Gene: FLNA

2316
ABP-280|ABPX|CSBS|CVD1|FGS2|FLN|FLN-A|FLN1|FMD|MNS|NHBP|OPD|OPD1|OPD2|XLVD|XMVD
filamin A
protein-coding
Xq28
Ensembl:ENSG00000196924 MIM:300017 Vega:OTTHUMG00000022712 UniprotKB:P21333
NG_011506.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLN10.861
LAMC10.848
VCL0.833
MYO1C0.833
ECE10.832
PTBP10.817
CD1510.816
HDAC70.806
EHD20.804
MYH90.799

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.442
OR4F29-0.439
SMIM18-0.37
PPEF1-0.339
CRH-0.325
ABCC12-0.311
OSTN-0.305
NMU-0.303
DRD5-0.29
NEUROD6-0.285

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0810141,2-bis(2,4,6-tribromophenoxy)ethane"1,2-bis(2,4,6-tribromophenoxy)ethane results in increased expression of FLNA mRNA"28249227
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FLNA mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FLNA mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FLNA mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FLNA mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FLNA mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FLNA mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLNA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLNA mRNA"27188386
C496492abrineabrine results in decreased expression of FLNA mRNA22595364
D000082AcetaminophenAcetaminophen results in increased expression of FLNA mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of FLNA mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of FLNA mRNA17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]25944616
C016601afimoxifeneafimoxifene results in increased expression of FLNA mRNA19698761
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of FLNA mRNA"22863853
D001151ArsenicArsenic results in increased expression of FLNA mRNA24019935
C050510arsenic trichlorideAcetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]25944616
C050510arsenic trichlorideAKT1 mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]25944616
C050510arsenic trichloridearsenic trichloride promotes the reaction [AKT1 protein binds to FLNA protein modified form]25944616
C050510arsenic trichloridearsenic trichloride promotes the reaction [AKT1 protein modified form binds to FLNA protein modified form]25944616
C050510arsenic trichloridearsenic trichloride results in increased phosphorylation of FLNA protein25944616
C050510arsenic trichloridewortmannin inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]25944616
C039726artesunateFLNA mRNA results in increased susceptibility to artesunate20144594
D001280AtrazineAtrazine results in increased expression of FLNA mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FLNA mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FLNA mRNA22228805
D004958EstradiolEstradiol affects the expression of FLNA mRNA23557687
D004958EstradiolEstradiol results in increased expression of FLNA mRNA19698761
C006780bisphenol Abisphenol A affects the expression of FLNA mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FLNA gene28505145
D002104CadmiumCadmium results in increased oxidation of FLNA protein24077948
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FLNA mRNA17582521
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FLNA mRNA19031917
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FLNA mRNA23741332
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of FLNA mRNA23650126
D002994ClofibrateClofibrate results in decreased expression of FLNA mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of FLNA mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of FLNA mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of FLNA mRNA19549813
D003471CuprizoneCuprizone results in increased expression of FLNA mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of FLNA mRNA20106945|2556210
C014347decitabinedecitabine results in increased expression of FLNA mRNA27915011
C007262deoxynivalenoldeoxynivalenol results in decreased phosphorylation of FLNA protein23811945
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of FLNA protein23811945
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FLNA mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FLNA mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FLNA mRNA27392435
D002945CisplatinCisplatin results in decreased expression of FLNA mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of FLNA mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of FLNA mRNA25016146
C039060dihydroartemisinindihydroartemisinin analog binds to FLNA protein26340163
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of FLNA mRNA25380136
D004237DiuronDiuron results in increased expression of FLNA mRNA21551480
D004317DoxorubicinDoxorubicin affects the expression of FLNA protein29385562
D004610Ellagic AcidEllagic Acid results in decreased expression of FLNA mRNA12002526
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FLNA protein23301498
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FLNA mRNA17942748
C540355fenamidonefenamidone results in increased expression of FLNA mRNA27029645
D005485FlutamideFlutamide results in decreased expression of FLNA mRNA24793618
D019833GenisteinESR2 promotes the reaction [Genistein results in decreased expression of FLNA protein]20884965
D019833GenisteinGenistein results in decreased expression of FLNA protein20884965
D005897GlafenineGlafenine results in increased expression of FLNA mRNA24136188
D006108GraphiteGraphite results in increased expression of FLNA protein22157353
D017313FenretinideFenretinide results in increased expression of FLNA mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of FLNA protein25944616
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FLNA mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FLNA mRNA27392435
D007854LeadLead affects the splicing of FLNA mRNA28903495
D064704LevofloxacinLevofloxacin results in decreased expression of FLNA mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of FLNA mRNA"24972896
C431023manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrinmanganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin results in decreased degradation of FLNA protein20584581
D008627Mercuric ChlorideMercuric Chloride affects the expression of FLNA mRNA20353558
D008694MethamphetamineMethamphetamine results in increased expression of FLNA mRNA26307267
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of FLNA mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FLNA protein"22157353
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FLNA mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FLNA mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of FLNA mRNA25380136
C028007nickel monoxidenickel monoxide results in increased expression of FLNA mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of FLNA mRNA18651567
D009534NiclosamideNiclosamide results in decreased expression of FLNA mRNA26452273
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FLNA mRNA"25510870
C046012pentanalpentanal results in increased expression of FLNA mRNA26079696
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of FLNA mRNA17616710
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLNA mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FLNA mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of FLNA mRNA21061450
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FLNA mRNA22714537
C005556propionaldehydepropionaldehyde results in increased expression of FLNA mRNA26079696
C513428pyrachlostrobinpyrachlostrobin results in increased expression of FLNA mRNA27029645
D011794QuercetinQuercetin results in increased expression of FLNA mRNA21632981
D015474IsotretinoinIsotretinoin results in increased expression of FLNA mRNA20436886
C089730rosiglitazonerosiglitazone affects the expression of FLNA protein19556978
D012643SeleniumSelenium results in increased expression of FLNA mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of FLNA protein25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FLNA mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FLNA mRNA11489354
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FLNA mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FLNA mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FLNA mRNA25613284
C096900thrombin receptor-activating peptide SFLLRNPNDKYthrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FLNA protein17303692
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FLNA mRNA28111298
D014520UrethaneUrethane results in increased expression of FLNA mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of FLNA mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of FLNA mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of FLNA gene29154799
D014640VancomycinVancomycin results in decreased expression of FLNA mRNA18930951
C025643vinclozolinvinclozolin affects the expression of FLNA mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of FLNA mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of FLNA mRNA26682919
D014810Vitamin EVitamin E results in increased expression of FLNA mRNA19244175
C009687wortmanninwortmannin inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]25944616

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IPI26460884  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IDA1833070  3138234  
GO:0005515protein binding-IPI4044584  9437013  9722563  10051605  10692483  12393796  
12577067  14573758  14743216  15225631  15684392  16076904  
16263121  16291724  16862148  17408621  17474147  17690686  
18177638  18322202  19828450  20236936  21228480  21524097  
21914078  21926999  22121117  24021649  25241761  25358863  
25666618  25849143  26496610  
GO:0008134transcription factor binding-IPI15684392  
GO:0015459potassium channel regulator activity-IDA24951510  
GO:0017048Rho GTPase binding-IDA10051605  
GO:0017160Ral GTPase binding-IDA10051605  
GO:0019900kinase binding-IPI20713593  
GO:0031267small GTPase binding-IDA10051605  
GO:0031852mu-type opioid receptor binding-IEA-  
GO:0034988Fc-gamma receptor I complex binding-IDA1833070  
GO:0042803protein homodimerization activity-IDA2391361  
GO:0044325ion channel binding-IPI24951510  
GO:0045296cadherin binding-HDA25468996  
GO:0046332SMAD binding-IEA-  
GO:0048365Rac GTPase binding-IDA10051605  
GO:0051015actin filament binding-IDA2391361  3138234  4044584  25358863  
GO:0051020GTPase binding-IPI16291724  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0007195adenylate cyclase-inhibiting dopamine receptor signaling pathway-IMP10692483  
GO:0016479negative regulation of transcription by RNA polymerase I-IDA22307607  
GO:0021943formation of radial glial scaffolds-IEA-  
GO:0021987cerebral cortex development-IEA-  
GO:0030168platelet activation-TAS-  
GO:0030334regulation of cell migration-IDA16291724  
GO:0031532actin cytoskeleton reorganization-IDA10051605  
GO:0032233positive regulation of actin filament bundle assembly-IEA-  
GO:0034329cell junction assembly-TAS-  
GO:0034394protein localization to cell surface-IDA18322202  
GO:0042177negative regulation of protein catabolic process-IMP18322202  
GO:0042789mRNA transcription by RNA polymerase II-IEA-  
GO:0043066negative regulation of apoptotic process-IMP18177638  
GO:0043113receptor clustering-IDA10692483  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-HMP12761501  
GO:0043433negative regulation of DNA-binding transcription factor activity-IDA15684392  
GO:0044319wound healing, spreading of cells-IDA16291724  
GO:0045184establishment of protein localization-IDA18322202  
GO:0050821protein stabilization-IMP18322202  
GO:0051220cytoplasmic sequestering of protein-IMP17536008  
GO:0051764actin crosslink formation-IDA10051605  
GO:0060271cilium assembly-IMP22121117  
GO:0070527platelet aggregation-HMP23382103  
GO:0071526semaphorin-plexin signaling pathway-IGI25358863  
GO:0072659protein localization to plasma membrane-IDA24951510  
GO:0090307mitotic spindle assembly-IDA18548008  
GO:0097368establishment of Sertoli cell barrier-IEA-  
GO:1900026positive regulation of substrate adhesion-dependent cell spreading-IMP18177638  
GO:1901381positive regulation of potassium ion transmembrane transport-IDA24951510  
GO:1902396protein localization to bicellular tight junction-IEA-  
GO:1905000regulation of membrane repolarization during atrial cardiac muscle cell action potential-IC-  
GO:1905031regulation of membrane repolarization during cardiac muscle cell action potential-ISS24951510  
GO:2000179positive regulation of neural precursor cell proliferation-IEA-  
GO:2001046positive regulation of integrin-mediated signaling pathway-IMP18177638  
GO:2001224positive regulation of neuron migration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-IDA15684392  
GO:0005730nucleolus-IMP22307607  
GO:0005737cytoplasm-IDA15684392  21914078  25468996  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA18322202  
GO:0005911cell-cell junction-IDA16291724  
GO:0005925focal adhesion-HDA21423176  
GO:0015629actin cytoskeleton-IC2391361  
GO:0015629actin cytoskeleton-IDA-  
GO:0016020membrane-HDA19946888  
GO:0030018Z disc-ISS24951510  
GO:0030863cortical cytoskeleton-IEA-  
GO:0031523Myb complex-IDA18548008  
GO:0031941filamentous actincolocalizes_withIDA25358863  
GO:0043025neuronal cell body-IEA-  
GO:0043198dendritic shaft-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070062extracellular exosome-HDA19056867  20458337  21362503  23533145  
GO:0097440apical dendrite-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04510Focal adhesion
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-430116GP1b-IX-V activation signallingTAS
R-HSA-446353Cell-extracellular matrix interactionsTAS
R-HSA-446728Cell junction organizationTAS
R-HSA-5627123RHO GTPases activate PAKsTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28420501Bioinformatics analysis of gene expression profiles in B cells of postmenopausal osteoporosis patients. (2017 Apr)Ma MTaiwan J Obstet Gynecol