Gene info: ID 23328

Gene: SASH1

GENE ID: 23328

Synonyms: SH3D6A|dJ323M4.1

Description: SAM and SH3 domain containing 1

Gene type: protein-coding

Location: 6q24.3-q25.1

dbXrefs: Ensembl:ENSG00000111961 MIM:607955 Vega:OTTHUMG00000015773 UniprotKB:O94885

RefSeq: NG_051927.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.389e-1 (AD) 9.224e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PPARA	0.9
ADD3	0.892
RHOBTB3	0.887
KANK1	0.887
KAT2B	0.884
MYO10	0.883
MSI2	0.883
TEAD1	0.879
TP53BP2	0.878
GOLIM4	0.872

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.496
OR4F5	-0.486
MCHR1	-0.428
RTP1	-0.428
ABCC12	-0.412
DUSP27	-0.412
CACNA1F	-0.411
MYOZ3	-0.411
RHO	-0.401
TRABD2A	-0.398

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of SASH1 mRNA"	20453058
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SASH1 mRNA"	19167446
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of SASH1 mRNA"	26238291
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SASH1 mRNA	19770486
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of SASH1 mRNA	21757418
C006632	arsenic trioxide	arsenic trioxide results in increased expression of SASH1 mRNA	20458559
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of SASH1 mRNA"	25351596
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SASH1 mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SASH1 mRNA	21632981\|2231617
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SASH1 mRNA"	19150397\|2001819
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SASH1 mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of SASH1 mRNA	19619570
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of SASH1 mRNA	17404688
C006780	bisphenol A	bisphenol A results in increased expression of SASH1 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of SASH1 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in decreased expression of SASH1 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SASH1 mRNA	20883709
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SASH1 mRNA	24763279
D003035	Cobalt	[tungsten carbide co-treated with Cobalt] results in decreased expression of SASH1 mRNA	18078969
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SASH1 mRNA	19320972
D019327	Copper Sulfate	Copper Sulfate results in increased expression of SASH1 mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SASH1 mRNA"	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of SASH1 mRNA	19167446
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SASH1 mRNA	22079256
D004397	Fonofos	Fonofos results in increased methylation of SASH1 promoter	22847954
C071834	glycidamide	glycidamide results in decreased expression of SASH1 mRNA	17822822
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SASH1 mRNA	24763279
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SASH1 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SASH1 mRNA	24796395
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SASH1 mRNA"	26251327
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of SASH1 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SASH1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of SASH1 mRNA"	25554681\|2562005
D010278	Parathion	Parathion results in increased methylation of SASH1 promoter	22847954
D010634	Phenobarbital	Phenobarbital affects the expression of SASH1 mRNA	23091169
C006253	pirinixic acid	pirinixic acid results in decreased expression of SASH1 mRNA	20813756
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SASH1 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of SASH1 mRNA	22079256
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of SASH1 mRNA	17404688
D011374	Progesterone	Progesterone affects the expression of SASH1 mRNA	17251523
C045950	propiconazole	propiconazole results in decreased expression of SASH1 mRNA	21278054
D011794	Quercetin	Quercetin results in increased expression of SASH1 mRNA	21632981
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of SASH1 mRNA	25351596
C017947	sodium arsenite	sodium arsenite results in decreased expression of and affects the splicing of SASH1 mRNA	25879800
C017947	sodium arsenite	sodium arsenite results in decreased expression of SASH1 protein	21925251
C017947	sodium arsenite	sodium arsenite results in increased expression of SASH1 mRNA	20883709
C012568	terbufos	terbufos results in increased methylation of SASH1 promoter	22847954
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SASH1 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SASH1 mRNA	11489354\|1961957
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SASH1 mRNA	19465110
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SASH1 mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of SASH1 mRNA	28065790
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in decreased expression of SASH1 mRNA"	17951470
D014212	Tretinoin	Tretinoin results in increased expression of SASH1 mRNA	21934132
C012589	trichostatin A	trichostatin A results in increased expression of SASH1 mRNA	24935251
C057693	troglitazone	troglitazone results in decreased expression of SASH1 mRNA	28973697
C002802	tungsten carbide	[tungsten carbide co-treated with Cobalt] results in decreased expression of SASH1 mRNA	18078969
D014520	Urethane	Urethane results in increased expression of SASH1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of SASH1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of SASH1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of SASH1 mRNA	19101580\|2317975
D014640	Vancomycin	Vancomycin results in decreased expression of SASH1 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SASH1 gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of SASH1 mRNA	23034163
D014810	Vitamin E	Vitamin E results in decreased expression of SASH1 mRNA	19244175
D024483	Vitamin K 3	Vitamin K 3 affects the expression of SASH1 mRNA	20044591
C088658	zoledronic acid	zoledronic acid results in decreased expression of SASH1 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0008022	protein C-terminus binding	-	IDA	23776175
GO:0019901	protein kinase binding	-	IDA	23776175
GO:0031435	mitogen-activated protein kinase kinase kinase binding	-	IBA	21873635
GO:0031435	mitogen-activated protein kinase kinase kinase binding	-	IDA	23776175
GO:0032947	protein-containing complex scaffold activity	-	IDA	23776175

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000209	protein polyubiquitination	-	IDA	23776175
GO:0009966	regulation of signal transduction	-	IBA	21873635
GO:0010595	positive regulation of endothelial cell migration	-	IDA	23776175
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	-	IMP	23776175
GO:0043507	positive regulation of JUN kinase activity	-	IBA	21873635
GO:0043507	positive regulation of JUN kinase activity	-	IMP	23776175
GO:0045766	positive regulation of angiogenesis	-	IMP	23776175
GO:1900044	regulation of protein K63-linked ubiquitination	-	IDA	23776175
GO:1900745	positive regulation of p38MAPK cascade	-	IMP	23776175
GO:1901224	positive regulation of NIK/NF-kappaB signaling	-	IBA	21873635
GO:1901224	positive regulation of NIK/NF-kappaB signaling	-	IMP	23776175
GO:1902498	regulation of protein autoubiquitination	-	IDA	23776175

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0032991	protein-containing complex	-	IMP	23776175

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28085253	Crowd-Sourced Verification of Computational Methods and Data in Systems Toxicology: A Case Study with a Heat-Not-Burn Candidate Modified Risk Tobacco Product. (2017 Apr 17)	Poussin C	Chem Res Toxicol
26318107	SASH1, a new potential link between smoking and atherosclerosis. (2015 Oct)	Weidmann H	Atherosclerosis
26614807	Identification of gene expression signature for cigarette smoke exposure response--from man to mouse. (2015 Dec)	Martin F	Hum Exp Toxicol
23372645	Graphical modeling of gene expression in monocytes suggests molecular mechanisms explaining increased atherosclerosis in smokers. (2013)	Verdugo RA	PLoS One