Gene: VPS13A

23230
CHAC|CHOREIN
vacuolar protein sorting 13 homolog A
protein-coding
9q21.2
Ensembl:ENSG00000197969 MIM:605978 Vega:OTTHUMG00000020055 UniprotKB:Q96RL7
NG_008931.1
SNP Mapped
5   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.400e-1 (AD)  5.935e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11145410chr9:77397484 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs12380218chr9:77320744 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs11145381chr9:77300225 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs2022443chr9:77254936 (GRCh38.p7)T>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs10869910chr9:77209086 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM126B0.943
RASAL20.934
SACS0.93
SYNJ10.929
SLC8A10.928
ZDHHC210.928
ADAM220.927
AAK10.926
PDS5B0.925
TTBK20.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.485
AQP5-0.479
MDFI-0.475
COPZ2-0.471
MYL3-0.466
BCL7C-0.466
TMEM102-0.462
S100A1-0.461
CSAG1-0.459
HEY2-0.455

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of VPS13A mRNA"26377693
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of VPS13A mRNA19933214
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VPS13A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VPS13A mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of VPS13A mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of VPS13A mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of VPS13A mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of VPS13A mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of VPS13A mRNA20064835|2010694
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of VPS13A mRNA"19150397|2623829
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of VPS13A mRNA28628672
C006780bisphenol Abisphenol A affects the expression of VPS13A mRNA21786754
C006780bisphenol Abisphenol A affects the expression of VPS13A mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of VPS13A mRNA25181051
D019256Cadmium ChlorideCadmium Chloride affects the expression of VPS13A mRNA18974090
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of VPS13A mRNA24982889
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VPS13A gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of VPS13A mRNA18353800
D003010ClorgylineClorgyline results in increased expression of VPS13A mRNA19691856
D019327Copper SulfateCopper Sulfate results in decreased expression of VPS13A mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of VPS13A mRNA25562108
D003703DemecolcineDemecolcine results in decreased expression of VPS13A mRNA23649840
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of VPS13A mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of VPS13A mRNA28628672
D002117CalcitriolCalcitriol results in decreased expression of VPS13A mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of VPS13A mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of VPS13A mRNA"22485181
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of VPS13A mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of VPS13A mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of VPS13A mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VPS13A gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of VPS13A mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of VPS13A mRNA22634610
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of VPS13A mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of VPS13A mRNA28628672
C544151jinfukangjinfukang results in decreased expression of VPS13A mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of VPS13A mRNA24796395
C410337K 7174K 7174 results in increased expression of VPS13A mRNA24086573
D007649KetamineKetamine results in decreased expression of VPS13A mRNA20080153
D008345ManganeseManganese results in decreased expression of VPS13A mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of VPS13A mRNA17175027
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VPS13A gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of VPS13A mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of VPS13A mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of VPS13A mRNA"26251327
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of VPS13A mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of VPS13A mRNA"21673326
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of VPS13A mRNA27153767
C006253pirinixic acidpirinixic acid results in increased expression of VPS13A mRNA20813756
D010936Plant ExtractsPlant Extracts results in increased expression of VPS13A mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of VPS13A mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of VPS13A mRNA22079256
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of VPS13A mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of VPS13A mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of VPS13A mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of VPS13A mRNA28922406
C012589trichostatin Atrichostatin A results in increased expression of VPS13A mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VPS13A mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of VPS13A mRNA23179753|2597931
D014635Valproic AcidValproic Acid results in increased expression of VPS13A mRNA24935251|2627250
D014638VanadatesVanadates results in decreased expression of VPS13A mRNA22714537
C025643vinclozolinvinclozolin results in increased expression of VPS13A mRNA23034163
D014750VincristineVincristine results in decreased expression of VPS13A mRNA23649840
C088658zoledronic acidzoledronic acid results in increased expression of VPS13A protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17474147  
GO ID GO Term Qualifier Evidence PubMed
GO:0006623protein targeting to vacuole-IBA21873635  
GO:0006895Golgi to endosome transport-NAS11381253  
GO:0006914autophagy-IMP25996471  
GO:0007399nervous system development-IEA-  
GO:0007626locomotory behavior-IEA-  
GO:0008104protein localization-NAS11381254  
GO:0015031protein transport-IEA-  
GO:0035176social behavior-IEA-  
GO:0045053protein retention in Golgi apparatus-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-NAS11381254  
GO:0005829cytosol-IEA-  
GO:0019898extrinsic component of membrane-IBA21873635  
GO:0031045dense core granule-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal