Gene: RGL1

23179
RGL
ral guanine nucleotide dissociation stimulator like 1
protein-coding
1q25.3
Ensembl:ENSG00000143344 MIM:605667 Vega:OTTHUMG00000035328 UniprotKB:Q9NZL6
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.901e-2 (AD)  6.406e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03467001chr1:183857649RGL13.800e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LONP20.903
AKAP100.892
CAPRIN10.88
RNF40.878
KPNB10.875
CSNK1A10.869
ADNP0.868
GSPT10.868
CSNK2A10.864
NCOA10.864

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.636
OR4F29-0.593
KLRB1-0.336
KLRK1-0.329
CETP-0.325
MTRNR2L6-0.321
GZMK-0.316
FCER2-0.309
FCRL3-0.306
KLRF1-0.304

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of RGL1 mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of RGL1 mRNA]"19414516
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RGL1 mRNA"21346803
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of RGL1 mRNA"26238291
D000082AcetaminophenAcetaminophen results in decreased expression of RGL1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of RGL1 mRNA17562736
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of RGL1 mRNA]"19414516
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RGL1 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of RGL1 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of RGL1 mRNA21298039
C006632arsenic trioxidearsenic trioxide results in increased expression of RGL1 mRNA19128835
D001280AtrazineAtrazine results in increased expression of RGL1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of RGL1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RGL1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RGL1 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of RGL1 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RGL1 mRNA20713471|2222880
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of RGL1 mRNA20404318
C006780bisphenol Abisphenol A results in increased expression of RGL1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of RGL1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of RGL1 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of RGL1 mRNA25979313
D003300CopperCopper affects the expression of RGL1 mRNA23825565
D019327Copper SulfateCopper Sulfate results in decreased expression of RGL1 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of RGL1 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of RGL1 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of RGL1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of RGL1 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of RGL1 mRNA25562108
D003561CytarabineCytarabine results in decreased expression of RGL1 mRNA21198554
C014347decitabinedecitabine affects the expression of RGL1 mRNA23300844
D003703DemecolcineDemecolcine results in increased expression of RGL1 mRNA23649840
D002945CisplatinCisplatin affects the expression of RGL1 mRNA23300844
D004317DoxorubicinDoxorubicin results in decreased expression of RGL1 mRNA19277126
C118739entinostatentinostat results in increased expression of RGL1 mRNA27188386
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of RGL1 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RGL1 mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RGL1 mRNA17942748
D005557FormaldehydeFormaldehyde results in increased expression of RGL1 mRNA23649840
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of RGL1 mRNA20044591
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of RGL1 mRNA19376150
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of RGL1 mRNA24796395
C045463leflunomideleflunomide results in increased expression of RGL1 mRNA28988120
D008558MelphalanMelphalan results in decreased expression of RGL1 mRNA22363485
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RGL1 mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RGL1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RGL1 mRNA23649840
C008493methylselenic acidmethylselenic acid results in increased expression of RGL1 mRNA18548127
C029938nickel sulfatenickel sulfate results in decreased expression of RGL1 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of RGL1 mRNA25729387
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of RGL1 mRNA26705709
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RGL1 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RGL1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RGL1 mRNA22079256|2271453
D011794QuercetinQuercetin results in increased expression of RGL1 mRNA21632981
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RGL1 mRNA19059307
D012834SilverSilver results in decreased expression of RGL1 mRNA27131904
C016766sulforafansulforafan results in decreased expression of RGL1 mRNA26833863
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of RGL1 mRNA19059307
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RGL1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RGL1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RGL1 mRNA17942748
D019284ThapsigarginThapsigargin results in decreased expression of RGL1 protein24648495
C009495titanium dioxidetitanium dioxide results in decreased expression of RGL1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of RGL1 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of RGL1 mRNA25729387
C012589trichostatin Atrichostatin A results in increased expression of RGL1 mRNA28542535
D014520UrethaneUrethane results in decreased expression of RGL1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of RGL1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RGL1 mRNA23179753|2493525
D014638VanadatesVanadates results in increased expression of RGL1 mRNA22714537
C025643vinclozolinvinclozolin results in increased expression of RGL1 mRNA23034163
D014750VincristineVincristine results in increased expression of RGL1 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of RGL1 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of RGL1 mRNA20044591
C111237vorinostatvorinostat results in increased expression of RGL1 mRNA22083351
C088658zoledronic acidzoledronic acid results in increased expression of RGL1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20936779  24441586  
GO:0008321Ral guanyl-nucleotide exchange factor activity-NAS10760592  
GO ID GO Term Qualifier Evidence PubMed
GO:0007264small GTPase mediated signal transduction-NAS10760592  
GO:0019216regulation of lipid metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26614807Identification of gene expression signature for cigarette smoke exposure response--from man to mouse. (2015 Dec)Martin FHum Exp Toxicol