Gene: CUX2

23316
CDP2|CUTL2
cut like homeobox 2
protein-coding
12q24.11-q24.12
Ensembl:ENSG00000111249 MIM:610648 Vega:OTTHUMG00000169546 UniprotKB:O14529
NG_023039.1
PubMed|SNP Mapped
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.275e-1 (AD)  4.809e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4766566chr12:111269073 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6490029chr12:111260653 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4766453chr12:111254320 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14565408chr12:111589389CUX2Gene body3.051e-4Alcohol use disorders26763658
cg16235197chr12:111758873CUX23.000e-9Maternal smoking in pregnancy27040690
cg00029284chr12:111731203CUX22.330e-8Maternal smoking in pregnancy27040690
cg16235197chr12:111758873CUX25.190e-11Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDH220.894
PCDH80.884
MGAT5B0.876
PIP5K1B0.873
KCNQ40.863
VSTM2A0.859
CBLN40.854
HAPLN40.853
CTXN30.852
FAM19A20.849

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAYN-0.619
SGMS2-0.618
TGFB3-0.609
VRK2-0.599
CTNNA3-0.59
FAM107B-0.585
SNHG18-0.579
ACAP1-0.578
WIPF1-0.578
SH2D1A-0.575

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CUX2 mRNA"28903501
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CUX2 mRNA"19692669
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUX2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CUX2 mRNA29067470
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CUX2 mRNA]22129741
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CUX2 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CUX2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CUX2 gene27153756
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of CUX2 mRNA17023530
D001151ArsenicArsenic affects the methylation of CUX2 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of CUX2 mRNA"19446018
D001280AtrazineAtrazine results in decreased expression of CUX2 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of CUX2 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of CUX2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CUX2 mRNA20106945
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of CUX2 mRNA17404688
C006780bisphenol Abisphenol A affects the methylation of CUX2 promoter27334623
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of CUX2 gene28505145
C006780bisphenol Abisphenol A results in increased methylation of CUX2 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of CUX2 mRNA22079614
D002330CarmustineCarmustine affects the expression of CUX2 mRNA19174181
D016572CyclosporineCyclosporine results in decreased expression of CUX2 mRNA20106945|2798913
D003976DiazinonDiazinon results in increased methylation of CUX2 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CUX2 mRNA21266533
D004052DiethylnitrosamineAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CUX2 mRNA]22129741
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CUX2 mRNA22129741
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CUX2 mRNA22129741
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CUX2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CUX2 mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of CUX2 intron27776689
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of CUX2 gene28505145
D005839GentamicinsGentamicins results in decreased expression of CUX2 mRNA22061828
C016517indole-3-carbinolAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CUX2 mRNA]22129741
C016517indole-3-carbinolindole-3-carbinol affects the expression of CUX2 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CUX2 mRNA22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CUX2 mRNA22129741
D007545IsoproterenolIsoproterenol results in decreased expression of CUX2 mRNA20003209
C017461lead nitratelead nitrate affects the reaction [CUX2 affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [CUX2 affects the expression of MT2 mRNA]11891201
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CUX2 mRNA12057914
D008752Methylene ChlorideMethylene Chloride results in decreased expression of CUX2 mRNA28392392
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CUX2 mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CUX2 mRNA24810058
D009020MorphineMorphine results in increased expression of CUX2 mRNA21178816
D009151Mustard GasMustard Gas results in increased expression of CUX2 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CUX2 mRNA"25620056
D019829NevirapineNevirapine metabolite results in decreased expression of CUX2 mRNA23947594
D010416PentachlorophenolPentachlorophenol results in increased expression of CUX2 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of CUX2 mRNA19159669
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CUX2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of CUX2 mRNA20813756|2381119
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of CUX2 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of CUX2 mRNA18070364
D011374ProgesteroneProgesterone results in increased expression of CUX2 mRNA17404688
D011794QuercetinQuercetin results in increased expression of CUX2 mRNA21565894
D015474IsotretinoinIsotretinoin results in decreased expression of CUX2 mRNA20436886
D013629TamoxifenTamoxifen results in decreased expression of CUX2 mRNA25123088
D013629TamoxifenTamoxifen results in increased expression of CUX2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CUX2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CUX2 mRNA19692669|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CUX2 mRNA28922406
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CUX2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CUX2 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CUX2 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CUX2 mRNA21889950|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CUX2 mRNA21215274
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUX2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CUX2 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of CUX2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUX2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CUX2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CUX2 mRNA23179753|2352703
D014635Valproic AcidValproic Acid results in increased expression of CUX2 mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of CUX2 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-ISS-  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0043565sequence-specific DNA binding-IDA15656993  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IDA15656993  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007614short-term memory-ISS-  
GO:0010628positive regulation of gene expression-ISS-  
GO:0048193Golgi vesicle transport-IBA21873635  
GO:0050775positive regulation of dendrite morphogenesis-ISS-  
GO:0050890cognition-IMP15389760  
GO:0051965positive regulation of synapse assembly-ISS-  
GO:0061003positive regulation of dendritic spine morphogenesis-ISS-  
GO:0071310cellular response to organic substance-IEA-  
GO:2000463positive regulation of excitatory postsynaptic potential-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IBA21873635  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA15656993  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21270382Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. (2011 Apr)Baik IAm J Clin Nutr