Gene: FLNC

2318
ABP-280|ABP280A|ABPA|ABPL|CMH26|FLN2|MFM5|MPD4|RCM5
filamin C
protein-coding
7q32.1
Ensembl:ENSG00000128591 MIM:102565 Vega:OTTHUMG00000023627 UniprotKB:Q14315
NG_011807.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.886e-1 (AD)  6.416e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03379100chr7:128494225FLNC2.300e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MICALL10.831
SYNE30.82
SHROOM40.814
MYO1E0.794
CNKSR30.789
NPC10.766
NDE10.76
TMC60.76
SLC4A20.758
UNC5B0.757

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.307
ST6GALNAC5-0.296
PAK6-0.295
PRTN3-0.293
CDH22-0.293
SPEF1-0.293
POU3F1-0.292
KCNQ4-0.286
TPBGL-0.285
CRYBA2-0.282

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of FLNC mRNA"19162173
C5736932-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in increased expression of FLNC mRNA22193206
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLNC mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLNC mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FLNC mRNA22230336
C016601afimoxifeneafimoxifene results in decreased expression of FLNC mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FLNC mRNA21527772|2715375
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of FLNC mRNA24449571
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of FLNC mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of FLNC gene25435355
D001564Benzo(a)pyrene[Soot co-treated with Benzo(a)pyrene] results in increased expression of FLNC protein24464499
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FLNC mRNA22610609
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of FLNC mRNA25566086
D004958EstradiolEstradiol promotes the reaction [FLNC protein binds to ESR1 protein]27156127
D004958EstradiolEstradiol results in decreased expression of FLNC mRNA16514628
C006780bisphenol Abisphenol A results in increased expression of FLNC mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FLNC mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FLNC protein24527689
D002220CarbamazepineCarbamazepine affects the expression of FLNC mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FLNC mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FLNC mRNA20938992
C039671ciglitazoneciglitazone results in increased expression of FLNC mRNA22193206
C018021cobaltous chloridecobaltous chloride results in increased expression of FLNC mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of FLNC mRNA20971185
D019327Copper SulfateCopper Sulfate affects the expression of FLNC mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of FLNC mRNA27523638
D003520CyclophosphamideCyclophosphamide results in increased expression of FLNC mRNA21527772
D003561CytarabineCytarabine results in decreased expression of FLNC mRNA21198554
D003609DactinomycinDactinomycin results in increased expression of FLNC mRNA21527772
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FLNC mRNA28628672
D002945CisplatinCisplatin results in decreased expression of FLNC mRNA22023808
D002117CalcitriolCalcitriol results in decreased expression of FLNC mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of FLNC mRNA"21527772
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of FLNC mRNA22193206
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of FLNC mRNA17347304
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FLNC mRNA23300682
D005047EtoposideEtoposide results in increased expression of FLNC mRNA21527772
C540355fenamidonefenamidone results in increased expression of FLNC mRNA27029645
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of FLNC mRNA17347304
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FLNC mRNA20938992
C070081fulvestrantfulvestrant results in decreased expression of FLNC mRNA16514628
C039281furanfuran results in increased expression of FLNC mRNA27387713
C492448ICG 001ICG 001 results in increased expression of FLNC mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FLNC mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FLNC mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FLNC mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of FLNC mRNA24796395
C042720mercuric bromidemercuric bromide results in increased expression of FLNC mRNA26272509
D008694MethamphetamineMethamphetamine results in increased expression of FLNC mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FLNC mRNA20938992
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of FLNC mRNA24810058
C008493methylselenic acidmethylselenic acid results in increased expression of FLNC mRNA18548127
C523799MRK 003FLNC results in increased susceptibility to MRK 00319903844
D009151Mustard GasMustard Gas results in increased expression of FLNC mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FLNC mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of FLNC mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of FLNC mRNA22714537
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of FLNC mRNA27935865
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of FLNC mRNA20971185
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of FLNC mRNA23948077
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLNC mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FLNC mRNA26272509
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of FLNC mRNA27935865
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of FLNC mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in decreased expression of FLNC mRNA23608068
C513428pyrachlostrobinpyrachlostrobin results in increased expression of FLNC mRNA27029645
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of FLNC mRNA"21152443
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of FLNC mRNA16514628
D012834SilverSilver results in increased expression of FLNC mRNA28959546
D012906SmokeSmoke results in increased expression of FLNC mRNA21095227
D012969Sodium FluorideSodium Fluoride results in increased expression of FLNC protein28918527
D012999SomanSoman results in increased expression of FLNC mRNA19281266
D053260Soot[Soot co-treated with Benzo(a)pyrene] results in increased expression of FLNC protein24464499
D013629TamoxifenTamoxifen affects the expression of FLNC mRNA14699072
C009495titanium dioxidetitanium dioxide results in decreased expression of FLNC mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of FLNC mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of FLNC mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FLNC mRNA28111298
D019772TopotecanFLNC protein affects the susceptibility to Topotecan16217747
C012589trichostatin Atrichostatin A results in decreased expression of FLNC mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of FLNC mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of FLNC gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of FLNC mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10629222  10984498  11038172  16076904  16631741  17474147  
21223964  23414517  
GO:0008092cytoskeletal protein binding-IPI17987659  
GO:0030506ankyrin binding-IPI21223964  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0034329cell junction assembly-TAS-  
GO:0048747muscle fiber development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA12393796  25351925  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005925focal adhesion-HDA21423176  
GO:0016528sarcoplasm-IEA-  
GO:0030018Z disc-IEA-  
GO:0042383sarcolemma-IDA21223964  
GO:0043034costamere-TAS21223964  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04510Focal adhesion
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-446353Cell-extracellular matrix interactionsTAS
R-HSA-446728Cell junction organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28111298Aerosol from Tobacco Heating System 2.2 has reduced impact on mouse heart gene expression compared with cigarette smoke. (2017 Mar)Szostak JFood Chem Toxicol