Gene: ASTN2

23245
bA67K19.1
astrotactin 2
protein-coding
9q33.1
Ensembl:ENSG00000148219 MIM:612856 Vega:OTTHUMG00000021013 UniprotKB:O75129
NG_021409.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.715e-1 (AD)  2.354e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13288277chr9:116947149 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1536428chr9:116853763 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1326814chr9:116849749 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCAM10.838
SLC35F10.838
GRID10.835
ADORA10.828
MPP20.816
PTPRS0.814
SYT110.812
CDS20.806
USP50.806
PODXL20.805

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.534
OR4F29-0.477
TFPI2-0.441
SIX1-0.413
TNFAIP8-0.408
PABPC4L-0.394
NAALADL1-0.391
FOXL1-0.384
GNG11-0.384
EBF1-0.384

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASTN2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASTN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASTN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASTN2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ASTN2 mRNA29067470
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ASTN2 mRNA]18700144
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ASTN2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ASTN2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ASTN2 mRNA21632981
D001152ArsenicalsArsenicals results in increased methylation of ASTN2 promoter26039340
D001241AspirinAspirin results in increased expression of ASTN2 mRNA11906190
C547126AZM551248AZM551248 results in decreased expression of ASTN2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of ASTN2 mRNA20106945|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ASTN2 mRNA21632981
D004958EstradiolEstradiol affects the expression of ASTN2 mRNA22574217
C006780bisphenol Abisphenol A results in increased expression of ASTN2 mRNA20678512
C006780bisphenol Abisphenol A results in increased expression of ASTN2 mRNA25594700
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ASTN2 mRNA21457566
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of ASTN2 mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of ASTN2 mRNA25596134
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of ASTN2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of ASTN2 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of ASTN2 mRNA26577399
D016572CyclosporineCyclosporine affects the expression of ASTN2 mRNA25596134
D016572CyclosporineCyclosporine results in decreased expression of ASTN2 mRNA25562108
C014347decitabinedecitabine affects the expression of ASTN2 mRNA23300844
D002945CisplatinCisplatin affects the expression of ASTN2 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of ASTN2 mRNA27594783
D002945CisplatinCisplatin results in increased expression of ASTN2 mRNA25596134
D004041Dietary FatsDietary Fats results in increased expression of ASTN2 mRNA25016146
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ASTN2 mRNA23649840
D004397FonofosFonofos results in increased methylation of ASTN2 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of ASTN2 mRNA23649840
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ASTN2 mRNA20044591
D008694MethamphetamineASTN2 gene SNP affects the susceptibility to Methamphetamine18316681
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ASTN2 mRNA23649840
D009532NickelNickel results in decreased expression of ASTN2 mRNA24768652|2558310
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of ASTN2 mRNA20971185
D010100OxygenOxygen deficiency results in increased expression of ASTN2 mRNA25596134
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASTN2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ASTN2 mRNA26272509
D010278ParathionParathion results in increased methylation of ASTN2 promoter22847954
D010936Plant ExtractsPlant Extracts results in decreased expression of ASTN2 mRNA23557933
C005556propionaldehydepropionaldehyde results in increased expression of ASTN2 mRNA26079696
C017947sodium arsenitesodium arsenite affects the methylation of ASTN2 gene28589171
C012568terbufosterbufos results in increased methylation of ASTN2 promoter22847954
C004648testosterone enanthatetestosterone enanthate affects the expression of ASTN2 mRNA17440010
D014212TretinoinTretinoin results in decreased expression of ASTN2 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of ASTN2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASTN2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ASTN2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ASTN2 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of ASTN2 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ASTN2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IDA-  
GO:0043533inositol 1,3,4,5 tetrakisphosphate binding-IDA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015031protein transport-IEA-  
GO:0048105establishment of body hair planar orientation-IEA-  
GO:2000009negative regulation of protein localization to cell surface-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005769early endosome-IEA-  
GO:0005770late endosome-IEA-  
GO:0005938cell cortex-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030136clathrin-coated vesicle-IEA-  
GO:0043204perikaryon-IEA-  
GO:0060187cell pole-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal