Gene: PHF8

23133
JHDM1F|KDM7B|MRXSSD|ZNF422
PHD finger protein 8
protein-coding
Xp11.22
Ensembl:ENSG00000172943 MIM:300560 Vega:OTTHUMG00000021622 UniprotKB:Q9UPP1
NG_021309.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUP980.91
BAZ2A0.88
CASP20.879
MAML10.876
ELMSAN10.867
MED120.864
NUP1880.862
NFKB10.862
SPEN0.859
PHF120.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.463
OR4F29-0.435
KLRC2-0.3
RERGL-0.267
CRH-0.252
PAGE4-0.237
HES5-0.225
GSDMC-0.215
SPRR2A-0.211
NANOGNB-0.21

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PHF8 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PHF8 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of PHF8 mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of PHF8 mRNA28959563
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PHF8 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PHF8 gene25435355
C038328BEP protocolBEP protocol results in increased expression of PHF8 mRNA18987330
D004958EstradiolEstradiol results in decreased expression of PHF8 mRNA19484750
C006780bisphenol Abisphenol A results in decreased methylation of PHF8 promoter27312807
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PHF8 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of PHF8 mRNA18353800
D002945CisplatinCisplatin results in decreased expression of PHF8 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of PHF8 mRNA28302478
C024565ethylene dichlorideethylene dichloride results in decreased expression of PHF8 mRNA28189721
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PHF8 gene20938992
C008261lead acetatelead acetate results in decreased expression of PHF8 mRNA21829687
C045463leflunomideleflunomide results in decreased expression of PHF8 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PHF8 gene20938992
D008727MethotrexateMethotrexate affects the expression of PHF8 mRNA18502557
C028007nickel monoxidenickel monoxide results in increased expression of PHF8 mRNA19167457
D009569Nitric OxideNitric Oxide results in increased expression of PHF8 mRNA23546878
D010100OxygenOxygen deficiency results in increased expression of PHF8 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of PHF8 mRNA]22629407
D011794QuercetinQuercetin results in decreased expression of PHF8 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PHF8 mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHF8 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PHF8 promoter]19654925
D013853ThioacetamideThioacetamide results in decreased expression of PHF8 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PHF8 mRNA28065790
C057693troglitazonetroglitazone results in decreased expression of PHF8 mRNA28973697
D014520UrethaneUrethane results in increased expression of PHF8 mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PHF8 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PHF8 mRNA21126777
C025643vinclozolinvinclozolin results in increased expression of PHF8 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IDA20622854  
GO:0005506iron ion binding-IDA20023638  
GO:0005515protein binding-IPI20208542  20346720  20622854  23022380  
GO:0008270zinc ion binding-IDA20023638  
GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors-IDA20023638  
GO:0032452histone demethylase activity-IDA19843542  
GO:0032452histone demethylase activity-TAS-  
GO:0032454histone demethylase activity (H3-K9 specific)-IDA20023638  20208542  20346720  20622853  20622854  
GO:0035064methylated histone binding-IDA20023638  20208542  20346720  20622853  20622854  21029866  
GO:0035575histone demethylase activity (H4-K20 specific)-IDA20622853  20622854  
GO:0051864histone demethylase activity (H3-K36 specific)-IDA20208542  20622853  
GO:0071558histone demethylase activity (H3-K27 specific)-IDA20622853  20622854  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-IMP20622854  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007420brain development-ISS-  
GO:0033169histone H3-K9 demethylation-IDA20023638  20208542  20346720  20622853  20622854  
GO:0035574histone H4-K20 demethylation-IDA20622853  20622854  
GO:0045893positive regulation of transcription, DNA-templated-IDA20622853  
GO:0045893positive regulation of transcription, DNA-templated-IMP20346720  20622854  
GO:0045943positive regulation of transcription by RNA polymerase I-IDA20208542  
GO:0055114oxidation-reduction process-IEA-  
GO:0061188negative regulation of chromatin silencing at rDNA-IDA20208542  
GO:0070544histone H3-K36 demethylation-IDA20208542  20622853  
GO:0071557histone H3-K27 demethylation-IDA20622853  20622854  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IC20023638  
GO:0005634nucleus-IDA19843542  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA20208542  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-2299718Condensation of Prophase ChromosomesTAS
R-HSA-3214842HDMs demethylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-68875Mitotic ProphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19843542PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. (2010 Jan 15)Loenarz CHum Mol Genet
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics