Gene: PLCB1

23236
EIEE12|PI-PLC|PLC-154|PLC-I|PLC-beta-1|PLC154|PLCB1A|PLCB1B
phospholipase C beta 1
protein-coding
20p12.3
Ensembl:ENSG00000182621 MIM:607120 Vega:OTTHUMG00000031849 UniprotKB:Q9NQ66
NG_028168.1
SNP Mapped
3   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.722e-1 (AD)  5.682e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6133573chr20:8311010 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2719791chr20:8287092 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs6086371chr20:8229070 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRA10.975
GABRB20.972
DLGAP10.969
HCN10.969
PRKCE0.966
CDK140.965
CAP20.964
SGTB0.963
CNTNAP20.962
ATRNL10.962

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.597
RNF135-0.549
RAB13-0.548
CMTM3-0.546
MYL3-0.542
HEY2-0.539
CNN2-0.532
WWTR1-0.528
TFPI2-0.527
RAI14-0.521

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of PLCB1 mRNA"19162173
C0150681-(3-chlorophenyl)piperazine1-(3-chlorophenyl)piperazine results in increased expression of PLCB1 mRNA12527476
C0150681-(3-chlorophenyl)piperazine1-(3-chlorophenyl)piperazine results in increased expression of PLCB1 protein12527476
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]"16714034
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]"16714034
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PLCB1 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PLCB1 mRNA"21394737
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]16714034
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]16714034
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PLCB1 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of PLCB1 mRNA"21703328
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PLCB1 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PLCB1 mRNA"15059925
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of PLCB1 mRNA"20206263
D000082AcetaminophenAcetaminophen results in decreased expression of PLCB1 mRNA29067470
C056165acetovanilloneacetovanillone inhibits the reaction [Glucose results in increased expression of PLCB1 protein]20691780
C056165acetovanilloneacetovanillone inhibits the reaction [Streptozocin results in increased expression of PLCB1 protein]20691780
D020106AcrylamideAcrylamide results in decreased expression of PLCB1 mRNA28959563
D000181AcrylonitrileAcrylonitrile affects the localization of PLCB1 protein12850505
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PLCB1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PLCB1 mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PLCB1 mRNA19770486
D000525AlprazolamAlprazolam results in decreased expression of PLCB1 mRNA12527476
D000525AlprazolamAlprazolam results in decreased expression of PLCB1 protein12527476
C032311aluminum fluoridePLCB1 protein promotes the reaction [aluminum fluoride results in increased abundance of Inositol Phosphates]11377826
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PLCB1 mRNA24449571
D001151ArsenicArsenic results in decreased expression of PLCB1 mRNA19654921
C006632arsenic trioxidearsenic trioxide results in decreased expression of PLCB1 mRNA24831965
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PLCB1 mRNA15894712
C015001arsenitearsenite results in increased expression of PLCB1 mRNA15894712
D001374AzacitidineAzacitidine results in decreased methylation of PLCB1 promoter19805378
D001374AzacitidineAzacitidine results in increased expression of PLCB1 mRNA19805378
D001374AzacitidineAzacitidine results in increased expression of PLCB1 protein19805378
D001374AzacitidinePLCB1 mRNA results in increased susceptibility to Azacitidine19805378
D001374AzacitidinePLCB1 promoter modified form results in decreased susceptibility to Azacitidine19805378
D001374AzacitidinePLCB1 protein results in increased susceptibility to Azacitidine19805378
D001464Barium[DRD2 protein results in increased activity of PLCB1 protein] which results in decreased transport of Barium11124974
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of PLCB1 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLCB1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLCB1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PLCB1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLCB1 mRNA20106945|2163298
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PLCB1 mRNA15894712
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLCB1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLCB1 mRNA15894712|1977048
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PLCB1 mRNA"20382639|2623829
D004958EstradiolEstradiol results in increased expression of PLCB1 mRNA23019147
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLCB1 mRNA28628672
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]16714034
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]16714034
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PLCB1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of PLCB1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of PLCB1 mRNA28079927
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of PLCB1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of PLCB1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PLCB1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLCB1 mRNA28628672
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PLCB1 mRNA20147733
D002065BuspironeBuspirone results in decreased expression of PLCB1 mRNA12527476
D002065BuspironeBuspirone results in decreased expression of PLCB1 protein12527476
C018475butyraldehydebutyraldehyde results in decreased expression of PLCB1 mRNA26079696
D002110CaffeineCaffeine inhibits the reaction [[dihydroxyphenylethylene glycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]15998294
D002110CaffeineCaffeine inhibits the reaction [dihydroxyphenylethylene glycol results in increased activity of PLCB1 protein]15998294
D002110CaffeineCaffeine inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein]15998294
D002110CaffeineCaffeine results in decreased expression of PLCB1 protein15998294
D002217CarbacholPLCB1 protein inhibits the reaction [Carbachol results in increased abundance of Inositol Phosphates]11377826
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PLCB1 mRNA20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLCB1 mRNA27858113
D002994ClofibrateClofibrate results in increased expression of PLCB1 mRNA17585979
D003024ClozapineClozapine results in increased expression of PLCB1 mRNA16465460
D003033Coal TarCoal Tar results in increased expression of PLCB1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of PLCB1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of PLCB1 mRNA24386269
D003042CocaineCocaine results in increased expression of PLCB1 mRNA18355967
D003300CopperCopper results in decreased expression of PLCB1 mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of PLCB1 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of PLCB1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of PLCB1 mRNA19770486
D003891DesipramineDesipramine results in decreased expression of PLCB1 mRNA12527476
D003891DesipramineDesipramine results in decreased expression of PLCB1 protein12527476
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLCB1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PLCB1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLCB1 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of PLCB1 gene22964155
D003976DiazinonDiazinon affects the expression of PLCB1 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PLCB1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of PLCB1 mRNA22023808
D004026DieldrinDieldrin affects the expression of PLCB1 mRNA22546817
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PLCB1 mRNA21527772
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PLCB1 mRNA19371625
D002117CalcitriolCalcitriol results in increased activity of PLCB1 protein12798493
D002117CalcitriolPLCB1 protein results in increased susceptibility to Calcitriol12798493
C010117dihydroxyphenylethylene glycolCaffeine inhibits the reaction [[dihydroxyphenylethylene glycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]15998294
C010117dihydroxyphenylethylene glycolCaffeine inhibits the reaction [dihydroxyphenylethylene glycol results in increased activity of PLCB1 protein]15998294
C010117dihydroxyphenylethylene glycol[dihydroxyphenylethylene glycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein15998294
C010117dihydroxyphenylethylene glycoldihydroxyphenylethylene glycol results in increased activity of PLCB1 protein15998294
C010117dihydroxyphenylethylene glycolTheophylline inhibits the reaction [[dihydroxyphenylethylene glycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]15998294
C010117dihydroxyphenylethylene glycolTheophylline inhibits the reaction [dihydroxyphenylethylene glycol results in increased activity of PLCB1 protein]15998294
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PLCB1 mRNA23649840
D015025ZearalenoneZearalenone results in increased expression of PLCB1 mRNA19371625
D005473FluoxetineFluoxetine results in decreased expression of PLCB1 mRNA12527476
D005473FluoxetineFluoxetine results in decreased expression of PLCB1 protein12527476
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PLCB1 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of PLCB1 mRNA23649840
C069837fullerene C60fullerene C60 results in increased expression of PLCB1 mRNA19167457
D019833GenisteinGenistein results in increased expression of PLCB1 mRNA19371625|2301914
D005947Glucoseacetovanillone inhibits the reaction [Glucose results in increased expression of PLCB1 protein]20691780
D005947GlucoseCAT protein inhibits the reaction [Glucose results in increased expression of PLCB1 protein]20691780
D005947GlucoseGlucose results in increased expression of PLCB1 protein20691780
D005985GlyceraldehydePLCB1 protein promotes the reaction [Glyceraldehyde results in increased abundance of Inositol Phosphates]11377826
D016244Guanosine 5'-O-(3-Thiotriphosphate)Caffeine inhibits the reaction [[dihydroxyphenylethylene glycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]15998294
D016244Guanosine 5'-O-(3-Thiotriphosphate)Caffeine inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein]15998294
D016244Guanosine 5'-O-(3-Thiotriphosphate)[dihydroxyphenylethylene glycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein15998294
D016244Guanosine 5'-O-(3-Thiotriphosphate)Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein15998294
D016244Guanosine 5'-O-(3-Thiotriphosphate)Theophylline inhibits the reaction [[dihydroxyphenylethylene glycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]15998294
D016244Guanosine 5'-O-(3-Thiotriphosphate)Theophylline inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein]15998294
D017313FenretinideFenretinide results in decreased expression of PLCB1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLCB1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PLCB1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLCB1 mRNA28628672
D007295Inositol Phosphates[PLCB1 protein co-treated with AVP protein] results in increased abundance of Inositol Phosphates11377826
D007295Inositol PhosphatesPLCB1 protein inhibits the reaction [Carbachol results in increased abundance of Inositol Phosphates]11377826
D007295Inositol PhosphatesPLCB1 protein promotes the reaction [aluminum fluoride results in increased abundance of Inositol Phosphates]11377826
D007295Inositol PhosphatesPLCB1 protein promotes the reaction [Glyceraldehyde results in increased abundance of Inositol Phosphates]11377826
D007295Inositol PhosphatesPLCB1 protein promotes the reaction [Ionomycin results in increased abundance of Inositol Phosphates]11377826
D015759IonomycinPLCB1 protein promotes the reaction [Ionomycin results in increased abundance of Inositol Phosphates]11377826
C051890irinotecanirinotecan results in decreased expression of PLCB1 mRNA20097248
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLCB1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PLCB1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLCB1 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of PLCB1 mRNA27392435
D007854LeadLead affects the expression of PLCB1 mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PLCB1 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PLCB1 protein25809596
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PLCB1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PLCB1 mRNA23649840
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of PLCB1 protein24625837
D009020MorphinePLCB1 protein affects the susceptibility to Morphine16405873
D009151Mustard GasMustard Gas affects the expression of PLCB1 mRNA15651846
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PLCB1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PLCB1 mRNA"25554681
D009532NickelNickel results in decreased expression of PLCB1 mRNA25583101
D009532NickelNickel results in increased expression of PLCB1 mRNA18922574
C022838nickel chloridenickel chloride affects the expression of PLCB1 mRNA22546817
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of PLCB1 mRNA19716841
D009638Norepinephrine"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]"16714034
D009638Norepinephrine"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]"16714034
D009638Norepinephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]16714034
D009638Norepinephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]16714034
D009638Norepinephrinebisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]16714034
D009638Norepinephrinebisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]16714034
D009638NorepinephrineNorepinephrine results in increased activity of PLCB1 protein16714034
D009638NorepinephrineNorepinephrine results in increased expression of and results in increased activity of PLCB1 protein19225867
D009638NorepinephrineNorepinephrine results in increased expression of PLCB1 mRNA16714034|1922586
D009638NorepinephrineNorepinephrine results in increased expression of PLCB1 protein16714034
D009638NorepinephrinePrazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB1 protein]19225867
D009638NorepinephrinePrazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]16714034|1922586
D009638NorepinephrinePrazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]16714034
D009638Norepinephrinepyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]19225867
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PLCB1 mRNA25729387
D010100OxygenOxygen deficiency affects the methylation of PLCB1 promoter24205000
D010100OxygenOxygen deficiency results in increased expression of PLCB1 mRNA24205000
D010121OxytocinOxytocin affects the localization of PLCB1 protein11579162
C410127PCB 180PCB 180 affects the expression of PLCB1 mRNA21703328
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PLCB1 mRNA17681415
D010624PhenelzinePhenelzine results in decreased expression of PLCB1 mRNA12527476
D010624PhenelzinePhenelzine results in decreased expression of PLCB1 protein12527476
D010656PhenylephrinePhenylephrine results in increased expression of PLCB1 mRNA16714034
D010665PhenylpropanolaminePhenylpropanolamine results in increased expression of PLCB1 mRNA16465460
C016658phorbolol myristate acetatephorbolol myristate acetate results in increased expression of PLCB1 mRNA16714034
C016658phorbolol myristate acetatephorbolol myristate acetate results in increased expression of PLCB1 protein16714034
C006253pirinixic acidpirinixic acid results in increased expression of PLCB1 mRNA18301758
D011070Poly I-CPoly I-C results in increased expression of PLCB1 mRNA24889602
D011224PrazosinPrazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB1 protein]19225867
D011224PrazosinPrazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]16714034|1922586
D011224PrazosinPrazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]16714034
D011374ProgesteroneProgesterone results in decreased expression of PLCB1 mRNA20864642
D011374ProgesteroneProgesterone results in decreased expression of PLCB1 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of PLCB1 mRNA24780913
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]19225867
D011794QuercetinQuercetin results in decreased expression of PLCB1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PLCB1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PLCB1 mRNA22431001
C016104sodium bichromatesodium bichromate affects the expression of PLCB1 mRNA22110744
C016104sodium bichromatesodium bichromate results in decreased expression of PLCB1 mRNA25993096
D053260SootSoot results in decreased expression of PLCB1 mRNA26551751
D013311Streptozocinacetovanillone inhibits the reaction [Streptozocin results in increased expression of PLCB1 protein]20691780
D013311StreptozocinCAT protein inhibits the reaction [Streptozocin results in increased expression of PLCB1 protein]20691780
D013311StreptozocinStreptozocin results in increased expression of PLCB1 protein20691780
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of PLCB1 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLCB1 mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLCB1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLCB1 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLCB1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLCB1 mRNA21215274
D013806TheophyllineTheophylline inhibits the reaction [[dihydroxyphenylethylene glycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]15998294
D013806TheophyllineTheophylline inhibits the reaction [dihydroxyphenylethylene glycol results in increased activity of PLCB1 protein]15998294
D013806TheophyllineTheophylline inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein]15998294
D013806TheophyllineTheophylline results in decreased expression of PLCB1 protein15998294
D013853ThioacetamideThioacetamide results in decreased expression of PLCB1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of PLCB1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PLCB1 mRNA20133372
D014050TolueneToluene affects the expression of PLCB1 mRNA21827849
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PLCB1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of PLCB1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of PLCB1 mRNA23724009
C012589trichostatin Atrichostatin A results in decreased expression of PLCB1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of PLCB1 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of PLCB1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PLCB1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of PLCB1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of PLCB1 gene29154799
C088658zoledronic acidzoledronic acid results in decreased expression of PLCB1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004435phosphatidylinositol phospholipase C activity-ISS-  
GO:0004435phosphatidylinositol phospholipase C activity-NAS11118617  
GO:0004435phosphatidylinositol phospholipase C activity-TAS-  
GO:0004629phospholipase C activity-TAS-  
GO:0005096GTPase activator activity-IDA1322796  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0005516calmodulin binding-IDA12821674  
GO:0005521lamin binding-IEA-  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-IDA12799190  
GO:0019899enzyme binding-IPI12799190  
GO:0042803protein homodimerization activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-ISS-  
GO:0007165signal transduction-NAS11118617  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007213G-protein coupled acetylcholine receptor signaling pathway-ISS-  
GO:0007215glutamate receptor signaling pathway-ISS-  
GO:0007223Wnt signaling pathway, calcium modulating pathway-TAS-  
GO:0007613memory-ISS-  
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-ISS-  
GO:0016042lipid catabolic process-IEA-  
GO:0021987cerebral cortex development-ISS-  
GO:0032735positive regulation of interleukin-12 production-ISS-  
GO:0035556intracellular signal transduction-IEA-  
GO:0035722interleukin-12-mediated signaling pathway-IDA11743656  
GO:0035723interleukin-15-mediated signaling pathway-IDA11743656  
GO:0040019positive regulation of embryonic development-ISS-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0043647inositol phosphate metabolic process-TAS-  
GO:0045444fat cell differentiation-IEA-  
GO:0045663positive regulation of myoblast differentiation-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0046330positive regulation of JNK cascade-IDA9500449  
GO:0046488phosphatidylinositol metabolic process-ISS-  
GO:0048009insulin-like growth factor receptor signaling pathway-ISS-  
GO:0048639positive regulation of developmental growth-ISS-  
GO:0060466activation of meiosis involved in egg activation-ISS-  
GO:0070498interleukin-1-mediated signaling pathway-IDA8872139  
GO:0080154regulation of fertilization-ISS-  
GO:1900087positive regulation of G1/S transition of mitotic cell cycle-ISS-  
GO:2000344positive regulation of acrosome reaction-ISS-  
GO:2000438negative regulation of monocyte extravasation-ISS-  
GO:2000560positive regulation of CD24 biosynthetic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-ISS-  
GO:0005634nucleus-NAS10760467  
GO:0005737cytoplasm-IDA11118617  
GO:0005829cytosol-TAS-  
GO:0016607nuclear speck-IDA12799190  
GO:0031965nuclear membrane-IEA-  
GO:0043209myelin sheath-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04020Calcium signaling pathway
hsa04062Chemokine signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04540Gap junction
hsa04720Long-term potentiation
hsa04730Long-term depression
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05010Alzheimer's disease
hsa05016Huntington's disease
hsa05142Chagas disease (American trypanosomiasis)
hsa05143African trypanosomiasis
hsa05146Amoebiasis
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingTAS
R-HSA-111885Opioid SignallingIEA
R-HSA-112040G-protein mediated eventsTAS
R-HSA-112040G-protein mediated eventsIEA
R-HSA-112043PLC beta mediated eventsTAS
R-HSA-112043PLC beta mediated eventsIEA
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-1483249Inositol phosphate metabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-163685Integration of energy metabolismTAS
R-HSA-163685Integration of energy metabolismIEA
R-HSA-1855204Synthesis of IP3 and IP4 in the cytosolTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-397795G-protein beta:gamma signallingTAS
R-HSA-399997Acetylcholine regulates insulin secretionTAS
R-HSA-399997Acetylcholine regulates insulin secretionIEA
R-HSA-400451Free fatty acids regulate insulin secretionTAS
R-HSA-400451Free fatty acids regulate insulin secretionIEA
R-HSA-4086398Ca2+ pathwayTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-416476G alpha (q) signalling eventsIEA
R-HSA-418217G beta:gamma signalling through PLC betaTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-422356Regulation of insulin secretionTAS
R-HSA-422356Regulation of insulin secretionIEA
R-HSA-434316Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretionTAS
R-HSA-434316Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretionIEA
R-HSA-451326Activation of kainate receptors upon glutamate bindingTAS
R-HSA-500657Presynaptic function of Kainate receptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal