Gene: ICOSLG

23308
B7-H2|B7H2|B7RP-1|B7RP1|CD275|GL50|ICOS-L|ICOSL|LICOS
inducible T cell costimulator ligand
protein-coding
21q22.3
Ensembl:ENSG00000160223 MIM:605717 Vega:OTTHUMG00000086920 UniprotKB:O75144
NC_000021.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.647e-1 (AD)  3.641e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYRF0.903
CDC42EP10.903
CLDN110.89
PRIMA10.882
SLC45A30.882
MOG0.882
MAG0.878
TMC70.875
TMC60.868
ELOVL10.865

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.424
CALB2-0.384
WTIP-0.381
NPBWR1-0.378
CNGB1-0.372
PRTN3-0.366
LTK-0.346
CHRNA2-0.345
GRB14-0.344
PCDH8-0.344

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ICOSLG mRNA"27188386
C0293704-toluidine4-toluidine results in decreased expression of ICOSLG mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ICOSLG mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ICOSLG mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ICOSLG mRNA21641981
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ICOSLG mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of ICOSLG mRNA22521957
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ICOSLG mRNA22316170
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ICOSLG mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ICOSLG mRNA25181051
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ICOSLG mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of ICOSLG mRNA26272509
D016572CyclosporineCyclosporine results in increased expression of ICOSLG mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ICOSLG mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ICOSLG mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ICOSLG mRNA27594783
D002945CisplatinCisplatin results in increased expression of ICOSLG mRNA27392435
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of ICOSLG mRNA27638505
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ICOSLG mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ICOSLG mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of ICOSLG mRNA23649840
D017313FenretinideFenretinide results in increased expression of ICOSLG mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ICOSLG mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ICOSLG mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ICOSLG mRNA27392435
D007854LeadLead affects the expression of ICOSLG mRNA28903495
C045463leflunomideleflunomide results in increased expression of ICOSLG mRNA28988120
D008727MethotrexateMethotrexate results in decreased expression of ICOSLG mRNA17400583
D010100OxygenOxygen deficiency results in increased expression of ICOSLG mRNA26516004
D052638Particulate MatterParticulate Matter results in increased expression of ICOSLG mRNA17987463
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ICOSLG mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ICOSLG mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ICOSLG mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ICOSLG mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ICOSLG mRNA20106945|2163298
D013853ThioacetamideThioacetamide results in decreased expression of ICOSLG mRNA23411599
D014520UrethaneUrethane results in decreased expression of ICOSLG mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of ICOSLG gene29154799
D014638VanadatesVanadates results in decreased expression of ICOSLG mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased expression of ICOSLG mRNA17987463
C088658zoledronic acidzoledronic acid results in increased expression of ICOSLG mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IBA21873635  
GO:0005102signaling receptor binding-TAS11429535  
GO:0005515protein binding-IPI11956294  16951355  
GO:0042802identical protein binding-IPI16951355  
GO ID GO Term Qualifier Evidence PubMed
GO:0001817regulation of cytokine production-IBA21873635  
GO:0002250adaptive immune response-IEA-  
GO:0006952defense response-NAS11983910  
GO:0006972hyperosmotic response-NAS12145647  
GO:0007165signal transduction-NAS12145647  
GO:0031295T cell costimulation-TAS-  
GO:0042104positive regulation of activated T cell proliferation-TAS11429535  
GO:0042110T cell activation-NAS11983910  
GO:0042113B cell activation-IEA-  
GO:0050776regulation of immune response-IBA21873635  
GO:0050852T cell receptor signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-NAS12145647  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04672Intestinal immune network for IgA production
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-388841Costimulation by the CD28 familyTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20217071Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function. (2010 Apr)Pan FImmunogenetics