Gene: RPGRIP1L

23322
CORS3|FTM|JBTS7|MKS5|NPHP8|PPP1R134
RPGRIP1 like
protein-coding
16q12.2
Ensembl:ENSG00000103494 MIM:610937 Vega:OTTHUMG00000173125 UniprotKB:Q68CZ1
NG_008991.2
PubMed
0   ANCO-SNPs
ND
1   
4.439e-1 (AD)  7.846e-1 (ND)   (Frontal_Cortex)
5.768e-1 (AD)  6.686e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DMXL20.933
LZTFL10.925
SLC35B40.924
PRKAA20.923
SCN2A0.922
GPRASP10.92
LMBR10.919
ST8SIA30.919
FZD30.918
OLFM30.918

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.58
RAB13-0.549
ROM1-0.54
MYL3-0.528
HEY2-0.517
CNN2-0.512
PXDC1-0.502
EMP3-0.501
RAI14-0.496
RNF135-0.492

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RPGRIP1L mRNA"28973690
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RPGRIP1L protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RPGRIP1L gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RPGRIP1L mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RPGRIP1L mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RPGRIP1L mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of RPGRIP1L mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RPGRIP1L gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of RPGRIP1L mRNA26079696
C026690cerous chloridecerous chloride results in decreased expression of RPGRIP1L mRNA23573234
D016572CyclosporineCyclosporine affects the expression of RPGRIP1L mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of RPGRIP1L mRNA25562108
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RPGRIP1L mRNA22079256
D007840LatexLatex analog results in decreased expression of RPGRIP1L mRNA24768652
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RPGRIP1L mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RPGRIP1L mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RPGRIP1L mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RPGRIP1L mRNA"25554681
D010936Plant ExtractsPlant Extracts results in increased expression of RPGRIP1L mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RPGRIP1L mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RPGRIP1L mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of RPGRIP1L mRNA23608068
D011794QuercetinQuercetin results in increased expression of RPGRIP1L mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of RPGRIP1L mRNA21632981
D010042OuabainOuabain results in decreased expression of RPGRIP1L mRNA16412265
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RPGRIP1L mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RPGRIP1L mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RPGRIP1L mRNA22298810
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of RPGRIP1L mRNA28065790
D014520UrethaneUrethane results in decreased expression of RPGRIP1L mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of RPGRIP1L mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RPGRIP1L mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17558407  19430481  21565611  26638075  27173435  
GO:0031870thromboxane A2 receptor binding-IPI19464661  
GO ID GO Term Qualifier Evidence PubMed
GO:0001736establishment of planar polarity-IEA-  
GO:0045744negative regulation of G-protein coupled receptor protein signaling pathway-IDA19464661  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA17558409  
GO:0005813centrosome-IDA17558409  21399614  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0005911cell-cell junction-IDA21565611  
GO:0005923bicellular tight junction-IEA-  
GO:0005929cilium-IDA17558409  
GO:0005930axoneme-IDA17558409  
GO:0035869ciliary transition zone-IDA26595381  
GO:0036064ciliary basal body-IDA17558409  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29455858A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018 Mar 1)Sung YJAm J Hum Genet