Gene: CAMTA2

23125
-
calmodulin binding transcription activator 2
protein-coding
17p13.2
Ensembl:ENSG00000108509 MIM:611508 Vega:OTTHUMG00000099417 UniprotKB:O94983
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.920e-1 (AD)  6.930e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08101329chr17:4884631CAMTA2Gene body5.830e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TAF60.969
RUSC20.964
LZTS30.963
SYNGR10.962
PACSIN10.962
CEP170B0.961
ZBTB7A0.961
DNAJC50.961
ATXN7L30.961
SCAMP50.96

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.61
OR4F29-0.568
TFPI2-0.488
MYL3-0.455
C9orf135-0.455
REST-0.449
IL18RAP-0.449
CST7-0.445
WWTR1-0.445
PROK2-0.442

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CAMTA2 mRNA"28973690
C0293704-toluidine4-toluidine results in decreased expression of CAMTA2 mRNA27638505
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CAMTA2 mRNA19770486
D001280AtrazineAtrazine results in decreased expression of CAMTA2 mRNA25929836
D001280AtrazineAtrazine results in increased expression of CAMTA2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CAMTA2 mRNA22228805
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CAMTA2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of CAMTA2 mRNA19619570
C006780bisphenol Abisphenol A affects the expression of CAMTA2 mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of CAMTA2 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of CAMTA2 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of CAMTA2 mRNA20106945|2556210
C014347decitabinedecitabine results in increased expression of CAMTA2 mRNA19194470
D003976DiazinonDiazinon results in increased methylation of CAMTA2 gene22964155
C000944dicrotophosdicrotophos results in increased expression of CAMTA2 mRNA28302478
D004397FonofosFonofos results in increased methylation of CAMTA2 promoter22847954
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CAMTA2 mRNA"24972896
D008694MethamphetamineMethamphetamine results in increased expression of CAMTA2 mRNA26307267
D010278ParathionParathion results in increased methylation of CAMTA2 promoter22847954
D010936Plant ExtractsPlant Extracts results in decreased expression of CAMTA2 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of CAMTA2 mRNA24780913
D011794QuercetinQuercetin results in increased expression of CAMTA2 mRNA21632981
C061133tamibarotenetamibarotene results in increased expression of CAMTA2 mRNA15498508
C012568terbufosterbufos results in increased methylation of CAMTA2 promoter22847954
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CAMTA2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CAMTA2 mRNA19619570
D014212TretinoinTretinoin results in increased expression of CAMTA2 mRNA15498508
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CAMTA2 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of CAMTA2 mRNA28001369|2915479
D014635Valproic AcidValproic Acid results in increased methylation of CAMTA2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of CAMTA2 mRNA17292431|1796380

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0003682chromatin binding-IDA16678093  
GO:0005515protein binding-IPI16678093  
GO:0008134transcription factor binding-IGI16678093  
GO:0042826histone deacetylase binding-IDA16678093  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IDA16678093  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0014898cardiac muscle hypertrophy in response to stress-IDA16678093  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IGI16678093  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA16678093  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26886562A functional variant in the coding region of CAMTA2 is associated with left ventricular hypertrophy by affecting the activation of Nkx2.5-dependent transcription. (2016 May)Song WHJ Hypertens