Gene: MCF2L2

23101
ARHGEF22
MCF.2 cell line derived transforming sequence-like 2
protein-coding
3q27.1
Ensembl:ENSG00000053524 Vega:OTTHUMG00000158388 UniprotKB:Q86YR7
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.004e-1 (AD)  3.845e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12635655chr3:183378194 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF5A0.838
RAPGEF40.788
PLEKHM20.729
UNC13C0.727
ZEB10.72
KIF5C0.68
SBF20.66
HIPK10.658
SCRIB0.648
TBC1D140.648

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.479
OR4F29-0.473
TH-0.331
CLPSL1-0.292
GHRH-0.281
HCRT-0.264
NHLH2-0.259
ERAS-0.257
TMEM114-0.255
NPFFR2-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MCF2L2 mRNA"28973690
D000082AcetaminophenAcetaminophen results in decreased expression of MCF2L2 mRNA22230336
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of MCF2L2 mRNA20404318
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of MCF2L2 mRNA24763279
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of MCF2L2 mRNA24763279
D008727MethotrexateMethotrexate results in decreased expression of MCF2L2 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MCF2L2 mRNA26011545
C029938nickel sulfatenickel sulfate results in increased expression of MCF2L2 mRNA22714537
C017947sodium arsenitesodium arsenite results in decreased expression of MCF2L2 protein24866292
D014635Valproic AcidValproic Acid results in increased methylation of MCF2L2 gene29154799
D014638VanadatesVanadates results in decreased expression of MCF2L2 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005089Rho guanyl-nucleotide exchange factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal