Gene: RCOR1

23186
COREST|RCOR
REST corepressor 1
protein-coding
14q32.31-q32.32
Ensembl:ENSG00000089902 MIM:607675 Vega:OTTHUMG00000171778 UniprotKB:Q9UKL0
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.454e-1 (AD)  5.477e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUP1530.889
SEC24B0.876
ANKHD10.871
CCNT10.869
ZNF2070.867
PROSER10.865
ATF60.864
UBR50.863
TTC170.859
PIAS30.859

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.506
OR4F29-0.462
KLRC2-0.274
APOA1-0.25
RERGL-0.241
CTNNA3-0.233
HES5-0.224
S100A1-0.219
C5orf64-0.212
TNFRSF13B-0.21

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of RCOR1 mRNA"20702594
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RCOR1 mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of RCOR1 mRNA"21346803
C496492abrineabrine results in increased expression of RCOR1 mRNA22595364
D000082AcetaminophenAcetaminophen affects the expression of RCOR1 mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of RCOR1 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of RCOR1 mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of RCOR1 mRNA21298039
D000638AmiodaroneAmiodarone affects the expression of RCOR1 mRNA25064622
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RCOR1 mRNA24449571
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RCOR1 mRNA"19150397|2038263
D004958EstradiolEstradiol inhibits the reaction [TNF protein inhibits the reaction [RCOR1 protein binds to IL6 promoter]]24771768
D004958EstradiolRCOR1 mutant form inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]24771768
D004958EstradiolEstradiol results in decreased expression of RCOR1 mRNA20068009
C006780bisphenol Abisphenol A affects the expression of RCOR1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of RCOR1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of RCOR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RCOR1 gene28505145
D002746ChlorpromazineChlorpromazine affects the expression of RCOR1 mRNA25064622
D002994ClofibrateClofibrate results in decreased expression of RCOR1 mRNA23811191
D016572CyclosporineCyclosporine affects the expression of RCOR1 mRNA25064622
D002945CisplatinCisplatin results in decreased expression of RCOR1 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of RCOR1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of RCOR1 mRNA25016146
D004237DiuronDiuron results in decreased expression of RCOR1 mRNA25152437
D004237DiuronDiuron results in increased expression of RCOR1 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RCOR1 mRNA25064622
C061365flusilazoleflusilazole results in increased expression of RCOR1 mRNA22382673
D005485FlutamideFlutamide results in decreased expression of RCOR1 mRNA24793618
C070081fulvestrantfulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [RCOR1 protein binds to IL6 promoter]]24771768
D005839GentamicinsGentamicins results in increased expression of RCOR1 mRNA22061828
C544151jinfukangjinfukang results in decreased expression of RCOR1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of RCOR1 mRNA22802445
D010100Oxygen[KDM1A protein binds to RCOR1 protein] promotes the reaction [Oxygen deficiency results in decreased expression of MLH1 mRNA]25043185
D010100Oxygen[KDM1A protein binds to RCOR1 protein] promotes the reaction [Oxygen deficiency results in decreased expression of MLH1 protein]25043185
D010100Oxygen[KDM1A protein binds to RCOR1 protein] promotes the reaction [Oxygen deficiency results in increased methylation of MLH1 promoter]25043185
D010100OxygenRCOR1 protein promotes the reaction [Oxygen deficiency results in increased methylation of MLH1 promoter]25043185
D010269ParaquatParaquat affects the expression of RCOR1 mRNA25064622
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of RCOR1 protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of RCOR1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of RCOR1 mRNA19270015
C059514resveratrolfulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [RCOR1 protein binds to IL6 promoter]]24771768
C059514resveratrolRCOR1 mutant form inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]24771768
C059514resveratrolresveratrol inhibits the reaction [TNF protein inhibits the reaction [RCOR1 protein binds to IL6 promoter]]24771768
C059514resveratrol[TNF protein co-treated with resveratrol] promotes the reaction [RCOR1 protein binds to IL6 promoter]24771768
C009277sodium arsenatesodium arsenate results in increased expression of RCOR1 mRNA27751817
D012969Sodium FluorideSodium Fluoride results in decreased expression of RCOR1 protein28918527
D013629TamoxifenTamoxifen affects the expression of RCOR1 mRNA14699072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RCOR1 mRNA16611356|2070259
D013752TetracyclineTetracycline affects the expression of RCOR1 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of RCOR1 mRNA25064622
C057693troglitazonetroglitazone results in decreased expression of RCOR1 mRNA28973697
D014520UrethaneUrethane results in increased expression of RCOR1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of RCOR1 mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of RCOR1 mRNA23527032
D014635Valproic AcidValproic Acid results in increased methylation of RCOR1 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of RCOR1 mRNA18042343

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10449787  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0004407histone deacetylase activity-TAS-  
GO:0005515protein binding-IPI10449787  12192000  16956976  17687328  17939992  17956988  
19497860  19703393  20389281  21258344  21300290  23592795  
23752268  26226427  26496610  
GO:0008134transcription factor binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IDA17555596  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0007596blood coagulation-TAS-  
GO:0016032viral process-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IDA10449787  
GO:0070933histone H4 deacetylation-IDA17555596  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA10734093  
GO:0005634nucleus-NAS10449787  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
GO:0017053transcriptional repressor complex-IDA10734093  
GO:1990391DNA repair complex-IDA24217620  
KEGG ID KEGG Term
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-162582Signal TransductionIEA
R-HSA-3214815HDACs deacetylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-9006925Intracellular signaling by second messengersIEA
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29618728Association between DNA methylation in cord blood and maternal smoking: The Hokkaido Study on Environment and Children's Health. (2018 Apr 4)Miyake KSci Rep