Gene: CLASP2

23122
-
cytoplasmic linker associated protein 2
protein-coding
3p22.3
Ensembl:ENSG00000163539 MIM:605853 Vega:OTTHUMG00000156489 UniprotKB:O75122
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.632e-1 (AD)  7.717e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9876025chr3:33656680 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LANCL10.961
PRKACB0.959
DNAJC180.954
PPM1A0.951
KLHL420.951
PTPRD0.95
FAM69A0.95
SRPK20.949
TRIM20.948
DNM30.947

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.622
OR4F29-0.583
CSAG1-0.448
PDZK1IP1-0.41
MTRNR2L10-0.399
EVC2-0.397
TFPI2-0.394
MTRNR2L6-0.389
CST7-0.388
RNF135-0.384

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CLASP2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CLASP2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CLASP2 mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of CLASP2 mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CLASP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLASP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CLASP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLASP2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CLASP2 gene27153756
D001280AtrazineAtrazine results in increased expression of CLASP2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CLASP2 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CLASP2 mRNA"19150397
D004958EstradiolEstradiol affects the expression of CLASP2 mRNA14699072
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of CLASP2 mRNA20404318
C006780bisphenol Abisphenol A affects the expression of CLASP2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CLASP2 mRNA25181051
C026690cerous chloridecerous chloride results in increased expression of CLASP2 mRNA23573234
D003703DemecolcineDemecolcine results in increased expression of CLASP2 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CLASP2 mRNA21266533
C118739entinostatentinostat results in decreased expression of CLASP2 mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CLASP2 protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CLASP2 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of CLASP2 mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of CLASP2 mRNA22634610
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CLASP2 mRNA17183730
D007657Ketone BodiesKetone Bodies results in increased expression of CLASP2 mRNA16807920
D007854LeadLead affects the expression of CLASP2 mRNA28903495
D007854LeadLead affects the splicing of CLASP2 mRNA28903495
D008628MercuryMercury results in increased expression of CLASP2 mRNA16823088
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CLASP2 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CLASP2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CLASP2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CLASP2 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CLASP2 mRNA"20188158
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of CLASP2 mRNA22401849
C025589ochratoxin Aochratoxin A results in decreased acetylation of CLASP2 promoter29098329
C025589ochratoxin A[ochratoxin A results in decreased acetylation of CLASP2 promoter] which results in decreased expression of CLASP2 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in decreased expression of CLASP2 mRNA29098329
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CLASP2 mRNA25729387
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CLASP2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CLASP2 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of CLASP2 mRNA23557933
D011794QuercetinQuercetin results in decreased expression of CLASP2 mRNA21632981
D013849ThimerosalThimerosal results in increased expression of CLASP2 mRNA27188386
D014050TolueneToluene results in decreased expression of CLASP2 mRNA22166486
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CLASP2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CLASP2 mRNA25729387
D014212TretinoinTretinoin results in increased expression of CLASP2 mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CLASP2 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLASP2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CLASP2 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of CLASP2 mRNA28973697
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CLASP2 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of CLASP2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CLASP2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of CLASP2 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CLASP2 gene25560391
D014750VincristineVincristine results in increased expression of CLASP2 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002162dystroglycan binding-IPI23940118  
GO:0005515protein binding-IPI11290329  17543864  19632184  26496610  27173435  
GO:0008017microtubule binding-IDA26003921  
GO:0051010microtubule plus-end binding-IDA11290329  19632184  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IMP24859005  26003921  
GO:0006903vesicle targeting-IMP24859005  
GO:0007020microtubule nucleation-IMP17543864  
GO:0007026negative regulation of microtubule depolymerization-NAS11290329  
GO:0007030Golgi organization-IMP24859005  
GO:0007052mitotic spindle organization-IMP16866869  
GO:0007163establishment or maintenance of cell polarity-TAS15928712  
GO:0010458exit from mitosis-IMP16866869  
GO:0010470regulation of gastrulation-IMP23940118  
GO:0010634positive regulation of epithelial cell migration-IMP24859005  
GO:0010717regulation of epithelial to mesenchymal transition-IMP23940118  
GO:0031023microtubule organizing center organization-IMP17543864  
GO:0031110regulation of microtubule polymerization or depolymerization-IMP11290329  
GO:0032886regulation of microtubule-based process-IMP20937854  
GO:0034453microtubule anchoring-IMP17543864  24859005  
GO:0045921positive regulation of exocytosis-IMP24859005  
GO:0051301cell division-IEA-  
GO:0051497negative regulation of stress fiber assembly-IMP24859005  
GO:0051895negative regulation of focal adhesion assembly-IMP24859005  
GO:0072659protein localization to plasma membrane-IMP23940118  
GO:0090091positive regulation of extracellular matrix disassembly-IMP24859005  
GO:1903690negative regulation of wound healing, spreading of epidermal cells-IMP24859005  
GO:1904261positive regulation of basement membrane assembly involved in embryonic body morphogenesis-IMP23940118  
GO ID GO Term Qualifier Evidence PubMed
GO:0000776kinetochorecolocalizes_withIMP16866869  
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0005737cytoplasm-NAS11290329  
GO:0005794Golgi apparatus-IDA11290329  
GO:0005802trans-Golgi network-IDA17543864  
GO:0005815microtubule organizing center-IEA-  
GO:0005828kinetochore microtubule-TAS12837247  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005874microtubule-IDA17543864  20937854  
GO:0005874microtubulecolocalizes_withIDA24859005  
GO:0005881cytoplasmic microtubule-IDA11290329  
GO:0005886plasma membrane-IDA20937854  
GO:0005925focal adhesioncolocalizes_withIDA24859005  
GO:0005938cell cortex-IDA17113391  
GO:0016020membrane-HDA19946888  
GO:0031252cell leading edge-IDA24859005  
GO:0032587ruffle membrane-IDA20937854  
GO:0045180basal cortex-IDA23940118  
GO:0072686mitotic spindlecolocalizes_withIMP16866869  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-428890Role of ABL in ROBO-SLIT signalingIEA
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal