of AKR1B1 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of AKR1B1 mRNA25729387
D010100OxygenAKR1B1 protein inhibits the reaction [Oxygen deficiency results in increased phosphorylation of EIF2AK3 protein]19041636
D010100OxygenAKR1B1 protein inhibits the reaction [Oxygen deficiency results in increased phosphorylation of EIF2A protein]19041636
D017239PaclitaxelAKR1B1 protein results in increased susceptibility to Paclitaxel16734730
D010278ParathionParathion results in increased methylation of AKR1B1 promoter22847954
C046012pentanalAKR1B1 protein affects the reduction of pentanal11306073
C046012pentanalAKR1B1 protein results in increased reduction of pentanal9890881
D010422Pentanones"[AKR1B1 protein results in increased reduction of 2,3-pentanedione] which results in increased chemical synthesis of Pentanones"23295224
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of AKR1B1 mRNA23602845
D015232Dinoprostone[sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]21334316
D015232Dinoprostone"[zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased secretion of Dinoprostone]"21334316
D010634PhenobarbitalPhenobarbital affects the expression of AKR1B1 mRNA19084549
D010658PhenylglyoxalAKR1B1 protein results in increased reduction of Phenylglyoxal10510318
C006253pirinixic acidpirinixic acid results in decreased activity of AKR1B1 protein17194029
D011192Potassium DichromatePotassium Dichromate results in decreased expression of AKR1B1 mRNA17547211
D011374ProgesteroneProgesterone results in decreased expression of AKR1B1 mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of AKR1B1 mRNA23018184
D011374ProgesteroneProgesterone results in decreased expression of AKR1B1 mRNA19690047
D0198402-Propanol2-Propanol results in increased expression of AKR1B1 mRNA20566472
C523189propioin[AKR1B1 protein results in increased reduction of Hexanones] which results in increased chemical synthesis of propioin23295224
C005556propionaldehydeAKR1B1 protein affects the reduction of propionaldehyde analog11306073
C005556propionaldehydeAKR1B1 protein results in increased reduction of propionaldehyde9890881
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]17640564
D011765PyruvaldehydeAKR1B1 protein results in increased reduction of Pyruvaldehyde10510318
D011794QuercetinQuercetin results in increased expression of AKR1B1 mRNA21632981
D017382Reactive Oxygen Species[sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species]21334316
D017382Reactive Oxygen Species"[zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased abundance of Reactive Oxygen Species]"21334316
C059514resveratrolresveratrol results in increased expression of AKR1B1 mRNA25905778
D012172RetinaldehydeAKR1B1 protein results in increased reduction of Retinaldehyde19014918
D012172RetinaldehydeAKR1B1 protein results in increased metabolism of Retinaldehyde metabolite23220004
C093642SB 203580SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]17640564
D012822Silicon DioxideSilicon Dioxide analog results in increased secretion of AKR1B1 protein25895662
C009277sodium arsenatesodium arsenate results in increased expression of AKR1B1 mRNA12727804
C017947sodium arsenitesodium arsenite results in increased expression of AKR1B1 mRNA20886546|2871322
C017947sodium arseniteBenzo(a)pyrene promotes the reaction [sodium arsenite results in increased expression of AKR1B1 protein]16456883
C017947sodium arsenitesodium arsenite promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1B1 protein]16456883
C017947sodium arsenitesodium arsenite results in increased expression of AKR1B1 protein16456883
C016104sodium bichromatesodium bichromate results in decreased expression of AKR1B1 mRNA24612858
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of AKR1B1 mRNA20566472
C026411sorbinilsorbinil inhibits the reaction [AKR1B1 protein results in decreased expression of CDH1 mRNA]28137510
C026411sorbinilsorbinil inhibits the reaction [AKR1B1 protein results in increased expression of ACTA2 mRNA]28137510
C026411sorbinilsorbinil inhibits the reaction [AKR1B1 protein results in increased expression of FN1 mRNA]28137510
C026411sorbinilsorbinil inhibits the reaction [AKR1B1 protein results in increased expression of FN1 protein]28137510
C026411sorbinilsorbinil inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK1 protein]28137510
C026411sorbinilsorbinil inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK3 protein]28137510
C026411sorbinilsorbinil results in decreased activity of AKR1B1 protein21334316
C026411sorbinil[sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species]21334316
C026411sorbinil[sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]21334316
C026411sorbinil[sorbinil results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to Lipopolysaccharides21334316
C026411sorbinil[sorbinil results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to TNF protein21334316
D013012SorbitolAKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol]25451566
D013012SorbitolAKR1B1 protein results in increased abundance of Sorbitol25541468
D013012SorbitolAKR1B1 protein results in increased chemical synthesis of Sorbitol9890881
D013311StreptozocinStreptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK1 protein]25541468
D013311StreptozocinStreptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK3 protein]25541468
D013311StreptozocinStreptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK8 protein]25541468
D013311StreptozocinStreptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK9 protein]25541468
D013467SulindacSulindac analog binds to and results in decreased activity of AKR1B1 protein25532697
D013467SulindacSulindac binds to and results in decreased activity of AKR1B1 protein25532697
C025463sulindac sulfonesulindac sulfone binds to and results in decreased activity of AKR1B1 protein25532697
C047246temozolomideAKR1B1 mRNA affects the susceptibility to temozolomide16365179
C012568terbufosterbufos results in increased methylation of AKR1B1 promoter22847954
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of AKR1B1 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AKR1B1 mRNA20106945|2229881
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AKR1B1 mRNA19684285|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AKR1B1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AKR1B1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased phosphorylation of AKR1B1 protein21439344
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of AKR1B1 mRNA25729387
C113580U 0126U 0126 inhibits the reaction [AKR1B1 protein results in increased expression of FN1 protein]28137510
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of AKR1B1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of AKR1B1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of AKR1B1 mRNA23179753|2438349
D014801Vitamin AAKR1B1 protein results in decreased susceptibility to Vitamin A19014918
D014801Vitamin AAKR1B1 protein results in decreased susceptibility to Vitamin A metabolite19014918
D014810Vitamin EVitamin E results in increased expression of AKR1B1 mRNA19244175
C088658zoledronic acidzoledronic acid results in increased expression of AKR1B1 mRNA24714768
C067172zopolrestatzopolrestat results in decreased activity of AKR1B1 protein21334316
C067172zopolrestat"[zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased abundance of Reactive Oxygen Species]"21334316
C067172zopolrestat"[zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased secretion of Dinoprostone]"21334316
C067172zopolrestat"[zopolrestat results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to Antigens, Plant"21334316

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004032alditol:NADP+ 1-oxidoreductase activity-EXP1420136  15272156  
GO:0004032alditol:NADP+ 1-oxidoreductase activity-IBA21873635  
GO:0004032alditol:NADP+ 1-oxidoreductase activity-IDA8435445  
GO:0008106alcohol dehydrogenase (NADP+) activity-IBA21873635  
GO:0009055electron transfer activity-TAS2112546  
GO:0016491oxidoreductase activity-IBA21873635  
GO:0043795glyceraldehyde oxidoreductase activity-IDA20837989  
GO ID GO Term Qualifier Evidence PubMed
GO:0001894tissue homeostasis-IEA-  
GO:0003091renal water homeostasis-IEA-  
GO:0005975carbohydrate metabolic process-TAS2112546  
GO:0006061sorbitol biosynthetic process-IEA-  
GO:0006700C21-steroid hormone biosynthetic process-TAS-  
GO:0009414response to water deprivation-IEA-  
GO:0018931naphthalene metabolic process-IEA-  
GO:0022900electron transport chain-IEA-  
GO:0031098stress-activated protein kinase signaling cascade-IEA-  
GO:0035809regulation of urine volume-IEA-  
GO:0042415norepinephrine metabolic process-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0044597daunorubicin metabolic process-IMP20837989  
GO:0044598doxorubicin metabolic process-IMP20837989  
GO:0046370fructose biosynthetic process-TAS-  
GO:0046427positive regulation of JAK-STAT cascade-IEA-  
GO:0048661positive regulation of smooth muscle cell proliferation-IEA-  
GO:0055114oxidation-reduction process-IDA8435445  
GO:0060135maternal process involved in female pregnancy-IEA-  
GO:0071475cellular hyperosmotic salinity response-IDA8435445  
GO:0072061inner medullary collecting duct development-IEA-  
GO:0097066response to thyroid hormone-IEA-  
GO:0097238cellular response to methylglyoxal-IEA-  
GO:1901653cellular response to peptide-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-TAS2112546  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0032838plasma membrane bounded cell projection cytoplasm-IEA-  
GO:0033010paranodal junction-IEA-  
GO:0042629mast cell granule-IEA-  
GO:0043220Schmidt-Lanterman incisure-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
GO:0097454Schwann cell microvillus-IEA-  
KEGG ID KEGG Term
hsa00040Pentose and glucuronate interconversions
hsa00051Fructose and mannose metabolism
hsa00052Galactose metabolism
hsa00561Glycerolipid metabolism
hsa00620Pyruvate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196071Metabolism of steroid hormonesTAS
R-HSA-196108Pregnenolone biosynthesisTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5652084Fructose metabolismTAS
R-HSA-5652227Fructose biosynthesisTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19028477Cancer biomarker AKR1B10 and carbonyl metabolism. (2009 Mar 16)Balendiran GKChem Biol Interact
24598757Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design. (2014 Mar)Cousido-Siah AActa Crystallogr D Biol Crystallogr