Gene: MAPK8IP3

23162
JIP-3|JIP3|JSAP1|SYD2|syd
mitogen-activated protein kinase 8 interacting protein 3
protein-coding
16p13.3
Ensembl:ENSG00000138834 MIM:605431 Vega:OTTHUMG00000128637 UniprotKB:Q9UPT6
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.502e-1 (AD)  6.133e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02295856chr16:1758935MAPK8IP3Gene body4.356e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTIF0.967
GPI0.967
AP2A10.966
RUSC20.963
SCYL10.962
KLC20.962
PPP6R20.962
ZER10.96
AP2A20.96
CLSTN10.959

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.705
OR4F29-0.663
TFPI2-0.388
KCNJ15-0.363
RAI14-0.358
PROK2-0.358
AGTR1-0.354
C9orf135-0.349
ZNF114-0.349
CD48-0.347

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MAPK8IP3 mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of MAPK8IP3 mRNA"20206263
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of MAPK8IP3 mRNA20829426
D000082AcetaminophenAcetaminophen results in increased expression of MAPK8IP3 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of MAPK8IP3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MAPK8IP3 mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of MAPK8IP3 mRNA20409345
C015001arsenitearsenite promotes the reaction [DUSP8 protein binds to MAPK8IP3 protein]23159405
C030935benz(a)anthracenebenz(a)anthracene affects the expression of MAPK8IP3 mRNA26377693
C044887beta-methylcholinebeta-methylcholine affects the expression of MAPK8IP3 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of MAPK8IP3 mRNA25181051
D002509CephaloridineCephaloridine results in increased expression of MAPK8IP3 mRNA18500788
D002994ClofibrateClofibrate results in increased expression of MAPK8IP3 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of MAPK8IP3 mRNA19320972|1937684
D003042CocaineCocaine affects the expression of MAPK8IP3 mRNA20187946
D003471CuprizoneCuprizone results in decreased expression of MAPK8IP3 mRNA26577399
D003634DDTDDT results in increased expression of MAPK8IP3 mRNA25014179
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MAPK8IP3 mRNA]27941970
D002945CisplatinCisplatin results in decreased expression of MAPK8IP3 mRNA27392435
D004008DiclofenacDiclofenac results in increased expression of MAPK8IP3 mRNA26934552
C000944dicrotophosdicrotophos results in increased expression of MAPK8IP3 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of MAPK8IP3 mRNA25016146
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli results in increased expression of MAPK8IP3 mRNA"15919760
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MAPK8IP3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAPK8IP3 mRNA17942748
C069837fullerene C60fullerene C60 results in increased expression of MAPK8IP3 mRNA19167457
D005897GlafenineGlafenine results in increased expression of MAPK8IP3 mRNA24136188
C004312glycidolglycidol results in decreased expression of MAPK8IP3 mRNA24915197
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of MAPK8IP3 mRNA22467014
C010974glyphosateglyphosate results in increased expression of MAPK8IP3 mRNA26302742
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MAPK8IP3 mRNA15919760
C018091maduramicinmaduramicin results in increased expression of MAPK8IP3 mRNA29128925
D008694MethamphetamineMethamphetamine results in increased expression of MAPK8IP3 mRNA26307267
D008731MethoxychlorMethoxychlor affects the expression of MAPK8IP3 mRNA20829426
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MAPK8IP3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MAPK8IP3 mRNA"25554681|2562005
C028007nickel monoxidenickel monoxide results in increased expression of MAPK8IP3 mRNA19167457
D011441PropylthiouracilPropylthiouracil results in decreased expression of MAPK8IP3 mRNA24780913
C009131pyrimidin-2-one beta-ribofuranosidepyrimidin-2-one beta-ribofuranoside results in increased expression of MAPK8IP3 mRNA19194470
D020280SertralineSertraline results in increased expression of MAPK8IP3 mRNA24865413
D012834SilverSilver results in increased expression of MAPK8IP3 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of MAPK8IP3 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of MAPK8IP3 mRNA21457566
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of MAPK8IP3 mRNA22467014
D013501Surface-Active AgentsSurface-Active Agents results in increased expression of MAPK8IP3 mRNA22467014
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAPK8IP3 mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of MAPK8IP3 gene28576685
D014635Valproic AcidValproic Acid results in increased methylation of MAPK8IP3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MAPK8IP3 gene25560391
C025643vinclozolinvinclozolin affects the expression of MAPK8IP3 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of MAPK8IP3 mRNA18042343
C025643vinclozolinvinclozolin results in increased expression of MAPK8IP3 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005078MAP-kinase scaffold activity-IBA21873635  
GO:0005078MAP-kinase scaffold activity-ISS-  
GO:0005515protein binding-IPI27107012  
GO:0008432JUN kinase binding-IBA21873635  
GO:0019894kinesin binding-IBA21873635  
GO:0019894kinesin binding-ISS-  
GO:0030159receptor signaling complex scaffold activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007257activation of JUN kinase activity-IBA21873635  
GO:0016192vesicle-mediated transport-IBA21873635  
GO:0016192vesicle-mediated transport-ISS-  
GO:0046328regulation of JNK cascade-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-ISS-  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28576685Aberrant DNA methylation patterns of human spermatozoa in current smoker males. (2017 Aug)Laqqan MReprod Toxicol