Gene: MAST2

23139
MAST205|MTSSK
microtubule associated serine/threonine kinase 2
protein-coding
1p34.1
Ensembl:ENSG00000086015 MIM:612257 Vega:OTTHUMG00000008007 UniprotKB:Q6P0Q8
NC_000001.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.182e-1 (AD)  8.643e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6680211chr1:45849335 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16730386chr1:46269394MAST2Promoter2.703e-4Alcohol use disorders26763658
cg04984052chr1:46268207MAST2Promoter3.220e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AP3D10.935
NISCH0.935
TAF60.933
DEF80.933
GBA20.93
DENND4B0.928
HTT0.927
SREBF20.926
EXOC70.925
AP2A10.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.651
OR4F29-0.594
IL18RAP-0.355
TFPI2-0.348
SH2D1A-0.343
PROK2-0.329
KLRB1-0.329
CST7-0.329
KCNJ15-0.327
CTNNA3-0.318

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MAST2 mRNA"22698814
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MAST2 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MAST2 mRNA"28973690
D000082AcetaminophenAcetaminophen results in increased expression of MAST2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MAST2 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MAST2 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MAST2 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of MAST2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of MAST2 protein24552547
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of MAST2 mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of MAST2 mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MAST2 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of MAST2 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of MAST2 mRNA25016146
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MAST2 mRNA26865667
C069837fullerene C60fullerene C60 results in increased expression of MAST2 mRNA19167457
D019833GenisteinGenistein results in increased expression of MAST2 mRNA26865667
D005839GentamicinsGentamicins results in decreased expression of MAST2 mRNA22061828
C004312glycidolglycidol results in decreased expression of MAST2 mRNA24915197
C008261lead acetatelead acetate results in increased expression of MAST2 mRNA21829687
D008694MethamphetamineMethamphetamine results in increased expression of MAST2 mRNA26307267
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MAST2 mRNA26011545
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MAST2 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MAST2 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of MAST2 mRNA19167457
D010416PentachlorophenolPentachlorophenol results in increased expression of MAST2 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of MAST2 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of MAST2 mRNA23811191
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAST2 mRNA21570461
D014635Valproic AcidValproic Acid affects the expression of MAST2 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-ISS-  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0005515protein binding-IPI12117771  16159897  
GO:0005524ATP binding-ISS-  
GO:0008017microtubule binding-IBA21873635  
GO:0019902phosphatase binding-IPI10646847  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-ISS-  
GO:0007010cytoskeleton organization-IBA21873635  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0045075regulation of interleukin-12 biosynthetic process-ISS-  
GO:0048515spermatid differentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0015630microtubule cytoskeleton-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal