Gene: COBL

23242
-
cordon-bleu WH2 repeat protein
protein-coding
7p12.1
Ensembl:ENSG00000106078 MIM:610317 Vega:OTTHUMG00000155999 UniprotKB:O75128
NG_051816.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.377e-1 (AD)  9.300e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLIP20.898
POGK0.88
LIMCH10.874
RAB11FIP40.874
SPTBN10.869
SH3PXD2A0.864
ASB10.858
SEPT80.854
CASC30.838
PEX50.838

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.637
OR4F5-0.56
GIPC2-0.269
GJB2-0.254
SDR42E1-0.245
TRIM10-0.243
UPK1B-0.241
PRRX2-0.24
SIX1-0.24
FOXI2-0.239

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of COBL mRNA"28903501
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of COBL mRNA19933214
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of COBL mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
C0293704-toluidine4-toluidine results in increased expression of COBL mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of COBL mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of COBL mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of COBL protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of COBL mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of COBL mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of COBL mRNA28522335
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of COBL mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of COBL mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of COBL mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of COBL mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of COBL mRNA20106945|2163298
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of COBL mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of COBL mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of COBL mRNA"19150397|2001819
D004958EstradiolEstradiol results in increased expression of COBL mRNA23019147
C006780bisphenol Abisphenol A results in decreased expression of COBL mRNA25181051
D002110CaffeineCaffeine affects the expression of COBL mRNA20864626
D002220CarbamazepineCarbamazepine affects the expression of COBL mRNA25979313
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of COBL mRNA28472532
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of COBL mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of COBL mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of COBL mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of COBL mRNA18579281
D003375CoumestrolCoumestrol results in decreased expression of COBL mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of COBL mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of COBL mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of COBL mRNA27392435
D002945CisplatinCisplatin results in decreased expression of COBL mRNA27392435
D004041Dietary FatsDietary Fats affects the expression of COBL mRNA19680557
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of COBL mRNA24535843
D004237DiuronDiuron results in decreased expression of COBL mRNA21551480
C118739entinostatentinostat results in increased expression of COBL mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
D005047EtoposideEtoposide results in decreased expression of COBL mRNA25270620
D005839GentamicinsGentamicins results in decreased expression of COBL mRNA22061828
D017313FenretinideFenretinide results in decreased expression of COBL mRNA28973697
D017313FenretinideFenretinide results in increased expression of COBL mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of COBL mRNA27392435
C410337K 7174K 7174 results in increased expression of COBL mRNA24086573
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of COBL mRNA12057914
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of COBL mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of COBL mRNA26011545
D016685MitomycinMitomycin results in decreased expression of COBL mRNA25270620
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of COBL mRNA"25554681
D009532NickelNickel results in decreased expression of COBL mRNA24768652|2558310
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of COBL mRNA26272509
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of COBL mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of COBL mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of COBL mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of COBL mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of COBL mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of COBL mRNA23557933
C045950propiconazolepropiconazole results in increased expression of COBL mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of COBL mRNA26079696
C059514resveratrolresveratrol results in increased expression of COBL mRNA19228061
D012906SmokeSmoke results in decreased expression of COBL mRNA21095227
D012999SomanSoman results in decreased expression of COBL mRNA19281266
D013096SpermineSpermine results in increased expression of COBL mRNA18673383
C013698tallowtallow affects the expression of COBL mRNA19680557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of COBL mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of COBL mRNA21215274
D013853ThioacetamideThioacetamide results in increased methylation of COBL promoter27914986
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of COBL mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of COBL gene26756918
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of COBL mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of COBL mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COBL mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of COBL mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of COBL mRNA15901671
D001335Vehicle EmissionsVehicle Emissions affects the methylation of COBL gene25560391
C025643vinclozolinvinclozolin affects the expression of COBL mRNA21636974

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003785actin monomer binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000578embryonic axis specification-ISS-  
GO:0001757somite specification-ISS-  
GO:0001843neural tube closure-ISS-  
GO:0001889liver development-ISS-  
GO:0030041actin filament polymerization-ISS-  
GO:0030903notochord development-ISS-  
GO:0033504floor plate development-ISS-  
GO:0048565digestive tract development-ISS-  
GO:0048669collateral sprouting in absence of injury-ISS-  
GO:0051639actin filament network formation-ISS-  
GO:1900006positive regulation of dendrite development-ISS-  
GO:1900029positive regulation of ruffle assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-ISS-  
GO:0005884actin filamentcolocalizes_withISS-  
GO:0005886plasma membrane-ISS-  
GO:0005938cell cortex-ISS-  
GO:0016020membranecolocalizes_withISS-  
GO:0030424axon-ISS-  
GO:0030425dendrite-ISS-  
GO:0043025neuronal cell body-ISS-  
GO:0044294dendritic growth cone-ISS-  
GO:0044295axonal growth cone-ISS-  
GO:0048471perinuclear region of cytoplasm-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27770636Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans. (2017 Feb)Mez JAlzheimers Dement