Gene: FMO1

2326
-
flavin containing monooxygenase 1
protein-coding
1q24.3
Ensembl:ENSG00000010932 MIM:136130 Vega:OTTHUMG00000035502 UniprotKB:Q01740
NC_000001.11
PubMed
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.612e-1 (AD)  4.165e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GADL10.86
LY90.785
SIX10.785
IL2RB0.775
BMP50.774
GSDMA0.773
ASB90.773
CD3G0.773
CD960.77
FER1L60.766

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP46A1-0.45
FUT9-0.44
ASPDH-0.436
PAQR4-0.434
FAM43B-0.434
CORO2B-0.433
SORCS2-0.426
GREB1-0.425
PTPRF-0.425
IGSF11-0.418

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00185CevimelineSmall Molecule107233-08-9ApprovedEnzyme
DB00501CimetidineSmall Molecule51481-61-9Approved|InvestigationalEnzyme
DB00582VoriconazoleSmall Molecule137234-62-9Approved|InvestigationalEnzyme
DB00675TamoxifenSmall Molecule10540-29-1ApprovedEnzyme
DB04871LorcaserinSmall Molecule616202-92-7ApprovedEnzyme
DB05294VandetanibSmall Molecule443913-73-3ApprovedEnzyme
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene affects the expression of FMO1 mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of FMO1 mRNA"19162173
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of FMO1 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of FMO1 mRNA"21394737
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FMO1 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of FMO1 mRNA"16984957
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FMO1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of FMO1 mRNA"21346803
C0121802-aminopyrimidine2-aminopyrimidine analog binds to FMO1 protein19317514
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of FMO1 mRNA"16984957
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FMO1 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of FMO1 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FMO1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FMO1 mRNA"27188386
C0267294-aminophenol[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of 4-aminophenol20369854
C0434554-fluoroaniline[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of 4-fluoroaniline20369854
C0810154-fluoro-N-methylaniline[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of 4-aminophenol20369854
C0810154-fluoro-N-methylaniline[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of 4-fluoroaniline20369854
C0810154-fluoro-N-methylaniline[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of 4-fluoro-N-methylaniline metabolite20369854
C0810154-fluoro-N-methylaniline[FMO1 protein co-treated with NADP] results in increased oxidation of 4-fluoro-N-methylaniline20369854
C0810154-fluoro-N-methylaniline[[FMO1 protein co-treated with NADP] results in increased oxidation of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of N-methyl-4-aminophenol20369854
C0810154-fluoro-N-methylaniline[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline20369854
C0810154-fluoro-N-methylaniline[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of N-methyl-4-aminophenol20369854
C0810154-fluoro-N-methylanilineMethimazole inhibits the reaction [[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of N-methyl-4-aminophenol]20369854
C5213345-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate affects the expression of FMO1 mRNA20932894
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FMO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FMO1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of FMO1 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of FMO1 mRNA11264010
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of FMO1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FMO1 mRNA]17585979
D000082AcetaminophenAcetaminophen results in decreased expression of FMO1 mRNA17202762|1752207
D024502alpha-Tocopherolalpha-Tocopherol results in increased expression of FMO1 mRNA16908007
D000638AmiodaroneAmiodarone affects the expression of FMO1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FMO1 mRNA16483693
D017636Asbestos, Amphibole"Asbestos, Amphibole results in decreased expression of FMO1 protein"20855422
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in decreased expression of FMO1 mRNA17639512
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FMO1 mRNA27858113
D001553BenzbromaroneBenzbromarone affects the expression of FMO1 mRNA19483382
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FMO1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of FMO1 mRNA26377693
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of FMO1 mRNA22258563
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FMO1 mRNA17879257
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of FMO1 mRNA]22228805
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FMO1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FMO1 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FMO1 mRNA19770486
D001591BenzydamineBenzydamine inhibits the reaction [FMO1 protein results in increased chemical synthesis of clozapine N-oxide]18809730
D001591BenzydamineFMO1 protein results in increased oxidation of Benzydamine21435388
D004958EstradiolEstradiol results in decreased expression of FMO1 mRNA14664709
D004958EstradiolEstradiol results in decreased expression of FMO1 protein12151634
D004958EstradiolEstradiol results in increased expression of FMO1 protein12151634
D004958EstradiolEstradiol results in decreased expression of FMO1 mRNA24894866
D004958EstradiolEstradiol results in decreased expression of FMO1 protein21966433
D004958Estradiolresveratrol inhibits the reaction [Estradiol results in decreased expression of FMO1]24894866
D004958Estradiolresveratrol inhibits the reaction [Estradiol results in decreased expression of FMO1 mRNA]24894866
C095105bexarotenebexarotene results in decreased expression of FMO1 mRNA16648578
C006780bisphenol Abisphenol A results in increased expression of FMO1 mRNA27685785
C006780bisphenol Abisphenol A affects the methylation of FMO1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of FMO1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FMO1 mRNA28628672
C016274bromoacetatebromoacetate results in decreased expression of FMO1 mRNA19753638
C032036bromobenzenebromobenzene results in increased expression of FMO1 mRNA15056800
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of FMO1 mRNA12419474
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FMO1 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FMO1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of FMO1 mRNA12734012|1596334
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FMO1 mRNA17522070
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FMO1 protein12629582
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of FMO1 mRNA17851650
D002725ChloroformChloroform results in decreased expression of FMO1 mRNA17522070
D002746ChlorpromazineFMO1 protein results in increased oxidation of Chlorpromazine6439199
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FMO1 mRNA27858113
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of FMO1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FMO1 mRNA]17585979
D002994ClofibrateClofibrate affects the expression of FMO1 mRNA19483382
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of FMO1 mRNA17602206
D003024ClozapineFMO1 protein results in increased metabolism of Clozapine18809730
C079149clozapine N-oxideBenzydamine inhibits the reaction [FMO1 protein results in increased chemical synthesis of clozapine N-oxide]18809730
C079149clozapine N-oxideFMO1 protein results in increased chemical synthesis of clozapine N-oxide18809730
D003033Coal TarCoal Tar results in decreased expression of FMO1 mRNA27858113
D009249NADP[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of 4-aminophenol20369854
D009249NADP[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of 4-fluoroaniline20369854
D009249NADP[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of 4-fluoro-N-methylaniline metabolite20369854
D009249NADP[FMO1 protein co-treated with NADP] results in increased oxidation of 4-fluoro-N-methylaniline20369854
D009249NADP[[FMO1 protein co-treated with NADP] results in increased oxidation of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of N-methyl-4-aminophenol20369854
D009249NADP[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline20369854
D009249NADP[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of N-methyl-4-aminophenol20369854
D009249NADPMethimazole inhibits the reaction [[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of N-methyl-4-aminophenol]20369854
D003300Copper[Copper co-treated with Dietary Sucrose] results in decreased expression of FMO1 mRNA26033743
D003345CorticosteroneCorticosterone results in increased expression of FMO1 mRNA15755911
C030123coumarincoumarin results in decreased expression of FMO1 mRNA18480146
D003407CreosoteCreosote results in increased expression of FMO1 mRNA19389177
D003471CuprizoneCuprizone results in increased expression of FMO1 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of FMO1 mRNA27989131
D016572CyclosporineCyclosporine results in decreased expression of FMO1 mRNA19770486
D003543CysteamineFMO1 protein results in increased metabolism of Cysteamine6439199
D003561CytarabineCytarabine results in decreased expression of FMO1 mRNA21198554
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FMO1 mRNA28628672
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FMO1 mRNA16054899
D003907DexamethasoneDexamethasone results in increased expression of FMO1 mRNA22733784
D003907DexamethasoneDexamethasone affects the expression of FMO1 mRNA15102944
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FMO1 mRNA21266533
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of FMO1 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of FMO1 mRNA18042831
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in decreased expression of FMO1 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in decreased expression of FMO1 mRNA26033743
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of FMO1 mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of FMO1 mRNA18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in increased expression of FMO1 mRNA18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of FMO1 mRNA25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of FMO1 promoter25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of FMO1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of FMO1 mRNA19638242
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of FMO1 mRNA18253720
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of FMO1 mRNA16636312
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of FMO1 mRNA15171707
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of FMO1 mRNA17072980|2538013
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of FMO1 mRNA26924002
D004726EndosulfanEndosulfan results in decreased expression of FMO1 mRNA22515965
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of FMO1 mRNA20064776
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of FMO1 mRNA17522070
D000431EthanolEthanol results in increased expression of FMO1 mRNA19167417
D000431EthanolEthanol results in increased expression of FMO1 mRNA16946407
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FMO1 mRNA17555576
D005001EthionineEthionine affects the expression of FMO1 mRNA19483382
D015025ZearalenoneZearalenone results in decreased expression of FMO1 mRNA25455459
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of FMO1 mRNA18253720
D005284FenthionFMO1 protein results in increased oxidation of Fenthion14976351
D005485FlutamideFlutamide results in decreased expression of FMO1 mRNA24136188
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of FMO1 mRNA21149847
D005897GlafenineGlafenine results in decreased expression of FMO1 mRNA24136188
C004312glycidolglycidol results in decreased expression of FMO1 mRNA24915197
C010974glyphosateglyphosate results in decreased expression of FMO1 mRNA26302742
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of FMO1 mRNA25270620
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of FMO1 mRNA12419474
D007099ImipramineFMO1 protein results in increased oxidation of Imipramine6439199
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FMO1 mRNA28628672
D007306InsecticidesFMO1 gene SNP affects the susceptibility to Insecticides20056567
D007306InsecticidesInsecticides results in increased mutagenesis of FMO1 gene20056567
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FMO1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FMO1 mRNA16054899
D007545IsoproterenolIsoproterenol results in increased expression of FMO1 mRNA20003209
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of FMO1 mRNA18544905
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in increased expression of FMO1 mRNA18544905
C099406L 742694L 742694 affects the expression of FMO1 mRNA15102944
D008070Lipopolysaccharides[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of FMO1 mRNA22777745
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of FMO1 mRNA10462538
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of FMO1 protein10462538
D008070Lipopolysaccharidespimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 mRNA]10462538
D008070Lipopolysaccharidespimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 protein]10462538
C030272maleic acidmaleic acid results in increased expression of FMO1 mRNA28392987
D008713MethimazoleFMO1 protein results in increased oxidation of Methimazole14976351
D008713MethimazoleMethimazole inhibits the reaction [[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of N-methyl-4-aminophenol]20369854
D008713MethimazoleFMO1 protein results in increased metabolism of Methimazole6439199
D008714MethiocarbFMO1 protein results in increased metabolism of Methiocarb27665777
D008714Methiocarb[FMO1 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide27665777
C097911methiocarb sulfoxideFMO1 protein results in increased abundance of methiocarb sulfoxide27665777
C097911methiocarb sulfoxide[FMO1 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide27665777
C544071methyl 4-tolylsulfideFMO1 protein results in increased oxidation of methyl 4-tolylsulfide19429252
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FMO1 mRNA23179753
D016686Monocrotaline[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA21224054
C517284monomethyl phthalatemonomethyl phthalate affects the expression of FMO1 mRNA26924002
C500085muraglitazarmuraglitazar results in decreased expression of FMO1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FMO1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FMO1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of FMO1 mRNA15913567
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of FMO1 mRNA17522070|2538013
C498045NCX 4040NCX 4040 results in increased expression of FMO1 mRNA20188076
D019829NevirapineNevirapine metabolite results in decreased expression of FMO1 mRNA23947594
D009532NickelNickel results in decreased expression of FMO1 mRNA24768652|2558310
D009532NickelNickel results in increased expression of FMO1 mRNA24084258
C028007nickel monoxidenickel monoxide results in decreased expression of FMO1 mRNA19167457
C012655nimesulidenimesulide results in decreased expression of FMO1 mRNA24136188
D005996NitroglycerinNitroglycerin results in decreased expression of FMO1 mRNA12102619
C014112N-methyl-4-aminophenol[[FMO1 protein co-treated with NADP] results in increased oxidation of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of N-methyl-4-aminophenol20369854
C014112N-methyl-4-aminophenol[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of N-methyl-4-aminophenol20369854
C014112N-methyl-4-aminophenolMethimazole inhibits the reaction [[[FMO1 protein co-treated with NADP] results in increased metabolism of 4-fluoro-N-methylaniline] which results in increased chemical synthesis of N-methyl-4-aminophenol]20369854
C015157N,N-dimethylaniline"FMO1 protein results in increased metabolism of N,N-dimethylaniline"6439199
D009853OmeprazoleOmeprazole affects the expression of FMO1 mRNA19483382
D009966OrphenadrineOrphenadrine affects the expression of FMO1 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of FMO1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of FMO1 mRNA25729387
D010098OxycodoneOxycodone affects the expression of FMO1 mRNA20487198
D010098OxycodoneOxycodone results in increased expression of FMO1 mRNA23439660
D010126OzoneOzone results in decreased expression of FMO1 mRNA12763052
D000073878Palm OilPalm Oil results in decreased expression of FMO1 mRNA18042831
D010396PenicillaminePenicillamine results in increased expression of FMO1 mRNA22843330
D010416PentachlorophenolPentachlorophenol results in increased expression of FMO1 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of FMO1 mRNA19162173
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of FMO1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of FMO1 mRNA19482888
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of FMO1 mRNA25374375
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of FMO1 promoter25374375
D010634PhenobarbitalPhenobarbital results in decreased expression of FMO1 mRNA19162173
D010672Phenytoin[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA21224054
D010695PhlorhizinPhlorhizin results in decreased expression of FMO1 mRNA22538082
D010705PhosgenePhosgene affects the expression of FMO1 mRNA16300373
C004479pimagedinepimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 mRNA]10462538
C004479pimagedinepimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 protein]10462538
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of FMO1 mRNA22484513
C006253pirinixic acidpirinixic acid results in decreased expression of FMO1 mRNA25270620
C006253pirinixic acidpirinixic acid results in increased expression of FMO1 mRNA15375163|1742611
C006253pirinixic acidpirinixic acid affects the expression of FMO1 mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of FMO1 mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of FMO1 mRNA27413110|2890350
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of FMO1 mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of FMO1 mRNA23012394
D011441PropylthiouracilPropylthiouracil affects the expression of FMO1 mRNA19483382
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of FMO1 mRNA25626140
C010423pyrithione zincpyrithione zinc results in increased expression of FMO1 mRNA21424779
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in decreased expression of FMO1 mRNA17639512
C059514resveratrolresveratrol inhibits the reaction [Estradiol results in decreased expression of FMO1]24894866
C059514resveratrolresveratrol inhibits the reaction [Estradiol results in decreased expression of FMO1 mRNA]24894866
D012293Rifampin[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA21224054
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FMO1 mRNA16054899
C089730rosiglitazonerosiglitazone results in decreased expression of FMO1 mRNA21515302
C016104sodium bichromatesodium bichromate results in decreased expression of FMO1 mRNA22155349
C016104sodium bichromatesodium bichromate results in decreased expression of FMO1 mRNA25993096
C016104sodium bichromatesodium bichromate results in increased expression of FMO1 mRNA12325037
D012965Sodium ChlorideSodium Chloride results in increased expression of FMO1 mRNA11719702
D012965Sodium ChlorideSodium Chloride results in increased expression of FMO1 mRNA19429252
D012965Sodium ChlorideSodium Chloride results in increased expression of FMO1 protein19429252
D013629TamoxifenTamoxifen affects the expression of FMO1 mRNA17555576
C501413tesaglitazartesaglitazar results in decreased expression of FMO1 mRNA21515302
D013739TestosteroneTestosterone results in decreased expression of FMO1 mRNA20600201|2166921
D013739TestosteroneTestosterone results in decreased expression of FMO1 protein12151634
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of FMO1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FMO1 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of FMO1 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of FMO1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FMO1 mRNA19933214|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FMO1 mRNA18765683|1879615
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FMO1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FMO1 mRNA11752688|1605489
D013752TetracyclineTetracycline results in decreased expression of FMO1 mRNA17522070
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of FMO1 mRNA28943392
D013853ThioacetamideThioacetamide affects the expression of FMO1 mRNA19483382
C009495titanium dioxidetitanium dioxide results in decreased expression of FMO1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of FMO1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of FMO1 mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FMO1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of FMO1 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of FMO1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of FMO1 mRNA19631733
C057693troglitazonetroglitazone results in increased expression of FMO1 mRNA19631733
C057693troglitazonetroglitazone results in decreased expression of FMO1 mRNA21515302
D014415TunicamycinTunicamycin results in decreased expression of FMO1 mRNA17127020
C073339usnic acid[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of FMO1 mRNA22777745
C406224valdecoxibvaldecoxib results in decreased expression of FMO1 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FMO1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of FMO1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of FMO1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of FMO1 mRNA17963808
C025643vinclozolinvinclozolin affects the expression of FMO1 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of FMO1 mRNA22570695
C029297vinylidene chloridevinylidene chloride results in decreased expression of FMO1 mRNA26682919
D014800VitalliumVitallium analog results in increased expression of FMO1 mRNA23825117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-IBA21873635  
GO:0004497monooxygenase activity-IDA19262426  
GO:0004499N,N-dimethylaniline monooxygenase activity-IDA15144220  
GO:0004499N,N-dimethylaniline monooxygenase activity-TAS-  
GO:0005515protein binding-IPI25910212  
GO:0050660flavin adenine dinucleotide binding-IEA-  
GO:0050661NADP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006082organic acid metabolic process-IDA15144220  
GO:0006805xenobiotic metabolic process-TAS-  
GO:0006970response to osmotic stress-IEA-  
GO:0009404toxin metabolic process-IDA15144220  
GO:0017144drug metabolic process-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0070995NADPH oxidation-IDA15144220  
GO ID GO Term Qualifier Evidence PubMed
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
KEGG ID KEGG Term
hsa00982Drug metabolism - cytochrome P450
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-217271FMO oxidises nucleophilesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28290528Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. (2018 Jan)Teitelbaum AMPharmacogenomics J
28413702Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American. (2017 Apr)Zhang TXBrain Behav
8117928Stereoselective metabolism of (S)-(-)-nicotine in humans: formation of trans-(S)-(-)-nicotine N-1'-oxide. (1993 Nov-Dec)Park SBChem Res Toxicol
21540762Common polymorphisms in FMO1 are associated with nicotine dependence. (2011 Jul)Hinrichs ALPharmacogenet Genomics