Gene: NEDD4L

23327
NEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
protein-coding
18q21.31
Ensembl:ENSG00000049759 MIM:606384 Vega:OTTHUMG00000179875 UniprotKB:Q96PU5
NG_029954.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.294e-1 (AD)  2.638e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ST8SIA30.945
TANC20.944
GABRB30.943
PDP10.943
CNKSR20.941
CELF20.94
ATP2B10.939
JPH10.938
KCNMA10.937
LONRF20.936

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.519
HEY2-0.499
OR4F5-0.49
SNHG18-0.482
COPZ2-0.481
FZD10-0.481
MYL3-0.479
MBNL3-0.476
REST-0.467
YES1-0.463

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of NEDD4L mRNA28329830
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NEDD4L mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NEDD4L mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NEDD4L mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NEDD4L mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NEDD4L mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NEDD4L mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NEDD4L mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NEDD4L mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEDD4L mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEDD4L mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEDD4L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEDD4L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEDD4L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEDD4L mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of NEDD4L mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of NEDD4L mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NEDD4L mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NEDD4L gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of NEDD4L mRNA21757418
D000450AldosteroneAldosterone inhibits the reaction [NEDD4L gene mutant form results in decreased cleavage of SCNN1A protein]23348737
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of NEDD4L mRNA28522335
D001151ArsenicArsenic affects the methylation of NEDD4L gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of NEDD4L mRNA"18687144
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NEDD4L mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NEDD4L mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NEDD4L mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NEDD4L mRNA"19150397|2623829
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NEDD4L mRNA20061341
D004958EstradiolEstradiol affects the expression of NEDD4L mRNA22574217
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NEDD4L mRNA19619570
D004958EstradiolEstradiol results in decreased expression of NEDD4L mRNA19167446
D004958EstradiolEstradiol results in increased expression of NEDD4L mRNA19619570
D004958EstradiolEstradiol affects the expression of NEDD4L mRNA15598610
C006780bisphenol Abisphenol A results in decreased expression of NEDD4L mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of NEDD4L mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of NEDD4L protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of NEDD4L mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of NEDD4L mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NEDD4L mRNA20061341
C037123cadmium sulfatecadmium sulfate results in increased expression of NEDD4L mRNA21783983
D002118Calcium"[NEDD4L gene mutant form results in increased susceptibility to Sodium, Dietary] which results in increased abundance of Calcium"23348737
D002118Calcium"Thiazides inhibits the reaction [[NEDD4L gene mutant form results in increased susceptibility to Sodium, Dietary] which results in increased abundance of Calcium]"23348737
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NEDD4L mRNA17484886
D004390ChlorpyrifosChlorpyrifos results in increased expression of NEDD4L mRNA21356183
D002994ClofibrateClofibrate results in decreased expression of NEDD4L mRNA17585979
D003042CocaineCocaine results in increased expression of NEDD4L mRNA15009677
D019327Copper SulfateCopper Sulfate results in decreased expression of NEDD4L mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NEDD4L mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of NEDD4L mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of NEDD4L mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of NEDD4L mRNA20106945
C017180decamethrindecamethrin results in increased expression of NEDD4L mRNA19017407
C014347decitabinedecitabine results in decreased expression of NEDD4L mRNA19363521
C014347decitabineTP53 protein affects the reaction [decitabine results in decreased expression of NEDD4L mRNA]19363521
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of NEDD4L mRNA27392435
D002945CisplatinCisplatin results in decreased expression of NEDD4L mRNA19561079
D004008DiclofenacDiclofenac results in increased expression of NEDD4L mRNA26934552
D004041Dietary FatsDietary Fats results in decreased expression of NEDD4L mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of NEDD4L mRNA15171707
D004237DiuronDiuron results in decreased expression of NEDD4L mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of NEDD4L mRNA25896364
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NEDD4L mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NEDD4L mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEDD4L mRNA17942748
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of NEDD4L mRNA28329830
D005839GentamicinsGentamicins results in decreased expression of NEDD4L mRNA22061828
D017313FenretinideFenretinide results in decreased expression of NEDD4L mRNA28973697
D017313FenretinideFenretinide results in increased expression of NEDD4L mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NEDD4L mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of NEDD4L mRNA27392435
C410337K 7174K 7174 results in increased expression of NEDD4L mRNA24086573
D007854LeadLead affects the splicing of NEDD4L mRNA28903495
C045463leflunomideleflunomide results in increased expression of NEDD4L mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NEDD4L mRNA"18930950
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NEDD4L mRNA16415329
C025340manganese chloridemanganese chloride results in increased expression of NEDD4L mRNA20737472
C025340manganese chloridemanganese chloride results in increased expression of NEDD4L protein20737472
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NEDD4L mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NEDD4L mRNA20061341
D020366MethylmethacrylateMethylmethacrylate results in increased expression of NEDD4L mRNA16916219
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NEDD4L mRNA26011545
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of NEDD4L protein24625837
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of NEDD4L mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NEDD4L mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NEDD4L mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NEDD4L mRNA"25620056
D009532NickelNickel results in decreased expression of NEDD4L mRNA24768652|2558310
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NEDD4L mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of NEDD4L mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of NEDD4L mRNA18042831
C016030pantogabpantogab results in increased expression of NEDD4L mRNA17379144
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NEDD4L mRNA"25510870
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of NEDD4L mRNA18593933
C046012pentanalpentanal results in decreased expression of NEDD4L mRNA26079696
D010634PhenobarbitalPhenobarbital results in decreased expression of NEDD4L mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEDD4L mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of NEDD4L mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of NEDD4L mRNA18301758|1844570
D010938Plant OilsPlant Oils results in increased expression of NEDD4L mRNA23370395
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NEDD4L mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NEDD4L mRNA22079256
D011441PropylthiouracilPropylthiouracil results in decreased expression of NEDD4L mRNA24780913
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of NEDD4L protein16020936
D011794QuercetinQuercetin results in decreased expression of NEDD4L mRNA21632981
D011899Ranitidine[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NEDD4L mRNA16415329
C059514resveratrolresveratrol results in decreased expression of NEDD4L mRNA22610192
C059514resveratrolresveratrol results in increased expression of NEDD4L mRNA19228061
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NEDD4L mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of NEDD4L mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of NEDD4L mRNA19073995
D012982Sodium, Dietary"NEDD4L gene mutant form results in increased susceptibility to Sodium, Dietary"23348737
D012982Sodium, Dietary"[NEDD4L gene mutant form results in increased susceptibility to Sodium, Dietary] which results in increased abundance of Calcium"23348737
D012982Sodium, Dietary"Thiazides inhibits the reaction [[NEDD4L gene mutant form results in increased susceptibility to Sodium, Dietary] which results in increased abundance of Calcium]"23348737
D053260SootSoot results in increased expression of NEDD4L mRNA26551751
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NEDD4L mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NEDD4L mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NEDD4L mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NEDD4L mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEDD4L mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NEDD4L mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NEDD4L mRNA18691609
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NEDD4L mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NEDD4L mRNA21724226
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NEDD4L mRNA25613284
D013806TheophyllineTheophylline results in increased expression of NEDD4L mRNA16083514
D049971Thiazides"Thiazides inhibits the reaction [[NEDD4L gene mutant form results in increased susceptibility to Sodium, Dietary] which results in increased abundance of Calcium]"23348737
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NEDD4L mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NEDD4L mRNA25729387
D019772TopotecanTopotecan results in decreased expression of NEDD4L mRNA25729387
D014212TretinoinTretinoin results in increased expression of NEDD4L mRNA23830798
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEDD4L mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of NEDD4L mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NEDD4L mRNA"26179874
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NEDD4L mRNA"18930950
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEDD4L mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NEDD4L mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NEDD4L mRNA19101580|2317975
D014635Valproic AcidValproic Acid affects the expression of NEDD4L mRNA17292431
C111237vorinostatvorinostat results in decreased expression of NEDD4L mRNA17218635
C070417Win 55212-2Win 55212-2 results in decreased expression of NEDD4L mRNA12237329
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of NEDD4L mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-EXP19028597  
GO:0004842ubiquitin-protein transferase activity-NAS11244092  
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0005515protein binding-IPI11244092  18577513  19664597  19706893  20086093  22024150  
23529131  23686771  25416956  27445338  
GO:0015459potassium channel regulator activity-IDA17289006  
GO:0017080sodium channel regulator activity-IDA11244092  
GO:0019870potassium channel inhibitor activity-IDA21463633  
GO:0019871sodium channel inhibitor activity-IDA15217910  
GO:0044325ion channel binding-IPI15217910  21463633  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS-  
GO:0000209protein polyubiquitination-IBA21873635  
GO:0000209protein polyubiquitination-TAS-  
GO:0003254regulation of membrane depolarization-IDA15217910  
GO:0006511ubiquitin-dependent protein catabolic process-IDA21463633  
GO:0006513protein monoubiquitination-IEA-  
GO:0006814sodium ion transport-NAS11244092  
GO:0006883cellular sodium ion homeostasis-NAS11244092  
GO:0007588excretion-NAS11244092  
GO:0010038response to metal ion-IDA11244092  
GO:0016567protein ubiquitination-IBA21873635  
GO:0016567protein ubiquitination-IDA15217910  25631046  
GO:0016567protein ubiquitination-IMP27445338  
GO:0016567protein ubiquitination-NAS11244092  
GO:0019058viral life cycle-TAS-  
GO:0030104water homeostasis-NAS11244092  
GO:0031647regulation of protein stability-IMP27445338  
GO:0034220ion transmembrane transport-TAS-  
GO:0034765regulation of ion transmembrane transport-IDA17289006  
GO:0042176regulation of protein catabolic process-NAS11244092  
GO:0042391regulation of membrane potential-IDA17289006  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IDA21463633  
GO:0045732positive regulation of protein catabolic process-IBA21873635  
GO:0045732positive regulation of protein catabolic process-IEA-  
GO:0045807positive regulation of endocytosis-NAS11244092  
GO:0048814regulation of dendrite morphogenesis-IBA21873635  
GO:0060306regulation of membrane repolarization-IDA21463633  
GO:0070936protein K48-linked ubiquitination-IDA21463633  
GO:0086005ventricular cardiac muscle cell action potential-ISS22879586  
GO:1901016regulation of potassium ion transmembrane transporter activity-IDA17289006  
GO:1901017negative regulation of potassium ion transmembrane transporter activity-IDA21463633  
GO:1901380negative regulation of potassium ion transmembrane transport-IBA21873635  
GO:1901380negative regulation of potassium ion transmembrane transport-IDA21463633  
GO:1902306negative regulation of sodium ion transmembrane transport-IDA15217910  
GO:1903861positive regulation of dendrite extension-IDA23999003  
GO:2000009negative regulation of protein localization to cell surface-IDA21463633  
GO:2000650negative regulation of sodium ion transmembrane transporter activity-IBA21873635  
GO:2000650negative regulation of sodium ion transmembrane transporter activity-IDA15217910  
GO:2001288positive regulation of caveolin-mediated endocytosis-ISS22879586  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IC11244092  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005771multivesicular body-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membranecolocalizes_withIDA22879586  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
hsa04144Endocytosis
hsa04960Aldosterone-regulated sodium reabsorption
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162587HIV Life CycleTAS
R-HSA-162588Budding and maturation of HIV virionTAS
R-HSA-162599Late Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionTAS
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2173788Downregulation of TGF-beta receptor signalingIEA
R-HSA-2173789TGF-beta receptor signaling activates SMADsIEA
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerTAS
R-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activityTAS
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-9006936Signaling by TGF-beta family membersTAS
R-HSA-9006936Signaling by TGF-beta family membersIEA
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23812770Identification of the NEDD4L gene as a prognostic marker by integrated microarray analysis of copy number and gene expression profiling in non-small cell lung cancer. (2013 Dec)Sakashita HAnn Surg Oncol
21154329[Association of the rs4149601 polymorphism of NEDD4L gene with obesity in Xinjiang Kazakh population]. (2010 Dec)Wang HMZhonghua Yi Xue Yi Chuan Xue Za Zhi
20003179Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study. (2009 Dec 9)Li NBMC Med Genet
24446284Gender flip-flop association between genetic variations of NEDD4L and metabolic syndrome in the Kazakh general population. (2014 Jan 8)Wang HMGenet Mol Res