Gene: FMO4

2329
FMO2
flavin containing monooxygenase 4
protein-coding
1q24.3
Ensembl:ENSG00000076258 MIM:136131 Vega:OTTHUMG00000035506 UniprotKB:P31512
NC_000001.11
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.148e-1 (AD)  2.942e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MCM50.798
C2orf680.768
RAD51B0.767
SLC35D20.754
FAM114A10.748
CPQ0.746
NPC20.743
PARP40.735
DERA0.735
GSN0.731

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TCERG1L-0.473
VGF-0.445
MARCH4-0.442
KCNK3-0.431
HUNK-0.431
GPR68-0.43
ADRA1D-0.43
OPRD1-0.429
KCNG1-0.427
FBLN7-0.426

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FMO4 mRNA"19114083
C5213345-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate affects the expression of FMO4 mRNA20932894
D000082AcetaminophenAcetaminophen results in decreased expression of FMO4 mRNA21420995|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FMO4 mRNA22100608|2715375
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FMO4 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FMO4 mRNA19770486
D047071beta-Glucansbeta-Glucans results in increased expression of FMO4 mRNA27910771
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FMO4 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FMO4 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of FMO4 mRNA25181051
D002737ChloropreneChloroprene results in increased expression of FMO4 mRNA23125180
D019826Cholic AcidCholic Acid results in increased expression of FMO4 mRNA17521389
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FMO4 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of FMO4 mRNA24386269
D003300CopperCopper results in decreased expression of FMO4 mRNA22465980
D016572CyclosporineCyclosporine results in decreased expression of FMO4 mRNA20106945|2798913
D003561CytarabineCytarabine results in decreased expression of FMO4 mRNA21198554
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FMO4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FMO4 mRNA28628672
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of FMO4 mRNA28962523
D002945CisplatinCisplatin results in decreased expression of FMO4 mRNA27392435
C121718dicyclanildicyclanil results in increased expression of FMO4 mRNA15664270
D002117CalcitriolCalcitriol results in increased expression of FMO4 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of FMO4 mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FMO4 mRNA"22485181
C509867E804 bisindoleE804 bisindole inhibits the reaction [Lipopolysaccharides results in increased expression of FMO4 mRNA]23107598
C509867E804 bisindoleE804 bisindole results in increased expression of FMO4 mRNA23107598
C509867E804 bisindoleLipopolysaccharides inhibits the reaction [E804 bisindole results in increased expression of FMO4 mRNA]23107598
C118739entinostatentinostat results in increased expression of FMO4 mRNA27188386
C010178heliotrineheliotrine results in decreased expression of FMO4 mRNA26100227
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FMO4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FMO4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of FMO4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FMO4 mRNA28628672
D008070LipopolysaccharidesE804 bisindole inhibits the reaction [Lipopolysaccharides results in increased expression of FMO4 mRNA]23107598
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [E804 bisindole results in increased expression of FMO4 mRNA]23107598
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of FMO4 mRNA23107598
D016686Monocrotaline[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA21224054
C498045NCX 4040NCX 4040 results in increased expression of FMO4 mRNA20188076
D009532NickelNickel results in decreased expression of FMO4 mRNA24768652|2558310
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of FMO4 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of FMO4 mRNA19270015|1948288
D010672Phenytoin[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA21224054
C006253pirinixic acidpirinixic acid results in increased expression of FMO4 mRNA18301758
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of FMO4 mRNA28903501
C005556propionaldehydepropionaldehyde results in increased expression of FMO4 mRNA26079696
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of FMO4 mRNA26100227
C059514resveratrol[resveratrol co-treated with Streptozocin] results in decreased expression of FMO4 mRNA25905778
D012293Rifampin[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA21224054
C009237senecioninesenecionine results in decreased expression of FMO4 mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of FMO4 mRNA26100227
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FMO4 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of FMO4 mRNA23221170
C017947sodium arsenitesodium arsenite affects the methylation of FMO4 gene28589171
C016104sodium bichromatesodium bichromate results in increased expression of FMO4 mRNA12325037
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in decreased expression of FMO4 mRNA25905778
D013629TamoxifenTamoxifen results in decreased expression of FMO4 mRNA25123088
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of FMO4 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of FMO4 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FMO4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FMO4 mRNA18765683
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FMO4 mRNA21215274|2172422
D013853ThioacetamideThioacetamide results in increased expression of FMO4 mRNA23411599
D014635Valproic AcidValproic Acid results in increased expression of FMO4 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of FMO4 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FMO4 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of FMO4 mRNA26682919
D015032ZincZinc deficiency results in decreased expression of FMO4 mRNA12888634

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-IBA21873635  
GO:0004499N,N-dimethylaniline monooxygenase activity-NAS1417778  
GO:0050660flavin adenine dinucleotide binding-IEA-  
GO:0050661NADP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0042737drug catabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
KEGG ID KEGG Term
hsa00982Drug metabolism - cytochrome P450
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal