Gene: ACSL6

23305
ACS2|FACL6|LACS 6|LACS2|LACS5
acyl-CoA synthetase long chain family member 6
protein-coding
5q31.1
Ensembl:ENSG00000164398 MIM:604443 Vega:OTTHUMG00000150692 UniprotKB:Q9UKU0
NG_028290.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.374e-1 (AD)  3.864e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LSAMP0.884
CNTN10.867
CTNNA20.863
SCG30.856
SLC6A10.851
NTM0.847
KIAA03190.846
ALDH5A10.844
ATPAF10.84
FUT90.839

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.558
TFPI2-0.496
SPINK8-0.493
OR4F29-0.486
SLAMF6-0.485
BEST3-0.479
DPPA4-0.452
GNG8-0.451
FOLR3-0.45
CD48-0.448

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of ACSL6 mRNA20566314
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ACSL6 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ACSL6 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ACSL6 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ACSL6 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ACSL6 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ACSL6 mRNA"25510870
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of ACSL6 mRNA10585473
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acidCycloheximide inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of ACSL6 mRNA]10585473
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acidDactinomycin inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of ACSL6 mRNA]10585473
D000082AcetaminophenAcetaminophen affects the expression of ACSL6 mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of ACSL6 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ACSL6 mRNA21641981
D000638AmiodaroneAmiodarone affects the expression of ACSL6 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ACSL6 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of ACSL6 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACSL6 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACSL6 mRNA22228805
C006780bisphenol Abisphenol A affects the methylation of ACSL6 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of ACSL6 mRNA25181051
D002746ChlorpromazineChlorpromazine affects the expression of ACSL6 mRNA25064622
D002994ClofibrateClofibrate results in decreased expression of ACSL6 mRNA18670166
D019327Copper SulfateCopper Sulfate results in decreased expression of ACSL6 mRNA19549813
D003513CycloheximideCycloheximide inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of ACSL6 mRNA]10585473
D016572CyclosporineCyclosporine affects the expression of ACSL6 mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of ACSL6 mRNA27989131
D003609DactinomycinDactinomycin inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of ACSL6 mRNA]10585473
D013759DronabinolDronabinol results in increased expression of ACSL6 mRNA16616335
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ACSL6 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of ACSL6 mRNA28302478
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in decreased expression of ACSL6 mRNA18313992
D004041Dietary FatsDietary Fats results in increased expression of ACSL6 mRNA18042831
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of ACSL6 mRNA]"23626681
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ACSL6 mRNA25064622
D011345FenofibrateFenofibrate results in increased expression of ACSL6 mRNA16595124
D005279FenoprofenACSL6 protein results in increased metabolism of Fenoprofen10725307
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of ACSL6 mRNA21782745
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of ACSL6 mRNA20566314
D007052IbuprofenACSL6 protein results in increased metabolism of Ibuprofen10725307
D008464MecamylamineMecamylamine inhibits the reaction [Nicotine results in increased expression of ACSL6 protein]22205969
D008694MethamphetamineACSL6 gene SNP affects the susceptibility to Methamphetamine18316681
D008727MethotrexateMethotrexate results in increased expression of ACSL6 mRNA17400583
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of ACSL6 mRNA21782745
C523799MRK 003ACSL6 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ACSL6 mRNA"25554681
D009538NicotineMecamylamine inhibits the reaction [Nicotine results in increased expression of ACSL6 protein]22205969
D009538NicotineNicotine results in increased expression of ACSL6 protein22205969
D009538NicotineNicotine results in increased expression of ACSL6 mRNA22205969
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in decreased expression of ACSL6 mRNA22561872
C464660obeticholic acidobeticholic acid results in increased expression of ACSL6 mRNA27939613
D000073878Palm OilPalm Oil results in increased expression of ACSL6 mRNA18042831
D010269ParaquatParaquat affects the expression of ACSL6 mRNA25064622
D052638Particulate MatterParticulate Matter results in decreased expression of ACSL6 mRNA17295261
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ACSL6 mRNA"25510870
C023036perfluorooctanoic acid"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of ACSL6 mRNA]"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ACSL6 mRNA23626681
D010852PicrotoxinPicrotoxin results in decreased expression of ACSL6 mRNA15170462
D011372ProgestinsProgestins results in increased expression of ACSL6 mRNA19609016
D011441PropylthiouracilPropylthiouracil results in decreased expression of ACSL6 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of ACSL6 mRNA21632981
C502851quinocetonequinocetone results in increased expression of ACSL6 mRNA27046791
D012999SomanSoman results in decreased expression of ACSL6 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ACSL6 mRNA11489354|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACSL6 mRNA28213091
D013752TetracyclineTetracycline affects the expression of ACSL6 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of ACSL6 mRNA25064622
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ACSL6 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of ACSL6 mRNA9452481
D014520UrethaneUrethane results in decreased expression of ACSL6 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ACSL6 mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of ACSL6 mRNA27188386|2915479
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ACSL6 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of ACSL6 mRNA17295261
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in decreased expression of ACSL6 mRNA18313992

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004467long-chain fatty acid-CoA ligase activity-NAS10548543  
GO:0004467long-chain fatty acid-CoA ligase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0042803protein homodimerization activity-IDA20429931  
GO:0102391decanoate-CoA ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001676long-chain fatty acid metabolic process-IEA-  
GO:0006637acyl-CoA metabolic process-NAS10548543  
GO:0035338long-chain fatty-acyl-CoA biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005741mitochondrial outer membrane-IEA-  
GO:0005778peroxisomal membrane-IEA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-NAS10548543  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00071Fatty acid degradation
hsa01100Metabolic pathways
hsa03320PPAR signaling pathway
hsa04146Peroxisome
hsa04920Adipocytokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-75105Fatty acyl-CoA biosynthesisTAS
R-HSA-75876Synthesis of very long-chain fatty acyl-CoAsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22205969ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. (2011)Chen JPLoS One