Gene: USP22

23326
USP3L
ubiquitin specific peptidase 22
protein-coding
17p11.2
Ensembl:ENSG00000124422 MIM:612116 Vega:OTTHUMG00000133621 UniprotKB:Q9UPT9
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.887e-1 (AD)  6.709e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25649826chr17:20938740USP223.000e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LARP10.968
EXOC70.963
MECP20.963
WDR820.961
PRRC2B0.959
ATP2A20.955
ATP9A0.955
CAMSAP10.955
KIAA01000.954
CYFIP20.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.668
OR4F29-0.631
CSAG1-0.394
TFPI2-0.379
IL18RAP-0.364
FMO3-0.359
CST7-0.357
MYL3-0.351
MTRNR2L6-0.342
CLEC2B-0.341

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of USP22 mRNA17562736
C006780bisphenol Abisphenol A affects the expression of USP22 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of USP22 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of USP22 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of USP22 mRNA15003993
C000944dicrotophosdicrotophos results in increased expression of USP22 mRNA28302478
D011345FenofibrateFenofibrate results in increased expression of USP22 mRNA21318169
D011345FenofibratePPARA protein affects the reaction [Fenofibrate results in increased expression of USP22 mRNA]21318169
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of USP22 mRNA"24972896
D008727MethotrexateMethotrexate results in decreased expression of USP22 mRNA24449571
C059539midostaurinmidostaurin results in decreased expression of USP22 mRNA20980353
D009151Mustard GasMustard Gas affects the expression of USP22 mRNA26392148
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of USP22 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of USP22 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of USP22 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of USP22 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of USP22 mRNA]17655762
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of USP22 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of USP22 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of USP22 mRNA]17655762
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of USP22 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of USP22 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of USP22 mRNA19482888
C049032pinosylvinpinosylvin results in decreased expression of USP22 mRNA23333577
C006253pirinixic acidpirinixic acid results in increased expression of USP22 mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of USP22 mRNA]21318169
C031280pyrazolepyrazole results in increased expression of USP22 mRNA17945193
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of USP22 mRNA21570461
D013853ThioacetamideThioacetamide results in increased expression of USP22 mRNA23411599
C012589trichostatin Atrichostatin A results in decreased expression of USP22 mRNA28542535
D014635Valproic AcidValproic Acid affects the expression of USP22 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of USP22 mRNA22083351|2915479
D014635Valproic AcidValproic Acid results in increased methylation of USP22 gene29154799
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of USP22 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of USP22 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of USP22 mRNA]17655762

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-IDA18206972  
GO:0004843thiol-dependent ubiquitin-specific protease activity-IDA16378762  
GO:0004843thiol-dependent ubiquitin-specific protease activitycontributes_toIMP18206973  
GO:0005515protein binding-IPI18206972  19615732  21779003  24561192  25416956  27601583  
GO:0008270zinc ion binding-IEA-  
GO:0010485H4 histone acetyltransferase activitycontributes_toIDA18206973  
GO:0019899enzyme binding-IPI23382074  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IMP18206972  
GO:0036459thiol-dependent ubiquitinyl hydrolase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006511ubiquitin-dependent protein catabolic process-IEA-  
GO:0007049cell cycle-IEA-  
GO:0009792embryo development ending in birth or egg hatching-NAS16378762  
GO:0016574histone ubiquitination-IDA18469533  
GO:0016578histone deubiquitination-IDA18206972  18206973  
GO:0016579protein deubiquitination-IDA16378762  
GO:0016579protein deubiquitination-TAS-  
GO:0043967histone H4 acetylation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IMP18206973  
GO:0045931positive regulation of mitotic cell cycle-IMP18206973  
GO ID GO Term Qualifier Evidence PubMed
GO:0000124SAGA complex-IDA18206972  18206973  27601583  
GO:0005654nucleoplasm-TAS-  
GO:0016607nuclear speck-IDA-  
GO:0070461SAGA-type complexcolocalizes_withIDA18838386  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-3214847HATs acetylate histonesIEA
R-HSA-3247509Chromatin modifying enzymesIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4839726Chromatin organizationIEA
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25241865[Expression of cancer stem cell marker USP22 in laryngeal squamous cell carcinoma]. (2014 Jun)Li LZhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi