Gene: FLI1

2313
BDPLT21|EWSR2|SIC-1
Fli-1 proto-oncogene, ETS transcription factor
protein-coding
11q24.3
Ensembl:ENSG00000151702 MIM:193067 Vega:OTTHUMG00000165792 UniprotKB:Q01543
NG_032912.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.937e-1 (AD)  4.783e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20374917chr11:128603874FLI13.200e-11Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGFBR20.909
CYYR10.893
MECOM0.893
RNF144B0.885
LY750.884
GIMAP80.881
SLC19A30.88
MFNG0.873
GIMAP40.872
CASP100.87

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.493
MAGIX-0.465
KCNIP3-0.461
HAS1-0.457
CHRNA4-0.454
ATP2C2-0.45
CYP46A1-0.449
ZNF835-0.448
MYADML2-0.446
TMEM121-0.445

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of FLI1 mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FLI1 mRNA"25380136
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of FLI1 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLI1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLI1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLI1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLI1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of FLI1 mRNA17562736
D000393Air PollutantsAir Pollutants analog results in increased expression of FLI1 mRNA21757418
C021139anagrelideanagrelide inhibits the reaction [THPO protein results in increased expression of FLI1 mRNA]20586925
C015001arsenitearsenite results in increased methylation of FLI1 promoter23974009
D001280AtrazineAtrazine results in decreased expression of FLI1 mRNA25929836
D001280AtrazineAtrazine results in increased expression of FLI1 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of FLI1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FLI1 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of FLI1 mRNA"20382639
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FLI1 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of FLI1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of FLI1 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FLI1 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of FLI120938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FLI1 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FLI1 mRNA20938992
D016572CyclosporineCyclosporine results in decreased methylation of FLI1 promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of FLI1 mRNA23640034
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FLI1 mRNA28628672
D004041Dietary FatsDietary Fats results in increased expression of FLI1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of FLI1 mRNA21852083
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of FLI1 mRNA25380136
D004317DoxorubicinFLI1 protein affects the susceptibility to Doxorubicin16217747
D018120FinasterideFinasteride results in decreased expression of FLI1 mRNA24136188
D005485FlutamideFlutamide results in decreased expression of FLI1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of FLI120938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FLI1 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FLI1 mRNA20938992
D005839GentamicinsGentamicins results in increased expression of FLI1 mRNA22061828
D017313FenretinideFenretinide results in increased expression of FLI1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FLI1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FLI1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FLI1 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FLI1 mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to BTK enhancer]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to BTK promoter]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to CCL4 enhancer]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to CCL4 promoter]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to FCGR2B enhancer]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to FCGR2B promoter]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to PECAM1 enhancer]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to PECAM1 promoter]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein] results in increased expression of BTK mRNA]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein] results in increased expression of CCL4 mRNA]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein] results in increased expression of FCGR2B mRNA]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein] results in increased expression of PECAM1 mRNA]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FLI1 mRNA25982114
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FLI1 protein25982114
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of FLI1 mRNA21641980
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLI1 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of FLI120938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FLI1 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FLI1 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FLI1 mRNA23649840
C028007nickel monoxidenickel monoxide results in decreased expression of FLI1 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of FLI1 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FLI1 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of FLI1 mRNA18042831
D010634PhenobarbitalPhenobarbital affects the expression of FLI1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLI1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FLI1 mRNA26272509
C014153pirimiphos methylpirimiphos methyl results in increased expression of FLI1 mRNA27845199
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FLI1 mRNA19710929
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FLI1 mRNA22714537
D011441PropylthiouracilPropylthiouracil results in increased expression of FLI1 mRNA24780913
C087123romidepsinromidepsin results in decreased activity of and results in decreased expression of FLI1 protein mutant form15849726
C087123romidepsinromidepsin results in decreased expression of FLI1 mRNA mutant form15849726
D012906SmokeSmoke results in increased expression of FLI1 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of FLI1 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of FLI1 mRNA12634122
D012999SomanSoman results in increased expression of FLI1 mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of FLI1 mRNA21641980
D013467SulindacSulindac results in decreased expression of FLI1 mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FLI1 mRNA21570461|2405805
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FLI1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of FLI1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FLI1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of FLI1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of FLI1 mRNA21934132
D014212TretinoinTretinoin results in increased expression of FLI1 mRNA16211290
C011559tributyltintributyltin results in increased expression of FLI1 mRNA21683754
C012589trichostatin Atrichostatin A results in increased expression of FLI1 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of FLI1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of FLI1 mRNA24935251|2800136
D014635Valproic AcidValproic Acid affects the expression of FLI1 mRNA17292431
D014747VinblastineFLI1 protein affects the susceptibility to Vinblastine16217747

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-TAS1522903  
GO:0003682chromatin binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS10891501  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007599hemostasis-TAS10891501  
GO:0008015blood circulation-IEA-  
GO:0009887animal organ morphogenesis-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0035855megakaryocyte development-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA26316623  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA28255014  
GO:0005829cytosol-IDA-  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28814981CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel. (2017)Morandi LClin Epigenetics