Gene: TTC28

23331
TPRBK
tetratricopeptide repeat domain 28
protein-coding
22q12.1
Ensembl:ENSG00000100154 MIM:615098 Vega:OTTHUMG00000151006 UniprotKB:Q96AY4
NC_000022.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.096e-2 (AD)  2.521e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6005754chr22:28286628 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MED120.803
EP3000.802
IGF1R0.784
ARID1A0.78
SPEN0.78
PHF120.772
KMT2C0.766
TAF80.761
BAZ2A0.758
ANKFY10.754

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.424
OR4F29-0.39
GHRH-0.311
KLRC2-0.294
C22orf42-0.283
HCRT-0.281
OTP-0.277
LHX5-0.272
ODAM-0.271
FOXB1-0.269

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TTC28 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TTC28 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TTC28 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TTC28 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TTC28 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TTC28 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTC28 mRNA"27188386
C0293704-toluidine4-toluidine results in decreased expression of TTC28 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTC28 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TTC28 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TTC28 mRNA21641981|2210060
D000393Air PollutantsAir Pollutants analog results in decreased expression of TTC28 mRNA21757418
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TTC28 mRNA24449571
D001151ArsenicArsenic affects the methylation of TTC28 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of TTC28 mRNA27829220
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TTC28 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to TTC28 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TTC28 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TTC28 mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TTC28 mRNA"20382639|2623829
C006780bisphenol Abisphenol A results in decreased expression of TTC28 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TTC28 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of TTC28 mRNA26079696
D003471CuprizoneCuprizone results in increased expression of TTC28 mRNA26577399
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TTC28 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TTC28 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TTC28 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of TTC28 mRNA28302478
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TTC28 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TTC28 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TTC28 mRNA27392435
C031895lead chromatelead chromate results in decreased expression of TTC28 mRNA23584427
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TTC28 mRNA28001369
D009151Mustard GasMustard Gas affects the expression of TTC28 mRNA15651846
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TTC28 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TTC28 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TTC28 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of TTC28 mRNA25729387
D010100OxygenOxygen deficiency affects the methylation of TTC28 promoter24205000
D010100OxygenOxygen deficiency results in increased expression of TTC28 mRNA24205000
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TTC28 mRNA"25510870
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TTC28 mRNA22714537
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TTC28 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TTC28 mRNA23221170
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of TTC28 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TTC28 mRNA19933214
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TTC28 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TTC28 mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of TTC28 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTC28 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of TTC28 mRNA26272509|2800136
D014635Valproic AcidValproic Acid results in increased methylation of TTC28 gene29154799
D014638VanadatesVanadates results in decreased expression of TTC28 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TTC28 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0019900kinase binding-IPI23036704  
GO ID GO Term Qualifier Evidence PubMed
GO:0007049cell cycle-IEA-  
GO:0007346regulation of mitotic cell cycle-IMP23036704  
GO:0051301cell division-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0005815microtubule organizing center-IEA-  
GO:0030496midbody-IDA23036704  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal