Gene: FMOD

2331
FM|SLRR2E
fibromodulin
protein-coding
1q32.1
Ensembl:ENSG00000122176 MIM:600245 Vega:OTTHUMG00000035910 UniprotKB:Q06828
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.104e-1 (AD)  3.229e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10800913chr1:203346765 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL8A10.797
COL14A10.796
OGN0.782
CYP1B10.748
C70.737
FBLIM10.735
ITIH30.723
SVIL0.718
DSP0.717
PLN0.716

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.36
HES6-0.347
NTSR2-0.344
CLDND2-0.339
C9orf24-0.337
BTBD17-0.332
HHATL-0.329
TTYH1-0.313
HAGHL-0.311
SLC25A48-0.308

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FMOD mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FMOD mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FMOD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FMOD mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of FMOD gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FMOD mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of FMOD mRNA"22863853
C006632arsenic trioxidearsenic trioxide results in decreased expression of FMOD mRNA26705709
C547126AZM551248AZM551248 results in increased expression of FMOD mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FMOD mRNA21871943|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FMOD mRNA20713471
D004958EstradiolEstradiol results in decreased expression of FMOD mRNA12469912
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FMOD mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of FMOD mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of FMOD mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FMOD mRNA28628672
C018475butyraldehydebutyraldehyde results in increased expression of FMOD mRNA26079696
D002211CapsaicinCapsaicin results in increased expression of FMOD mRNA20349343
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FMOD mRNA17484886
C084597chlorcyclizinechlorcyclizine results in increased expression of FMOD mRNA21058326
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in decreased expression of FMOD mRNA18078969
D003471CuprizoneCuprizone results in increased expression of FMOD mRNA26577399
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FMOD mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FMOD mRNA28628672
D003975DiazepamDiazepam results in decreased expression of FMOD mRNA19114084
D002945CisplatinFMOD protein affects the susceptibility to Cisplatin16217747
D004008DiclofenacDiclofenac results in decreased expression of FMOD mRNA26934552
D004041Dietary FatsDietary Fats results in increased expression of FMOD mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of FMOD mRNA15171707
D004237DiuronDiuron results in decreased expression of FMOD mRNA21551480|2515243
D004317DoxorubicinDoxorubicin results in decreased expression of FMOD mRNA19073829
C118739entinostatentinostat results in increased expression of FMOD mRNA27188386
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in increased expression of FMOD mRNA]15016801
D005473FluoxetineFluoxetine results in decreased expression of FMOD mRNA17033635
C039281furanfuran results in increased expression of FMOD mRNA27387713
D005839GentamicinsGentamicins results in decreased expression of FMOD mRNA22061828
C004312glycidolglycidol results in decreased expression of FMOD mRNA24915197
D017313FenretinideFenretinide results in decreased expression of FMOD mRNA28973697
D017313FenretinideFenretinide results in increased expression of FMOD mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of FMOD mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FMOD mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FMOD mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FMOD mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FMOD mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FMOD mRNA26644586
D008727MethotrexateFMOD protein affects the susceptibility to Methotrexate16217747
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of FMOD mRNA20713471
C523799MRK 003MRK 003 results in decreased expression of FMOD mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FMOD mRNA"25554681
D000073878Palm OilPalm Oil results in increased expression of FMOD mRNA18042831
D010672PhenytoinPhenytoin results in decreased expression of FMOD mRNA14741686
D011374ProgesteroneProgesterone results in decreased expression of FMOD mRNA23012394
C005556propionaldehydepropionaldehyde results in increased expression of FMOD mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of FMOD mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of FMOD mRNA27029645
D012402RotenoneRotenone results in decreased expression of FMOD mRNA27900601
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FMOD mRNA25895662
D012834SilverSilver results in decreased expression of FMOD mRNA27131904
D012969Sodium FluorideSodium Fluoride results in decreased expression of FMOD protein28918527
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of FMOD mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FMOD mRNA20106945|2163298
C009495titanium dioxidetitanium dioxide affects the expression of FMOD mRNA23557971
D014241TrichloroethyleneTrichloroethylene results in increased methylation of FMOD gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of FMOD mRNA19042947
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in decreased expression of FMOD mRNA18078969
D014520UrethaneUrethane results in decreased expression of FMOD mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FMOD mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of FMOD mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of FMOD mRNA26272509|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of FMOD mRNA19165385

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030021extracellular matrix structural constituent conferring compression resistance-HDA20551380  27559042  
GO ID GO Term Qualifier Evidence PubMed
GO:0007181transforming growth factor beta receptor complex assembly-TAS8093006  
GO:0018146keratan sulfate biosynthetic process-TAS-  
GO:0030199collagen fibril organization-IEA-  
GO:0042340keratan sulfate catabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA20551380  
GO:0005796Golgi lumen-TAS-  
GO:0031012extracellular matrix-TAS8093006  
GO:0043202lysosomal lumen-TAS-  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638074Keratan sulfate/keratin metabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-2022854Keratan sulfate biosynthesisTAS
R-HSA-2022857Keratan sulfate degradationTAS
R-HSA-3000178ECM proteoglycansIEA
R-HSA-3560782Diseases associated with glycosaminoglycan metabolismTAS
R-HSA-3656225Defective CHST6 causes MCDC1TAS
R-HSA-3656243Defective ST3GAL3 causes MCT12 and EIEE15TAS
R-HSA-3656244Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)TAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal