Gene: CIC

23152
MRD45
capicua transcriptional repressor
protein-coding
19q13.2
Ensembl:ENSG00000079432 MIM:612082 Vega:OTTHUMG00000182794 UniprotKB:Q96RK0
NG_042060.1
PubMed
0   ANCO-SNPs
ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.910e-1 (AD)  6.081e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRRC2A0.878
ATN10.876
MLLT60.874
MINK10.87
PPARD0.87
MTA10.867
RAPGEF10.865
SBF10.863
HCFC10.862
ZMIZ20.861

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.695
OR4F29-0.665
UTS2-0.238
NANOGNB-0.228
ODAM-0.224
MOGAT2-0.205
TSPAN8-0.2
OR6C74-0.193
HMHB1-0.187
LHX5-0.183

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of CIC mRNA17562736
D001280AtrazineAtrazine results in decreased expression of CIC mRNA25929836
D001280AtrazineAtrazine results in increased expression of CIC mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CIC mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of CIC mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of CIC mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of CIC mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CIC mRNA17484886
D002945CisplatinCisplatin results in decreased expression of CIC mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of CIC mRNA28302478
D000431EthanolEthanol results in decreased expression of CIC mRNA29018328
D005485FlutamideFlutamide results in decreased expression of CIC mRNA24136188
D005839GentamicinsGentamicins results in increased expression of CIC mRNA22061828
D005897GlafenineGlafenine results in increased expression of CIC mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CIC mRNA25613284
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CIC mRNA"24972896
D008694MethamphetamineMethamphetamine results in increased expression of CIC mRNA26307267
D010936Plant ExtractsPlant Extracts results in decreased expression of CIC mRNA23557933
D012999SomanSoman results in increased expression of CIC mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CIC mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CIC mRNA25613284
D014635Valproic AcidValproic Acid results in increased methylation of CIC gene29154799
D014635Valproic AcidValproic Acid affects the expression of CIC mRNA17963808
D015032ZincZinc deficiency results in increased expression of CIC mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IEA-  
GO:0003682chromatin binding-IEA-  
GO:0005515protein binding-IPI16713569  18337722  29568061  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007420brain development-ISS-  
GO:0007612learning-ISS-  
GO:0007613memory-ISS-  
GO:0035176social behavior-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0048286lung alveolus development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0032991protein-containing complex-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
9734701Antioxidant status and alpha1-antiproteinase activity in subarachnoid hemorrhage patients. (1998)Marzatico FLife Sci
2632033[Effects of smoking on human health]. (1989 Oct)Du BYZhonghua Jie He He Hu Xi Za Zhi
17288190[Influence of tobacco smoking on the level of alfafetoprotein and circuleting immune complexes in serum of smokinig and nonsmoking women being in second trimester of pregnancy]. (2006)Golda RPrzegl Lek
8880689Activity of alpha 1-antitrypsin and cigarette smoking in subarachnoid haemorrhage from ruptured aneurysm. (1996 Sep 15)Gaetani PJ Neurol Sci
23421022[Circulating immune complexes, heat shock proteins in the serum of smoking allergy sufferers--preliminary results]. (2012)Golda RPrzegl Lek
9816580[The effects of occupational exposure to nitrogen dioxide (NO2) on the immunological parameters in workers]. (1998)Rutowski JMed Pr
24501795[Analysis of occurrence atypical proteins in the serum at smoking and non-smoking cigarettes patients with lung cancer]. (2013)Golda RPrzegl Lek