Gene: FLG

2312
ATOD2
filaggrin
protein-coding
1q21.3
Ensembl:ENSG00000143631 MIM:135940 Vega:OTTHUMG00000012202 UniprotKB:P20930
NG_016190.1
PubMed
0   ANCO-SNPs
ND
5   
6.673e-1 (AD)  1.933e-1 (ND)   (Frontal_Cortex)
6.144e-2 (AD)  6.838e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TTN0.738
COMP0.62
MEOX10.611
XIRP20.603
C9orf1310.6
GPR870.597
OR56A40.596
ERVH48-10.596
ILDR10.595
SPDYE60.594

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FXYD4-0.306
S1PR5-0.266
SPATA3-0.261
CLDND2-0.26
NRN1L-0.257
COL9A2-0.252
CMTM5-0.252
NKX6-2-0.25
BTBD16-0.249
TMEM31-0.248

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0514502-ethyl-5-carboxypentyl phthalate[FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of 2-ethyl-5-carboxypentyl phthalate24380925
C0022024-oxoretinoic acid4-oxoretinoic acid results in decreased expression of FLG mRNA15982314
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of FLG mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FLG mRNA]17585979
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FLG mRNA22129741
D020106AcrylamideAcrylamide results in increased expression of FLG mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FLG gene27153756
C103303alitretinoinalitretinoin results in decreased expression of FLG mRNA15982314
C011512alpha-naphthoflavone[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG mRNA]21835898
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FLG mRNA16483693
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of FLG mRNA28713220
D001149ArsenatesArsenates results in decreased expression of FLG mRNA9219563
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of FLG gene25435355
C075388beta-damascenonebeta-damascenone results in increased expression of FLG mRNA22982537
C075388beta-damascenonebeta-damascenone results in increased expression of FLG protein22982537
D004958EstradiolEstradiol results in decreased expression of FLG mRNA28701262
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in decreased expression of FLG mRNA]28701262
D004958EstradiolEstradiol results in increased expression of FLG mRNA19484750
C006780bisphenol Abisphenol A affects the expression of FLG mRNA28701262
C006780bisphenol Afulvestrant affects the reaction [bisphenol A affects the expression of FLG mRNA]28701262
C006780bisphenol Abisphenol A results in decreased expression of FLG mRNA25181051
C027561butylbenzyl phthalate[FLG gene polymorphism affects the susceptibility to butylbenzyl phthalate] which affects the abundance of mono-benzyl phthalate24380925
D002104CadmiumCadmium results in increased expression of FLG mRNA23369406
C055085calcipotrienecalcipotriene results in decreased expression of FLG protein7508215
D002840ChromatesChromates results in decreased expression of FLG mRNA9219563
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of FLG mRNA17585979
D002994ClofibrateClofibrate results in increased expression of FLG mRNA10951269
D002994ClofibrateClofibrate results in increased expression of FLG protein10951269
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FLG mRNA]17585979
D003033Coal TarCoal Tar inhibits the reaction [[IL4 protein co-treated with IL13 protein] results in decreased expression of FLG mRNA]23348739
D003033Coal TarCoal Tar results in increased expression of FLG mRNA23348739
D003033Coal TarCoal Tar results in increased expression of FLG protein23348739
C009160cyclonitecyclonite results in increased expression of FLG mRNA25559034
D003993Dibutyl Phthalate[FLG gene polymorphism affects the susceptibility to Dibutyl Phthalate] which affects the abundance of monobutyl phthalate24380925
D004051Diethylhexyl Phthalate[FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of 2-ethyl-5-carboxypentyl phthalate24380925
D004051Diethylhexyl Phthalate[FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate24380925
D004051Diethylhexyl Phthalate[FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono(2-ethyl-5-oxohexyl)phthalate24380925
D004051Diethylhexyl Phthalate[FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono-(2-ethylhexyl)phthalate24380925
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FLG mRNA22129741
C007379diethyl phthalate[FLG gene polymorphism affects the susceptibility to diethyl phthalate] which affects the abundance of monoethyl phthalate24380925
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of FLG mRNA15171707
D002117CalcitriolCalcitriol results in decreased expression of FLG protein7508215
C025605diisobutyl phthalate[FLG gene polymorphism affects the susceptibility to diisobutyl phthalate] which affects the abundance of mono-isobutyl phthalate24380925
C012125diisononyl phthalate[FLG gene polymorphism affects the susceptibility to diisononyl phthalate] which affects the abundance of monoisononylphthalate24380925
D005230Fatty Acids, Nonesterified"FLG mutant form results in increased abundance of Fatty Acids, Nonesterified"24061166
C025164fucoxanthinfucoxanthin results in decreased expression of FLG mRNA27590588
C069837fullerene C60fullerene C60 results in decreased expression of FLG mRNA19167457
C070081fulvestrantfulvestrant affects the reaction [bisphenol A affects the expression of FLG mRNA]28701262
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in decreased expression of FLG mRNA]28701262
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FLG mRNA22129741
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of FLG mRNA"24972896
D008154LucanthoneLucanthone results in decreased expression of FLG mRNA21148553
C479069mono(2-ethyl-5-hydroxyhexyl) phthalate[FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate24380925
C080276mono(2-ethyl-5-oxohexyl)phthalate[FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono(2-ethyl-5-oxohexyl)phthalate24380925
C016599mono-(2-ethylhexyl)phthalate[FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono-(2-ethylhexyl)phthalate24380925
C103325mono-benzyl phthalate[FLG gene polymorphism affects the susceptibility to butylbenzyl phthalate] which affects the abundance of mono-benzyl phthalate24380925
C028577monobutyl phthalate[FLG gene polymorphism affects the susceptibility to Dibutyl Phthalate] which affects the abundance of monobutyl phthalate24380925
C581825monoethyl phthalate[FLG gene polymorphism affects the susceptibility to diethyl phthalate] which affects the abundance of monoethyl phthalate24380925
C575690mono-isobutyl phthalate[FLG gene polymorphism affects the susceptibility to diisobutyl phthalate] which affects the abundance of mono-isobutyl phthalate24380925
C471400monoisononylphthalate[FLG gene polymorphism affects the susceptibility to diisononyl phthalate] which affects the abundance of monoisononylphthalate24380925
D009532NickelFLG protein affects the susceptibility to Nickel21166815
C028007nickel monoxidenickel monoxide results in decreased expression of FLG mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of FLG mRNA22714537
D052638Particulate MatterParticulate Matter results in increased expression of FLG mRNA28341207
D010615PhenacetinPhenacetin results in increased expression of FLG mRNA17082564
C030299phenylhydrazinephenylhydrazine results in increased expression of FLG mRNA17082564
D010795Phthalic AcidsFLG gene polymorphism affects the susceptibility to and affects the transport of and affects the metabolism of Phthalic Acids24380925
C006253pirinixic acidpirinixic acid results in increased expression of FLG mRNA10951269|2081375
C006253pirinixic acidpirinixic acid results in increased expression of FLG protein10951269
C012526quercitrinquercitrin results in increased expression of FLG mRNA25193878
D015474IsotretinoinIsotretinoin results in decreased expression of FLG mRNA15982314
C009277sodium arsenatesodium arsenate results in decreased expression of FLG mRNA11485391|1272780
C017947sodium arsenitesodium arsenite results in decreased expression of FLG mRNA11485391|1272780
C017947sodium arsenitesodium arsenite results in increased expression of FLG mRNA19524636
C017947sodium arsenitesodium arsenite results in increased expression of FLG protein19524636
D013749Tetrachlorodibenzodioxin[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG mRNA]21835898
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FLG gene]21835898
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to FLG gene] which results in increased expression of FLG mRNA]21835898|2183589
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FLG mRNA21835898|2315218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FLG protein21835898
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG protein]12151643
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FLG protein12151643
D013749Tetrachlorodibenzodioxin[EGF protein results in increased activity of EGFR protein] inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to FLG gene] which results in increased expression of FLG mRNA]]21835898|2183589
D013749Tetrachlorodibenzodioxin[EGF protein results in increased activity of EGFR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG mRNA]21835898
D013749Tetrachlorodibenzodioxin[EGF protein results in increased activity of EGFR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG protein]21835898
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FLG mRNA27480279
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of FLG mRNA27404394
D014212TretinoinTretinoin metabolite results in increased expression of FLG mRNA15982314
D014212TretinoinTretinoin results in decreased expression of FLG mRNA15982314
D014560Urocanic AcidFLG mutant form results in decreased abundance of Urocanic Acid24061166
D014638VanadatesVanadates results in decreased expression of FLG mRNA9219563

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-NAS2740331  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI23629652  
GO:0030280structural constituent of epidermis-IBA21873635  
GO:0030280structural constituent of epidermis-IDA7543090  
GO:0046914transition metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-NAS2740331  
GO:0018149peptide cross-linking-IDA7543090  
GO:0030216keratinocyte differentiation-TAS17704059  
GO:0061436establishment of skin barrier-IBA21873635  
GO:0061436establishment of skin barrier-IEP23403047  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-IBA21873635  
GO:0001533cornified envelope-IDA7543090  
GO:0005634nucleus-HDA21630459  
GO:0005829cytosol-TAS-  
GO:0005882intermediate filament-NAS2740331  
GO:0036457keratohyalin granule-IBA21873635  
GO:0036457keratohyalin granule-IDA1429717  12850301  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27282435Quality of life and disease severity in patients with atopic dermatitis. (2016 Oct)Holm JGJ Eur Acad Dermatol Venereol
26124566An in silico analytical study of lung cancer and smokers datasets from gene expression omnibus (GEO) for prediction of differentially expressed genes. (2015)Hasan ANBioinformation
23809981Risk factors for developing atopic dermatitis. (2013 Jul)Carson CGDan Med J
28164424Filaggrin loss-of-function mutations as risk factors for ischemic stroke in the general population. (2017 Apr)Varbo AJ Thromb Haemost
22088612Interaction between filaggrin null mutations and tobacco smoking in relation to asthma. (2012 Feb)Berg NDJ Allergy Clin Immunol