Gene: PHLDB1

23187
LL5A
pleckstrin homology like domain family B member 1
protein-coding
11q23.3
Ensembl:ENSG00000019144 MIM:612834 Vega:OTTHUMG00000166341 UniprotKB:Q86UU1
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.783e-1 (AD)  1.239e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLEKHG30.908
KIF13B0.908
USP540.903
TTYH20.901
SEMA6A0.885
PLEKHH10.884
CNP0.876
PDE8A0.876
MOG0.874
FNBP10.872

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.397
CALB2-0.397
CHRNA2-0.381
OR4F5-0.375
PRTN3-0.369
CUX2-0.363
TAC3-0.363
VIP-0.359
DLX5-0.341
LYPD6B-0.335

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of PHLDB1 mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PHLDB1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PHLDB1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PHLDB1 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of PHLDB1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PHLDB1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PHLDB1 mRNA24449571
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of PHLDB1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PHLDB1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PHLDB1 mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of PHLDB1 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PHLDB1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of PHLDB1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PHLDB1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHLDB1 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of PHLDB1 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of PHLDB1 mRNA26191083
D002104CadmiumCadmium results in decreased expression of PHLDB1 mRNA24067728
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PHLDB1 gene20938992
C018021cobaltous chloridecobaltous chloride affects the expression of PHLDB1 mRNA alternative form19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of PHLDB1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of PHLDB1 mRNA24386269
D003471CuprizoneCuprizone results in decreased expression of PHLDB1 mRNA26577399|2752363
D013759DronabinolDronabinol results in decreased expression of PHLDB1 mRNA21955143
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PHLDB1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHLDB1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PHLDB1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PHLDB1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PHLDB1 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of PHLDB1 mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PHLDB1 mRNA22079256
D000431EthanolEthanol results in decreased expression of PHLDB1 mRNA21955143
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PHLDB1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHLDB1 mRNA17942748
C026098etiracetametiracetam results in decreased expression of PHLDB1 mRNA20345932
C082360fipronilfipronil results in decreased expression of PHLDB1 mRNA23962444
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PHLDB1 gene20938992
C039281furanfuran results in increased expression of PHLDB1 mRNA26194646
D017313FenretinideFenretinide results in decreased expression of PHLDB1 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of PHLDB1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PHLDB1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHLDB1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PHLDB1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHLDB1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PHLDB1 mRNA27392435
D008694MethamphetamineMethamphetamine results in increased expression of PHLDB1 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PHLDB1 gene20938992
D009020MorphineMorphine results in decreased expression of PHLDB1 mRNA21955143
C523799MRK 003PHLDB1 results in increased susceptibility to MRK 00319903844
C500085muraglitazarmuraglitazar results in decreased expression of PHLDB1 mRNA21515302
D009532NickelNickel results in decreased expression of PHLDB1 mRNA25583101
D009538NicotineNicotine results in increased expression of PHLDB1 mRNA21955143
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PHLDB1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PHLDB1 mRNA22079256
D011441PropylthiouracilPropylthiouracil results in decreased expression of PHLDB1 mRNA24780913
C009131pyrimidin-2-one beta-ribofuranosidepyrimidin-2-one beta-ribofuranoside results in decreased expression of PHLDB1 mRNA19194470
D011794QuercetinQuercetin results in decreased expression of PHLDB1 protein19207037
C089730rosiglitazonerosiglitazone results in decreased expression of PHLDB1 mRNA21515302
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of PHLDB1 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PHLDB1 mRNA25895662
D013629TamoxifenTamoxifen results in increased expression of PHLDB1 mRNA25123088
C501413tesaglitazartesaglitazar results in decreased expression of PHLDB1 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHLDB1 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHLDB1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PHLDB1 mRNA19465110
D013853ThioacetamideThioacetamide results in increased expression of PHLDB1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PHLDB1 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PHLDB1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of PHLDB1 mRNA21515302
D014520UrethaneUrethane results in increased expression of PHLDB1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of PHLDB1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PHLDB1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PHLDB1 gene25560391
C088658zoledronic acidzoledronic acid results in decreased expression of PHLDB1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0010470regulation of gastrulation-IMP23940118  
GO:0010717regulation of epithelial to mesenchymal transition-IMP23940118  
GO:0070507regulation of microtubule cytoskeleton organization-IGI23940118  
GO:1904261positive regulation of basement membrane assembly involved in embryonic body morphogenesis-IGI23940118  
GO:1904261positive regulation of basement membrane assembly involved in embryonic body morphogenesis-IMP23940118  
GO ID GO Term Qualifier Evidence PubMed
GO:0045180basal cortex-IDA23940118  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21742680Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking. (2011 Sep 1)Lachance DHAm J Epidemiol