Gene: SIK2

23235
LOH11CR1I|QIK|SIK-2|SNF1LK2
salt inducible kinase 2
protein-coding
11q23.1
Ensembl:ENSG00000170145 MIM:608973 Vega:OTTHUMG00000150644 UniprotKB:Q9H0K1
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.160e-2 (AD)  2.652e-3 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11344533chr11:111475393SIK21.000e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KPNA60.93
SMG70.928
AMBRA10.923
AP1G10.922
PRPF80.921
SMURF10.92
MGAT50.917
FOXJ30.911
VPS13D0.908
LARP4B0.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.589
OR4F29-0.541
ASB4-0.34
COPZ2-0.334
COX4I2-0.307
KLRB1-0.306
MYL3-0.305
FMO3-0.299
KLRC2-0.298
CSAG1-0.297

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SIK2 mRNA19933214
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SIK2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SIK2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SIK2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SIK2 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SIK2 mRNA19770486
D001151ArsenicArsenic affects the methylation of SIK2 gene25304211
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SIK2 mRNA]22228805
C006780bisphenol Abisphenol A results in decreased expression of SIK2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of SIK2 mRNA26079696
C018021cobaltous chloridecobaltous chloride results in decreased expression of SIK2 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of SIK2 mRNA19549813
D003907DexamethasoneDexamethasone results in increased expression of SIK2 mRNA25047013
C000944dicrotophosdicrotophos results in increased expression of SIK2 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of SIK2 mRNA18042831|2501614
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SIK2 mRNA22129741
C024629dimethyl phthalatedimethyl phthalate affects the expression of SIK2 mRNA26924002
D005839GentamicinsGentamicins results in increased expression of SIK2 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of SIK2 mRNA28973697
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SIK2 mRNA22129741
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SIK2 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SIK2 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of SIK2 mRNA29191790
D009532NickelNickel results in decreased expression of SIK2 mRNA25583101
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SIK2 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of SIK2 mRNA18042831
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SIK2 mRNA18593933
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SIK2 mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of SIK2 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SIK2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SIK2 mRNA26272509
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of SIK2 mRNA22484513
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SIK2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of SIK2 mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SIK2 mRNA19162173
D012293RifampinRifampin results in decreased expression of SIK2 mRNA24552687
D012999SomanSoman results in increased expression of SIK2 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SIK2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SIK2 mRNA19933214
D013853ThioacetamideThioacetamide results in increased expression of SIK2 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SIK2 mRNA25729387
C406224valdecoxibvaldecoxib results in increased expression of SIK2 mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of SIK2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of SIK2 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SIK2 gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SIK2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA14976552  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA14976552  18348280  
GO:0005515protein binding-IPI20708153  25416956  27478041  
GO:0005524ATP binding-IDA14976552  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IBA21873635  
GO:0006468protein phosphorylation-IDA14976552  
GO:0032007negative regulation of TOR signaling-IBA21873635  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0035556intracellular signal transduction-IDA14976552  
GO:0042149cellular response to glucose starvation-IBA21873635  
GO:0046626regulation of insulin receptor signaling pathway-ISS-  
GO:0046777protein autophosphorylation-IDA18348280  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-ISS-  
GO:0031588nucleotide-activated protein kinase complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22980975Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. (2012 Sep 14)Imielinski MCell