Gene: MDN1

23195
Rea1
midasin AAA ATPase 1
protein-coding
6q15
Ensembl:ENSG00000112159 Vega:OTTHUMG00000015213 UniprotKB:Q9NU22
NG_034012.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.450e-1 (AD)  4.250e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9362672chr6:89696274 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRRAP0.926
C2CD30.922
EP4000.92
NSD10.919
UBR40.918
KMT2A0.917
TNRC6C0.913
HERC20.912
EPG50.912
CHD80.909

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.48
OR4F29-0.459
OR4F16-0.372
MTRNR2L6-0.345
MTRNR2L9-0.327
MTRNR2L10-0.323
KLRC2-0.315
TTLL10-0.303
KLRB1-0.285
RSPO1-0.284

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of MDN1 mRNA"20406850
D000082AcetaminophenAcetaminophen results in decreased expression of MDN1 mRNA21420995
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of MDN1 mRNA21298039
D001280AtrazineAtrazine results in decreased expression of MDN1 mRNA22378314
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MDN1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MDN1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene affects the splicing of MDN1 exon26001963
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MDN1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MDN1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MDN1 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of MDN1 mRNA23019147
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MDN1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of MDN1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MDN1 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of MDN1 mRNA26079696
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MDN1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of MDN1 mRNA19320972
D003703DemecolcineDemecolcine results in increased expression of MDN1 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MDN1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MDN1 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of MDN1 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of MDN1 mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of MDN1 mRNA27614199
D004147DioxinsDioxins affects the expression of MDN1 mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MDN1 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDN1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of MDN1 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of MDN1 mRNA24793618
D005485FlutamideFlutamide results in increased expression of MDN1 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of MDN1 mRNA20655997|2364984
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MDN1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MDN1 mRNA28628672
C051890irinotecanirinotecan analog affects the expression of MDN1 mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MDN1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MDN1 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MDN1 mRNA25982114
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MDN1 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MDN1 mRNA26272509
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MDN1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MDN1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MDN1 mRNA"25554681
C572573N-nitroso-tris-chloroethylureaN-nitroso-tris-chloroethylurea results in increased expression of MDN1 mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MDN1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of MDN1 mRNA18301758|2381119
D011374ProgesteroneProgesterone affects the expression of MDN1 mRNA17251523
D012999SomanSoman results in increased expression of MDN1 mRNA19281266
C061133tamibarotenetamibarotene affects the expression of MDN1 mRNA15498508
D013629TamoxifenTamoxifen affects the expression of MDN1 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDN1 mRNA17942748
D014212TretinoinTretinoin results in decreased expression of MDN1 mRNA15498508
C012589trichostatin Atrichostatin A results in increased expression of MDN1 mRNA24935251|2627250
D014520UrethaneUrethane results in decreased expression of MDN1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of MDN1 mRNA23179753
C025643vinclozolinvinclozolin results in increased expression of MDN1 mRNA20566332
D014750VincristineVincristine results in increased expression of MDN1 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21326211  
GO:0005524ATP binding-IEA-  
GO:0016887ATPase activity-NAS12102729  
GO:0051082unfolded protein binding-NAS12102729  
GO ID GO Term Qualifier Evidence PubMed
GO:0000027ribosomal large subunit assembly-IBA21873635  
GO:0006364rRNA processing-IBA21873635  
GO:0065003protein-containing complex assembly-NAS12102729  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005634nucleus-NAS12102729  
GO:0005654nucleoplasm-IEA-  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IDA-  
GO:0016020membrane-HDA19946888  
GO:0045111intermediate filament cytoskeleton-IDA-  
KEGG ID KEGG Term
hsa03008Ribosome biogenesis in eukaryotes
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal