Gene: MTUS2

23281
CAZIP|ICIS|KIAA0774|TIP150
microtubule associated scaffold protein 2
protein-coding
13q12.3
Ensembl:ENSG00000132938 Vega:OTTHUMG00000016657 UniprotKB:Q5JR59
NC_000013.11
SNP Mapped
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.841e-1 (AD)  7.935e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1543660chr13:29281513 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs327127chr13:28944763 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCN8A0.953
LHFPL40.945
CACNG20.942
KCNH10.941
TMEM178B0.938
NBEA0.93
GRIN2B0.929
FAM78B0.927
PLXNA40.926
PCDHGC50.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.636
RAB13-0.631
ROM1-0.628
COPZ2-0.621
MYL3-0.592
YES1-0.582
CHST14-0.576
AGTRAP-0.573
S100A16-0.57
SNHG18-0.567

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MTUS2 mRNA"22698814
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTUS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTUS2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MTUS2 mRNA19770486
D001151ArsenicArsenic affects the methylation of MTUS2 gene25304211
C006780bisphenol Abisphenol A results in decreased expression of MTUS2 mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of MTUS2 protein28903499
D016572CyclosporineCyclosporine results in increased methylation of MTUS2 promoter27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MTUS2 mRNA21266533
C118739entinostatentinostat results in decreased expression of MTUS2 mRNA27188386
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MTUS2 mRNA26752646
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MTUS2 mRNA"26251327
D052998MicrocystinsMicrocystins results in increased expression of MTUS2 protein22430071
C028473N-acetyl-4-benzoquinoneimineMTUS2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MTUS2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MTUS2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MTUS2 mRNA"25620056
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MTUS2 mRNA23806026
D012834SilverSilver results in decreased expression of MTUS2 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of MTUS2 gene28589171
C009495titanium dioxidetitanium dioxide results in decreased expression of MTUS2 mRNA23557971
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTUS2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of MTUS2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of MTUS2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MTUS2 gene25560391
D015034Zinc OxideZinc Oxide analog results in decreased expression of MTUS2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  19060904  19543227  21516116  25416956  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-IDA19543227  
GO:0042803protein homodimerization activity-IPI19543227  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA19806667  
GO:0005737cytoplasmCOLOCALIZES_WITHIBA21873635  
GO:0005813centrosomecolocalizes_withIDA19543227  
GO:0005881cytoplasmic microtubulecolocalizes_withIDA19543227  
GO:0015630microtubule cytoskeletonCOLOCALIZES_WITHIBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal