Gene: RAP1GAP2

23108
GARNL4|RAP1GA3
RAP1 GTPase activating protein 2
protein-coding
17p13.3
Ensembl:ENSG00000132359 Vega:OTTHUMG00000177642 UniprotKB:Q684P5
NG_013030.2
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.163e-1 (AD)  5.011e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17835089chr17:2907378 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2317457chr17:2849919 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16037981chr17:2700093RAP1GAP21.300e-9Smoking27651444
cg18394567chr17:2758375RAP1GAP21.300e-9Smoking27651444
cg01076459chr17:2908230RAP1GAP21.400e-8Smoking27651444
cg12537003chr17:2886453RAP1GAP23.520e-10Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPTX10.968
KIF3C0.963
EHD30.956
BSN0.955
ARHGAP440.954
PI4KA0.953
SYN20.952
CNTNAP10.95
ATCAY0.948
MICAL20.947

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.544
RNF135-0.531
REST-0.52
WWTR1-0.518
GNG11-0.513
YES1-0.508
COPZ2-0.502
ASB4-0.501
MYL3-0.501
FAM89A-0.498

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAP1GAP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAP1GAP2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of RAP1GAP2 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RAP1GAP2 mRNA19770486
D001151ArsenicArsenic affects the methylation of RAP1GAP2 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of RAP1GAP2 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAP1GAP2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RAP1GAP2 mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RAP1GAP2 mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of RAP1GAP2 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of RAP1GAP2 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of RAP1GAP2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of RAP1GAP2 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of RAP1GAP2 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of RAP1GAP2 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RAP1GAP2 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of RAP1GAP220938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RAP1GAP2 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RAP1GAP2 mRNA20938992
D016572CyclosporineCyclosporine results in increased expression of RAP1GAP2 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RAP1GAP2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of RAP1GAP2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of RAP1GAP2 mRNA27392435|2759478
C000944dicrotophosdicrotophos results in increased expression of RAP1GAP2 mRNA28302478
D002117CalcitriolCalcitriol results in increased expression of RAP1GAP2 mRNA26485663
C118739entinostatentinostat results in increased expression of RAP1GAP2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAP1GAP2 mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of RAP1GAP220938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RAP1GAP2 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RAP1GAP2 mRNA20938992
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of RAP1GAP2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RAP1GAP2 mRNA23086925
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of RAP1GAP220938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RAP1GAP2 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RAP1GAP2 mRNA20938992
C028473N-acetyl-4-benzoquinoneimineRAP1GAP2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
C028007nickel monoxidenickel monoxide results in decreased expression of RAP1GAP2 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of RAP1GAP2 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of RAP1GAP2 mRNA26516004
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RAP1GAP2 mRNA19710929
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RAP1GAP2 mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAP1GAP2 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RAP1GAP2 mRNA23238561
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RAP1GAP2 mRNA23238561
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of RAP1GAP2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of RAP1GAP2 mRNA25729387
D014212TretinoinTretinoin results in increased expression of RAP1GAP2 mRNA16169686
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of RAP1GAP2 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of RAP1GAP2 mRNA29024780
C111237vorinostatvorinostat results in decreased expression of RAP1GAP2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-EXP16076873  
GO:0005515protein binding-IPI24284068  
GO ID GO Term Qualifier Evidence PubMed
GO:0008361regulation of cell size-IGI24284068  
GO:0008361regulation of cell size-IMP24284068  
GO:0010977negative regulation of neuron projection development-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005813centrosome-IDA21399614  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IGI24284068  
GO:0031965nuclear membrane-IDA-  
GO:0043005neuron projection-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392517Rap1 signallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal