Gene: KAZN

23254
KAZ
kazrin, periplakin interacting protein
protein-coding
1p36.21
Ensembl:ENSG00000189337 Vega:OTTHUMG00000002042 UniprotKB:Q674X7
NG_029844.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.031e-1 (AD)  7.252e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7529561chr1:15001655 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10928056chr1:14259153 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAJC60.929
PPM1H0.924
DUSP30.923
TDRKH0.922
PAFAH1B10.922
MAPK90.92
SRPK20.918
CAMSAP10.917
ATP9A0.917
FAM131B0.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.513
RNF135-0.492
OR4F29-0.483
STON2-0.469
TGIF1-0.46
RAB13-0.455
HVCN1-0.452
RHOD-0.45
ALAS2-0.448
CSAG1-0.448

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of KAZN mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of KAZN mRNA"19114083
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of KAZN mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of KAZN mRNA]28655636
D020106AcrylamideAcrylamide results in increased expression of KAZN mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of KAZN gene27153756
D001151ArsenicArsenic affects the methylation of KAZN gene25304211
D001280AtrazineAtrazine results in decreased expression of KAZN mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of KAZN mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of KAZN mRNA26377693
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of KAZN mRNA20404318
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of KAZN mRNA20660070
D004958EstradiolEstradiol results in increased expression of KAZN mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of KAZN mRNA23019147
C006780bisphenol Abisphenol A results in decreased methylation of KAZN promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of KAZN promoter27312807
C006780bisphenol Abisphenol A affects the expression of KAZN mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of KAZN protein28903499
C018475butyraldehydebutyraldehyde results in increased expression of KAZN mRNA26079696
D019327Copper SulfateCopper Sulfate results in decreased expression of KAZN mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of KAZN mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of KAZN mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of KAZN mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of KAZN mRNA25016146
D004317DoxorubicinKAZN protein affects the susceptibility to Doxorubicin16217747
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KAZN mRNA22079256
D005557FormaldehydeFormaldehyde results in decreased expression of KAZN mRNA20655997
D019833GenisteinGenistein results in increased expression of KAZN mRNA23019147
D007649KetamineKetamine results in increased expression of KAZN mRNA20080153
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of KAZN mRNA23649840
D016685MitomycinKAZN protein affects the susceptibility to Mitomycin16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KAZN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KAZN mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of KAZN mRNA19167457
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of KAZN mRNA"12756304
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of KAZN mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of KAZN mRNA28655636
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KAZN mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of KAZN mRNA22079256
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of KAZN mRNA20660070
C005556propionaldehydepropionaldehyde results in increased expression of KAZN mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of KAZN mRNA24780913
D011794QuercetinQuercetin results in decreased expression of KAZN mRNA21632981
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KAZN mRNA19059307
C017947sodium arsenitesodium arsenite affects the methylation of KAZN gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of KAZN protein21925251
D053260SootSoot affects the expression of KAZN mRNA26551751
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of KAZN mRNA19059307
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KAZN mRNA26377647
C012589trichostatin Atrichostatin A results in increased expression of KAZN mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of KAZN mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KAZN mRNA"26179874
D014501UraniumUranium affects the expression of KAZN mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of KAZN mRNA15672453
D014635Valproic AcidValproic Acid results in increased expression of KAZN mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of KAZN mRNA17292431
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of KAZN mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of KAZN mRNA28655636
D014747VinblastineKAZN protein affects the susceptibility to Vinblastine16217747
D019287Zinc SulfateZinc Sulfate results in increased expression of KAZN mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-IDA15337775  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0016607nuclear speck-IDA-  
GO:0030057desmosome-IDA15337775  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal