Gene: CAMTA1

23261
CANPMR
calmodulin binding transcription activator 1
protein-coding
1p36.31-p36.23
Ensembl:ENSG00000171735 MIM:611501 Vega:OTTHUMG00000001212 UniprotKB:Q9Y6Y1
NG_053148.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.563e-1 (AD)  3.676e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs75562159chr1:7444081 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10489142chr1:7303250 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04874074chr1:6855140CAMTA1Gene body2.276e-5Alcohol use disorders26763658
cg20972269chr1:7739821CAMTA1Gene body4.117e-4Alcohol use disorders26763658
cg04218548chr1:6941387CAMTA1Gene body6.880e-4Alcohol use disorders26763658
cg24999973chr1:7311132CAMTA11.260e-8Maternal smoking in pregnancy27040690
cg24999973chr1:7311132CAMTA15.160e-9Maternal smoking in pregnancy27040690
cg24999973chr1:7311132CAMTA15.370e-9Maternal smoking in pregnancy27040690
cg23972860chr1:7395024CAMTA13.200e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP6V1A0.972
TRIM370.97
PNMA20.97
MOAP10.966
SNAP910.965
PPP3CB0.963
ATP6V1C10.961
WDR470.961
KIF3A0.96
SUCLA20.96

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.581
OR4F29-0.534
CSAG1-0.49
RAI14-0.444
TFPI2-0.443
REST-0.432
CXCR2-0.428
FZD10-0.427
IL18RAP-0.423
MAGEA12-0.419

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of CAMTA1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CAMTA1 gene27153756
D000447AldehydesAldehydes results in increased expression of CAMTA1 mRNA25014914
D001151ArsenicArsenic results in decreased methylation of CAMTA1 promoter26771251
C044887beta-methylcholinebeta-methylcholine affects the expression of CAMTA1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased methylation of CAMTA1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of CAMTA1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CAMTA1 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of CAMTA1 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CAMTA1 gene20938992
D016572CyclosporineCyclosporine results in increased expression of CAMTA1 mRNA25562108
C014347decitabinedecitabine affects the expression of CAMTA1 mRNA23300844
D002945CisplatinCisplatin affects the expression of CAMTA1 mRNA23300844
D004041Dietary FatsDietary Fats results in increased expression of CAMTA1 mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CAMTA1 mRNA25242112
D004317DoxorubicinDoxorubicin affects the methylation of CAMTA1 gene28962528
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of CAMTA1 mRNA"23811387
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CAMTA1 mRNA23649840
C540355fenamidonefenamidone results in decreased expression of CAMTA1 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CAMTA1 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of CAMTA1 mRNA23649840
D017313FenretinideFenretinide results in increased expression of CAMTA1 mRNA28973697
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CAMTA1 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CAMTA1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CAMTA1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CAMTA1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CAMTA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CAMTA1 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of CAMTA1 mRNA23811387
D000073878Palm OilPalm Oil results in increased expression of CAMTA1 mRNA18042831
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of CAMTA1 mRNA18593933
C046012pentanalpentanal results in increased expression of CAMTA1 mRNA26079696
D011374ProgesteroneProgesterone results in decreased expression of CAMTA1 mRNA23018184
C005556propionaldehydepropionaldehyde results in increased expression of CAMTA1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of CAMTA1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CAMTA1 mRNA23806026|2589566
D012822Silicon DioxideSilicon Dioxide results in increased expression of CAMTA1 mRNA25351596
D012834SilverSilver results in increased expression of CAMTA1 mRNA26014281
C017947sodium arsenitesodium arsenite affects the expression of CAMTA1 mRNA29319823
D013739TestosteroneTestosterone results in increased expression of CAMTA1 mRNA21475673
D014050TolueneToluene results in decreased expression of CAMTA1 mRNA22967744
D014212TretinoinTretinoin results in decreased expression of CAMTA1 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of CAMTA1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CAMTA1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of CAMTA1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CAMTA1 mRNA24935251
D014635Valproic AcidValproic Acid results in increased methylation of CAMTA1 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of CAMTA1 mRNA23034163
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of CAMTA1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0035307positive regulation of protein dephosphorylation-IMP23853098  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0050885neuromuscular process controlling balance-IEA-  
GO:0070886positive regulation of calcineurin-NFAT signaling cascade-IMP23853098  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25466412Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis. (2015 Feb)Schaefer ASCirc Cardiovasc Genet