Gene: TBC1D1

23216
TBC|TBC1
TBC1 domain family member 1
protein-coding
4p14
Ensembl:ENSG00000065882 MIM:609850 Vega:OTTHUMG00000150302 UniprotKB:Q86TI0
NC_000004.12
SNP Mapped
1   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.477e-1 (AD)  5.934e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16994074chr4:37924357 (GRCh38.p7)T>Ccocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM430.837
RAF10.831
CWC250.829
ZDHHC70.823
MARK30.821
PACSIN20.821
MGAT10.821
MAP3K30.82
PPT20.818
STAT60.815

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.607
OR4F29-0.584
PDE11A-0.241
C5orf64-0.238
REN-0.231
SOX3-0.221
KLRC2-0.206
HPDL-0.206
CTNNA3-0.19
OR9A2-0.181

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TBC1D1 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TBC1D1 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of TBC1D1 mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBC1D1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBC1D1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TBC1D1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of TBC1D1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TBC1D1 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TBC1D1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TBC1D1 mRNA19770486
C031143AICA ribonucleotideAICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D1 protein]26627467
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TBC1D1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TBC1D1 mRNA20064835|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TBC1D1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TBC1D1 mRNA"26238291
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TBC1D1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of TBC1D1 mRNA19619570
C006780bisphenol Abisphenol A results in decreased expression of TBC1D1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of TBC1D1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of TBC1D1 protein24552547
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TBC1D1 mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of TBC1D1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TBC1D1 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of TBC1D1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of TBC1D1 mRNA24386269
D003471CuprizoneCuprizone results in decreased expression of TBC1D1 mRNA26577399
D003471CuprizoneCuprizone results in increased expression of TBC1D1 mRNA27523638
D003474CurcuminCurcumin results in decreased expression of TBC1D1 mRNA17198877
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TBC1D1 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TBC1D1 mRNA21266533
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of TBC1D1 mRNA15171707
D002117CalcitriolCalcitriol results in increased expression of TBC1D1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of TBC1D1 mRNA21592394
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TBC1D1 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of TBC1D1 mRNA23649840
D017313FenretinideFenretinide results in increased expression of TBC1D1 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of TBC1D1 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TBC1D1 mRNA25613284
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of TBC1D1 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TBC1D1 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TBC1D1 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TBC1D1 mRNA"25554681
D009532NickelNickel results in increased expression of TBC1D1 mRNA24768652|2558310
C025589ochratoxin Aochratoxin A results in decreased methylation of TBC1D1 gene26431795
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TBC1D1 mRNA25729387
D019308Palmitic AcidTBC1D1 protein results in decreased uptake of and results in decreased oxidation of Palmitic Acid18931681
D011374ProgesteroneProgesterone results in increased expression of TBC1D1 mRNA18037150
D011794QuercetinQuercetin inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D1 protein]26627467
D011794QuercetinQuercetin results in increased phosphorylation of TBC1D1 protein26627467
D015474IsotretinoinIsotretinoin results in increased expression of TBC1D1 mRNA20436886
D012999SomanSoman results in increased expression of TBC1D1 mRNA19281266
D053260SootSoot results in increased expression of TBC1D1 mRNA26551751
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of TBC1D1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of TBC1D1 mRNA21592394
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TBC1D1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TBC1D1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TBC1D1 mRNA11489354
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBC1D1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of TBC1D1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TBC1D1 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBC1D1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TBC1D1 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of TBC1D1 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TBC1D1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of TBC1D1 mRNA23830798
C012589trichostatin Atrichostatin A results in increased expression of TBC1D1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TBC1D1 mRNA"26179874
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of TBC1D1 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBC1D1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TBC1D1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TBC1D1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of TBC1D1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of TBC1D1 mRNA17292431
C025643vinclozolinvinclozolin results in decreased expression of TBC1D1 mRNA23555832
C029297vinylidene chloridevinylidene chloride results in increased expression of TBC1D1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0005515protein binding-IPI22354992  
GO:0017137Rab GTPase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0032880regulation of protein localization-IEA-  
GO:0061024membrane organization-TAS-  
GO:0090630activation of GTPase activity-IBA21873635  
GO:1902017regulation of cilium assemblyNOTIMP17646400  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1445148Translocation of GLUT4 to the plasma membraneIEA
R-HSA-1445148Translocation of GLUT4 to the plasma membraneTAS
R-HSA-199991Membrane TraffickingIEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportIEA
R-HSA-5653656Vesicle-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal