Gene: EXOC6B

23233
SEC15B|SEC15L2
exocyst complex component 6B
protein-coding
2p13.2
Ensembl:ENSG00000144036 MIM:607880 Vega:OTTHUMG00000152723 UniprotKB:Q9Y2D4
NG_050967.1
SNP Mapped
5   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.485e-2 (AD)  1.306e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1446891chr2:72579122 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1446890chr2:72568601 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs12471136chr2:72562188 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2138683chr2:72508380 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs11126370chr2:72498818 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RABGAP10.936
BACE10.931
CDC42BPA0.929
SORT10.911
UBE4B0.908
KIDINS2200.908
USP480.908
ELP20.907
RPS6KC10.907
ANAPC50.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.632
OR4F5-0.628
MTRNR2L6-0.31
PRRX2-0.304
MTRNR2L10-0.301
PDZK1IP1-0.299
NKX6-1-0.286
TTLL10-0.285
MTRNR2L9-0.284
SIX1-0.281

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of EXOC6B mRNA"23829299
D000082AcetaminophenAcetaminophen results in increased expression of EXOC6B mRNA22230336
D001280AtrazineAtrazine results in decreased expression of EXOC6B mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of EXOC6B mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EXOC6B mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EXOC6B mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EXOC6B mRNA"26238291
C006780bisphenol Abisphenol A affects the expression of EXOC6B mRNA25181051
C031180chrysenechrysene results in increased expression of EXOC6B mRNA26377693
D002945CisplatinCisplatin results in decreased expression of EXOC6B mRNA27594783
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of EXOC6B mRNA24796395
D007854LeadLead affects the expression of EXOC6B mRNA28903495
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of EXOC6B mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EXOC6B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EXOC6B mRNA"25554681
D010416PentachlorophenolPentachlorophenol results in increased expression of EXOC6B mRNA24642059
C006253pirinixic acidpirinixic acid results in increased expression of EXOC6B mRNA18301758|2381119
D011192Potassium DichromatePotassium Dichromate results in increased expression of EXOC6B protein23718831
D014212TretinoinTretinoin results in increased expression of EXOC6B mRNA18230668
D014635Valproic AcidValproic Acid results in decreased expression of EXOC6B mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of EXOC6B mRNA23179753|2800136

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI27173435  
GO ID GO Term Qualifier Evidence PubMed
GO:0006887exocytosis-IBA21873635  
GO:0006893Golgi to plasma membrane transport-IBA21873635  
GO:0006904vesicle docking involved in exocytosis-IEA-  
GO:0015031protein transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000145exocyst-IBA21873635  
GO:0000145exocyst-IEA-  
GO:0016020membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal