Gene: SYNE2

23224
EDMD5|KASH2|NUA|NUANCE|Nesp2|Nesprin-2|SYNE-2|TROPH
spectrin repeat containing nuclear envelope protein 2
protein-coding
14q23.2
Ensembl:ENSG00000054654 MIM:608442 Vega:OTTHUMG00000140349 UniprotKB:Q8WXH0
NG_011756.1
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.985e-1 (AD)  2.557e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2297301chr14:64177487 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs2275019chr14:63941390 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18110741chr14:64419267SYNE2Gene body6.529e-4Alcohol use disorders26763658
cg13057576chr14:64692154SYNE29.320e-18Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PODXL0.82
LAMC10.795
LEF10.778
ITPR30.777
ABCB10.777
PTPRB0.77
MYO1C0.769
FLT10.769
TGFBR20.766
ESAM0.765

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.339
ALG1L-0.332
OR4F29-0.318
CLDND2-0.305
OR4F5-0.3
ZSCAN1-0.284
GHRH-0.27
TH-0.269
NKX2-8-0.264
TMEM114-0.259

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate results in decreased expression of SYNE2 mRNA"24211530
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SYNE2 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SYNE2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SYNE2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SYNE2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SYNE2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SYNE2 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYNE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYNE2 mRNA"27188386
C0307357-aminocephalosporanic acid7-aminocephalosporanic acid results in decreased expression of SYNE2 mRNA24211530
D000082AcetaminophenAcetaminophen results in decreased expression of SYNE2 mRNA21420995
D000171AcroleinAcrolein results in decreased expression of SYNE2 mRNA24211530
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SYNE2 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of SYNE2 mRNA21757418
C018453ammonium hexachloroplatinateammonium hexachloroplatinate results in decreased expression of SYNE2 mRNA24211530
C547126AZM551248AZM551248 results in decreased expression of SYNE2 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of SYNE2 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SYNE2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SYNE2 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of SYNE2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SYNE2 mRNA22316170|2623829
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SYNE2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SYNE2 mRNA21715664
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SYNE2 mRNA"19150397|2623829
C044887beta-methylcholinebeta-methylcholine affects the expression of SYNE2 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of SYNE2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of SYNE2 mRNA26079696
C005563captaxcaptax results in decreased expression of SYNE2 mRNA24211530
D002509CephaloridineCephaloridine results in decreased expression of SYNE2 mRNA18500788
C100187chloropicrinchloropicrin results in decreased expression of SYNE2 mRNA24211530
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SYNE2 mRNA27858113
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of SYNE2 mRNA24211530
D003033Coal TarCoal Tar results in decreased expression of SYNE2 mRNA27858113
D003375CoumestrolCoumestrol results in increased expression of SYNE2 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of SYNE2 mRNA26577399
D003703DemecolcineDemecolcine results in decreased expression of SYNE2 mRNA23649840
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SYNE2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of SYNE2 mRNA27392435
D004811EpichlorohydrinEpichlorohydrin results in decreased expression of SYNE2 mRNA24211530
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of SYNE2 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SYNE2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SYNE2 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SYNE2 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of SYNE2 intron27776689
D018120FinasterideFinasteride results in increased expression of SYNE2 mRNA24136188
D005485FlutamideFlutamide results in decreased expression of SYNE2 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of SYNE2 mRNA27664576
D008299Maleic AnhydridesMaleic Anhydrides results in decreased expression of SYNE2 mRNA24211530
D005897GlafenineGlafenine results in decreased expression of SYNE2 mRNA24136188
D017313FenretinideFenretinide results in increased expression of SYNE2 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SYNE2 mRNA27392435
D007854LeadLead affects the splicing of SYNE2 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SYNE2 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SYNE2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SYNE2 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SYNE2 protein26558463
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of SYNE2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SYNE2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SYNE2 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of SYNE2 mRNA24136188
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SYNE2 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SYNE2 mRNA17560707
D016226Phosphorus, Dietary"Phosphorus, Dietary affects the expression of SYNE2 mRNA"17651324
C006253pirinixic acidpirinixic acid results in decreased expression of SYNE2 mRNA18445702
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SYNE2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SYNE2 mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of SYNE2 mRNA24780913
D012715Sesame OilSesame Oil results in increased expression of SYNE2 mRNA29191790
D012906SmokeSmoke results in decreased expression of SYNE2 mRNA21095227
D053260SootSoot results in decreased expression of SYNE2 mRNA26551751
D013629TamoxifenTamoxifen affects the expression of SYNE2 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SYNE2 mRNA19933214
D013849ThimerosalThimerosal results in decreased expression of SYNE2 mRNA27188386
D013893ThiramThiram results in decreased expression of SYNE2 mRNA24211530
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SYNE2 mRNA28065790
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SYNE2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SYNE2 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of SYNE2 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of SYNE2 mRNA23179753|2800136
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SYNE2 gene25560391
D014750VincristineVincristine results in decreased expression of SYNE2 mRNA23649840
C111237vorinostatvorinostat results in decreased expression of SYNE2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-ISS-  
GO:0005515protein binding-IPI15671068  18396275  22555292  22632968  23414517  24880667  
26506308  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006998nuclear envelope organization-IEA-  
GO:0007097nuclear migration-IMP20724637  
GO:0007163establishment or maintenance of cell polarity-IEA-  
GO:0010457centriole-centriole cohesion-IBA21873635  
GO:0010761fibroblast migration-IEA-  
GO:0021817nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration-IEA-  
GO:0030335positive regulation of cell migration-ISS-  
GO:0031022nuclear migration along microfilament-ISS-  
GO:0034504protein localization to nucleus-IEA-  
GO:0051642centrosome localization-IMP20724637  
GO:0090286cytoskeletal anchoring at nuclear membrane-IDA18396275  
GO:1902017regulation of cilium assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12118075  
GO:0005635nuclear envelope-IDA15671068  
GO:0005640nuclear outer membrane-IEA-  
GO:0005654nucleoplasm-IEA-  
GO:0005737cytoplasm-IDA12118075  15671068  
GO:0005739mitochondrion-IDA15671068  
GO:0005813centrosome-IBA21873635  
GO:0005925focal adhesion-IDA15671068  
GO:0016021integral component of membrane-IEA-  
GO:0016235aggresome-IDA-  
GO:0016529sarcoplasmic reticulum-IDA15671068  
GO:0030018Z disc-IDA15671068  
GO:0031258lamellipodium membrane-IDA15671068  
GO:0031527filopodium membrane-IDA15671068  
GO:0031965nuclear membrane-IDA-  
GO:0031981nuclear lumen-IDA15671068  
GO:0033017sarcoplasmic reticulum membrane-IEA-  
GO:0034993meiotic nuclear membrane microtubule tethering complex-IDA18396275  
GO:0045111intermediate filament cytoskeleton-IDA-  
GO:0070062extracellular exosome-HDA18570454  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal