Gene: ATP10B

23120
ATPVB
ATPase phospholipid transporting 10B (putative)
protein-coding
5q34
Ensembl:ENSG00000118322 Vega:OTTHUMG00000163551 UniprotKB:O94823
NC_000005.10
SNP Mapped
1   ANCO-SNPs
ND
0   
5.706e-1 (AD)  5.847e-1 (ND)   (Frontal_Cortex)
3.150e-1 (AD)  8.235e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12188645chr5:160869226 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRR180.797
PLEKHG30.79
TTYH20.786
DOCK50.786
PHLDB10.785
COL4A50.784
ZBED30.773
EFS0.772
TSPAN150.769
SEMA6A0.766

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLK5-0.398
BEND4-0.381
HCN4-0.368
KCNG1-0.365
PRTN3-0.361
RTP1-0.358
WNT2-0.342
PNOC-0.342
TWIST2-0.337
CHRNA2-0.334

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP10B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP10B mRNA"27188386
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ATP10B mRNA21298039
C006780bisphenol Abisphenol A results in decreased expression of ATP10B mRNA25181051
D003035Cobalt[tungsten carbide binds to Cobalt] which results in decreased expression of ATP10B mRNA20105288
D017313FenretinideFenretinide results in increased expression of ATP10B mRNA28973697
D007854LeadLead affects the expression of ATP10B mRNA28903495
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ATP10B mRNA"25554681
D010126OzoneOzone results in decreased expression of ATP10B mRNA28623178
D011192Potassium DichromatePotassium Dichromate results in increased expression of ATP10B mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of ATP10B mRNA22238285
D012834SilverSilver results in increased expression of ATP10B mRNA27131904
C012589trichostatin Atrichostatin A results in increased expression of ATP10B mRNA24935251
C002802tungsten carbide[tungsten carbide binds to Cobalt] which results in decreased expression of ATP10B mRNA20105288
C002802tungsten carbidetungsten carbide results in decreased expression of ATP10B mRNA20105288
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP10B mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ATP10B mRNA24383497|2627250
D015034Zinc OxideZinc Oxide analog results in increased expression of ATP10B mRNA27215404
C088658zoledronic acidzoledronic acid results in increased expression of ATP10B mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IEA-  
GO:0004012phospholipid-translocating ATPase activity-IBA21873635  
GO:0005515protein binding-IPI21914794  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0045332phospholipid translocation-IBA21873635  
GO:0045332phospholipid translocation-NAS21914794  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA21914794  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0030659cytoplasmic vesicle membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-936837Ion transport by P-type ATPasesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal